13734, B&T Ontwerp en advies (http://www.b-en-t.nl)

13734, B&T Ontwerp en advies (http://www.b-en-t.nl)

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EMC OR-01-34-01 - Hospital pharmacy and clinical pharmacology
Programme (brief description)
Pharmacokinetics (PK) describe how the organism handles a drug, pharmacodynamics (PD) deal with the effects of the drug on the organism. Pharmacogenetics studies the genetic factors that contribute to variability in both pharmacokinetics and pharmacodynamics.
In our research program we are active in all three topics. At present the focus of our activities is in the following areas of interest:
1.Pharmacogenetics, both in epidemiologic studies, as well as in clinical trials.
2.PK/PD studies, in collaborative studies with the departments of neurology, internal medicine, pediatrics, oncology, and dermatology.
3.Medication safety, including studies focused on prescription errors, electronic prescribing, and drug adherence.
4.Chronopharmacology, in collaborative studies with oncology and molecular biology.
Key Figures
Department Sp1 Sp2 Sp3 Sp4 SpTot T1 T2 T3 Ttot IS FS OP Ptot internal medicine 0,1 0,1 pharmacy 3,2 1 4,2
Total 3,3 1 0 0 4,3 0 0 0 0 39 11 4 54
Article/Letter to the editor
Al Hadithy, A.F.Y., Leeffers, E & Bruggeman, R. (2012). Clozapine Levels Might Be Affected by Excessive
Cola Consumption. Journal of Clinical Psychopharmacology, 32
Tissue Antigens, 79 (3), 174-185.
(5), 717-719.
Allard, SD, Goede, A.L. de, Keersmaecker, B De, Heirman, C., Lacor, P, Osterhaus, A.D.M.E., Demanet,
C, Thielemans, K., Gruters, R.A. & Aerts, JL (2012). Sequence evolution and escape from specific immune pressure of an HIV-1 Rev epitope with extensive sequence similarity to human nucleolar protein 6.
Amidi, M, Helden, MJG van, Tabataei, NR, Goede, A.L. de, Schouten, M., Bot, V de, Lanzi, A, Gruters,
R.A., Rimmelzwaan, G.F., Sijts, AJAM & Mastrobattista, E (2012). Induction of humoral and cellular immune responses by antigen-expressing immunostimulatory liposomes.
164 (3), 323-330.
Candidate Genes: A Prospective Study. PLoS One, 7 (12).
Journal of Controlled Release,
Bakker, P.R., Al Hadithy, A.F.Y., Amin, N., Duijn, C.M. van, Os, J. van & Harten, PN van (2012).
Antipsychotic-Induced Movement Disorders in Long-Stay Psychiatric Patients and 45 Tag SNPs in 7
Binkhorst, L., Gelder, T. van, Loos, W.J., Jongh, F.E. de, Hamberg, A.P., Ghobadi
Moghaddam-Helmantel, I., Jonge, E. de, Jager, A., Seynaeve, C., Schaik, R.H.N. van, Mathijssen, R.H.J.
& Verweij, J. (2012). Effects of CYP Induction by Rifampicin on Tamoxifen Exposure. Clinical
Pharmacology & Therapeutics, 92 (1), 62-67.
Binkhorst, L., Gelder, T. van & Mathijssen, R.H.J. (2012). Individualization of Tamoxifen Treatment for
Breast Carcinoma. Clinical Pharmacology & Therapeutics, 92 (4), 431-433.
Boer, E. den, Heil, S.G., Zelst, B.D. van, Meesters, R.J.W., Koch, B.C.P., Winkel, M.L. te, Heuvel-Eibrink,
M.M. van den, Luider, T.M. & Jonge, R. de (2012). A U-HPLC-ESI-MS/MS-based stable isotope dilution method for the detection and quantification of methotrexate in plasma. Therapeutic Drug Monitoring,
34 (4), 432-439.
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Bouamar, R., Elens, L.L.F.S., Shuker, N.M., Schaik, R.H.N. van, Weimar, W., Hesselink, D.A. & Gelder,
T. van (2012). Mycophenolic Acid-Related Anemia and Leucopenia in Renal Transplant Recipients Are
Related to Genetic Polymorphisms in CYP2C8. Transplantation, 93 (10), E39-E40.
Bouamar, R., Hesselink, D.A., Schaik, R.H.N. van, Weimar, W., Heiden, I.P. van der, Fijter, J.W. de,
Kuypers, DRJ & Gelder, T. van (2012). Mycophenolic acid-related diarrhea is not associated with polymorphisms in SLCO1B nor with ABCB1 in renal transplant recipients. Pharmacogenetics Genomics,
22 (6), 399-407.
Cheung, K.C., Wensing, M., Bouvy, ML, Smet, P.A.G.M. de & Bemt, P.M.L.A. van den (2012).
Self-reported uptake of recommendations after dissemination of medication incident alerts. BMJ Quality
& Safety, 21 (12), 1009-1018.
Dylst, P, Vulto, A.G. & Simoens, S (2012). How can pharmacist remuneration systems in Europe contribute to generic medicines dispensing? Pharmacy Practice, 10 (1), 3-8.
Dylst, P, Vulto, A.G. & Simoens, S (2012). Overcoming challenges in market access of generic medicines in the European Union. Journal of Generic Medicines, 9
Nature Biotechnology, 30 (12), 1186-1190.
(1), 21-28.
Ebbers, HC, Crow, S.A., Vulto, A.G. & Schellekens, H. (2012). Interchangeability, immunogenicity and biosimilars.
Elens, L.L.F.S., Hesselink, D.A., Schaik, R.H.N. van & Gelder, T. van (2012). Pharmacogenetics in
Kidney Transplantation Recent Updates and Potential Clinical Applications. Molecular Diagnosis &
Therapy, 16 (6), 331-345.
Elens, L.L.F.S., Bouamar, R., Hesselink, D.A., Haufroid, V, Gelder, T. van & Schaik, R.H.N. van (2012).
The new CYP3A4 intron 6 C > T polymorphism (CYP3A4*22) is associated with an increased risk of delayed graft function and worse renal function in cyclosporine-treated kidney transplant patients.
Pharmacogenetics Genomics, 22 (5), 373-380.
Goede, A.L. de, Boedhram, R.R., Eckhardt, M., Hanff, L.M., Koch, B.C.P., Vermaat, C.H. & Vermes, A.
(2012). Development and validation of a paediatric oral formulation of clonidine hydrochloride.
International Journal of Pharmaceutics, 433 (1-2), 119-120.
Hassink, J.J.M., Duisenberg-van Essenberg, M. & Bemt, P.M.L.A. van den (2012). De invloed van elektronische toedienregistratie op de frequentie van toedienfouten op een chirurgische afdeling.
6 , 95-98.
PW,
Herwaarden, MFWV, Kramers, C., Sturkenboom, M.C.J.M., Bemt, P.M.L.A. van den & Smet, P.A.G.M. de
(2012). Targeting Outpatient Drug Safety Recommendations of the Dutch HARM-Wrestling Task Force.
Drug Safety, 35 (3), 245-259.
Huang, L., Schoonenboom, J.E., Dongen, M.J.A. van, Maingay - de Groof, F, Minderman-Voortman,
G.J., Schierbeek, H., Twisk, J.W.R., Vermes, A., Chen, C, Huang, Y. & Goudoever, J.B. van (2012).
Methionine requirement of the enterally fed term infant in the first month of life in the presence of cysteine. American Journal of Clinical Nutrition, 95 , 1048-1054.
Hunfeld, N.G.M., Touw, D.J., Mathot, R.A.A., Schaik, R.H.N. van & Kuipers, E.J. (2012). A comparison of the acid-inhibitory effects of esomeprazole and rabeprazole in relation to pharmacokinetics and
CYP2C19 polymorphism. Alimentary Pharmacology & Therapeutics, 35 (7), 810-818.
Hunfeld, N.G.M., Touw, D.J., Mathot, R.A.A., Mulder, P.G.H., Schaik, R.H.N. van, Kuipers, E.J.,
Kooiman, J.C. & Geus, W.P. (2012). Vergelijking van de zuurremmende effecten van esomeprazol en pantoprazol in relatie tot farmacokinetiek en CYP2C19-polymorfisme. PW, 6 .
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Ivanova, SA, Al Hadithy, A.F.Y., Brazovskaya, N, Semke, A, Wilffert, B, Fedorenko, O, Brouwers, J.R.B.J.
& Loonen, A.J.M. (2012). No involvement of the adenosine A2A receptor in tardive dyskinesia in Russian psychiatric inpatients from Siberia.
334-337.
Human Psychopharmacology-Clinical and Experimental, 27 (3),
Kaaij, A.D.M. van der, Zaal, R.J., Evenhuis, H.M. & Bemt, P.M.L.A. van den (2012). Voorschrijffouten bij ouderen met een verstandelijke beperking: prevalentie en mogelijke risicofactoren.
209-214.
Annals of Pharmacotherapy, 46 (3), 329-338.
PW, 6 (12),
Karapinar-Carkit, F, Borgsteede, SD, Zoer, J, Egberts, TCG, Bemt, P.M.L.A. van den & Tulder, M. van
(2012). Effect of Medication Reconciliation on Medication Costs After Hospital Discharge in Relation to
Hospital Pharmacy Labor Costs.
Keyser, C.E. de, Stricker, B.H.C. & Becker, M.L. (2012). Genetic determinants of statin therapy: studies after the GWA. Pharmacogenomics, 13 (1), 15-16.
Kuip, E.J.M., Zandvliet, M.L., Mathijssen, R.H.J. & Rijt, C.C.D. van der (2012). Pharmacological and clinical aspects of immediate release fentanyl preparations: criteria for selection. EUROPEAN JOURNAL
OF HOSPITAL PHARMACY-SCIENCE AND PRACTICE, 19 (1), 38-40.
Leendertse, AJ, Dijk, E.A. van, Smet, P.A.G.M. de, Egberts, TCG & Bemt, P.M.L.A. van den (2012).
Contribution of Renal Impairment to Potentially Preventable Medication-Related Hospital Admissions.
Annals of Pharmacotherapy, 46 (5), 625-633.
Leeuwen, N. van, Nijpels, G., Becker, M.L., Deshmukh, H, Zhou, K, Stricker, B.H.C., Uitterlinden, A.G.,
Hofman, A., Riet, E van, Palmer, CNA, Guigas, B, Slagboom, P.E., Durrington, P, Calle, RA, Neil, A,
Hitman, G, Livingstone, SJ, Colhoun, H, Holman, RR, McCarthy, MI, Dekker, J.M., Hart, L.M. 't &
Pearson, E.R. (2012). A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts.
1971-1977.
Diabetologia, 55 (7),
Paling, FP, Andrews, L.M., Valk, GD & Blom, H.J. (2012). Life-threatening complications of ibogaine: three case reports. Netherlands Journal of Medicine, 70 (9), 422-424.
Prytula, A.A., Bouts, AH, Mathot, R.A.A., Gelder, T. van, Croes, LK, Hop, W.C.J. & Cransberg, K. (2012).
Intra-patient variability in tacrolimus trough concentrations and renal function decline in pediatric renal transplant recipients. Pediatric Transplantation, 16 (6), 613-618.
