1 Think about… 6.1 The process of human nutrition 6.2 The human digestive system 6.3 Ingestion of food 6.4 Movement of food along the alimentary canal 6.5 Digestion of food 6.6 Absorption of digested food 6.7 Assimilation of absorbed food 6.8 Egestion Recall ‘Think about…’ Summary concept map 2 Weight loss surgery can help obese people lose weight 3 stomach ileum small bag created at the top of stomach it connects directly to ileum food bypasses larger stomach and duodenum duodenum 4 1 What is the role of the stomach 5 2 How does the surgery help people lose weight 6 3 What will happen if the food does not pass through the ileum also 7 6.1 The processes of human nutrition food 1 ingestion (攝食) 2 digestion (消化) complex and insoluble food molecules simple and soluble food molecules 8 6.1 The processes of human nutrition 1 ingestion (攝食) 2 digestion (消化) 5 egestion (排遺) digested 3 absorption food (吸收) 4 assimilation (同化) 9 faeces 6.1 The processes of human nutrition The five main processes of nutrition in humans are ingestion digestion , absorption , assimilation and egestion . 10 6.2 The human digestive system What does our digestive system (消化系統) consist of? 11 6.2 The human digestive system Digestive system Alimentary canal (消化道) Glands (腺) 12 6.2 The human digestive system Alimentary canal 1 mouth cavity 2 pharynx (咽) 3 oesophagus (食道) 4 stomach 13 6.2 The human digestive system Alimentary canal duodenum 5 small intestine 6 large intestine ileum colon rectum 7 anus (肛門) 14 6.2 The human digestive system Glands salivary glands pancreas (胰) liver 15 6.2 The human digestive system 6.1 Video Examination of the mammalian alimentary canal and its associated glands 1 Examine the digestive system of a dissected rat (or a human torso model). 16 17 6.2 The human digestive system 6.1 2 Identify the structures as shown in the figure. 18 6.2 The human digestive system 1 Our digestive system consists of the alimentary canal and its associated glands . 19 6.2 The human digestive system 2 Alimentary canal: mouth cavity pharynx start oesophagus stomach small intestine end anus large intestine 20 6.2 The human digestive system 3 Associated glands: salivary glands , pancreas , liver 21 6.3 Ingestion of food mouth cavity • food is taken in through the mouth 22 6.3 Ingestion of food teeth • mastication (咀嚼): chewing food into small pieces 23 24 6.3 Ingestion of food A) Types of teeth 1 Incisors (門齒) • for biting and cutting food chisel-shaped (鑿形的) flat sharp edges one root 25 6.3 Ingestion of food A) Types of teeth 2 Canine (犬齒) • well-developed in carnivores • for tearing flesh pointed and curved one root 26 6.3 Ingestion of food A) Types of teeth 3 Premolar (前臼齒) • for cutting and grinding food broad top with cusps 1 or 2 roots 27 6.3 Ingestion of food A) Types of teeth 4 Molar (臼齒) • similar to premolar but larger 2 or 3 roots 28 6.3 Ingestion of food B) Structure of a tooth • divided into crown (齒冠) neck (齒頸) root (齒根) 29 6.3 Ingestion of food 1 Enamel (琺瑯質) • the outermost, hardest region • non-living and is made mainly of calcium salt • protects teeth from wearing off 30 6.3 Ingestion of food 1 Enamel (琺瑯質) Around the roots… • replaced by cement (牙骨質) • fibres from cement form periodontal membrane (牙周膜) cement periodontal membrane 31 6.3 Ingestion of food 2 Dentine (牙本質) • the middle region of the tooth • contains strands of living cytoplasm 32 6.3 Ingestion of food 3 Pulp cavity (髓腔) living cells nerve fibres blood vessels 33 6.3 Ingestion of food 3 Pulp cavity (髓腔) nerve fibres • detect temperature and pressure blood vessels • supply oxygen and nutrient • remove waste 34 6.3 Ingestion of food C) Dentition of humans • dentition (齒系): number and arrangement of different types of teeth • represented by a dental formula (齒式) 35 6.3 Ingestion of food C) Dentition of humans • on each side of the upper jaw: 2 incisors 1 canine 2 premolars 3 molars 36 6.3 Ingestion of food C) Dentition of humans • on each side of the lower jaw: 2 incisors 1 