Endocrine Abstracts May 2014 Volume 35 ISSN 1479-6848 (online) 16th European Congress of Endocrinology 2014 3 –7 May 2014, Wrocław, Poland published by bioscientifica Online version available at www.endocrine-abstracts.org Volume 35 May 2014 Endocrine Abstracts 16th European Congress of Endocrinology 3–7 May 2014, Wrocław, Poland EDITORS The abstracts were marked by the Abstract Marking Panel selected by the Programme Organising Committee ECE 2014 Programme Organising Committee Paolo Beck-Peccoz Anna Spada Chair Chair Members Max Bielohuby Justo Castan˜o Niki Karavitaki Marta Korbonits Krzysztof Kula Agnes Linlart Sten Lund Valeriya Lyssenko Andrej Milewicz Efisio Puxeddu Hans Romjin Allan Vaag Peter Varnai M Donath Switzerland J Drouin Canada L Duntas Greece G Eisenhofer Germany S Farooqi UK M Felicia Italy A Ferlin Italy C Follin Sweden J Frystyk Denmark L Fugazzola Italy C Gaston UK A-P Gimenez-Roqueplo France E Gregoraszczu Poland S Hahner Germany N Hamdy Netherlands T Hansen Denmark TK Hansen Denmark B Hemmingsen A Hoeflich Germany L Hofbauer Germany P-M Holterhus Germany E S Husebye Norway A Januszewic Poland N Jessen Denmark D Jezova A Juul Denmark G Kahaly Germany F Karpe UK M Keil F Kelestimur Turkey RD Kineman USA P King UK ST Knudsen Denmark M Korbonits UK K Kula Poland J Lenders Netherlands NR Leslie UK A Luger Austria RM Luque Spain M Luster Germany M Manelli Italy C Mathieu Belgium J Mittag Sweden J Newell-Price UK M Niedziela Poland S Nielsen Denmark E Nieschlag Germany P Nilsson Sweden S Pearce UK S Petersenn Germany JR Petrie UK M Pfeifer Sweden V Pirags Latvia A Pizzocaro Italy D Power Portugal PL Poulsen Denmark M Puig Spain S Radian UK M Robledo Spain C Ronchi Italy M Rossini Italy D Salvatore Italy L Sa¨vendahl Sweden N Skakkebaek Denmark J Smit Netherlands R Sustarsic N Taylor UK J Toppari Finland M Toth Z Toth M Tzanela Greece AJ Van der Lely Netherlands J van Eck Netherlands V Volke Estonia J L Wemeau France I Wilkinson UK Z Wu Germany P Yeoh UK J Young France L Zabuilene MC Zatelli Italy C Zillikens Netherlands Abstract Marking Panel A Agha Ireland M Albiero M Alevizaki Greece MS Andersen Denmark F Antoni A Beckers Belgium I Bernabeu Spain J Bertherat France F Beuschlein Germany M Bidlingmaier Germany M Blomberg-Jensen Netherlands J Bollerslev Norway C Bousquet France T Brue France C Buchanan UK F Cardona J Castano Spain P Chanson France M Charalambous UK B Chini Italy I Chiondini Italy L Chiovato Italy MS Cooper Australia L Czupryniak Poland C Daousi UK MT Dattani UK W De Herder Netherlands 16th European Congress of Endocrinology 2014, Wrocław, Poland SPONSORS The ESE would like to thank its Corporate Members and the ECE 2014 sponsors ECE Corporate Members Eli Lilly Ipsen Laboratoire HRA Pharma Merck Serono Novartis Pharmacueticals Novo Nordisk Pfizer Sandoz International Gmbh ViroPharma SPRL Gold Sponsors Ipsen Novartis Bronze Sponsors Alexion ESE Office Euro House 22 Apex Court Woodlands Bradley Stoke Bristol BS32 4JT, UK ECE 2014 Secretariat Bioscientifica Ltd Euro House, 22 Apex Court Woodlands Bradley Stoke Bristol BS32 4JT, UK Endocrine Abstracts (2014) Vol 35 Contact: Tel: Fax: E-mail: Web site: Contact: Tel: Fax: E-mail: Website: Andrea Davis +44 (0)1454 642247 +44 (0)1454 642222 info@euro-endo.org www.ese-hormones.org Claire Arrigoni +44 (0)1454 642240 +44 (0)1454 642222 conferences@bioscientifica.com http://www.bioscientifica.com 16th European Congress of Endocrinology 2014, Wrocław, Poland CONTENTS 16th European Congress of Endocrinology 2014 PRIZE LECTURES AND BIOGRAPHICAL NOTES The European Journal of Endocrinology Prize Lecture . