Establishment of a Multipurpose Gamma Irradiation Facility (MGIF) in Sri Lanka by Samantha Kulatunge Head Radiation Processing Section Atomic Energy Authority No. 60/460, Baseline Road Orugodawatte, Wellampitiya Content: What is radiation and related units? What is Gamma irradiator? What are the applications of Gamma radiation and why do we use radiation? Multipurpose Gamma Irradiation Facility in Sri Lanka Selection of land Throughput (Capacity) of the facility Potential revenue Estimated Irradiation Market Profit & Loss Analysis What is radiation? Electromagnetic radiation Measurements: QUANTITIES UNITS Length Dose Activity (Source strength) Meters or Km Grays or kGy Curie or kCi Dose: The quantity of energy that the irradiated product absorbs. 1GRAY (Gy) = 1J/kg Activity: Number of curies. Also improperly called source strength. 1 Curie (Ci) = Activity of 1g of 226Ra 1g of 226Ra disintegrate 3.7x1010 atoms per second 1 Ci = 3.7 x 1010 dis/s GAMMA RADIATION Emitted when radioisotope cobalt-60 decays Beta Particle Gamma Rays (photons) Made from cobalt-59 Half life : 5.24 years Becomes nickel How Co-60 produces gamma radiation How it can be used in processing of products? g :- Surgical gloves (gamma rays) Co-60 radioactive source Kills microorganisms Sterilized rubber glove When a product expose to radiation; Delivered energy = dose (in Grays = Joules per kilogram) OVER PROCESSING L Maximum dose : threshold of undesirable effect PROCESSING WINDOW J Minimum dose : threshold to achieve effect UNDER PROCESSING L Multipurpose Gamma Irradiation Facility (MGIF) Multipurpose Gamma Irradiation Facility Bunker Conveyor unloading Conveyor loading Source rack in pool Gamma Irradiator Principle Bunker Conveyor Source rack in pool Slug & Pencil of cobolt-60 (Buiding blocks of a radiation source rack) Cobolt 60 slug Cobolt 60 source element (an inner capsule containing slug of cobolt-60) Source pencil (contain 2 source elements) Source module (contains up to 48source pencils) Source rack (contains modules in different configurations, depending on irradiator design) GAMMA IRRADIATOR Pose no environmental problem Radiation stopped by walls No radioactivity in the air Ozone formed by irradiation of oxygen in air Air continuously ejected through chimney Ozone concentration < 1 ppm in limit of site Pool water is safe to drink Radiation stopped by water and ground Sources returned to supplier after 20 years of usage. No longer radioactive after 180 years Control panel of the irradiator Application of MGIF: Immediate applications Sterilization of surgical gloves & medical products Decontamination of spices, dried vegetables Decontamination of medicinal herbs, Ayuvedic products, health diet supplements Sterilization of food and pharmaceutical packaging Decontamination of dried pharmaceutical and cosmetic ingredients Mid term application Quarantine treatment of wooden objects and coir pith Pasteurization of frozen or fresh seafood Long term applications Sprouting inhibition of onions and garlic Why Radiation Sterilization ? No recontamination Non-toxic No chemical residues Reliable & safe Treated product can be used immediately Complete product penetration Gamma irradiation produces no heat( therefore preserves properties & characteristics) Precise and reproducible treatment process Proven use for 30 years Environmental friendly Radiation Sterilization of Medical Products Human Tissue Sterilization: PHARMACEUTICAL PRODUCTS EXAMPLES Medicinal herbs and food supplements Antibiotics in dried form Eye ointments and veterinary products with antibiotics COSMETIC PRODUCTS EXAMPLES Plants, Seaweeds Talcum powder Clay and sea mud Mineral and organic dyes Shampoo and shower gel Brushes Contd.. Food Irradiation Application: Delay in ripening Disinfestation / Insect control Microbial control Quarantine treatment Shelf life extension Sprout inhibition Sterilization Why food Irradiation ? No chemical residues Preservation can be done after packaging Environmental friendly process Proven for more than 30 years Insect Control Shelf-life extension Sprout Inhibition Food Item Purpose Max Dose (kGy) Spices Microbial control Disinfestation 10 1 Rice Rice products Disinfestation Disinfestation 1 1 Potatoes Sprouting inhibition 0.15 Garlic Sprouting inhibition 0.15 Onions Sprouting inhibition 0.15 