Baytril Max swine

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Baytril Max in swine
Baytril max swine
- Bayer an investigation company
- Mechanism of action
- Pharmacokinetics
- USA experience
- Application to the brand plan
Baytril Max swine
- Bayer an investigation company
- Mechanism of action
- Pharmacokinetics
- USA experience
- Application to the brand plan
Bayer Animal Health:
More than
100 products
In the world
~ 2.800
colleagues
Bayer in
120 países
Global sales:
Mio EUR 905
Different
production
sites
MONHEIM INVESTIGATION CENTRE, GERMANY
Bayer AH developments:
2007 Kinetomax
2006 Baycox® Bovis
®
1999 Checkmite+ 2005 Profender®
1996 Advantage® 2004 Advocate®
1995 IBR Marker 2003 Baycox® Piglets
1995 Aviguard®
®
2002 Advantix®
1988 Drontal Plus
®
1994 Drontal Cat 2000 Vivobay®
1987 Baytril®
1994 Hyonate®
1986 Baycox® Poultry 1991 Kiltix®
1984 Perizin®
1991 Bayvarol®
1983 Bayticol®
1979 Sebacil®
1979 Bayovac®
1977 Rintal®
1975 Bayo-n-ox®
1975 Droncit®
1969 Rompun®
1968 Bolfo®
1966 Citarin®
1958 Neguvon®
1958 Catosal®
1957 Asuntol®
1948 MKS-Impfstoffe
1937 Prontosil
1935 Acaprin
1923 Naganol®
1899
Baytril max swine
- Bayer an investigation company
- Mechanism of action
- Pharmacokinetics
- USA experience
- Application to the brand plan
Baytril Max® interferes with the DNA metabolism by inhibiting:
•
Topoisomerase II (DNA-girase)
• Topoisomerase IV
Ex.: E. coli DNA is about 1.300 μm lenght,
and is hold by a 2 μm long bacteria
Bacterial
Baytril Max: fast bactericide
http://baytril.bayer-ag.com/ah/web/Baytril/bhcbaytrilcms.nsf/id/EN_Baykilll_Animation
Intact E. coli
After some minutes of
enrofloxacin application,
bacteria start “swelling”
and exploting
Size: 1000 x
After 7 horasall bacteria
exploted.
Bayer, Wuppertal Lab, Germany
Bacteria explote because of the uncoiled DNA expansion
Baytril Max swine
- Bayer an investigation company
- Mechanism of action
- Pharmacokinetics
- USA experience
- Application to the brand plan
What is new in Kinetomax?
Arginine based
formulation
ONE SHOT!
Tissue
concentration
(times) in
comparison to
that reached in
serum
1,4
2,5
1,4
1
8,3
2,3
1,8
2,1
2,5 - 2,8
3,1
2,4
1,4
3
2,1
3
2,4
Comparative MIC values for
Baytril Max, Nuflor y Micotil
BACTERIA
Pausteurella haemolytica
Pasteurella multocida
Haemopilus somnus
BAYTRIL
100
MIC 50
(g/ml)
BAYTRIL
100
MIC 90
(g/ml
NUFLOR
NUFLOR
MICOTIL
MIC 50
(g/ml)
MIC 90
(g/ml)
MIC90
(g/ml)
0.06
0.015
0.015
0.06
0.03
0.03
0.50
0.50
0.25
1.00
0.50
0.50
3.12
6.25
6.25
(Pirro et al, 2000)
Dose depending serum kinetics of Baytril Max in swine
(Ewert, K. 1997)
MIC values for Baytril Max®
Baytril
Max®
Serum
Lungs
IM
0,5
2,7
concentrations
No. of
isolates
Min
MIC
Max
MIC
Actinobacillus pleuropneumoniae
Bordetella bronchiseptica
Erysipelothrix rhusiopathiae
Escherichia coli
Haemophilus parasuis
Mycoplasma hyopneumoniae
108
 0.008
1
0.03
0.06
102
0.25
2
0.5
1
9
0.06
0.25
na*
na
104
0.015
0.5
0.03
0.125
107
 0.008
0.5
 0.008
0.03
19
0.03
0.25
0.06
0.06
Pasteurella multocida Tipo A
Pasteurella multocida Tipo D
Salmonella choleraesuis
Streptococcus suis
105
 0.008
0.25
0.015
0.125
38
 0.008
0.06
0.015
0.03
108
0.015
0.25
0.125
0.125
93
0.06
1
0.5
0.5
Patogen
*
Via
MIC
MIC 90
50
No applicable or small number of isolates to clacuate significative values
(Ewert, K. 1997)
(Wetzstein et al, 1996)
Peracute APP infection
(fotos: Peter Høgedah)
Economical losses due to respiratory diseases in swine