Ray, K, Wainwright, NWJ, Visser, L., Witteman, J.C.M., Breteler, M.M.B., Ambegaonkar, B, Hofman, A.,
Stricker, B.H.C., Wareham, N, Khaw, KT & Sandhu, M (2012). Changes in HDL cholesterol and cardiovascular outcomes after lipid modification therapy. Heart, 98 (10), 780-785.
Rodenburg, E.M., Eijgelsheim, M., Geleijnse, J.M., Amin, N., Duijn, C.M. van, Hofman, A., Uitterlinden,
A.G., Stricker, B.H.C. & Visser, L.E. (2012). CYP1A2 and coffee intake and the modifying effect of sex, age, and smoking. American Journal of Clinical Nutrition, 96 adverse reactions causing hospital admissions.
1045-1052.
(1), 182-187.
Rodenburg, E.M., Stricker, B.H.C. & Visser, L.E. (2012). Sex differences in cardiovascular drug-induced
British Journal of Clinical Pharmacology, 74 (6),
Rodenburg, E.M., Stricker, B.H.C. & Visser, L.E. (2012). Ziekenhuisopname door bijwerkingen: verschillen tussen man en vrouw.
Roomer, R., Bergmann, J.F., Boonstra, P.A., Hansen, B.E., Haagmans, B.L., Kwadijk, S., Vuuren, A.J. van, Knegt, R.J. de & Janssen, H.L.A. (2012). Continuous interferon-alpha 2b infusion in combination with ribavirin for chronic hepatitis C in treatment-experienced patients.
509-517.
Nederlands Tijdschrift voor Geneeskunde, 156 (49).
Antiviral Therapy, 17 (3),
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Ruiter, R, Visser, L.E., Rodenburg, E.M., Trifiro, G., Ziere, G. & Stricker, B.H.C. (2012). .
Ziekenhuisopnames door geneesmiddelbijwerkingen bij 55-plussers in Nederland. Nederlands
Tijdschrift voor Geneeskunde, 156 .
Ruiter, R. de, Visser, L.E., Rodenburg, E.M., Trifiro, G., Ziere, G. & Stricker, B.H.C. (2012). Adverse
Drug Reaction-Related Hospitalizations in Persons Aged 55 Years and Over: A Population-Based Study in the Netherlands. Drugs & Aging, 29
Dispensing Data in the Netherlands.
(3), 225-232.
Ruiter, R. de, Teichert, M., Straus, S.M.J.M., Stricker, B.H.C. & Visser, L.E. (2012). Concomitant Use of
Contraceptives and Potentially Teratogenic Medicinal Products-Results From a Study Using Pharmacy
Reproductive Sciences, 19 (9), 987-994.
Ruiter, R. de, Visser, L.E., Herk-Sukel, M.P.P., Coebergh, J.W.W., Haak, H.R., Geelhoed-Duijvestijn, PH,
Straus, S.M.J.M., Herings, R.M.C. & Stricker, B.H.C. (2012). Lower Risk of Cancer in Patients on
Metformin in Comparison With Those on Sulfonylurea Derivatives Results from a large population-based follow-up study.
1998 to 2008.
Diabetes Care, 35
Ruiter, R. de, Visser, L.E., Herk-Sukel, MPP van, Geelhoed-Duijvestijn, PH, Bie, S. de, Straus, S.M.J.M.,
Mol, PGM, Romio, S.A., Herings, R.M.C. & Stricker, B.H.C. (2012). Prescribing of Rosiglitazone and
Pioglitazone Following Safety Signals Analysis of Trends in Dispensing Patterns in the Netherlands from
Drug Safety, 35
(1), 119-124.
(6), 471-480.
Ruiter, R., Visser, L.E., Herk-Sukel, M.P.P., Coebergh, J.W.W., Haak, H.R., Geelhoed-Duijvestijn, PH,
Straus, S.M.J.M., Herings, R.M.C. & Stricker, B.H.C. (2012). Risk of cancer in patients on insulin glargine and other insulin analogues in comparison with those on human insulin: results from a large population-based follow-up study. maintenance dose.
Diabetologia, 55
Schie, R.M.F. van, Wessels, J.A.M., Verhoef, T.I., Schalekamp, T., Cessie, S. le, Meer, F.J.M. van der,
Rosendaal, F.R., Visser, L.E., Teichert, M., Hofman, A., Buhre, PNM, Boer, A. den & Zee, A.H. (2012).
Evaluation of the effect of genetic variations in GATA-4 on the phenprocoumon and acenocoumarol
Pharmacogenomics, 13
, 51-62.
(16), 1917-1923.
Shuker, N.M., Bouamar, R., Weimar, W., Schaik, R.H.N. van, Gelder, T. van & Hesselink, D.A. (2012).
ATP-binding cassette transporters as pharmacogenetic biomarkers for kidney transplantation. Clinica
Chimica Acta, 413 (17-18), 1326-1337.
Vehof, J, Burger, H., Wilffert, B, Al Hadithy, A.F.Y., Alizadeh, B.Z. & Snieder, H (2012). Clinical response to antipsychotic drug treatment: Association study of polymorphisms in six candidate genes. European
Neuropsychopharmacology, 22 (9), 625-631.
Verhoef, T.I., Redekop, W.K., Buikema, M.M., Schalekamp, T., Meer, F.J.M. van der, Cessie, S. le,
Wessels, J.A.M., Schie, R.M.F. van, Boer, A. den, Teichert, M., Visser, L.E. & Zee, A.H. (2012).
Long-term anticoagulant effects of the CYP2C9 and VKORC1 genotypes in acenocoumarol users.
Journal of Thrombosis and Haemostasis, 10 (4), 606-614.
Verschoor, S.P., Nagel, B.C.H. van der, Sibbles, B.J. & Koch, B.C.P. (2012). Meconiumtest spoort alcoholische moeder op. Pharmaceutisch Weekblad, 40
Vulto, A.G. (2012). A new chapter.
, 18-20.
EUROPEAN JOURNAL OF HOSPITAL PHARMACY-SCIENCE AND
PRACTICE, 19 (1), 1-1.
Vulto, A.G. (2012). Clinical trials on trial. EUROPEAN JOURNAL OF HOSPITAL PHARMACY-SCIENCE AND
PRACTICE, 19 (4), 347-347.
Vulto, A.G. (2012). Effective, safe and efficient. EUROPEAN JOURNAL OF HOSPITAL
PHARMACY-SCIENCE AND PRACTICE, 19 (5), 425-426.
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Vulto, A.G. (2012). Resolution in patient data. EUROPEAN JOURNAL OF HOSPITAL
PHARMACY-SCIENCE AND PRACTICE, 19 (3), 275-U117.
Vulto, A.G. & Crow, S.A. (2012). Risk management of biosimilars in oncology: each medicine is a work in progress. TARGETED ONCOLOGY, 7 , S43-S49.
Vulto, A.G. (2012). Special patients, specialised care.
PHARMACY-SCIENCE AND PRACTICE, 19 (2), 65-66.
EUROPEAN JOURNAL OF HOSPITAL
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EMC OR-01-39-07 - The allergic immune response and related allergic reactions
Programme (brief description)
The program is focused on the allergic immune response, the pathophysiological backgrounds of allergic disorders and the different forms of intervention. The induction of the allergic reaction by allergens is the basis of research to characterization of allergens, the relation between inhalant and food allergics and the modulation of the allergic reactions. Apart from classical pharmacotherapy and environmental control immunomodulation of the allergic response is the most promising form of intervention.
The main components of research comprise:
Occupational allergy. Erasmus MC has a unique location in a heavily industrialize environment, providing an excellent opportunity for research in occupational allergy.
This is reflected by research to allergy in horticulture and health professionals. Patient care in occupational allergy is organized in a multidisciplinary initiative instituted by the section of
Allergology in collaboration with the departments of Dermatology, Pulmonology, ENT and Public health. There is a close connection between this initiative and our research. The focus of research is on the incidence of occupational disease and the effects of occupational disease on sick leave, work performance, costs and health related quality of life. The results of these studies have been published as PhD thesis in the beginning of 2012.
Food allergy. Research focuses on the optimization of diagnostic procedures.
Research objectives are closely related with patient care initiatives. In particular, the new initiative "Kinderhaven" - collaboration between Allergology, Paediatric
Pulmonology and Paediatric Dermatology provides an environment for research to this topic.
Several studies from the section of Allergology focus on the discrepancy between sensitization and clinical allergy. A large study to the positioning of MRA's (mediator release assays) and other tools in the diagnosis of cashew nut allergy is financially supported by STW/NWO. The study has started in 2012
Immunomodulation. The section Allergology is taking part in large scale RCT's to the effectiveness of sublingual immunotherapy. There is collaboration with the dept. of General
Practice. A study to the efficacy of sublingual immunotherapy in children allergic to house dust mites has recently been finalised. Another immunotherapy study in children with a grass pollen allergy resulted in a PhD thesis in the beginning of 2012. A large cost- effectiveness study with regard to allergen immunotherapy among adults has been started in 2009. The section of
Allergology is taking the lead in this multi-centre study financially supported by ZonMW. The study was finalized at the end of 2012.
The section co-operates with the dept. of Parasitology, LUMC to the role of regulatory B-cells in subcutaneous immunotherapy in asthmatics. At the Erasmus MC the section is collaborating with the dept. of Immunology in a study to the role of IgE bearing B-cells in treatment of patients with either anti-IgE or immunotherapy. With prof. Barbara Bohle (department of Pathophysiology,
Medical University of Vienna) the section is studying the clinical and immunological effects of inhalant immunotherapy on cross-reactive food allergy. A clinical responder-analysis to immunotherapy is being carried out. Currently, the section is involved in new studies to the use of anti-IgE and epicutaneous immunotherapy in patients with a peanut allergy.
Key Figures
Department Sp1 Sp2 Sp3 Sp4 SpTot T1 T2 T3 Ttot IS FS OP Ptot family practice 0,7 0,7 internal medicine 0,9 1,4 2,3
Total
Thesis
0,9 2,1
Patiwael, J.A. (2012, maart 14).
Prof. Dr. R. Gerth van Wijk.
0 0 3 2 0 0 2 9 3 0 14
Interplay between allergy and work.
EUR (143 pag.). Prom./coprom.:
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Roder, E. (2012, februari 29). Sublingual immunotherapy in children with allergic rhinitis.
pag.). Prom./coprom.: Prof. Dr. R. Gerth van Wijk & M.Y. Berger.
EUR (179
Article/Letter to the editor
Bot, C.M.A. de, Moed, H., Berger, M.Y., Roder, E., Hop, W.C.J., Groot, H. de, Jongste, J.C. de, Gerth van
Wijk, R., Bindels, P. & Wouden, J.C. v.d. (2012). SIT: efficacy depends on product, not on route of application Reply. Pediatric Allergy and Immunology, 23 allergische rinitis in de huisartsenpraktijk.
(4), 401-402.
Bot, C.M.A. de, Moed, H., Berger, M.Y., Roder, E., Hop, W.C.J., Groot, H. de, Jongste, J.C. de, Gerth van
Wijk, R., Bindels, P.J.E. & Wouden, J.C. van der (2012). Sublinguale immunotherapie bij kinderen met
Nederlands Tijdschrift voor Geneeskunde, 156 .