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . EJE1 The Geoffrey Harris Prize Lecture . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . GH1 PLENARY LECTURES Genes, environment and endocrine disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Advances in molecular pathogenesis of thyroid cancer – therapeutic implications . . . . . . . . . Good times, bad times: (patho)physiology of diurnal rhythms . . . . . . . . . . . . . . . . . . . . Islet transplantation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Simultaneous treatment of menopausal symptoms and prevention of breast cancer: Is it possible? Hypothalamic inflammation - cause or consequence of obesity? . . . . . . . . . . . . . . . . . . . Reproduction and energy metabolism, an ancestral balance to be preserved for women’s health . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . PL1 PL2 PL3 PL4 PL5 PL6 PL7 Endocrine changes and treatment needs in critically ill patients . . . . . . . . . . . . . . . . . . . . Pituitary development – from basic research to clinical practice . . . . . . . . . . . . . . . . . . . . News from thyroid hormones: central transport, energy control and oxidative stress . . . . . . . . Endocrine Nurses Session 1: Craniopharyngioma . . . . . . . . . . . . . . . . . . . . . . . . . . . . Obesity Beyond BMI . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Focus on novel developments of PCOS - conclusions from the PCOS Task Force . . . . . . . . . . . Nontumorous pituitary diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Membrane lipid composition and receptor function. Signalling and trafficking . . . . . . . . . . . . EYES Session - Cold metabolic inflammation in obesity: ignored complication and treatment target? Difficulties in the treatment of Graves’ orbitopathy . . . . . . . . . . . . . . . . . . . . . . . . . . . Long term outcome of ‘cured’ pituitary patients . . . . . . . . . . . . . . . . . . . . . . . . . . . . Gut microbiota in diabetes and obesity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Endocrine Nurse Session 3: Meet the Nurse Expert - Management of Endocrine Emergencies . . . . Clinical outcome of medical intervention in Disorder of Sex Development (DSD) . . . . . . . . . . . Thromboembolism and contraception . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Metformin: old dog, new tricks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Cushing’s syndrome . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Endocrine disease during pregnancy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Osteoporosis - An update . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . New hormones and endocrine tissues . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Dilemmas in hormonal replacements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Novel therapies for thyroid cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Neuroendocrine tumours . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Nutrient regulation of metabolism and endocrine systems . . . . . . . . . . . . . . . . . . . . . . . Gonadal hormones and obesity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Pitfalls in hormone measurement . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Brown Adipose Tissue . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Molecular pathophysiology for clinicians: receptor-related disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . S1.1– S1.3 . S2.1– S2.3 . S3.1– S3.3 . S4.1– S4.3 . S5.1– S5.3 . S6.1– S6.3 . S7.1– S7.3 . S8.1– S8.3 . S9.1– S9.3 S10.1– S10.3 S11.1– S11.3 S12.1– S12.3 S13.1– S13.3 S14.1– S14.3 S15.1– S15.3 S16.1– S16.3 S17.1– S17.3 S18.1– S18.3 S19.1– S19.3 S20.1– S20.3 S21.1– S21.3 S22.1– S22.3 S23.1– S23.3 S24.1– S24.3 S25.1– S25.3 S26.1– S26.3 S27.1– S27.3 S28.1– S28.3 SYMPOSIA Endocrine Abstracts (2014) Vol 35 16th European Congress of Endocrinology 2014, Wrocław, Poland MEET THE EXPERT SESSIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MTE1 –MTE17 ORAL COMMUNICATIONS Thyroid clinical . . . . . . . . . Adrenal Clinical . . . . . . . . . Neuroendocrinology & Signalling Diabetes and Obesity 1 . . . . . Adrenal & Thyroid . . . . . . . . Bone, Calcium & Vitamin D . . . IGF-1 and Thyroid Basic . . . . Pituitary Clinical . . . . . . . . . Reproduction . . . . . . . . . . . Endocrine Tumours . . . . . . . Diabetes and Obesity 2 . . . . . Pituitary Basic . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . OC1.1– OC1.5 . . OC2.1– OC2.5 . . OC3.1– OC3.5 . . OC4.1– OC4.5 . . OC5.1– OC5.5 . . OC6.1– OC6.5 . . OC7.1 OC7.5 . . OC8.1– OC8.5 . . OC9.1– OC9.5 OC10.1 – OC10.5 OC11.1 – OC11.5 OC12.1 – OC12.5 NURSE POSTERS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . N1–N8 POSTER PRESENTATIONS Adrenal cortex . . . . . . . . . . . . . . . . . . . . Adrenal Medulla . . . . . . . . . . . . . . . . . . . Bone and Osteoporosis . . . . . . . . . . . . . . . Calcium and Vitamin D metabolism . . . . . . . . Cardiovascular Endocrinology & Lipid Metabolism Clinical case reports – Pituitary / Adrenal . . . . Clinical case reports – Thyroid / Others . . . . . . Developmental Endocrinology . . . . . . . . . . . Diabetes (epidemiology, pathophysiology) . . . . . Diabetes complications . . . . . . . . . . . . . . . Diabetes therapy . . . . . . . . . . . . . . . . . . . Endocrine disruptors . . . . . . . . . . . . . . . . . Endocrine tumours and neoplasia . . . . . . . . . Female reproduction . . . . . . . . . . . . . . . . . Growth hormone IGF axis – basic . . . . . . . . . Male reproduction . . . . . . . . . . . . . . . . . . Neuroendocrinology . . . . . . . . . . . . . . . . . Nuclear receptors and signal transduction . . . . . Obesity . . . . . . . . . . . . . . . . . . . . . . . . Paediatric endocrinology . . . . . . . . . . . . . . Pituitary – Basic (Generously supported by IPSEN) . Pituitary – Clinical (Generously supported by IPSEN) Steroid metabolism and action . . . . . . . . . . . Thyroid (non-cancer) . . . . . . . . . . . . . . . . Thyroid cancer . . . . . . . . . . . . . . . . . . . . INDEX OF AUTHORS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P1– P56 . . . P57– P64 . . P65 – P100 . P101 – P168 . P169 – P209 . P210 – P260 . P261 – P332 . P333 – P339 . P340 – P402 . P403 – P461 . P462 – P501 . P502 – P513 . P514 – P613 . P614 – P667 . P668 – P683 . P684 – P708 . P709 – P735 . P736 – P739 . P740 – P792 . P793 – P825 . P826 – P836 . P837 – P945 . P946 – P957 . P958 –P1082 P1083 –P1152 16th European Congress of Endocrinology 2014, Wrocław, Poland Poster Presentations Endocrine Abstracts (2014) Vol 35 16th European Congress of Endocrinology 2014, Wrocław, Poland P955 Testosterone supplementation and sexual function: a meta-analysis study Giovanni Corona1, Andrea M Isidori3, Jaques Buvat4, Antonio Aversa3, Giulia Ratrelli2, Geoff Hackett5, Vincenzo Rochira6, Andrea Lenzi3 & Mario Maggi2 1 Endocrinology Unit, Bologna, Italy; 2Sexual Medicine and Andrology Unit, Florence, Italy; 3Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy; 4Centre ETPARP, Lille, France; 5Good Hope Hospital, Sutton Coldfield, UK; 6Department of Biochemical, Metabolic and Neural Sciences, Chair of Endocrinology, University of Modena and Reggio Emilia and Azienda USL of Modena, Modena, Italy. Introduction The role of testosterone supplementation (TS) as a possible treatment for male sexual dysfunction remains questionable. The aim of the present study is to metaanalyse data evaluating the effects of TS on male sexual function and its therapeutic synergism with the use of phosphodiesterase type 5 (PDE5i). Methods An extensive Medline Embase and Cochrane search was performed including the following words: ‘testosterone’, ‘erectile dysfunction’. All randomized controlled trials (RCTs) comparing the effect of TS vs placebo on sexual function or the effect of TS as add on to PDE5ı` s on sexual function were included. Data extraction was performed independently by two of the authors (A.M.I, G.C), and conflicts resolved by the third investigator (M.M). Results. Out of 1702 retrieved articles, 41 were included in the study. In particular, 29 compared TS vs placebo, whereas 12 trials evaluated the effect of TS as add on to PDE5ı`s. TS is able to significantly ameliorate erections and to improve other aspects of male sexual response in hypogonadal patients. However, the presence of publication bias was detected. After applying Duval and Tweedie ‘trim and fill’ method, the positive effect of TS on erectile function and libido components retained significance only in RCTs partially or completed supported from pharmaceutical companies (CI (0.04–0.53) and (0.12;0.52) respectively). In addition, we also report that TS could be associated with an improvement in PDE5i outcome. These results were not confirmed when placebo-controlled studies were selectively analysed. The majority of them, however, included mixed eugonadal/hypogonadal subjects. Conclusions TS plays positive effects on male sexual function in hypogonadal subjects. The apparent difference between industry-supported and independent studies could depend on trial design more than on publication bias. New RCTs exploring the effect of TS in selected cases of PDE5i failure who persistently retain low T levels are advisable. DOI: 10.1530/endoabs.35.P955 of adrenal cortex as mechanism enabling a consequent synthesis of neuroprotective steroids in various human