Lower weight gain
Lower carcass
quality
Reduced fertility
Fatality
Lung damages
Lower daily weight gain
Up to 230 g
Longer fattening period
Up to 24 d
Higher feed cost
Up to 5%
Lower weight at slaughter
Up to 16,5 kg
Lower proportion of high quality meet
and lower carcass ranking
Up to 6%
Lower proportion of fertile gilts
Up to 12%
Lower litter size
Up to 1,1
piglets
Mortality in piglets
Up to 23%
Mortality in fatteners
Up to 10%
Rejected lungs at slaughter
Up to 95%
Consequences of APP
Mortality
- Increased mortality by 1,75%
- Mortality in acute cases from 1 to 9% (Ø 3,1%)
- Mortality of 1% is equivalent to losses of 1.25€
per piglet, in consequence 3.87€
- Economical loss in Germany: 30-50 mio€/year
Chiers (2004) Detection of pigs carrying Actinobacillus pleuropneumoniae in their upper respiratory tract using polymerase chain
reaction. Ph D Thesis, pp. 134, PORCILIS Produktinfo
Field trial in Sonora, México
Objective:
Evaluation of efficacy of Baytril Max
respiratory problems (APP, P. multocida)
Treatment : Kinetomax 1 injection of 7,5 mg /kg
(en caso de recaída se repitió el tratamiento)
Animals:
144 hogs 50 to 52 days of age
Observation period: 30 days after the 1st treatment
Parameters: Dyspnoea, nasal discharge, sneezing
and mortality ; local and systemic
reactions
Ing. José Hidalgo
Field trial in Sonora, México
Baytril Max ®
• 86.8% recovery in 48h
• 97.9% of recovery was achieved with a second
application of Baytril Max®
• 90% of the treated animals shown a health improvement
12 h pt.
• Only one animal showed a slight loal reation at the
injection site (0.006%).
E. coli cystitis
E. coli cystitis (x 5000)
E. coli cystitis (x 25000)
E. coli + streptococci cystitis
E. coli + streptococci cystitis
(x 2500/25000)
Treatment of UTI with Baytril max
(Wendt & Sobastiansky, 1995)
60%
(p<0.001)
50%
40%
30%
(p<0.01)
20%
10%
0%
Bacteriuria
A. suis positive
pregnant sows
(n=73)
90%
80%
70%
60%
50%
40%
30%
20%
10%
0%
(p<0.05)
pre-treatment
(p<0.05)
post-treatment
Bacteriuria
A. suis positive
lactating sows
(n=27)
Indication in infectious
diseases:
•
•
•
•
•
•
Gastro-intestinal
Respiratory
Septicemic
Genito-urinary
Umbilical
Cutaneous
Injection route and dosage:
Dosage:7,5 mg / kg
Via:
– SC, IM, IV
ONE SHOT!
Body weight
40 Kg
3 mL
80 Kg
6 mL
200 Kg
15 mL
400 Kg
30 mL
Easy application
Comparative viscocity among Baytril max®, water and other
antibacterials
Produto
0oC
10oC
25oC
40oC
Water
3
4
3
3
Kinetomax
15
10
7
6
Tilmicosina
209
127
49
28
Ceftiofur
218
131
72
46
Florfenicol
396
194
72
43
Valores de viscosidade (centipoise)
Qualitative study of generic
enrofloxacines
AUC (µg*h/mL) en relación a Baytril (100%)
100
90
80
70
60
50
40
30
20
10
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DEFICIENT QUALITY
Baytril
QUALITY COMPLIANCE
Withdrawal period
Meat : 14 dias
Presentations
50 mL
100 mL
(caixa com 24 frascos)
(caixa com 12 frascos)
Bayer Animal Health:
endorses the responsible use
of antimicrobial products in
veterinary medicine
Baytril Max, the right choice to treat porcine respiratory diseases; works:
Quickly:
Fast recovery
Potently:
High antimicrobial activity, synergy with leukocytes
Better:
Experimental comparison with other antimicrobials
Economicaly: Excellent Cost-benefit rate
Efficaciously: 5 to 6 fold concentration in respiratory tissues
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