Vegetables Disinfestation 1 Meat Microbial control 7 Other Applications Sanitation of rawhide pet toys Quarantine treatment of wooden pallets, souvenirs and handicrafts Sanitation of stuffed toys Preservation of antiques, artefacts, mummies Coloration of glass Etc. Multipurpose Gamma Irradiation Facility in Sri Lanka MGIF in Sri Lanka Required land area Total area of the building Activity Initial activity Power requirement Water :02 acres :3250 M2 :3 million ci :150 kCi : 45 kw (200kw) : comparable to a large house Capital cost Cost Component Project Management Land Consultancy Civil Construction Machinery Taxes Vehicles Others Total Estimated cost ( Rs. Million) 7.03 15 25.6 320 151.7 65 7.5 18 609.83 Operating Costs (per year) Item Amount (1000Rs) Salaries (Manager, Engineer, secretary, 2 Operators and 6 Helpers) 3,000 Maintenance and repairs 1,000 Utilities and communication 1,000 Miscellaneous supplies and services 1,000 Annual replacement and up-grading of Co60(12.5% of initial load)* 40,000 Total 46,000 * Can vary depending on the demand for irradiation services Total Cost for the facility: purpose Estimated Cost (1000SLRs) Capital Cost 610,00 Operating cost (including annual replacement and upgrading of Co60 which is 12.5 % of initial load) 46,000 Total Cost 656,000 Selection of a location Criteria for selection of a location: Absence of opposition to the project Relative proximity to main users Good accessibility to main roads and port Privileges that can be obtained Price of land and management fee Security of the location Absence of vulnerability to natural hazards such as floods and landslides Soil characteristics Proposed site for Irradiator Area to be acquired to provide vehicular access for non BOI products RETAINING WALL Site Levelling R E T A IN IN G W ALL VEHICULAR ACCESS FOR BOI PRODUCTS ENTRANCE FOR OFFICE 6.0m. min. VEHICULAR ACCESS FOR NON BOI PRODUCTS Throughput or Capacity of the facility Throughput of the facility Potential throughput is proportional to the source activity Actual throughput depend on Proportion of the time that facility is used for Downtime for maintenance Lack of products at certain periods Throughput of a Gamma Irradiator with 150 kCi will be 100,000 kGy of products With a density of 0.2 tons/m3 If facility operates for 7880 hrs per annum (or utilization ratio is 90%) The quantity of products that can be irradiated with the initial capacity of 150,000 Ci Product Minimum dose (kGy) Throughput per annum Product density Onions - Sprouting inhibition 0.1 500,000 tons 0.5 ton / m3 Cereal products- Insect control 0.5 30,000 tons 0.6 ton / m3 Dried fruit- Insect control 0.5 60,000 tons 0.3 ton / m3 Spices-Microbial control 5 6,000 tons 0.3 ton / m3 Latex glovesSterilization 25 4,000 m3 0.2 ton / m3 Potential revenue Potential revenue for different products with an activity of 150,000 curies Potential revenue for different products with an activity of 150,000 Curies Minimum Throughput dose per annum (kGy) Product Tentative density unit price (ton / m3) (1) Potential revenue per annum (2) USD Onions Sprouting inhibition 0.1 500,000 tons 0.5 10 USD / ton Cereal products Insect control 0.5 30,000 tons 0.6 20 USD / ton Dried fruit Insect control 0.5 60,000 tons 0.3 20 USD / ton Spices Microbial control 5 6,000 tons 0.3 100 USD / ton 600,000 Latex gloves Sterilization 25 4,000 m3 0.2 60 USD / m3 240,000 5,000,000 1,200,000 1,200,000 Estimated Irradiation Market Estimated Irradiation Market Year Volume (m3) Total Lalan Prime Need (m3 x kGy) Glob Surg Spice Source (kCi) Gloves (% total) Free capacity Total 2010 11,927 7,000 3,333 260 1,333 316,691 443 95% 85% 2011 16,694 11,000 3,500 527 1,667 450,964 631 94% 79% 2012 22,902 16,500 3,675 727 2,000 621,305 870 93% 71% 2013 24,619 17,500 3,859 927 2,333 665,090 993 92% 69% 2014 26,345 18,500 4,052 1,127 2,667 709,213 1,033 91% 68% +4 % 1,074 67% 2016 1,117 66% 2017 1,162 64% 2018 1,208 63% 2015 2019 61% 2020 60% Why starting with small Co 60 activity? It limits the cost of decay during the learning phase. Time is needed To test and commission the plant, perform the safety various tests that need to be done and characterize the dose distribution pattern within a range of products of different densities used as models To implement a quality system that is not only on paper but