Cover Page
The handle http://hdl.handle.net/1887/32666 holds various files of this Leiden University
dissertation
Author: Schilder, Janneke
Title: Motor dysfunction in complex regional pain syndrome : studies on objective
measures
Issue Date: 2015-04-07
Motor dysfunction in complex regional pain syndrome
Studies on objective measures
Johanna C.M. Schilder
Johanna C.M. Schilder
Motor dysfunction in complex regional pain syndrome: studies on objective measures
PhD Thesis, Leiden University Medical Center, Leiden 2015
ISBN: 978-94-6299-052-4
Printed by: Ridderprint BV, Ridderkerk
Cover lay-out: Büro Dynamo; cover photo: cliparea.com
Lay-out: J.C.M. Schilder
© J.C.M. Schilder, Leiden, 2015. All rights reserved. No part of this thesis may be
reproduced or transmitted in any form or by any means without prior permission of
the copyright owner. Copyright of the articles that have been published or accepted
for publication has been transferred to the respective journals.
Motor dysfunction in complex regional pain syndrome
Studies on objective measures
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties
te verdedigen op dinsdag 7 april 2015
klokke 13.45 uur
door
Johanna Cornelia Maria Schilder
geboren te Purmerend
in 1983
Promotie commissie
Promotor
Prof. dr. J.J. van Hilten
Co-promotor
Dr. J. Marinus
Overige leden
Prof. dr. J.H. Arendzen
Prof. dr. R.A.C. Roos
Prof. dr. W.W.A. Zuurmond (Vrije Universiteit Amsterdam)
These studies were performed within TREND (Trauma RElated Neuronal Dysfunction),
a knowledge consortium that integrates research on Complex Regional Pain
Syndrome type 1. The project was supported by a Dutch government grant
(BSIK03016).
Financial support for the publication of this thesis has been provided by the
Patiëntenvereniging Complex Regionaal Pijn Syndroom.
The fox knows many things, but the hedgehog knows one big thing.
Archilochus, 680-645 B.C.
Voor mijn ouders
CONTENTS
Chapter 1
General introduction and aims
9
Chapter 2
The terminology of akinesia, bradykinesia, and hypokinesia:
past, present and future (Submitted)
19
Chapter 3
Motor control in complex regional pain syndrome – a
kinematic analysis (Pain 2012; 153(4): 805-12)
47
Chapter 4
Pain relief is associated with improvement in motor
function in complex regional pain syndrome type 1:
secondary analysis of a placebo-controlled study on the
effects of ketamine (J Pain 2013; 14(11): 1514-21)
71
Chapter 5
Responsiveness to botulinum toxin type A in muscles of
complex regional pain syndrome patients with tonic
dystonia (J Neural Transm 2014; 121(7): 761-7)
89
Chapter 6
Diurnal and nocturnal skin temperature regulation in
chronic complex regional pain syndrome (Accepted for
publication, J Pain 2014 Dec)
107
Chapter 7
Summary, conclusions and future perspectives
125
Chapter 8
Samenvatting, conclusie en toekomstperspectieven
137
List of publications
151
Dankwoord
153
Curriculum vitae
155