peripheral tissues. The neuroprotective effects of individual steroids and a possible utilization of the results for the diagnosis and treatment of MS were discussed. DOI: 10.1530/endoabs.35.P956 P957 Role of clinical risk factors and polymorphisms in glucocorticoid receptor gene in the determining the risk of developing new-onset diabetes after kidney transplantation Grazia Michetti1, Laura Trementino1, Giorgia Marcelli1, Gloria Apolloni1, Domenica Taruscia2, Giovanni Maria Frasca2, Marco Boscaro1, Emanuela Faloia1 & Giorgio Arnaldi1 1 Division of Endocrinology, Polytechnic University of Marche, ANCONA, Italy; 2Nephrology and Dialysis Uinit, Polytechnic University of Marche, ANCONA, Italy. Introduction New onset diabetes after transplantation (NODAT) is a recognized metabolic complication of kidney transplantation: its rates at 12 months after transplantation is between 20 and 50% for kidney recipients and it is associated with increased risks of graft rejection, infection, cardiovascular disease and death. Transplantspecific risk factors for NODAT,such as corticosteroids and calcineurin inhibitors, play a dominant role in its pathogenesis. Furthermore polymorphisms in GR gene are common in the human population and play a role in regulation of glucocrticoid sensitivity. Objective Determine the incidence genetic and clinical risk factors for NODAT among kidney recipients in our centre. Patients and methods We studied 96 kidney allograft recipients without preexisting diabetes. The presence of arterial hypertension, blood chemistry and BMI were assessed at 3, 6 and 12 months. GR gene polymorphism (BclI, A3669G) were analyzed using RT-PCR System and Taqman allelic discrimination assays. Results Three months after renal transplantation 27% recipients developed NODAT. There were no significant differences in age, mean daily steroids doses and genetic polymorphism in GR between patients with NODAT and healthy control. Patients with NODAT had a BMI significantly increased compared with healthy control (25.4 vs 21.8, PZ0.02). Conclusions The prevalence of NODAT in our center is similar to that found in the literature. BMI and obesity are a risk factors for NODAT. Age, daily steroids doses and genetic polymorphism in GR are not correlates with its development. DOI: 10.1530/endoabs.35.P957 P956 Profiling of neuroactive steroids, their precursors and metabolites in patients suffering from multiple sclerosis Radmila Kancheva1, Martin Hill1, Lyudmila Kancheva1, Marta Velikova1, Miluse Pavelcova2, Luboslav Starka1 & Eva Havrdova2 1 Institute of Endocrinology, Prague, Czech Republic; 2Department of Neurology, First Faculty of Medicine, Center of Demyellinating Diseases, Charles University, Prague, Czech Republic. Some steroids modulate the permeability of ionotropic receptors on cell membranes and therefore may activate or inhibit neuronal activity depending on the steroid structure. These neuroactive steroids (NAS) exert neuroprotective effects like the neuronal remyelination. Multiple sclerosis (MS) is the most common cause of neurological disability in young adults. Therefore, the authors have followed the neuroprotective, GABAergic, glycinergic, glutamatergic acetylcholinergic and purinergic NAS, their precursors and