canine 2 premolars 3 molars 37 6.3 Ingestion of food C) Dentition of humans • dental formula of an adult: 3 2 1 2 i , c , pm , m 3 2 1 2 2123 2123 38 6.3 Ingestion of food D) Milk teeth and permanent teeth • first set of teeth: milk teeth (乳齒) • appear during the first two years 2102 • dental formula: 2102 39 6.3 Ingestion of food D) Milk teeth and permanent teeth • second set of teeth: permanent teeth (恆齒) • replace milk teeth between the ages of 6 and 12 • will not be replaced when lost 40 6.3 Ingestion of food D) Milk teeth and permanent teeth permanent teeth milk teeth 41 6.3 Ingestion of food 1 Food is put into the mouth cavity and cut up by teeth . The process of chewing food into small pieces is called mastication . 42 6.3 Ingestion of food 2 Match the functions of different types of teeth: incisors canine premolars molars tearing flesh biting and cutting crushing and grinding 43 6.3 Ingestion of food 3a Label the structure of the tooth. crown neck root 44 6.3 Ingestion of food 3b Label the structure of the tooth. enamel dentine pulp cavity 45 6.3 Ingestion of food 4a Dentition refers to the number and arrangement of different types of teeth in a mammal. It can be represented by a dental formula . 46 6.3 Ingestion of food 4b Humans have two sets of teeth in a lifetime: i) milk teeth ii) permanent teeth 47 6.4 Movement of food along the alimentary canal What will happen to us after mastication? 48 6.4 Movement of food along the alimentary canal 1 Swallowing Animation • before swallowing: bolus (食團) Food is chewed teeth The tongue shapes the food into a bolus tongue 49 6.4 Movement of food along the alimentary canal 1 Swallowing • during swallowing: 1 The tongue pushes the bolus towards pharynx 50 51 6.4 Movement of food along the alimentary canal 1 Swallowing • during swallowing: 2 The soft palate (軟腭) moves up to prevent the bolus from entering the nasal cavity 52 6.4 Movement of food along the alimentary canal 1 Swallowing • during swallowing: 3 The epiglottis (會厭) covers the trachea 4 The bolus enters the oesophagus 53 6.4 Movement of food along the alimentary canal 2 Peristalsis (蠕動) • rhythmic contraction and relaxation of the muscles circular muscle (環肌) longitudinal muscle (縱肌) lumen (管腔) alimentary canal 54 6.4 Movement of food along the alimentary canal 2 Peristalsis (蠕動) circular muscles contract, longitudinal muscles relax circular muscles relax, longitudinal muscles contract food food moved forward 55 6.4 Movement of food along the alimentary canal 1 Food is moved from the mouth cavity down the oesophagus by swallowing and down from the oesophagus towards the anus by peristalsis . 56 6.4 Movement of food along the alimentary canal 2 Peristalsis is the rhythmic contraction and relaxation of the circular and longitudinal muscles in the wall of alimentary canal. It causes the food to move forward along the canal. 57 6.5 Digestion of food • undigested food is too large to pass through the wall wall of alimentary canal (differentially permeable) blood alimentary canal undigested food molecules 58 6.5 Digestion of food • digestion makes the food smaller, simpler and soluble for absorption blood alimentary canal digested food molecules 59 6.5 Digestion of food Physical digestion (機械消化) • breaks down food into smaller pieces • increases surface area for action of digestive juices (消化酶) food physical action smaller surface area larger surface area 60 6.5 Digestion of food Physical digestion (機械消化) • examples: 1 Chewing by teeth 2 Churning (劇烈攪動) in the stomach 61 6.5 Digestion of food Physical digestion (機械消化) • examples: 3 Peristalsis along alimentary canal 4 Emulsification (乳化) by bile salts lipid s small droplets 62 6.5 Digestion of food Chemical digestion (化學消化) • chemical reactions in which large, complex food molecules are broken down digestive enzymes (消化酶) large, complex small, simple 63 6.5 Digestion of food • three types of digestive enzymes 1 Carbohydrases (碳水化合酶) e.g. amylase, sucrase and maltase complex carbohydrates simpler sugars 64 6.5 Digestion of food • three types of digestive enzymes 2 Proteases (蛋白酶) e.g. pepsin, trypsin and peptidases polypeptides protein peptides amino acids65 6.5 Digestion of food • three types of digestive enzymes 3 Lipase (脂肪酶) e.g. pancreatic lipase fat fatty acids glycerol 66 6.5 Digestion of food 6.2 Design an investigation of the action of digestive enzymes Tina’s mother added some powder to the steaks when she was preparing the dinner. Tina was curious about the purpose of the powder. 