Scientific Spring Meeting
Friday April 11, 2014
Dutch Society for Clinical Pharmacology and Biopharmacy
Nederlandse Vereniging voor Klinische Farmacologie en Biofarmacie
PROGRAMME of the SCIENTIFIC MEETING
Friday, April 11, 2014
LUMC, Leiden
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SCIENTIFIC MEETING OF THE DUTCH SOCIETY FOR CLINICAL PHARMACOLOGY AND BIOPHARMACY (NVKFB)
The Dutch Society for Clinical Pharmacology and Biopharmacy receives an Educational Grant from MSD (Merck Sharp & Dohme) BV, Haarlem, the
Netherlands, once a year.
09.00 h
Welcome & coffee
ORAL PRESENTATIONS
09.30 h
D.R. Wong, M.J.H. Coenen, L.J.J. Derijks, S.H. Vermeulen, A.L.M. Verbeek, B. Franke, H-J. Guchelaar, D.J. de Jong,
L.G.J.B. Engels, P.M. Hooymans; on behalf of the TOPIC study group (Sittard-Geleen): Early elevated 6TGN and 6MMPR
thiopurine metabolite concentrations predict thiopurine-induced leukopenia in inflammatory bowel disease patients
09.45 h
T. De Backer, M. Petrovic, K. Audenaert, D. De Bacquer (Gent): SERotonergic antidepressants and the risk of VALvular heart
disease. A case-control study.
10.00 h
L.A. Lammers, R. Achterbergh, E.M. De Vries, F.S. Van Nierop, H.J. Klümpen, M.R. Soeters, A. Boelen, J.A. Romijn, R.A.A. Mathôt
(Amsterdam): The influence of short term fasting on CYP450 drug metabolism in healthy subjects
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10.15 h
P.M. Bet, E.C. Verbeek, Y. Milaneschi, D.B.M. Straver, T. Uithuisje, M.R. Bevova, J.G. Hugtenburg, P. Heutink, B.W.J.H. Penninx,
W.J.G. Hoogendijk (Amsterdam): A common polymorphism in the ABCB1 gene is associated with side effects of PGP-dependent
antidepressants in a large naturalistic Dutch cohort
Highlights of clinical pharmacology in 2013
10.30 h
Dr. A.H. Maitland van der Zee: To genotype or not to genotype? Pharmacogenetics of coumarins.
11.00 h
Coffee and Tea Break
Highlights of clinical pharmacology in 2013
11.15 h
Dr. L. Verkooijen: Cohort multiple randomised controlled trial design
11.45 h
Prof. dr. P. van Riel: Pathogenesis and treatment of rheumatoid arthritis
12.15 h
LUNCH and POSTER SESSION
1.
R. Noordam, M.E. van den Berg, N. Aarts, J.A. Kors, A. Hofman, B.H. Stricker, L.E. Visser (Rotterdam): Tricyclic antidepressants
prolong the Bazett’s heart rate corrected QT interval, but do not cause repolarization disturbances
2.
J.H.M. Driessen, H.A. van Onzenoort, A. Lalmohamed, R. van der Zanden, K. Neef, F. de Vries (Maastricht): Use of glucagon-like
peptide 1 analogues and the risk of fracture in type 2 diabetes patients
3.
B.H. Schievink, H.J. Lambers Heerspink, H.G. Leufkens, D. de Zeeuw, J. Hoekman (Groningen): Surrogate endpoint use in drug
marketing authorization: opinions of stakeholders
4.
N. Aarts, J.C. van Blijderveen, R. Noordam, E.M. Rodenburg, B.H. Stricker, L.E. Visser (Rotterdam): SSRIs and TCAs are associated
with an increased risk for hyponatremia in a community-dwelling adult population
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5.
M.J.E. Brill, A. van Rongen, A.P.I. Houwink, B. van Ramshorst, R.J. Wiezer, E.P.A. van Dongen, C.A.J. Knibbe (Leiden): Midazolam
pharmacokinetics following semi-simultaneous oral and intravenous administration in morbidly obese patients before and 1 year after
bariatric surgery
6.
D. de Wit, N.P. van Erp, J. den Hartigh, R. Wolterbeek, M. den Hollander-van Deursen, M. Labots, H.J. Guchelaar, H.M. Verheul,
H. Gelderblom (Leiden): Therapeutic drug monitoring to individualize the dosing of pazopanib: a pharmacokinetic feasibiliy study
7.
M.I. Blonk, M.W. Van Beek, A.P. Colbers, M.M. Roukens, B.J. Schouwenberg, D.M. Burger (Nijmegen): A pharmacokinetic drugdrug interaction study between raltegravir and atorvastatin
8.
R. van der Zanden, F. de Vries, A. Lalmohamed, A. Driessen, A. de Boer, G. Rohde, L. Stolk, C. Neef, C. Den Heijer (Maastricht):
The risk of pneumonia during the use of dipeptidyl-peptidase-4 inhibitors: a retrospective population based cohort study
9.
P. De Bruyne, A. De Guchtenaere, C. Van Herzeele, A. Raes, J. Dehoorne, P. Hoebeke, E. van Laecke, J. Vande Walle (Gent):
Adult bioequivalence studies insufficient for paediatric use: the case of desmopressin
10.
T. Kröpelin, H. Lambers Heerspink, D. Andress, D. de Zeeuw (Groningen): Optimizing clinical trial design in nephrology: how often
should albuminuria be measured to assess drug efficacy?
11.
E.C.T. Geijteman, J.M. van Pelt-Sprangers, J. Alsma, I.A. Boere, S.C.E. Schuit, R.H.J. Mathijssen (Rotterdam): Oromandibular
dystonia: a rare but serious side effect of capecitabine
12.