metabolites and their conjugates (64 steroids)in the D4 and D5 steroidogenic pathways, estrogens, 5a/b-reduced pregnanes and androstanes (both 17-oxo and 17b-hydroxy), 7a/b- and 16a-hydroxyderivatives of the D5 steroids, and 20a-hydroxyderivatives of the D4 and D5 steroids, and 5a/b-reduced pregnanes in the circulation and cerebrospinal fluid of 13 female patients – 36 years old median age and 8 sex age matched healthy controls (both in the follicular menstrual phase) with the use of gas chromatography – mass spectrometry. The steroid conjugates were hydrolyzed and the released steroids were detected like the case of the unconjugated ones. The primary finding was the increased levels of C21 steroids in body fluids, which points to increased activity Endocrine Abstracts (2014) Vol 35 Thyroid (non-cancer) P958 A case of primary hypothyroidism: Lingual thyroid ¨ ztu¨rk1, S¸enay Arıkan2, Yunus I˙lyas Kibar1, Ahmet Tay1 & Yasin O Mehmet Emin Ayhan1 1 Erzurum Bo¨lge Eg˘itim ve Aras¸tırma Hastanesi ˙Ic¸ Hastalıkları, Erzurum, Turkey; 2Erzurum Bo¨lge Eg˘itim ve Aras¸tırma Hastanesi Endokrinoloji Ve Metabolizma Klinig˘i, Erzurum, Turkey. Lingual thyroid is an abnormal formation appearing as the result of a deficient descent during embryological development of the thyroid gland through the thyroglossal duct to its normal pretracheal location, and it is a rare embryological aberration. A 19 years old woman was admitted to with foreign-body-feeling, dysphonia, hoarseness, constipation. Examination showed a spherical, red fleshy and smooth contoured mass rat back of the tongue. Thyroid scan with technetium 99 m revealed isotope uptake in the base of tongue area and no uptake in the normal thyroid location. With these findings lingual thyroid was diagnosed. Surgical exision was not recommended since the lingual mass was the only functioning thyroid gland and medical treatment was appropriate. We aimed to present a case of lingual thyroid and hypothyroidism with laboratory and imaging findings. DOI: 10.1530/endoabs.35.P958 16th European Congress of Endocrinology 2014, Wrocław, Poland Author Index Abaci, N P593 Abarikwu, S P708 Abbara, A OC3.1, OC9.4 & P617 Abbaszadegan, MR P108 Abdallah, NB P840 Abdelrazek, S P1041 & P1055 Abdin, A P320 & P552 Abdollahi, M P405 Abdulla, H P848 Abeguile, G P148 Aberer, F P488 Aberle, J P581 Abeysinghe, P P786 Abi, A P472 Abouglila, K P846 Abrahamsson, N P770 Abraitiene, A P838 Abramavicius, S P369 Abreu, A P711 Abrosimov, AY P1108 Abs, R S21.3 Acar, B P343 Acar, FZ P1036 & P31 Acibucu, F P1120 Acikgoz, E P753 Ackermans, MT P946 Adamcova, M P22 Adamek, D P829 Adamidou, F P167 & P314 Adamska, A P134 & P663 Adamska, E OC4.1 & P776 Adas, G P14 Adas, M P14 Ademoglu, E P115 Adhiyaman, V P249 Adorini, L P696 Adukauskiene, D P931 Adversi, F P643 Ae Lee, K P1085 Aflorei, ED OC12.1 Afzal, N P1032 Agackiran, Y P136 Agapito, A P654 & P780 Agata, K P124 Agbaht, K P742 Aghaei, M P71 Aghajanova, Y P120 & P477 Aghili, R P405 Agnieszka, C OC5.5 Aguiar, A P631 Aguilar-Diosdado, M P206, P393, P395, P398 & P496 Ahmed, A P1089 Ahmeti, I P248 Ahn, KJ P342 & P429 Aigelsreiter, A P192 Aimaretti, G P145 AiMin, X P771 Ajduk, M P785 Akc¸ay, G P66 Akbal, E P968 Akbay, E P270 & P271 Akcay, T P821 Akgul, OF P244, P245 & P632 