tested in reality. This is required by organizations that will have to certify the quality system to ISO 9000, ISO 13485 and EN 552, certificates that are necessary to sterilize medical products that are exported to Europe, the US, Japan or Australia. For the personnel to learn the job For the customers to learn how to use the facility (packing, logistics, paper flow, etc.). This amount of cobalt-60 can be transported in a single F-168 type transportation container, thus minimizing the cost of source transportation. C0-60 purchase cost Year 1 2 3 4 5 6 Installed kilo curies 150 443 631 870 931 993 1033 1074 1117 1162 Occupied design capacity 5% 15% 21% 29% 31% 33% 34% 36% 311 241 314 166 174 159 165 172 Purchased curies (kCi) Cost of decay (‘000LKR) Cost of purchased cobalt (‘000LKR) 3928 7 8 9 10 37% 39% 179 186 13,966 20,683 29,635 32,993 36,589 39,574 42,804 46,29750,074 67,872 63,311 85,787 47,040 51,233 48,785 52,766 57,072 61,729 66,766 Export of spices: Tons 2001 2002 2003 2004 2005 Cinnamon 10,444 10,837 11,025 11,391 12,367 Pepper 2,161 8,026 7,859 5,003 8,248 Cloves 1,964 4,044 2,489 3,428 5,517 Nutmeg & Mace 1,138.1 1,665 1,833 1,368 1,935 Cardamom 3 3 4 4 11 Total 15,710 24,574 23,210 21,194 28,078 Profit & Loss Analysis Profit & Loss Analysis (b) Project Year 0 1 2 3 4 5 6 7 8 9 10 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 76,498 104,827 142,877 153,032 162,616 169,121 175,885 182,921 190,238 197,847 (850) (1,003) (1,158) (1,254) (1,317) (1,383) (1,452) (1,525) (1,601) (1,681) Insurance (1,000) (1,030) (1,061) (1,093) (1,126) (1,159) (1,194) (1,230) (1,267) (1,305) Other operating cost (830) General Administration cost (1,850) (4,500) (4,680) (4,867) (5,062) (5,264) (5,475) (5,694) (5,922) (6,159) (6,405) (3,600) (2,386) (2,481) (2,581) (2,684) (2,791) (2,903) (3,019) (3,140) (3,265) Total Depreciation Cobalt- 60 Depreciation Plant and equipment Depreciation (51,601) (56,456) (62,616) (64,200) (65,795) (66,821) (67,888) (68,997) (70,151) (71,352) (11,452) (16,308) (22,468) (24,051) (25,647) (26,672) (27,739) (28,849) (30,003) (31,203) (40,149) (40,149) (40,149) (40,149) (40,149) (40,149) (40,149) (40,149) (40,149) (40,149) Calendar Year TURNOVER COST Staff (418) TOTAL COST Earnings Before Interest and Tax (3,098) Interest Earnings Before Tax - Taxation @ 15% Net profit (loss) (61,551) (3,098) 14,947 (3,098) (3,098) (65,556) (72,184) (74,189) (76,186) 39,271 70,694 78,843 (31,750) (30,186) (28,388) (16,802) 9,085 42,306 (16,802) (1,363) 7,723 (6,346) 35,960 (79,131) (80,693) (82,318) (84,008) 91,491 96,754 102,228 107,920 113,840 (26,320) (23,941) (21,206) (18,061) (14,444) (10,285) (5,501) 52,523 70,285 78,693 87,784 97,636 108,338 (7,879) 44,645 86,430 (77,630) 62,489 (9,373) 53,115 (10,543) 59,742 (11,804) 66,889 (13,168) 74,616 (14,645) (16,251) 82,990 92,088 Profit & loss analysis (a) Project Year Calendar Year 0 1 2 3 4 5 6 7 8 9 10 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 TURNOVER 63,632 87,333 119,050 127,642 135,760 141,190 146,838 152,711 158,820 165,172 (850) (1,003) (1,158) (1,254) (1,317) (1,383) (1,452) (1,525) (1,601) (1,681) (1,000) (1,030) (1,061) (1,093) (1,126) (1,159) (1,194) (1,230) (1,267) (1,305) Other operating cost (830) (4,500) General Administration cost (1,850) (3,600) (4,680) (4,867) (5,062) (5,264) (5,475) (5,694) (5,922) (6,159) (6,405) (2,386) (2,481) (2,581) (2,684) (2,791) (2,903) (3,019) (3,140) (3,265) Total Depreciation (32,790) (36,999) (42,337) (43,709) (45,092) (45,981) (46,906) (47,868) (48,868) (49,908) Cobalt- 60 Depreciation Plant and Equipment Depreciation (9,925) (14,133) (19,472) (20,844) (22,227) (23,116) (24,041) (25,002) (26,002) (27,043) (22,865) (22,865) (22,865) (22,865) (22,865) (22,865) (22,865) (22,865) (22,865) (22,865) COST Staff (418) Insurance TOTAL COST Earnings Before Interest and Tax Interest Earnings Before Tax Taxation @ 15% (3,098) (42,740) (3,098) 20,892 - (19,060) (3,098) 1,832 - (275) (46,098) (51,905) (53,699) (55,483) (56,790) (58,149) (59,563) (61,034) (62,564) 41,235 67,145 73,943 80,276 84,400 88,689 93,148 97,786 102,608 (18,121) (17,042) (15,800) (14,373) (12,731) (10,843) (8,671) (6,174) (3,302) 23,114 50,103 58,142 65,904 71,670 77,846 84,477 91,612 99,306 (3,467) (7,516) (8,721) (9,886) (10,750) (11,677) (12,672) (13,742) (14,896) Thank you