Bousquet, J., Schunemann, HJ, Samolinski, B, Demoly, P, Baena-Cagnani, CE, Bachert, C., Bonini, S,
Boulet, L.P., Bousquet, PJ, Brozek, JL, Canonica, G.W., Casale, T.B., Cruz, AA, Fokkens, W.J., Fonseca,
JA, Gerth van Wijk, R., Grouse, L, Haahtela, T, Khaltaev, N, Kuna, P, Lockey, RF, Carlsen, KCL, Mullol, J,
Naclerio, R, O'Hehir, RE, Ohta, K, Palkonen, S, Papadopoulos, NG, Passalacqua, G., Pawankar, R., Price,
D, Ryan, D, Simons, FER, Togias, A, Williams, D, Yorgancioglu, A, Yusuf, OM, Aberer, W, Adachi, M,
Agache, I, Ait-Khaled, N, Akdis, CA, Andrianarisoa, A, Annesi-Maesano, I, Ansotegui, IJ., Baiardini, I,
Bateman, E.D., Bedbrook, A, Beghe, B, Beji, M, Bel, E.H., Kheder, A Ben, Bennoor, KS, Bergmann, KC,
Berrissoul, F, Bieber, T, Jensen, C.B., Blaiss, MS, Boner, A.L., Bouchard, J, Braido, F, Brightling, CE,
Bush, A., Caballero, F, Calderon, MA, Calvo, MA, Camargos, PAM, Caraballo, LR, Carlsen, K.H., Carr, W,
Cepeda, AM, Cesario, A, Chavannes, NH, Chen, YZ, Chiriac, AM, Perez, TC, Chkhartishvili, E, Ciprandi,
G, Costa, DJ, Cox, L, Custovic, A., Dahl, R, Darsow, U, Blay, F de, Deleanu, D, Denburg, JA, Devillier, P,
Didi, T, Dokic, D, Dolen, WK, Douagui, H, Dubakiene, R, Durham, S.R., Dykewicz, MS, El-Gamal, Y,
El-Meziane, A, Emuzyte, R, Fiocchi, A, Fletcher, M, Fukuda, T, Gamkrelidze, A, Gereda, JE, Diaz, SG,
Gotua, M, Guzman, MA, Hellings, P.W., Hellquist-Dahl, B, Horak, F, Hourihane, JO, Howarth, P,
Humbert, M, Ivancevich, JC, Jackson, C., Just, J, Kalayci, O, Kaliner, MA, Kalyoncu, AF, Keil, T, Keith,
PK, Khayat, G, Kim, YY, N'Goran, BK, Koppelman, G.H., Kowalski, ML, Kull, I, Kvedariene, V,
Larenas-Linnemann, D, Le, LT, Lemiere, C, Li, J., Lieberman, P, Lipworth, B, Mahboub, B, Makela, MJ,
Martin, F., Marshall, GD, Martinez, FD, Masjedi, MR, Maurer, M, Mavale-Manuel, S, Mazon, A, Melen, E,
Meltzer, EO, Mendez, NH, Merk, H, Mihaltan, F, Mohammad, Y, Morais-Almeida, M, Muraro, A., Nafti, S,
Namazova-Baranova, L, Nekam, K, Neou, A, Niggemann, B., Nizankowska-Mogilnicka, E, Nyembue, TD,
Okamoto, Y., Okubo, K, Orru, MP, Ouedraogo, S, Ozdemir, C., Panzner, P, Pali-Scholl, I, Park, HS,
Pigearias, B, Pohl, W, Popov, TA, Postma, D.S., Potter, P, Rabe, K.F., Ratomaharo, J, Reitamo, S, Ring,
J., Roberts, R., Rogala, B, Romano, A, Rodriguez, MR, Rosado-Pinto, J, Rosenwasser, L, Rottem, M,
Sanchez-Borges, M, Scadding, G.K., Schmid-Grendelmeier, P, Sheikh, A, Sisul, JC, Sole, D, Sooronbaev,
T, Spicak, V, Spranger, O, Stein, RT, Stoloff, S.W., Sunyer, J., Szczeklik, A, Todo-Bom, A, Toskala, E,
Tremblay, Y, Valenta, R, Valero, AL, Valeyre, D, Valiulis, A., Valovirta, E, Cauwenberge, P. van,
Vandenplas, O, Weel, C. van, Vichyanond, P, Viegi, G., Wang, DY, Wickman, M., Wohrl, S, Wright, J,
Yawn, B.P., Yiallouros, PK, Zar, HJ, Zernotti, ME, Zhong, N, Zidarn, M & Zuberbier, T (2012). Allergic
Rhinitis and its Impact on Asthma (ARIA): Achievements in 10 years and future needs. Journal of
Allergy and Clinical Immunology, 130 (5), 1049-1062.
Bousquet, J., Heinzerling, L, Bachert, C., Papadopoulos, NG, Bousquet, PJ, Burney, PG, Canonica, G.W.,
Carlsen, K.H., Cox, L, Haahtela, T, Carlsen, KCL, Price, D, Samolinski, B, Simons, FER, Wickman, M.,
Annesi-Maesano, I, Baena-Cagnani, CE, Bergmann, KC, Bindslev-Jensen, C, Casale, T.B., Chiriac, A,
Cruz, AA, Dubakiene, R, Durham, S.R., Fokkens, W.J., Gerth van Wijk, R., Kalayci, O, Kowalski, ML,
Mari, A, Mullol, J, Nazamova-Baranova, L, O'Hehir, RE, Ohta, K, Panzner, P, Passalacqua, G., Ring, J.,
Rogala, B, Romano, A, Ryan, D, Schmid-Grendelmeier, P, Todo-Bom, A, Valenta, R, Woehrl, S, Yusuf,
OM, Zuberbier, T & Demoly, P (2012). Practical guide to skin prick tests in allergy to aeroallergens.
Allergy, 67 (1), 18-24.
Bousquet, J., Anto, JM, Demoly, P, Schunemann, HJ, Togias, A, Akdis, M, Auffray, C, Bachert, C.,
Bieber, T, Bousquet, PJ, Carlsen, K.H., Casale, T.B., Cruz, AA, Keil, T, Carlsen, KCL, Maurer, M, Ohta, K,
Papadopoulos, NG, Rodriguez, MR, Samolinski, B, Agache, I, Andrianarisoa, A, Ang, CS,
Annesi-Maesano, I, Ballester, F., Baena-Cagnani, CE, Basagana, X, Bateman, E.D., Bel, E.H., Bedbrook,
A, Beghe, B, Beji, M, Kheder, A Ben, Benet, M, Bennoor, KS, Bergmann, KC, Berrissoul, F, Jensen, C.B.,
Bleecker, ER, Bonini, S, Boner, A.L., Boulet, L.P., Brightling, CE, Brozek, JL, Bush, A., Busse, W.W.,
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Camargos, PAM, Canonica, G.W., Carr, W, Cesario, A, Chen, YZ, Chiriac, AM, Costa, DJ, Cox, L,
Custovic, A., Dahl, R, Darsow, U, Didi, T, Dolen, WK, Douagui, H, Dubakiene, R, El-Meziane, A, Fonseca,
JA, Fokkens, W.J., Fthenou, E, Gamkrelidze, A, Garcia-Aymerich, J, Gerth van Wijk, R., Gimeno-Santos,
E, Guerra, S, Haahtela, T, Haddad, H, Hellings, P.W., Hellquist-Dahl, B, Hohmann, C., Howarth, P,
Hourihane, JO, Humbert, M, Jacquemin, B, Just, J, Kalayci, O, Kaliner, MA, Kauffmann, F, Kerkhof, M.,
Khayat, G, N'Goran, BK, Kogevinas, M, Koppelman, G.H., Kowalski, ML, Kull, I, Kuna, P, Larenas, D,
Lavi, I, Le, LT, Lieberman, P, Lipworth, B, Mahboub, B, Makela, MJ, Martin, F., Martinez, FD, Marshall,
GD, Mazon, A, Melen, E, Meltzer, EO, Mihaltan, F, Mohammad, Y, Mohammadi, A, Momas, I,
Morais-Almeida, M, Mullol, J, Muraro, A., Naclerio, R, Nafti, S, Namazova-Baranova, L, Nawijn, M.C.,
Nyembue, TD, Oddie, S, O'Hehir, RE, Okamoto, Y., Orru, MP, Ozdemir, C., Ouedraogo, GS, Palkonen, S,
Panzner, P, Passalacqua, G., Pawankar, R., Pigearias, B, Pin, I, Pinart, M, Pison, C, Popov, TA, Porta, D,
Postma, D.S., Price, D, Rabe, K.F., Ratomaharo, J, Reitamo, S, Rezagui, D, Ring, J., Roberts, R., Roca,
J, Rogala, B, Romano, A, Rosado-Pinto, J, Ryan, D, Sanchez-Borges, M, Scadding, G.K., Sheikh, A,
Simons, FER, Siroux, V, Schmid-Grendelmeier, PD, Smit, H.A., Sooronbaev, T, Stein, RT, Sterk, P.J.,
Sunyer, J., Terreehorst, I., Toskala, E, Tremblay, Y, Valenta, R, Valeyre, D, Vandenplas, O, Weel, C. van, Vassilaki, M, Varraso, R, Viegi, G., Wang, DY, Wickman, M., Williams, D, Wohrl, S, Wright, J,
Yorgancioglu, A, Yusuf, OM, Zar, HJ, Zernotti, ME, Zidarn, M, Zhong, N & Zuberbier, T (2012). Severe
Chronic Allergic (and Related) Diseases: A Uniform Approach - A MeDALL - GA(2)LEN - ARIA Position
Paper. International Archives of Allergy and Immunology, 158 (3), 216-231.
Calderon, MA, Demoly, P, Gerth van Wijk, R., Bousquet, J., Sheikh, A, Frew, A., Scadding, G.K.,
Bachert, C., Malling, H.-J., Valenta, R, Bilo, B., Nieto, A, Akdis, CA, Just, J, Vidal, C., Varga, EM,
Alvarez-Cuesta, E., Bohle, E., Bufe, A, Canonica, G.W., Cardona, V, Dahl, R, Didier, A, Durham, S.R.,
Eng, P, Fernandez-Rivas, M., Jacobsen, L., Jutel, M., Klein-Tebbe, J, Klimek, L., Lotvall, J, Moreno, C,
Mosges, R, Muraro, A., Niggemann, B., Pajno, G, Passalacqua, G., Pfaar, O, Rak, S, Senna, GE, Senti, G,
Valovirta, E, Hage, M van, Virchow, JC, Wahn, U. & Papadopoulos, N (2012). EAACI: a European declaration on immunotherapy. Design the future of allergen specific immunotherapy. Clinical and
Translational Allergy, 2 (1), 20.