Akhtar, S P951 Akin, F OC9.5, P1027, P263, P264 & P380 Akin, S P48 & P917 Akkurt, A P531 Akopyan, S P120 Akpinar, G P1010 Akpinar, S P275 Aksana, K P805 Aksoy, A P115 Aksyonova, E P778 Aktimur, R P126 Akturk, M P1030, P151, P492 & P700 Akyildiz, M P171 & P172 Al-Dujaili, E P170 Al-Hayek, A P351 Al-Sabaan, F P351 Al-Saeed, A P351 Alacacioglu, A P332 Albarel, F P875 Alberiche, MdP P1073 Albersmeyer, M P868 Alborg, VC P909 Albrecht, E P739 Alebic, MS P686 Aled Rees, D OC5.2 Aleksandra, K OC5.5 Alesse, E P834 & P835 Alevizaki, M P1080 & P1102 Alexander Iwen, K OC7.5 Alexandraki, K P537, P598 & P608 Alexianu, M P815 Alexopoulou, O P860 Alfaro, JJ P467 Algu¨n, E P10 Alhumaidi, N P77 Ali Alhamza, AH P1 Ali Mansour, A P1 Ali, LA P542 Aliev, A P1050 & P584 Alikasifoglu, M P388 Alimova, N P358 & P417 Alkhalaf, F P77 Allelein, S P613 Allolio, B OC2.2, OC3.2, OC5.3, P2, P533 & P535 Almagro, RM P1002 & P1003 Almanza, MR P909 Almeida, R P823, P926 & P943 Almeida, T P654 Almomin, AMS P1 Alobedallah, A P351 Alonso, AA P575 Aloumanis, K P67 & P68 Alt-Tebacher, M P1042 Altas, A P1058 Altieri, B P535 Altinok, M P618 Altinova, A P446 & P492 Altinova, AE P1030 & P151 Altun, B P968 Altunbas, HA P131, P74 & P900 Altundal, N P894 Altunel, MS P432 & P433 Altunkaya, C P279 & P285 Altunoren, O P238 Altuntas, Y P221 & P472 Alves, M P1009, P327, P53, P546 & P547 Alves, MG P571 Alves, MR P702 Alves, R P461 Amani, MEA P984 & P985 Amar, L P49 Amaral, C P329, P457, P764 & P769 Amaral, D P807 Amaral, FG P719 Amaro, T P1149 Ambroziak, U P338 Ammini, A P335 Ammini, AC P580 & P582 Amrani-Raissouni, T P106 Amselem, S P675 Amzar, D P543, P573 & P893 Anaforog˘lu, P10, P23 & P729 Anagnostis, P P167 & P314 Anastasiu, D P65 Andersen, AS P337 Andersen, LLT P621 Andersen, M P618, P621 & P673 Andersen, MN OC1.2 Anderwald, C P129 Andrada, P P781 Andreas, B P714 Andreas, H P714 Andres, E P1042 Androulakis, I P641 Andrusiewicz, M P1119 & P836 Andrysiak-Mamos, E P100, P604 & P99 Andujar-Plata, P P731 Anelli, S P530 Angelini, F P937 Angelini, M S16.3 Angelopoulou, A P1102 Angelova, P P156 Anghel, GC P733 Anghel, R P734 Anheˆ, GF P719 Anil, C P403 & P468 Anna, S P180 Ansaloni, A P1053 & P924 Ansari, NE P72 Antic, IB P299, P313, P623, P624 & P625 Antic, S P828 Antiguedad, CG P445 Anton, M P814 Antonelou, M P920 Antosz, A P587 Antunes, A P823 Anwer, U P685 & P699 Aout, M P885 & P907 Apaydin, MA P863 Apollonatou, S P950 Apolloni, G P957 Apostolakis, M P1102 Arıkan, P958 Arau´jo-Vilar, D P811 Arabaci, E OC1.1 Aragu¨e´s, JM P350 Arakelyan, L P120 Aral, F P593 Aral, Y P385 16th European Congress of Endocrinology 2014, Wrocław, Poland Regadera, J P738 Reghina, AD P431 Reimondo, G P8 Reincke, M MTE5, OC2.2, OC5.4, P203, P37, P564, P568 & P7 Reisch, N S14.1 Renata, C P1103 Rentziou, G P1102 Requena, JR P811 Requena, M P237 & P445 Rese´ndiz, KH P918 Resch, J OC7.5 Resmini, E OC12.5 Ress, C P861 Reyes-Garcı´a, R P91 Rezvani, R P773 Rheinheimer, J P365 Ribalta, MT P722 Ribeiro, C P1111 Riesco-Eizaguirre, G PL2 Ricciuti, A OC12.3 Richard, N P148 Richter-Unruh, A S14.1 Ricotti, R P145 & P27 Ridruejo, E P687 Ries, M P2 Rieske, P P97 & P98 Riester, A P37 & P568 Rigas, G P748 Rimpau, J P735 Rinaldi, E P47 Rinco´n-Ferna´ndez, D P516 Rindi, G P549, P551 & P578 Ripoll, RQ P909 