M.G. Caris, J.J. Sikkens, A.B.D. van Doorn, M.A. van Agtmael (Amsterdam): Personalised post-graduate education: intrinsic
motivation as a predictor of participation in e-learning on antimicrobial therapy
13.
S.E. Rongen, A.I.A. Ahmed, T.B. Feuth (Venray): Prevalence of potential inappropriate prescribing in older patients admitted to
psychiatric hospital: a cross-sectional, cohort study
14.
R.J.M. Brüggemann, W.J.F. Van Der Velden, C.A.J. Knibbe, A. Colbers, S. Hol, D.M. Burger, N.M.A. Blijlevens, J.P. Donnelly
(Nijmegen): A pharmacokinetic rationale for alternate dosing strategies of anidulafungin
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15.
V.J.C. Lempers, J.J.M.W. van den Heuvel, F.G.M. Russel, D.M. Burger, J.B. Koenderink, R.J.M. Brüggemann (Nijmegen): Novel
molecular insights into the inhibitory potential of antifungal drugs on ATP-binding cassette transporters MRP1-5, P-gp, BCRP and
BSEP
16.
J.C.G.H. van der Stegen, A.M. Harmsze, W. van ‘t Geloof, A.T.M. Wasylewicz, C.H.M. Kerskes, R.J.E. Grouls (Eindhoven): Clivital:
proof-of-principle study on the added value of clinical rule assisted medication review in Vitalis nursing homes
17.
P.C. Bank, J.J. Swen, H.J. Guchelaar, R.J. van der Straaten (Leiden): Concordance of Genochip Tamox array CYP2D6 genotyping
results with amplichip
18.
M.J.A. Janssen, N.B. Mahmood, F. Karapinar-Çarkıt (Amsterdam): Patient satisfaction survey regarding communication about
medications
19.
E. Haegeman, F. Buyle, A. Somers, D. Vogelaers, L. Van Bortel (Gent): Interaction between voriconazole and rifampicin: a case
report
20.
R. Fijn, T. ter Brake, J. de Waard, V.H.M. Deneer, E.H.H. Wiltink (Nieuwegein): Gerontopharmacological interventions in
hospitalised post surgical frail elderly: assessment of nature, extent and risk factors
21.
L. van Onzenoort, L.J. Schultze Kool, M. Wijnen, D.M. te Loo (Nijmegen): Experimental thalidomide treatment in two paediatric
patients with severe congenital arteriovenous malformations of the face
22.
L.M. Hanff, P.J. de Pagter, S.N. de Wildt, B.C.P. Koch (Rotterdam): Drugs of abuse as cause of coma in young children
23.
J. van der Valk, M. Zeeman, M. Arbouw, H. van den Oever (Deventer): Off-label use of clonidine for sedation in Dutch intensive care
units
24.
M.E Vromen, A.T.M. Wasylewicz, H.A. Verburg, W. van ’t Geloof, C.H.M. Kerskes, R.J.E. Grouls (Utrecht): Unnecessary
continuation of proton pump inhibitors at hospital discharge
25.
H.A. Verburg, A.T.M. Wasylewicz, M.E. Vromen, W. van ’t Geloof, C.H.M. Kerskes, R.J.E. Grouls (Utrecht): Clinical rule reduces
time to normalisation of serum potassium level
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26.
E.J.H. Janssen, K. Allegaert, J.N. van den Anker, A. Smits, R.F. de Cock, M. Danhof, C.A.J. Knibbe (Leiden): Simulations of
vancomycin exposure in neonates upon commonly used dosing guidelines: towards a model-based dosing guideline
13.45 h
GENERAL MEETING of the ‘NVKFB’
14.15 h
Lecture of the winner of the ‘NVKFB’-Thesis Award 2013: Dr. E. Krekels
14.45 h
Lecture of the winner of the ‘NVKFB’-TOP Publication Award 2013: Dr. E. Krekels
15.00 h
Coffee and Tea Break
15.15 h
ORAL PRESENTATIONS
15.15 h
H.N. Blufpand, A.J. Wilhelm, G.J.L Kaspers, G.J. Peters, A. Bökenkamp (Amsterdam): A simple formula based on cystatin C for
individual carboplatin dosing in children
15.30 h
M.J.E. Brill, A. van Rongen, A.P.I. Houwink, J. Burggraaf, B. van Ramshorst, R.J. Wiezer, E.P.A. van Dongen, C.A.J. Knibbe
(Leiden): Population pharmacokinetics of midazolam in morbidly obese patients versus healthy volunteers following semisimultaneous oral and intravenous administration
15.45 h
R. Noordam, M. Peters, A. Hofman, B.H. Stricker, L.E. Visser (Rotterdam): Association between the VKORC1 -1639G>A
polymorphism, mRNA expression levels, methylation and coumarin maintenance dosage
16.00 h
C.E. de Keyser, E.M. Koehler, J.N.L. Schouten, L.E. Visser, A. Hofman, H.L.A. Janssen, B.H. Stricker (Rotterdam): Statin therapy is
associated with a reduced risk of non-alcoholic fatty liver disease in overweight individuals
16.15 h`
H. Yu, J.S.L. Kloth, D. de Wit, J.H.M. Schellens, J.H. Beijnen, N. Steeghs, N.P. van Erp, R.H.J. Mathijssen, A.D.R. Huitema
(Amsterdam): Integrated semi-physiological pharmacokinetic model for sunitinib and its active metabolite
16.30 h
B.A.W. Jacobs, J.H. Beijnen, J.H.M. Schellens, A.D.R. Huitema (Amsterdam): Capecitabine population pharmacokinetics and the
effect of food
16.45 h
Closure
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