Calderon, MA, Demoly, P, Gerth van Wijk, R., Bousquet, J., Sheikh, A, Frew, A., Scadding, G.K.,
Bachert, C., Malling, H.-J., Valenta, R, Bilo, B., Nieto, A, Akdis, CA, Just, J, Vidal, C., Varga, EM,
Alvarez-Cuesta, E., Bohle, B., Bufe, A, Canonica, G.W., Cardona, V, Dahl, R, Didier, A, Durham, S.R.,
Eng, P, Fernandez-Rivas, M., Jacobsen, L., Jutel, M., Kleine-Tebbe, J., Klimek, L., Lotvall, J, Moreno, C,
Mosges, R, Muraro, A., Niggemann, B., Pajno, G, Passalacqua, G., Pfaar, O, Rak, S, Senna, GE, Senti, G,
Valovirta, E, Hage, M van, Virchow, JC, Wahn, U. & Papadopoulos, N (2012). EAACI: a European declaration on immunotherapy: designing the future of allergen specific immunotherapy. Clinical and
Translational Allergy, 2 (1), 20.
Calderon, MA, Gerth van Wijk, R., Eichler, I, Matricardi, PM, Varga, EM, Kopp, MV, Eng, P, Niggemann,
B., Nieto, A, Valovirta, E, Eigenmann, PA, Pajno, G, Bufe, A, Halken, S., Beyer, K & Wahn, U. (2012).
Perspectives on allergen-specific immunotherapy in childhood: An EAACI position statement. Pediatric
Allergy and Immunology, 23 (4), 300-306.
Dieleman, M., Bettink-Remeijer, M.W., Jansen, J., Hoppenreijs, V.P.T., Pol, R van der, Baarsma, S.,
Dijk, K. van, Waard- van der Spek, F.B. de, Gerth van Wijk, R. & Zijlmans, B.L.M. (2012). High incidence of adverse reactions to locoregional anaesthesia containing hyaluronidase after uneventful ophthalmic surgery. Acta Ophthalmologica, 90 (3), e245-e246.
Eilers, P.H.C., Roder, E., Savelkoul, H.F.J. & Gerth van Wijk, R. (2012). Quantile regression for the statistical analysis of immunological data with many non-detects. BMC Immunology, 13 .
Moscato, G, Pala, G., Barnig, C, Blay, F de, Giacco, SR Del, Folletti, I, Heffler, E, Maestrelli, P, Pauli, G,
Perfetti, L, Quirce, S, Sastre, J., Siracusa, A, Walusiak-Skorupa, J & Gerth van Wijk, R. (2012). EAACI consensus statement for investigation of work-related asthma in non-specialized centres. Allergy,
67 (4), 491-501.
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Sampson, HA, Gerth van Wijk, R., Bindslev-Jensen, C, Sicherer, S, Teuber, SS, Burks, AW, Dubois, AEJ,
Beyer, K, Eigenmann, PA, Spergel, JM, Werfel, T. & Chinchilli, VM (2012). Standardizing double-blind, placebo-controlled oral food challenges: American Academy of Allergy, Asthma &
Immunology-European Academy of Allergy and Clinical Immunology PRACTALL consensus report.
Journal of Allergy and Clinical Immunology, 130 (6), 1260-1274.
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EMC OR-01-39-08 - Determinants of falls and disability in older persons
Programme (brief description)
A - Determinants of falls
B - Drugs: effects and side effects, drug-related hospital admission, drug-related falls
C - Vascular ageing
D - Dementia - Co-morbidity in Alzheimer's disease
E - Delirium - Determinants and prognosis
F - Transmural projects with Stichting `De StromenOpmaatGroep' in Rotterdam, Stichting
Elisabeth in Breda and with the Department of Industrial Design of Delft Technical University
Key Figures
Department Sp1 Sp2 Sp3 Sp4 SpTot T1 T2 T3 Ttot IS FS OP Ptot internal medicine 2,8 1 1,25 5,05
Total 2,8 1 1,25
Article/Letter to the editor
0 5,05 0 0 0 0 32 0 2 34
Asselt, DZB van, Schueren, MAE van Bokhorst-de, Cammen, T.J.M. van der, Disselhorst, LGM, Janse,
A., Lonterman-Monasch, S, Maas, H.A.A.M., Popescu, ME, Scholzel-Dorenbos, CJM, Sipers, WMWH,
Veldhoven, CMM, Wijnen, H.H. & Rikkert, MGMO (2012). Assessment and treatment of malnutrition in
Age & Ageing, 41 (3), 399-404. Dutch geriatric practice: consensus through a modified Delphi study.
Bolignano, D, Mattace Raso, F.U.S., Torino, C, Arrigo, G. d', ElHafeez, S.A., Provenzano, F., Zoccali, C &
Tripepi, G (2012). Prognostic models in the clinical arena. Aging Clinical and Experimental Research, 24 ,
300-304.
Bortel, LM Van, Laurent, S, Boutouyrie, P, Chowienczyk, P, Cruickshank, JK, Backer, T. de, Filipovsky, J,
Huybrechts, S, Mattace-Raso, F.U.S., Protogerou, AD, Schillaci, G, Segers, P., Vermeersch, S & Weber,
T. (2012). Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity.
Age & Ageing, 41
Journal of Hypertension, 30
(4), 534-540.
Bone, 50 (6), 1260-1265.
(3), 445-448.
Dijk, S.C. van, Meiracker, A.H. van den, Cammen, T.J.M. van der, Raso, FM & Velde, N. van der (2012).
Central but not peripheral fat mass percentage is associated with blood pressure components in the elderly.
Dijk, S.C. van, Herder, W.W. de, Kwekkeboom, D.J., Zillikens, M.C., Feelders, R.A., Schaik, R.H.N. van,
Driel, M. van & Leeuwen, J.P.T.M. van (2012). 5-HIAA excretion is not associated with bone metabolism in carcinoid syndrome patients.
Durik, M., Kavousi, M., Pluijm, I. van der, Isaacs, A.J., Cheng, C., Verdonk, K., Loot, A.E., Oeseburg, H.,
Bhaggoe, U.M., Leijten, F.P.J., Veghel, R. van, Vries, R.D. de, Rudez, G., Brandt, R.M.C., Ridwan, YR,
Deel, E.D. van, Tempel, D., Fleming, I., Mitchell, GF, Verwoert, G.C., Tarasov, KV, Uitterlinden, A.G.,
Hofman, A., Duckers, H.J., Duijn, C.M. van, Oostra, B.A., Witteman, J.C.M., Duncker, D.J.G.M., Danser,
A.H.J., Hoeijmakers, J.H.J., Roks, A.J.M. & Boer, MF de (2012). Nucleotide Excision DNA Repair Is
Associated With Age-Related Vascular Dysfunction. Circulation, 126 (4), 468-478.
ElHafeez, S.A., Torino, C, Arrigo, G. d', Bolignano, D, Provenzano, F., Mattace Raso, F.U.S., Zoccali, C &
Tripepi, G (2012). An overview on standard statistical methods for assessing exposure-outcome link in survival analysis (Part II) the Kaplan-Meier analysis and the Cox regression method. Aging Clinical and
Experimental Research, 24 (3), 203-206.
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Elskamp, A.B.M., Hartholt, K.A., Patka, P., Beeck, E.F. van & Cammen, T.J.M. van der (2012). Why older people refuse to participate in falls prevention trials: A qualitative study. Experimental Gerontology,
47 (4), 342-345.
Enneman, A.W., Velde, N. van der, Jonge, R. de, Heil, S.G., Stolk, L., Hofman, A., Rivadeneira, F.,
Zillikens, M.C., Uitterlinden, A.G. & Meurs, J.B.J. van (2012). The association between plasma homocysteine levels, methylation capacity and incident osteoporotic fractures.
Etman, A., Burdorf, A., Cammen, T.J.M. van der, Mackenbach, J.P. & Lenthe, F.J. van (2012).
Socio-demographic determinants of worsening in frailty among community-dwelling older people in 11
European countries. Journal of Epidemiology & Community Health, 66
Bone, 50 (6), 1401-1405.
(12), 1116-1121.
Fedorowski, A, Franceschini, N, Brody, J, Liu, CY, Verwoert, G.C., Boerwinkle, E., Couper, D, Rice, KM,
Rotter, JI, Mattace-Raso, F., Uitterlinden, A., Hofman, A., Almgren, P, Sjogren, M, Hedblad, B, Larson,
MG, Newton-Cheh, C, Wang, T.J., Rose, KM, Psaty, B.M., Levy, D., Witteman, J.C.M. & Melander, O
(2012). Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of
Postural Hemodynamics (GPH) Consortium. European Heart Journal, 33
Management of falls: France, the Netherlands, Poland.
(18), 2331-2341.
Gilbert, T, Szczerbinska, K, Ziere, G., Ait, S, Bonnefoy, M, Velde, N. van der & Cruz-Jentoft, AJ (2012).
European Geriatric Medicine, 3 (4), 246-253.
Hartholt, K.A., Polinder, S., Cammen, T.J.M. van der, Panneman, MJM, Velde, N. van der, Lieshout,
E.M.M. van, Patka, P. & Beeck, E.F. van (2012). Costs of falls in an ageing population: A nationwide study from the Netherlands (2007-2009).
Are Catching Up.
Injury-International Journal of the Care of the Injured, 43 (7),
1199-1203.
Hartholt, K.A., Polinder, S., Beeck, E.F. van, Velde, N. van der, Lieshout, E.M.M. van, Patka, P. &
Cammen, T.J.M. van der (2012). End of the Spectacular Decrease in Fall-Related Mortality Rate: Men
American Journal of Public Health, 102 , S207-S211.
Hartholt, K.A., Cammen, T.J.M. van der & Klimek, M. (2012). Postoperative cognitive dysfunction in geriatric patients. Zeitschrift für Gerontologie und Geriatrie, 45 (5), 411-415.
Hartholt, K.A., Velde, N. van der, Looman, C.W.N., Lieshout, E.M.M. van, Beeck, E.F. van, Patka, P. &
Cammen, T.J.M. van der (2012). Valgerelateerde ziekenhuisopnamen bij ouderen in Nederland.
Nederlands Tijdschrift voor Heelkunde, 21 (1), 9-11.
Huijben, AM, Mattace Raso, F.U.S., Deinum, J., Lenders, J & Meiracker, A.H. van den (2012). Aortic augmentation index and pulse wave velocity in response to head-up tilting: effect of autonomic failure.
Journal of Hypertension, 30 (2), 307-314.
Kavousi, M., Elias-Smale, S.E., Rutten, J.H.W., Leening, M.J.G., Vliegenthart, R., Verwoert, G.C.,
Krestin, G.P., Oudkerk, M.., Maat, M.P.M. de, Leebeek, F.W.G., Mattace-Raso, FUS, Lindemans, J.,
Hofman, A., Steyerberg, E.W., Lugt, A. van der, Meiracker, A.H. van den & Witteman, J.C.M. (2012).
Evaluation of Newer Risk Markers for Coronary Heart Disease Risk Classification A Cohort Study. Annals of Internal Medicine, 156 (6), 438-444.
Leening, M.J.G., Kavousi, M., Heeringa, J., Rooij, F.J.A. van, Heemst, J. van, Deckers, J.W., Mattace
Raso, F.U.S., Ziere, G., Hofman, A., Stricker, B.H.C. & Witteman, J.C.M. (2012). Methods of data collection and definitions of cardiac outcomes in the Rotterdam Study. European Journal of
Epidemiology, 27 (3), 173-185.