67 6.5 Digestion of food 6.2 The meat tenderizer contains an enzyme that can soften the meat. Our bodies also have a similar enzyme called pepsin for digestion. 68 6.5 Digestion of food 6.2 Design and perform an investigation to find out the action of pepsin on protein digestion. Is it true? 69 6.5 Digestion of food Digestion in mouth cavity • food is chewed into small pieces and mixed with saliva Animation 70 71 6.5 Digestion of food Digestion in mouth cavity Saliva • secreted by salivary glands • slightly alkaline salivary glands 72 6.5 Digestion of food Digestion in mouth cavity Saliva • consists of i) salivary amylase starch maltose ii) mucus (黏液) - moistens and lubricates (潤滑) food 73 6.5 Digestion of food Digestion in mouth cavity Saliva • consists of iii) water - dissolves soluble substances in food 74 6.5 Digestion of food Digestion in stomach Structure of the stomach oesophagus muscle bag duodenum 75 6.5 Digestion of food Digestion in stomach Structure of the stomach cardiac sphincter (賁門括約肌) - closes the entrance pyloric sphincter (幽門括約肌) - regulates the release of food into duodenum 76 6.5 Digestion of food Digestion in stomach Structure of the stomach gastric glands inside pits stomach wall (450) • gastric glands secrete gastric juice (胃液) 77 6.5 Digestion of food Digestion in stomach Gastric juice • contains i) proteases protein peptides 78 6.5 Digestion of food Digestion in stomach HCl Gastric juice • contains ii) hydrochloric acid - provides an acidic medium for the action of proteases - kills most bacteria in food bacteria 79 6.5 Digestion of food Digestion in stomach Gastric juice • contains iii) mucus - protects stomach from being damaged by proteases and hydrochloric acid mucus proteases & HCl 80 6.5 Digestion of food Digestion in stomach food churning & chemical digestion semi-solid paste called chyme (食糜) 81 6.5 Digestion of food Digestion in small intestine • three digestive juices 1 Bile • secreted by liver • stored in gall bladder • released to duodenum through bile duct (膽管) 82 6.5 Digestion of food Digestion in small intestine • three digestive juices 1 Bile • secreted by liver • stored in gall bladder • released to duodenum through bile duct (膽管) 83 6.5 Digestion of food Digestion in small intestine 1 Bile • has no enzymes but contains i) bile salts - emulsify lipids into small droplets lipid s emulsification smaller surface area larger surface 84 area 6.5 Digestion of food Digestion in small intestine 1 Bile ii) bile pigments - give green colour to bile iii) sodium hydrogencarbonate - neutralizes the acidic chyme - provides an alkaline medium for the actions of enzymes in duodenum 85 6.5 Digestion of food Digestion in small intestine 1 Bile Bile is produced by the gall bladder. 86 6.5 Digestion of food Digestion in small intestine 1 Bile Bile is produced by the liver and temporarily stored in the gall bladder. 87 6.5 Digestion of food 6.3 Animation Investigation of the effect of bile salts on oil 1 Add 10 drops of bile salt solution to 1 cm3 of peanut oil. bile salt solution peanut oil 88 89 6.5 Digestion of food 6.3 2 Stopper the test tube and shake for 30 seconds. Observe the mixture and note any changes. shake Results and discussion An emulsion (乳狀物) is formed. This shows that bile salts can break down lipids into tiny droplets. 