Risbridger, G OC10.4 Ritvonen, E P881 Ritzel, K P7 Rivadeneira, L P237 & P445 Rivera, NG P51 & P597 Rivera, R P741 Rivero-Corte´s, E OC12.2 Rivory, P P652 Rizoulis, A P1054 Rizvi, S P1031 Rizvi, SSR P1032, P685 & P699 Roa, R P487 Roberts, J P914 Robledo, M P1095 Roca, M P500 Roca-Rodrı´guez, M P261 Roccio, M P27 Rochira, V P1053, P519, P701, P924 & P955 Rodrı´guez Gutie´rrez, FJ P1003 Rodrı´guez, C P1073 Rodrı´guez, E P1073 Rodrı´guez, JP P51 & P597 Rodrı´guez, R P322 Rodrı´guez-Medina, B P695 Rodrı´guez-Molina, JM P186 Rodrigues, D P1009, P296, P325 & P327 Rodrigues, E P889 Rodrigues, P P17 Rodrigues, SC P719 Rodriguez, JP P498 Roemmler-Zehrer, J P735 Rogin´ska, D P54 Rogowicz-Frontczak, A P378 & P420 Roine, R P881 Rojo-Martinez, G P789 Roma´n, MM P376 Romanelli, MMC P766 Romero, AO P743 Romero, MF P743 Romualdi, D P653 Ronchi, C OC2.3 & P533 Ronchi, CL OC2.2, OC5.3 & P535 Rosłonowska, E P557 Rosado, V P1095 Rosc, D P408 Rosca, R P204 Rosca, RI P529 Rosell, J P515 Rosenwald, A OC5.3 Roskosz, J OC1.5 & P1098 Roslon, M P1139 Ross, I P40 Ross, R P30 & P825 Ross, RJ OC5.2 Rossetti, P P1007 Rossetti, R P646 Rossi, M P692, P694 & P704 Rossi, S P1126 Rostomyan, L P834 Roszak, M P1021 Rotermund, R P581 Rothenbuhler, A P140 Rotondi, S P834 & P835 Rousso, D P1047 Roux, A P652 Rozhinskaya, L P119, P24, P730, P912, P919 & P934 Rozhko, A P181 Rozkowszka, K P557 Ruas, L P1008, P1009, P1111 & P296 Rubin, B P12 & P536 Rubino, M P128 Ruby, LCH P771 Ruchała, M P1035, P1044, P1119, P202, P338, P36, P836, P982 & P983 Ruchala, M P326, P563, P996 & S10.2 Rudnicka, M P99 Rudnik, A P832 Rudzinska, M P1131 & P1135 Rudzki, G P254, P258 & P556 Ruiz-Riquelme, A P811 Rupa, R P849 Ruprecht, Z P408 Rusak, M P776 & P818 Rusakov, V P266, P267 & P268 Rusalenko, M P181 Rusinek, D OC3.5 & P1152 Rusu, C P795, P814 & P819 Ruszkowska-Ciastek, B P408 Ruszniewski, P P577 & P578 Rutishauser, J OC3.2 & P18 Rutkowska, A P511 Rutkowska, B P952 Rutter, M OC11.2 Ruvo, MD P831 Rybalchenko, V P422 Rybka, J P372 Rybka, W P372 Rydzanicz, M P338 Rymaszewska, J P127 & P930 Rys, A P157, P309 & P777 Ryu, OH P384 Ryzhenkova, MI P1108 Sa´, J P389 & P390 Sa´daba, MC P669 Sa´nchez, A P1073 Sa´nchez, F P205 Sa´nchez, JRC P575 Sa´nchez, R P1073 Sa´nchez-Garcı´a, F P515 Sa´nchez-Iglesias, S P811 Sa´nchez-Zambrano, M P205 Sa´sikova´, M P884 Se˛siadek, M P890 Słapa, R P557 Słoka, N P127 Słowin´ska-Srzednicka, J P557 Sørensen, H P673 Sørensen, JA P621 Saad, F P478, P696, P754 & P755 Saaid, N P107 Saavedra, A P936 Sabino, T P654 & P780 Sabir, I P335 Sabt, A P77 Sacchi, S P639 Sacikara, M P136, P305, P635, P980 & P987 Sadikova, E P142 & P375 Sadowski, T P160 Sadurska, E P1004 Sadykova, A P417 & P418 Saeger, W P901 Safari, R P71 Sag, S P753 Sagala, M P806 Saglam, F P1065, P305, P421, P78 & P981 Sagliker, HS P231 & P301 Sahin, D P442 Sahin, F P69 Sahin, H P244 & P295 Sahin, I P1048 & P490 Sahin, M OC8.3, P139, P146, P183, P228, P230, P231, P238, P244, P245, P295, P301, P437, P5, P632, P638 & P994 Saini, S P746 Saito, H P76 Sajardo, RB P575 Sajevets, T P277 Sajid, W P337 Sak, SD P61 Sakamoto, M P232 & P897 Sakamoto, N P232 Saklamaz, A P171 & P172 Sala, E P845 & P898 Sala, GBL P643 Salam, R P107 & P959 Salas, MS P237 & P445 Salas-Salvado´, J S29.1 Salcuni, AS P81 Salgado, C P1149