Linde, D. van der, Laar, I.M.B.H. van de, Bertoli-Avella, A.M., Oldenburg, R.A., Bekkers, J.A.,
Mattace-Raso, F.U.S., Meiracker, A.H. van den, Moelker, A., Kooten, F. van, Frohn-Mulder, I.M.E.,
Timmermans, J, Moltzer, E., Cobben, JM, Laer, L Van, Loeys, B, Backer, J De, Coucke, P.J., Paepe, A. de, Hilhorst-Hofstee, Y., Wessels, M.W. & Roos-Hesselink, J.W. (2012). Aggressive Cardiovascular
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Phenotype of Aneurysms-Osteoarthritis Syndrome Caused by Pathogenic SMAD3 Variants. Journal of the American College of Cardiology, 60 (5), 397-403.
Mitchell, GF, Verwoert, G.C., Tarasov, KV, Isaacs, A, Smith, AV, Yasmin, ., Rietzschel, ER, Tanaka, T,
Liu, YM, Parsa, A, Najjar, SS, O'Shaughnessy, KM, Sigurdsson, S, Buyzere, ML De, Larson, MG, Sie,
M.P.S., Andrews, JS, Post, WS, Mattace-Raso, F.U.S., McEniery, CM, Eiriksdottir, G, Segers, P., Vasan,
RS, Rijn, M.J.E. van, Howard, TD, McArdle, PF, Dehghan, A., Jewell, ES, Newhouse, SJ, Bekaert, S,
Hamburg, NM, Newman, AB, Hofman, A., Scuteri, A, Bacquer, D. De, Ikram, M.A., Psaty, B.M.,
Fuchsberger, C, Olden, M, Wain, LV, Elliott, P., Smith, NL, Felix, J.F., Erdmann, J., Vita, JA,
Sutton-Tyrrell, K, Sijbrands, E.J.G., Sanna, S, Launer, L.J., Meyer, T, Johnson, AD, Schut, A.F.C.,
Herrington, DM, Rivadeneira, F., Uda, M, Wilkinson, IB, Aspelund, T, Gillebert, TC, Bortel, L Van,
Benjamin, EJ, Oostra, B.A., Ding, JZ, Gibson, Q, Uitterlinden, A.G., Abecasis, GR, Cockcroft, JR,
Gudnason, V, Backer, GG De, Ferrucci, L, Harris, T.B., Shuldiner, AR, Duijn, C.M. van, Levy, D., Lakatta,
EG & Witteman, J.C.M. (2012). Common Genetic Variation in the 3 '-BCL11B Gene Desert Is Associated
With Carotid-Femoral Pulse Wave Velocity and Excess Cardiovascular Disease Risk The AortaGen
Consortium. Circulation-cardiovascular genetics, 5 (1), 81-90.
Oudshoorn, C., Hartholt, K.A., Zillikens, M.C., Panneman, MJM, Velde, N. van der, Colin, E.M., Patka, P.
& Cammen, T.J.M. van der (2012). Emergency department visits due to vertebral fractures in the
Netherlands, 1986-2008: Steep increase in the oldest old, strong association with falls.
Injury-International Journal of the Care of the Injured, 43 (4), 458-461.
Petrovic, M, Cammen, T.J.M. van der & Onder, G (2012). Adverse Drug Reactions in Older People
Detection and Prevention. Drugs & Aging, 29 (6), 453-462.
Poels, M.M.F., Zaccai, K., Verwoert, G.C., Vernooij, M.W., Hofman, A., Lugt, A. van der, Witteman,
J.C.M., Breteler, M.M.B., Mattace-Raso, F.U.S. & Ikram, M.A. (2012). Arterial Stiffness and Cerebral
Small Vessel Disease The Rotterdam Scan Study. Stroke, 43 (10), 2637-2642.
Ruiter, R. de, Visser, L.E., Rodenburg, E.M., Trifiro, G., Ziere, G. & Stricker, B.H.C. (2012). Adverse
Drug Reaction-Related Hospitalizations in Persons Aged 55 Years and Over: A Population-Based Study in the Netherlands.
Somers, A, Mallet, L, Cammen, T.J.M. van der, Robays, H & Petrovic, M (2012). Applicability of an
Adapted Medication Appropriateness Index for Detection of Drug-Related Problems in Geriatric
Inpatients.
Drugs & Aging, 29 (3), 225-232.
AMERICAN JOURNAL OF GERIATRIC PHARMACOTHERAPY, 10
Spoto, B, Mattace-Raso, F., Sijbrands, E.J.G., Mallamaci, F, Leonardis, D, Aucella, F, Testa, A, Gesuete,
A, Sanguedolce, MC, D'Arrigo, G, Parlongo, RM, Pisano, A, Torino, C, Enia, G, Tripepi, G, Postorino, M &
Zoccali, C (2012). The fat-mass and obesity-associated gene (FTO) predicts mortality in chronic kidney disease of various severity. Nephrology Dialysis Transplantation, 27
(2), 101-109.
, iv58-iv62.
Sterke, C.S., Beeck, E.F. van, Looman, C.W.N., Kressig, RW & Cammen, T.J.M. van der (2012). An electronic walkway can predict short-term fall risk in nursing home residents with dementia. Gait &
Posture, 36 (1), 95-101.
Sterke, C.S., Ziere, G., Beeck, E.F. van, Looman, C.W.N. & Cammen, T.J.M. van der (2012).
Dose-response relationship between selective serotonin re-uptake inhibitors and injurious falls: a study in nursing home residents with dementia. British Journal of Clinical Pharmacology, 73 (5), 812-820.
Taal, H.R., Verwoert, G.C., Demirkan, A., Janssens, A.C.J.W., Rice, K, Ehret, G, Smith, AV, Verhaaren,
B.F.J., Witteman, J.C.M., Hofman, A., Vernooij, M.W., Uitterlinden, A.G., Rivadeneira, F., Ikram, M.A.,
Levy, D., Heijden, A.J. van der, Jaddoe, V.W.V.K. & Duijn, C.M. van (2012). Genome-Wide Profiling of
Blood Pressure in Adults and Children. Hypertension, 59 (2), 241-247.
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Verheij, S., Muilwijk, D., Pel, J.J.M., Cammen, T.J.M. van der, Mattace-Raso, F.U.S. & Steen, J. van der
(2012). Visuomotor Impairment in Early-Stage Alzheimer's Disease: Changes in Relative Timing of Eye and Hand Movements. Journal of Alzheimers Disease, 30 (1), 131-143.
Verwoert, G.C., Elias-Smale, S.E., Rizopoulos, D., Koller, M.T., Steyerberg, E.W., Hofman, A., Kavousi,
M., Sijbrands, E.J.G., Hoeks, A.P.G., Reneman, R.S., Mattace Raso, F.U.S. & Witteman, J.C.M. (2012).
Does aortic stiffness improve the prediction of coronary heart disease in elderly? The Rotterdam Study.
Journal of Human Hypertension, 26 (1), 28-34.
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EMC OR-01-45-01 - Neurotraumatology and intracranial hydrodynamics
Programme (brief description)
The program is devoted to experimental and clinical research in the field of traumatic brain injury
(TBI) and hydrocephalus. The program on TBI focuses on three themes: 1) Trial methodology,guidelines and evidence based medicine, 2) Intensive care monitoring/therapy and neuroprotection, 3) Ethics and outcome. The program on intracranial hydrodynamics mainly concentrates on normal pressure hydrocephalus.
Head injury is the most common cause of death and disability in young adults in the Western world. As such it constitutes a major health and socio-economic problem. The initial trauma initiates complex pathophysiologic mechanisms, leading to secondary brain damage. Basic research has elucidated many of these mechanisms and has resulted in the development of promising neuroprotective agents.
Various of these agents are being tested in our in vitro model of experimental TBI. We have participated in the clinical evaluation of neuroprotective agents. This translational research has proveed complex, and none of the randomised controlled trials on neuroprotective agents with demonstrated efficacy in the experimental situation, has shown convincing benefit in the overall population of TBI. Problems in clinical trial design and analysis, specific to the field of TBI may have contributed to this failure. Methodologic challenges are related to the heterogeneity of the population, outcome assessment, detection of treatment effects, the use of surrogate markers and interim analyses. These observations have prompted a significant research effort, organised as an international collaboration based on extensive analyses of data available from studies and trials in TBI encompassing approximately 10.000 patients.
International recognition of the importance of this study was illustrated by the receipt of a NIH
RO1 grant for the period 2003-2006.
In the clinical situation cerebral ischemia is considered the central factor in the development of secondary damage. Experimental and clinical programs focus on techniques for monitoring cerebral oxygenation and metabolism. Previous work has demonstrated the value of clinical monitoring of local brain oxygen tension in patients with TBI, and the current research focuses on possibilities to target therapy towards cerebral oxygenation
The third theme of the TBI program focuses on outcome assessment, including evaluation of cognitive functioning, and the development jand evaluation of a disease specific scale for quality of life assessment in TBI. Ethical considerations are relevant to neuro-intensive care in general and particularly to the field of neuro-traumatology. The main focus of ethical research and evaluation concentrates on informed consent procedures in acutely in capacitated patients following TBI.
Normal pressure hydrocephalus is a treatable disease common to elderly patients with symptomatology often akin to Alzheimer"s disease or vascular dementia. In this theme specific attention is paid to clinical diagnostic criteria and to shunt hydrodynamics. The department of neurosurgery currently co-ordinates a national multi-center study evaluating the use of a programmable shunt device for treatment of normal pressure hydrocephalus.
Key Figures
Department Sp1 Sp2 Sp3 Sp4 SpTot T1 T2 T3 Ttot IS FS OP Ptot neurosurgery 6,1
Total 6,1 0 0
Article/Letter to the editor
0
6,1
6,1 0 0 0 0 12 0 0 12
Berghauser Pont, L.M.E., Dammers, R., Schouten, J.W., Lingsma, H.F. & Dirven, C.M.F. (2012). Clinical
Factors Associated With Outcome in Chronic Subdural Hematoma: A Retrospective Cohort Study of
Patients on Preoperative Corticosteroid Therapy. Neurosurgery, 70 (4), 873-880.
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Berghauser Pont, L.M.E., Dammers, R., Schouten, J.W., Lingsma, H.F. & Dirven, C.M.F. (2012).
Corticosteroid Suppression of Vascular Endothelial Growth Factor and Recurrence of Chronic Subdural
Hematoma Reply. Neurosurgery, 70 (5), E1334-E1336.
Berghauser Pont, L.M.E., Dirven, C.M.F. & Dammers, R. (2012). Currarino's triad diagnosed in an adult woman. European Spine Journal, 21 (supp 4), 569-572.
Berghauser Pont, L.M.E., Dirven, C.M.F., Dippel, D.W.J., Verweij, BH & Dammers, R. (2012). The role of corticosteroids in the management of chronic subdural hematoma: a systematic review. European
Journal of Neurology, 19 (11), 1397-1403.
Biersteker, HAR, Andriessen, TMJC, Horn, J, Franschman, G, Naalt, J van der, Hoedemaekers, CWE,
Lingsma, H.F., Haitsma, I. & Vos, P.E. (2012). Factors influencing intracranial pressure monitoring guideline compliance and outcome after severe traumatic brain injury.
1914-1922.
Critical Care Medicine, 40 (6),
Bleeker, FE, Molenaar, RJ & Leenstra, S. (2012). Recent advances in the molecular understanding of glioblastoma. Journal of Neuro-Oncology, 108 with craniosynostosis.