90 6.5 Digestion of food Digestion in small intestine 2 Pancreatic juice • secreted by pancreas pancreatic duct • released to duodenum through pancreatic duct • slightly alkaline pancreas 91 6.5 Digestion of food Digestion in small intestine 2 Pancreatic juice • contains: i) pancreatic amylase starch maltose 92 6.5 Digestion of food Digestion in small intestine 2 Pancreatic juice • contains: ii) protease protein peptides 93 6.5 Digestion of food Digestion in small intestine 2 Pancreatic juice • contains: ii) protease peptides amino acids 94 6.5 Digestion of food Digestion in small intestine 2 Pancreatic juice • contains: iii) lipase lipid fatty acids glycerol 95 6.5 Digestion of food Digestion in small intestine 2 Pancreatic juice • contains: iv) sodium hydrogencarbonate - neutralizes the acidic chyme - provides an alkaline medium for the actions of enzymes in duodenum 96 6.5 Digestion of food Digestion in small intestine 3 Intestinal juice • secreted by the glands on the wall of the small intestine duodenum ileum 97 6.5 Digestion of food Digestion in small intestine 3 Intestinal juice • slightly alkaline duodenum • contains mucus • no enzymes ileum 98 6.5 Digestion of food Digestion in small intestine • some specialized cells on the wall also involved in digestion duodenum specialized cells ileum 99 6.5 Digestion of food Digestion in small intestine • enzymes present on their cell membrane duodenum enzymes here specialized cells ileum 100 6.5 Digestion of food Digestion in small intestine • The enzymes include: i) carbohydrases disaccharides monosaccharides 101 6.5 Digestion of food Digestion in small intestine • The enzymes include: ii) proteases peptides amino acids 102 6.5 Digestion of food Digestion in small intestine • Digestion completed at the end of ileum monosaccharides amino acids glycerol ready for absorption fatty acids 103 6.5 Digestion of food 1 The food we take in is too large to pass through the wall of the alimentary canal, which is differentially permeable. Digestion makes the food smaller , simpler and soluble for absorption. 104 6.5 Digestion of food 2a Physical digestion is mainly brought about by chewing action of the teeth, churning in the stomach, peristalsis along the alimentary canal, and emulsification of lipids by bile salts. 105 6.5 Digestion of food 2b Physical digestion increases the surface area of food for chemical digestion. 106 6.5 Digestion of food 3a Chemical digestion involves chemical reactions in which large, complex food molecules are broken down into smaller, simpler forms. The reactions are catalysed by digestive enzymes . 107 6.5 Digestion of food 3b Some digestive enzymes are present in the digestive juices secreted by the digestive glands . 108 6.5 Digestion of food 4a Digestion of carbohydrates: Mouth cavity starch salivary amylase in saliva maltose Duodenum pancreatic amylase maltose starch in pancreatic juice 109 6.5 Digestion of food 4a Digestion of carbohydrates: Small intestine disaccharides monosaccharides carbohydrases on the cell membranes of the specialized cells in the intestinal wall 110 6.5 Digestion of food 4b Digestion of proteins: Stomach protein proteases in gastric juice peptides Duodenum proteases protein, peptides, peptides in pancreatic juice amino acids 111 6.5 Digestion of food 4b Digestion of proteins: Small intestine proteases amino peptides on the cell membrane acids of the specialized cells in the intestinal wall 112 6.5 Digestion of food 4c Digestion of lipids: Duodenum lipids bile salt in bile small droplets lipase fatty acids, lipids in pancreatic juice glycerol 113 6.6 Absorption of digested food mainly takes place in ileum 114 6.6 Absorption of digested food Adaptation of small intestine for food absorption 1 Long intestine • allows sufficient time for absorption It’s 7m long! 115 6.6 Absorption of digested food Adaptation of small intestine for food absorption 2 Highly-folded intestinal wall and numerous villi (絨毛) epithelium covered with villi cross-section of small intestine 116 6.6 Absorption of digested food Adaptation of small intestine for food absorption 2 Highly-folded intestinal wall and numerous villi (絨毛) epithelium covered with villi inner surface of ileum 117 6.6 Absorption of digested food Adaptive features of villi 1 Finger-like projections • increases surface area for absorption 118 6.6 Absorption of digested food Adaptive features of villi 2 Thin epithelium • reduces the distance for diffusion of food molecules 119 6.6 Absorption of digested food Adaptive features of villi lacteal 3 Presence of lacteal and a network of blood capillaries • carry away the absorbed food molecules rapidly blood capillary 120 6.6 Absorption of digested food Adaptive features of villi 4 Movement of villi caused by peristalsis • keeps a steep concentration gradient of food molecules 121 6.6 Absorption of digested food Absorption of digested food Into the blood Animation monosaccharides diffusion amino acids active transport minerals water-soluble vitamins 122 123 6.6 Absorption of digested food Absorption of digested food Into the blood hepatic vein liver hepatic portal vein all parts of the body 124 6.6 Absorption of digested food Absorption of digested food Into the lymph lumen epithelium fatty acid fatty acid glycerol glycerol lipid lacteal lipid 125 6.6 Absorption of digested food Absorption of digested food Into the lymph lymph vessel all parts of the body 126 6.6 Absorption of digested food Absorption of water • most water is absorbed in stomach and small intestine osmosis water blood capillary 127 6.6 Absorption of digested food 6.4 Simulation of digestion and absorption in the small intestine using dialysis tubing 1 Tie a knot at one end of a dialysis tubing. Fill the tubing with equal volumes of starch solution and amylase solution. 128 6.6 Absorption of digested food 6.4 2 Tie the other end of the tubing. 3 Immerse the tubing in water at 37°C. dialysis tubing water at 37oC starch and amylase 129 6.6 Absorption of digested food 6.4 4 Test the water outside the tubing immediately for starch and reducing sugars using iodine solution and Benedict’s solution respectively. Perform the same tests after one hour. 130 6.6 Absorption of digested food 6.4 Results and discussion • At the beginning of the experiment, neither starch nor reducing sugars are present in the water. However, reducing sugars are detected after one hour. 131 6.6 Absorption of digested food 6.4 Results and discussion • These results show that amylase helps break down starch into reducing sugars and only the reducing sugar molecules are small enough to pass through the dialysis tubing. 132 6.6 Absorption of digested food 1 Absorption is the movement of food molecules from the alimentary canal into the circulatory system. It takes place mainly in the ileum. 133 6.6 Absorption of digested food 2a How is the small intestine adapted for food absorption? Adaptation Significance Highly-folded wall and numerous villi Increase surface area for absorption 134 6.6 Absorption of digested food 2b How is the small intestine adapted for food absorption? Adaptation Significance Thin epithelium Reduces the distance for diffusion of food molecules 135 6.6 Absorption of digested food 2c How is the small intestine adapted for food absorption? Adaptation Significance Presence of lacteal Carry away the and a network of absorbed food blood capillaries molecules rapidly 136 6.6 Absorption of digested food 2d How is the small intestine adapted for food absorption? Adaptation Significance Movement of villi caused by peristalsis Keeps a steep concentration gradient of food molecules 137 6.6 Absorption of digested food 3a Monosaccharides, amino acids, minerals and water-soluble vitamins are absorbed into the blood capillaries of the villi by diffusion and active transport. They are carried to the liver via the hepatic portal vein . 138 6.6 Absorption of digested food 3b Fatty acids and glycerol diffuse into the epithelium of the villi. Here they recombine to form lipids before entering the lacteals . 