(1), 11-27.
Driessen, C., Veelen, M.L.C. van, Lequin, M.H., Joosten, K.F.M. & Mathijssen, I.M.J. (2012). Nocturnal ultrasound measurements of optic nerve sheath diameter correlate with intracranial pressure in children
Plastic and Reconstructive Surgery, 130 , 448e-451e.
Grauwmeijer, E., Heijenbrok-Kal, M.H., Haitsma, I.K. & Ribbers, G.M. (2012). A Prospective Study on
Employment Outcome 3 Years After Moderate to Severe Traumatic Brain Injury. Archives of Physical
Medicine and Rehabilitation, 93 (6), 993-999.
Jong, T. de, Rijken, B.F.M., Lequin, M.H., Veelen, M.L.C. van & Mathijssen, I.M.J. (2012). Brain and ventricular volume in patients with syndromic and complex craniosynostosis. Childs Nervous System,
28 (1), 137-140.
Ottenhoff, MJ, Dammers, R., Kompanje, E.J.O., Tibboel, D. & Jong, T.H.R. de (2012). Discomfort and
Pediatrics, 129 (3), E741-E747. Pain in Newborns With Myelomeningocele: A Prospective Evaluation.
Satoer, D.D., Vork, J, Visch-Brink, E.G., Smits, M., Dirven, C.M.F. & Vincent, A. (2012). Cognitive functioning early after surgery of gliomas in eloquent areas. Journal of Neurosurgery, 117 (5), 831-838.
Veelen, M.L.C. van & Mathijssen, I.M.J. (2012). Spring-assisted correction of sagittal suture synostosis.
Childs Nervous System, 28 (9), 1347-1351.
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EMC OR-01-49-02 - The urinary tract: Physics, function, epidemiology and reconstructive surgery
Programme (brief description)
The program concentrates on physical and (neuro)physiological modelling of the urinary tract.
Models are developed on the basis of measurements in single smooth muscle cells, muscle fibres and complete organ systems in vitro. Passive and active mechanical properties, electrophysiological properties and excitation-contraction coupling are described in this way.
The innervation and function of the organ systems are studied in situ in rats using morphological and neurophysiological methods. The models are applied for the development of diagnostic and therapeutic methods in a clinical setting. Epidemiological studies such as ¿A longitudinal non-invasive study of changes in urinary bladder contractility secundary to benign prostatic hyperplasia¿ and ¿Non-invasive evaluation of urinary bladder contractility and urethral resistance before and after transurethral resection of the prostate¿ provide normative data that are important for modelling and clinical analysis as well. In this way function and dysfunction are described quantitatively and new treatment modalities are evaluated objectively. Automated analysis of clinical data and non-invasive diagnostic methods are important issues in the diagnostic field. Currently the non-invasive condom catheter method, perineal noise recording and ultrasonic imaging of velocity and turbulence of the urinary flow using radiofrequency (rf) based techniques and displacement analysis of urethral tissue during voiding are studied and applied. In the therapeutic field, emphasis is placed on the development and evaluation of neural stimulation techniques to modulate organ (dys)function based on neurophysiologic principles and on stemcell therapy of incontinence.
Key Figures
Department Sp1 Sp2 Sp3 Sp4 SpTot T1 T2 T3 Ttot IS FS OP Ptot radiology urology
0,1
1,45 2,9
0,1
0,3 4,65
Total 1,55 2,9 0 0,3 4,75 0 0 0
Article/Letter to the editor
0 2 1 0 3
Dubbelman, Y., Groen, J., Wildhagen, M.F., Rikken, B. & Bosch, R. van den (2012). Quantification of changes in detrusor function and pressure-flow parameters after radical prostatectomy: Relation to postoperative continence status and the impact of intensity of pelvic floor muscle exercises.
Neurourology and Urodynamics, 31 (5), 637-641.
Dubbelman, Y., Groen, J., Wildhagen, M.F., Rikken, B. & Bosch, J.L.H.R. (2012). Urodynamic quantification of decrease in sphincter function after radical prostatectomy: Relation to postoperative continence status and the effect of intensive pelvic floor muscle exercises. Neurourology and
Urodynamics, 31 (5), 646-651.
Groen, J., Marchand, W.J.C., Blok, B.F.M. & Dohle, G.R. (2012). Low dose intradetrusor injections of onabotulinumtoxinA in women with overactive bladder symptoms or the painful bladder syndrome: unfavorable balance between clinical efficacy and the need for catheterization. Urogynaecologia
International Journal, 26 (130), 30-33.
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EMC OR-01-54-02 - Pathofysiology and treatment of asthma, atopy and cystic fibrosis
Programme (brief description)
This programme aims (I) to elucidate the etiology and pathogenesis of childhood asthma and asthma-like lung disease and allergy and determining the effects of chronic inflammation on the development and function of the respiratory system and (2) to determine the effects of therapeutic and preventive interventions in chronic inflammatory lung disease and atopy in children.
Chronic lung disease, especially asthma, is one of the leading causes of chronic morbidity in children. Childhood asthma and other obstructive lung diseases predispose for obstructive lung disease in adults, an important health care issue with great socioeconomic impact. The search for causal and contributing factors, development of new diagnostic techniques and the determination of optimal treatment modalities for childhood asthma and allergy has the potential to improve morbidity and prognosis, and thus to reduce the burden of these diseases. In this respect, the development and validation of new techniques to mmeasure lung function and airway inflammation in infants and young children has priority.
Infant lung function testing and new image analysis techniques using CT scan are developed as sensitive, objective endpoints for assessment of airway inflammation and damage. The development of structural lung damage is studied in a cohort of CF patients using CT and extensive lung function testing.
Inhalation of aerosolized medication is an important aspect of the treatment of lung disease, and poses specific problems in the pediatric age group. In this project, we examine the factors that determine lung deposition and effects of inhaled drugs in young children to optimize the effects of treatment.
The therapeutic and preventive intervention studies carried out within this project are important for specific patient groups (asthma, cystic fibrosis), and have impact for the treatment of childhood obstructive lung disease in primary and secondary health care practice.
The development of allergic diseases with age is studied in two large birth cohorts (Prevention and Incidence of Asthma and Mite Allergy, "PIAMA", and "Generation R"). These focus on interaction of genetic and environmental factors in relation to immunopathology and clinical phenotypes
Thesis
Bakker, E.M. (2012, oktober 03). Detection and aerosol treatment of small airway disease in pediatric cystic fibrosis and asthma.
EUR (208 pag.) (Rotterdam: Optima Grafische Communicatie).
Prom./coprom.: Prof. Dr. H.A.W.M. Tiddens.
Loeve, M. (2012, januari 20). Chest computed tomography in early and advanced cystic fibrosis lung disease.
EUR (219 pag.). Prom./coprom.: Prof. Dr. H.A.W.M. Tiddens & Prof. Dr. G.P. Krestin.
Spoel, M. (2012, juni 15). The air that we breathe: Respiratory morbidity in children with congenital pulmonary malformations.
EUR (172 pag.) (Rotterdam: Optima Grafische Communicatie).
Prom./coprom.: Prof. Dr. D. Tibboel, Prof. Dr. J.C. de Jongste & Dr. H. IJsselstijn.
Article/Letter to the editor
Amin, R., Charron, M., Grinblat, L., Shammas, A., Grasemann, H., Graniel, K., Ciet, P., Tiddens,
H.A.W.M. & Ratjen, F. (2012). Cystic Fibrosis: Detecting changes in airway inflammation with FDG
PET/CT1. Radiology, 264 (3), 868-875.
Bakker, E.M., Meijden, J.C. van der, Nieuwhof, EM, Hop, W.C.J. & Tiddens, H.A.W.M. (2012).
Determining presence of lung disease in young children with cystic fibrosis: Lung clearance index, oxygen saturation and cough frequency. Journal of Cystic Fibrosis, 11
PLoS One, 7 (12), e51801.
(3), 223-230.
Bekkers, M.B.M., Brunekreef, B., Koppelman, G.H., Kerkhof, E., Jongste, J.C. de, Smit, H.A. & Wijga,
A.H. (2012). BMI and waist circumference; cross-sectional and prospective associations with blood pressure and cholesterol in 12-year-olds.
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Bekkers, M.B.M., Brunekreef, B., Jongste, J.C. de, Kerkhof, M., Smit, H.A., Postma, D.S., Gehring, U. &
Wijga, A.H. (2012). Childhood overweight and asthma symptoms, the role of pro-inflammatory proteins. Clinical & Experimental Allergy, 42 , 95-103.
Bekkers, M.B.M., Elstgeest, L.E.M., Scholtens, s., Haveman-Nies, A., Jongste, J.C. de, Kerkhof, M.,
Koppelman, G.H., Gehring, U., Smit, H.A. & Wijga, A.H. (2012). Maternal use of folic acid supplements during pregnancy, and childhood respiratory health and atopy.
1468-1474.
Boluyt, N., Rottier, B.L., Jongste, J.C. de, Riemsma, R, Vrijlandt, E.J.L.E. & Brand, P.L.P. (2012).
Assessment of controversial pediatric asthma management options using GRADE. e658-e668.
European Respiratory Journal, 39
Pediatrics, 130
,
(3),
Bot, C.M.A. de, Moed, H., Berger, M.Y., Roder, E., Hop, W.C.J., Groot, H. de, Jongste, J.C. de, Gerth van
Wijk, R., Bindels, P. & Wouden, J.C. v.d. (2012). SIT: efficacy depends on product, not on route of application Reply. Pediatric Allergy and Immunology, 23 allergische rinitis in de huisartsenpraktijk.
(4), 401-402.
Bot, C.M.A. de, Moed, H., Berger, M.Y., Roder, E., Hop, W.C.J., Groot, H. de, Jongste, J.C. de, Gerth van
Wijk, R., Bindels, P.J.E. & Wouden, J.C. van der (2012). Sublinguale immunotherapie bij kinderen met
Nederlands Tijdschrift voor Geneeskunde, 156 .
Bradfield, JP, Taal, H.R., Timpson, NJ, Scherag, A, Lecoeur, C, Warrington, NM, Hypponen, E, Holst, C,
Valcarcel, B, Thiering, E, Salem, RM, Schumacher, FR, Cousminer, DL, Sleiman, PMA, Zhao, JH,
Berkowitz, RI, Vimaleswaran, KS, Jarick, I, Pennell, CE, Evans, DM, Pourcain, B St, Berry, DJ,
Mook-Kanamori, D.O., Hofman, A., Rivadeneira, F., Uitterlinden, A.G., Duijn, C.M. van, Valk, R.J.P. van der, Jongste, J.C. de, Postma, D.S., Boomsma, D.I., Gauderman, WJ, Hassanein, MT, Lindgren, CM,
Magi, R, Boreham, CAG, Neville, CE, Moreno, L.A., Elliott, P., Pouta, A, Hartikainen, AL, Li, MY,
Raitakari, O, Lehtimaki, T, Eriksson, JG, Palotie, A, Dallongeville, J., Das, S., Deloukas, P, McMahon, G,
Ring, SM, Kemp, JP, Buxton, JL, Blakemore, AIF, Bustamante, M., Guxens, M, Hirschhorn, JN, Gillman,
MW, Kreiner-Moller, E, Bisgaard, H, Gilliland, FD, Heinrich, J., Wheeler, E, Barroso, I, O'Rahilly, S,
Meirhaeghe, A, Sorensen, T.I.A., Power, C, Palmer, LJ, Hinney, A, Widen, E, Farooqi, IS, McCarthy, MI,
Froguel, P, Meyre, D, Hebebrand, J., Jarvelin, MR, Jaddoe, V.W.V.K., Smith, G.D., Hakonarson, H &
Grant, S.F.A. (2012). A genome-wide association meta-analysis identifies new childhood obesity loci.
Nature Genetics, 44 (5), 526-+.
Duijts, L. (2012). Fetal and infant origins of asthma. European Journal of Epidemiology, 27
Chest, 141 (4), 876-885.
, 5-14.
Duijts, L., Jaddoe, V.W.V.K., Valk, R.J.P. van der, Henderson, JA, Hofman, A., Raat, H., Steegers,
E.A.P., Moll, H.A. & Jongste, J.C. de (2012). Fetal Exposure to Maternal and Paternal Smoking and the
Risks of Wheezing in Preschool Children The Generation R Study.
Durmus, B., Ay, L., Duijts, L., Moll, H.A., Hokken-Koelega, A.C.S., Raat, H., Hofman, A., Steegers, E.A.P.
& Jaddoe, V.W.V.K. (2012). Infant diet and subcutaneous fat mass in early childhood: The Generation R
Study. European Journal of Clinical Nutrition, 66 (2), 253-260.
Ent, C.K. van der & Tiddens, H.A.W.M. (2012). Cystic fibrosis. Kinderarts en Wetenschap, 2 , 47-52.
Gabriele, C., Silva, L.M., Arends, L.R., Raat, H., Moll, H.A., Hofman, A., Jaddoe, V.W.V.K. & Jongste, J.C. de (2012). Early respiratory morbidity in a multicultural birth cohort: the Generation R Study. European
Journal of Epidemiology, 27 (6), 453-462.
Gabriele, C., Silva, L.M., Arends, L.R., Raat, H., Moll, H., Hofman, A., Jaddoe, V.W.V.K. & Jongste, J.C. de (2012). Early respiratory morbidity in a multicultural birth cohort: the Generation R Study. European
Journal of Epidemiology, 27 (6), 453-462.
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Gabriele, C., Jaddoe, V.W.V.K., Mastrigt, E. van, Arends, L.R., Hofman, A., Moll, H.A. & Jongste, J.C. de
(2012). Exhaled nitric oxide and the risk of wheezing in infancy, the generation R study. European
Respiratory Journal, 39 (3), 567-572.
Gehring, U., Jongste, J.C. de, Kerkhof, M., Oldewening, M., Postma, D, Strien, R.T. van, Wijga, A.H.,
Willers, S.M., Wolse, A., Gerritsen, J., Smit, H.A. & Brunekreef, B. (2012). The 8-year followup of the
PIAMA intervention study assessing the effectof mite-impermeable mattress covers.
248-256.
Giessen, L.J. van der, Bakker, E.M., Joosten, K.F.M., Hop, W.C.J. & Tiddens, H.A.W.M. (2012).
Nocturnal oxygen saturation in children with stable cystic fibrosis.
1123-1130.
Allergy, 67
Pediatric Pulmonology, 47 ,
,
Gorbunova, V, Sporring, J, Lo, M., Loeve, M., Tiddens, H.A.W.M., Nielsen, M, Dirksen, A. & Bruijne, M. de (2012). Mass preserving image registration for lung CT.
BMC Pulmonary Medicine, 12 , 65-76.
Medical Image Analysis, 16 , 786-795.
Groen, E. de, Lingsma, H.F., Caudri, D., Wijga, A., Jaddoe, V.W.V.K., Steyerberg, E.W., Jongste, J.C. de
& Raat, H. (2012). Predicting asthma in preschool children with asthma symptoms: study rationale and design.
Groen, E. de, Rossem, L. van, Jongste, J.C. de, Mohangoo, A.D., Moll, H.A., Jaddoe, V.W.V.K., Hofman,
A., Mackenbach, J.P. & Raat, H. (2012). The role of prenatal, perinatal en postnatal factors in the explanation of socioeconomic inequalities in preschool asthma symptoms: the Generation R Study.
Journal of Epidemiology & Community Health, 66 , 1017-1024.
Holster, I.L., Vila Wittenberg, A.M.J., Caudri, D., Hoed, C.M. den, Perez, GI, Blaser, M.J., Jongste, J.C. de & Kuipers, E.J. (2012). The impact of Helicobacter pylori on atopic disorders in childhood.
Helicobacter .
Jaddoe, V.W.V.K., Duijn, C.M. van, Franco, O.H., Heijden, A.J. van der, IIzendoorn, MH van, Jongste,
J.C. de, Lugt, A. van der, Mackenbach, J.P., Moll, H.A., Raat, H., Rivadeneira Ramirez, F., Steegers,
E.A.P., Tiemeier, H.W., Uitterlinden, A.G., Verhulst, F.C. & Hofman, A. (2012). The Generation R Study:
European Journal of Epidemiology, 27 (9), 739-756. design and cohort update 2012.
Kerkhof, M., Daley, D., Postma, D.S., Park, J.E., Yeung, M.C., Wijga, A.H., Gehring, U., Jongste, J.C. de,
Smit, H.A., Brunekreef, B., Schayck, O.C.P. van, Becker, A & Koppelman, G.H. (2012). Opposite effects of allergy prevention depending on CD14 rs2569190 genotype in 3 intervention studies. Journal of
Allergy and Clinical Immunology, 129 (1), 256-258.
Kiefte- de Jong, J.C., Vries, J.H. de, Franco Duran, O.H., Jaddoe, V.W.V.K., Hofman, A., Raat, H.,
Jongste, J.C. de & Moll, H.A. (2012). Fish consumption in infancy and asthma-like symtoms at preschool age. Pediatrics, 130 , 1060-1068.
Kiefte- de Jong, J.C., Timmermans, S., Jaddoe, V.W.V.K., Hofman, A., Tiemeier, H.W., Steegers, E.A.P.,
Jongste, J.C. de & Moll, H.A. (2012). High Circulating Folate and Vitamin B-12 Concentrations in Women
During Pregnancy Are Associated with Increased Prevalence of Atopic Dermatitis in Their Offspring.
Journal of Nutrition, 142 (4), 731-738.
Langen, AMM, Loeber, JG, Elvers, L.H., Triepels, R.H., Gille, J.J.P., Ploeg, C.P.B. van der, Reijntjes, S.,
Dompeling, E., Dankert-Roelse, J.E. & CHOPIN Study Group, the (2012). Novel strategies in newborn screening for cystic fibrosis: a prospective controlled study. Thorax, 67 , 289-295.
Levy, M.L., Quanjer, P.H., Booker, R., Holmes, S. & Small, I (2012). Standards for diagnostic spirometry within-session repeatability in primary care. Primary Care Respiratory Journal, 21 (3), 252-253.
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Littlewood, K.J., Higashi, K., Jansen, J.P., Capkun-Niggli, G., Balp, M.M., Doering, G, Tiddens, H.A.W.M.
& Angyalosi, G. (2012). A network meta-analysis of the efficacy of inhaled antibiotics for chronic
Pseudomonas infections in cystic fibrosis. Journal of Cystic Fibrosis, 11 , 419-426.
Loeve, M., Hop, W.C.J., Bruijne, M. de, Hal, P.T.W. van, Robinson, P., Aitken, ML, Dodd, J.D. & Tiddens,
H.A.W.M. (2012). Chest Computed Tomography Scores Are Predictive of Survival in Patients with Cystic
Fibrosis Awaiting Lung Transplantation. American Journal of Respiratory and Critical Care Medicine,
185 (10), 1096-1103.
Loeve, M., Bruijne, M. de, Hartmann, I.J.C., Straten, M. van, Hop, W.C.J. & Tiddens, H.A.W.M. (2012).
Three-Section Expiratory CT: Insufficient for Trapped Air Assessment in Patients with Cystic Fibrosis?
Radiology, 262 (3), 969-976.
McEvoy, S., Lavelle, L., Kilcoyne, A., McCarthy, C., Jong, P.A. de, Loeve, M., Tiddens, H.A.W.M.,
McKone, E.F., Gallagher, C.G. & Dodd, J.D. (2012). High-resolution CT of nontuberculous
European Radiology, 22 , 2736-2742. mycobacterium infection in adult CF patients: diagnostic accuracy.
Merkus, P.J.F.M., Gappa, M., Janssens, H.M. & Pijnenburg, M.W.H. (2012). Extrafine aerosols and peripheral airway function in asthma. Pediatric Pulmonology, 47 , 626.
Miedema, K.G.E., Tissing, W.J.E., Poele, E.M. te, Kamps, W.A., Kerkhof, M., Jongste, J.C. de, Smit, H.A.,
Pagter, APJ de, Bierings, M., Boezen, H.M., Postma, D.S., Bont, E.S.J.M. de & Koppelman, G.H. (2012).
Polymorphisms in the TLR6 gene associated with the inverse association between childhood acute lymphoblastic leukemia and atopic disease. Leukemia, 26 , 1203-1210.
Mohangoo, A.D., Koning, H.J. de, Jongste, J.C. de, Landgraf, J.M., Wouden, J.C. van der, Jaddoe,
V.W.V.K., Hofman, A., Moll, H.A., Mackenbach, J.P. & Raat, H. (2012). Asthma-like symptoms in the first year of life and health-related quality of life at 12 months: the Generation R Study. Quality of Life
Research, 21 , 545-554.
Mutsaerts, E.R.V.M., Winters, A.E., Bakker, MJ, Stel, H.F. van, Meer, V van der, Jongste, J.C. de, Sont,
J.K. & SMASHING Study Group, the (2012). Internet-Based self-management compared with usual care
Pediatric Pulmonology, 47 , 1170-1179. in adolescents with asthma: a randomized controlled trial.
Papadopoulos, NG, Arakawa, H, Carlsen, K.H., Custovic, A., Gern, J, Lemanske, R, Souef, P Le, Makela,
M., Roberts, G, Wong, G, Zar, H, Akdis, CA, Bacharier, LB, Baraldi, E., Bever, H.P. van, Blic, J. de, Boner,
A, Burks, W, Casale, T.B., Castro-Rodriguez, J.A., Chen, YZ, El-Gamal, YM, Everard, M.L., Frischer, T,
Geller, M, Gereda, J, Goh, DY, Guilbert, TW, Hedlin, G., Heymann, PW, Hong, SJ, Hossny, EM, Huang,
JL, Jackson, DJ, Jongste, J.C. de, Kalayci, O, Ait-Khaled, N, Kling, S, Kuna, P, Lau, S, Ledford, DK, Lee,
SI, Liu, AH, Lockey, RF, Lodrup-Carlsen, K, Lotvall, J, Morikawa, A, Nieto, A, Paramesh, H, Pawankar,
R., Pohunek, P., Pongracic, J, Price, D, Robertson, C., Rosario, N, Rossenwasser, LJ, Sly, P.D., Stein, R,
Stick, S., Szefler, S, Taussig, LM, Valovirta, E, Vichyanond, P, Wallace, D, Weinberg, E, Wennergren, G.,
Allergy, 67 (8), Wildhaber, J & Zeiger, R.S. (2012). International consensus on (ICON) pediatric asthma.