139 6.7 Assimilation of absorbed food • the uptake and use of absorbed food molecules for metabolism 140 6.7 Assimilation of absorbed food The fate of absorbed food 1 Glucose i) for releasing energy respiration glucose energy 141 6.7 Assimilation of absorbed food The fate of absorbed food 1 Glucose ii) excess glucose is converted into glycogen or lipid in liver glycogen lipid stored stored in liver / muscle under skin / around internal organs 142 6.7 Assimilation of absorbed food The fate of absorbed food 2 Amino acids i) for making proteins enzymes proteins for growth antibodies proteins for repair hormones ii) excess amino acids are deaminated in liver 143 6.7 Assimilation of absorbed food The fate of absorbed food 3 Lipids i) as energy reserve ii) for making cell membrane iii) for protecting internal organs or reducing heat loss subcutaneous fat 144 6.7 Assimilation of absorbed food The roles of the liver 1 Regulate blood glucose level • blood glucose level > normal glucose liver glycogen • blood glucose level < normal liver glycogen glucose 145 6.7 Assimilation of absorbed food The roles of the liver 2 Storage of glycogen, iron and fat-soluble vitamins • main site for storing glycogen glycogen 146 6.7 Assimilation of absorbed food The roles of the liver 2 Storage of glycogen, iron and fat-soluble vitamins • stores fat-soluble vitamins vitamin A vitamin D 147 6.7 Assimilation of absorbed food The roles of the liver 2 Storage of glycogens, iron and fat-soluble vitamins • for storing iron from the breakdown of red blood cells red blood cells iron 148 6.7 Assimilation of absorbed food The roles of the liver 3 Production of bile, vitamin A and heat heat • secretes bile • changes carotene to vitamin A metabolic activities • produces heat 149 6.7 Assimilation of absorbed food The roles of the liver 4 Deamination amino group excess amino acids remaining parts urea carbohydrates lipids 150 6.7 Assimilation of absorbed food The roles of the liver 5 Detoxification (解毒) toxins (e.g. alcohol, drugs) harmless substances 151 6.7 Assimilation of absorbed food 1 Assimilation is the uptake and use of absorbed food molecules by cells for metabolism. 152 6.7 Assimilation of absorbed food 2 How are the absorbed food molecules assimilated inside cells? glucose for releasing energy amino acids for making proteins lipids for making cell membrane as energy reserve 153 6.7 Assimilation of absorbed food 3 The roles of the liver include: • regulates blood glucose level • stores glycogen , iron and fat-soluble vitamins • produces bile , vitamin A and heat 154 6.7 Assimilation of absorbed food 3 The roles of the liver include: • deaminates excess amino acids • detoxifies mild toxins 155 6.8 Egestion • the process of expelling faeces (糞便) from the body • also called defaecation (排糞) • faeces consist of dietary fibre bacteria secretions from alimentary canal dead cells 156 6.8 Egestion faeces stored in rectum temporarily anal sphincter muscle relaxes and rectum muscle contracts to push the faeces out 157 6.8 Egestion Egestion is the process of expelling faeces from the body. 158 1 What is the role of the stomach? • The stomach churns to break down food into smaller pieces physically. • It secretes proteases to chemically digest proteins. • It also releases hydrochloric acid which kills most bacteria in food. 159 2 How does the surgery help people lose weight? Without passing through the stomach and duodenum, the food cannot be fully digested. Therefore, fewer food molecules are absorbed by the body. 160 3 What will happen if the food does not pass through the ileum also? It may result in malnutrition as most consumed food is undigested and the body cannot get enough nutrients for healthy growth. 161 Nutrition consists of ingestion absorption digestion egestion assimilation occurs mainly in villi occurs in body cells 162 digestion involves physical digestion chemical digestion brought about by enzymes 163 physical digestion brought about by chewing churning in peristalsis by teeth stomach emulsification of lipids by bile salts 164