976-997.
Paternoster, L, Standl, M, Chen, C.M., Ramasamy, A, Bonnelykke, K, Duijts, L., Ferreira, MA, Alves, AC,
Thyssen, JP, Albrecht, E, Baurecht, H, Feenstra, B.W.A., Sleiman, PMA, Hysi, P, Warrington, NM,
Curjuric, I, Myhre, R, Curtin, JA, Groen-Blokhuis, MM, Kerkhof, M., Saaf, A, Franke, A, Ellinghaus, D,
Folster-Holst, R, Dermitzakis, E, Montgomery, SB, Prokisch, H, Heim, K, Hartikainen, AL, Pouta, A,
Pekkanen, J, Blakemore, AIF, Buxton, JL, Kaakinen, M, Duffy, DL, Madden, PA, Heath, AC, Montgomery,
GW, Thompson, PJ, Matheson, MC, Souef, P Le, Pourcain, B St, Smith, G.D., Henderson, J., Kemp, JP,
Timpson, NJ, Deloukas, P, Ring, SM, Wichmann, HE, Muller-Nurasyid, M, Novak, N, Klopp, N,
Rodriguez, E, McArdle, W, Linneberg, A, Menne, T, Nohr, EA, Hofman, A., Uitterlinden, A.G., Duijin, CM van, Rivadeneira Ramirez, F., Jongste, J.C. de, Valk, R.J.P. van der, Wjst, M, Jogi, R, Geller, F, Boyd,
HA, Murray, JC, Kim, C, Mentch, F, March, M, Mangino, M, Spector, T.D., Bataille, V, Pennell, CE, Holt,
P.G., Sly, P, Tiesler, CMT, Thiering, E, Illig, T, Imboden, M, Nystad, W, Simpson, A, Hottenga, J.J.,
Postma, D, Koppelman, G.H., Smit, H.A., Soderhall, C, Chawes, B, Kreiner-Moller, E, Bisgaard, H, Melen,
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E, Boomsma, D.I., Custovic, A., Jacobsson, B, Probst-Hensch, NM, Palmer, LJ, Glass, D, Hakonarson, H,
Melbye, M, Jarvis, DL, Jaddoe, V.W.V.K., Gieger, C, Strachan, DP, Martin, NG, Jarvelin, MR, Heinrich, J.,
Evans, DM & Weidinger, S (2012). Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nature Genetics, 44 (2), 187-192.
Quanjer, P.H., Hall, G.L., Stanojevic, S., Cole, T.J. & Stocks, J. (2012). Age- and height-based prediction bias in spirometry reference equations. European Respiratory Journal, 40
Quanjer, P.H. & Cole, T.J. (2012). COPD and GOLD Stage I.
International Journal of Epidemiology, 41
Chest, 141
, 14901494.
, 190-197.
(4), 1122-1122.
Quanjer, P.H., Stanojevic, S., Stocks, J. & Cole, T.J. (2012). Ethnically specific norms for ventilatory function.
Quanjer, P.H. & Furberg, CD (2012). GOLD COPD stage I is not associated with increased risk of death.
Respiratory Medicine, 106 , 153.
Quanjer, P.H., Vaz Fragoso, C.A., Miller, MR, Guder, G., Stork, S, Hoes, A..W. & Rutten, F. (2012).
GOLD of lower limit of normal definition? a letter and authors' response. Respiratory Research, 13
Respiratory Medicine Case Reports, 7 , 4-7.
, 61.
Razenberg, FGEM, Heynens, J.W.C.M., Vries, G.J. de, Duijts, L., Jongste, J.C. de, Blic, J. de & Rosias,
P.P.R. (2012). Clinical presentation of Churg-Strauss syndrome in children. A 12-year-old-by with
ANCA-negative Churg-Strauss syndrome.
Rossem, L. van, Wijga, A.H., Jongste, J.C. de, Koppelman, G.H., Oldenwening, M., Postma, D.S.,
Abrahamse-Berkeveld, M., Heijning, B. v.d., Brunekreef, B. & Smit, H.A. (2012). Blood pressure in
12-year-old children is associated with fatty acid composition of human milk.
1055-1060.
Hypertension, 60
Nederlands Tijdschrift voor Geneeskunde .
,
Rottier, B.L., Janssens, H.M., Jongste, J.C. de, Brouwer, M.L., Vrijlandt, E.J.L.E. & Boluyt, N. (2012).
Richtlijn 'Behandeling van astma bij kinderen'.
Sawicki, G.S. & Tiddens, H.A.W.M. (2012). Managing treatment complexity in Cystic Fibrosis:
Challenges and opportunities. Pediatric Pulmonology, 47 , 523-533.
Spoel, M., Laas, R, Gischler, S., Hop, WJC, Tibboel, D., Jongste, J.C. de & IJsselstijn, H. (2012).
Diagnosis-related deterioration of lung function after extracorporeal membrane oxygenation. European
Respiratory Journal, 40 (6), 1531-1537.
Spoel, M., Hout, L. van den, Gischler, S., Hop, W.C.J., Reiss, I.K.M., Tibboel, D., Jongste, J.C. de &
IJsselstijn, H. (2012). Prospective longitudinal evaluation of lung function during the first year of life after repair of congenital diaphragmatic hernia. Pediatric Critical Care Medicine, 13 (3), E133-E139.
Spoel, M., Meeussen, C.J.H.M., Gischler, S., Hop, W.C.J., Bax, N.M.A., Wijnen, R.M.H., Tibboel, D.,
Jongste, J.C. de & IJsselstijn, H. (2012). Respiratory morbidity and growth after open thoracotomy of thorascopic repair of esophageal atresia. Journal of Pediatric Surgery, 47 potential role in the early treatment of cystic fibrosis.
, 1975-1983.
Tiddens, H.A.W.M. (2012). Editorial for effect of dornase alfa on inflammation and lung function:
Journal of Cystic Fibrosis, 11 , 77.
Tromp, I.I.M., Kiefte- de Jong, J.C., Vries, J.H. de, Jaddoe, V.W.V.K., Raat, H., Hofman, A., Jongste,
J.C. de & Moll, H.A. (2012). Dietary patterns and respiratory symptoms in pre-school children: the
Generation R Study. European Respiratory Journal, 40
Valk, R.J.P. van der, Caudri, D., Savenije, O.E.M., Koppelman, G.H., Smit, H.A., Wijga, A.H., Postma,
D.S., Kerkhof, M., Brunekreef, B. & Jongste, J.C. de (2012). Childhood wheezing phenotypes and FeNO in atopic children at age 8.
, 681-689.
Clinical & Experimental Allergy, 42 , 1329-1336.
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Valk, R.J.P. van der, Baraldi, E., Stern, G., Frey, U. & Jongste, J.C. de (2012). Daily exhaled nitric oxide measurements and asthma exacerbations in children. Allergy, 67 , 265-271.
Valk, R.J.P. van der, Duijts, L., Kerkhof, M., Willemsen, S.P., Hofman, A., Moll, H.A., Smit, H.A.,
Brunekreef, B., Postma, D.S., Jaddoe, V.W.V.K., Koppelman, G.H. & Jongste, J.C. de (2012).
Interaction of a 17q12 variant with both fetal and infant smoke exposure in the development of childhood asthma-like symptoms.
Environmental Health, 11
Allergy, 67
, 91-100.
(6), 767-774.
Voort, A.M.M. van der, Kluizenaar, Y. de, Jaddoe, V.W.V.K., Gabriele, C., Raat, H., Moll, H.A., Hofman,
A., Pierik, F.H., Miedema, HME, Jongste, J.C. de & Duijts, L. (2012). Air pollution, fetal and infant tobacco smoke exposure, and wheezing in preschool children: a population-based prospective birth cohort.
Voort, A.M.M. van der, Jaddoe, V.W.V.K., Valk, R.J.P. van der, Willemsen, S.P., Hofman, A., Moll, H.A.,
Jongste, J.C. de & Duijts, L. (2012). Duration and exclusiveness of breastfeeding and childhood asthma-related symptoms. European Respiratory Journal, 39 , 81-89.
Voort, A.M.M. van der, Jaddoe, V.W.V.K., Raat, H., Moll, H.A., Hofman, A., Jongste, J.C. de & Duijts, L.
(2012). Fetal and Infant Growth and Asthma Symptoms in Preschool Children The Generation R Study.
American Journal of Respiratory and Critical Care Medicine, 185 (7), 731-737.
Willers, S.M., Brunekreef, B., Smit, H.A., Beek, E.M. van der, Gehring, U., Jongste, J.C. de, Kerkhof, M.,
Koppelman, G.H. & Wijga, A.H. (2012). BMI development of normal weight and overweight children in the PIAMA Study. PLoS One, 7 (6), e39517.
Zijtregtop, E.A.M., Pijnenburg, M.W.H., Rottier, B.L. & Duijts, L. (2012). Bronchiolitis obliterans na stevens-johnsonsyndroom. Nederlands Tijdschrift voor Geneeskunde, 156 , A4387.
Part of book - Abstract
Ent, K. van der, Rottier, B.L. & Tiddens, H.A.W.M. (2012). Cysticsche fibrose. In R. van Gent, P. Merkus,
M. Pijnenburg & B. Rottier (Eds.),
University Press.
Werkboek Kinderlongziekten (pp. 221-227). Amsterdam: VU
Griendt, E.J. van de, Vaessen-Verberne, AAPH & Jongste, J.C. de (2012). Astma. In
Kinderlongziekten (pp. 159-171). Amsterdam: VU University Press.
Werkboek
Groot, K de & Pijnenburg, M.W.H. (2012). pleuravocht en empyeem. In R. van Gent, P. Merkus, M.
Pijnenburg & B. Rottier (Eds.),
Press.
Werkboek Kinderlongziekten (pp. 203-208). Amsterdam: UV University
Janssens, H.M. & Rottier, B.L. (2012). Inhalatietherapie. In R. van Gent, P. Merkus, M. Pijnenburg & B.
Rottier (Eds.),
Jobsis, AC & Kwee, H.L. (2012). Bronchiestasieen. In R. van Gent, P. Merkus, M. Pijnenburg & B. Rottier
(Eds.),
(Eds.),
Werkboek Kinderlongziekten (pp. 335-341). Amsterdam: VU University Press.
Werkboek Kinderlongziekten
Kwee, H.L. & Brackel, H.J.L. (2012). Piepen. In R. van Gent, P. MerkusP., M. Pijnenburg & B. Rottier
Werkboek Kinderlongziekten
(pp. 291-294). Amsterdam: VU Univesity Press.
(pp. 51-55). Amsterdam: VU University Press.
Merkus, P.J.F.M., Kuethe, M.C. & Jongste, J.C. de (2012). Ernstige meervoudige beperkingen. In R. van
Gent, P. Merkus, M Pijnenburg & B. Rottier (Eds.),
Amsterdam: VU University Press.
Pijnenburg, M.W.H. & Corel, L.J.A. (2012). Neuromusculaire aandoeningen. In R. van Gent, P. Merkus,
M. Pijnenburg & B. Rottier (Eds.),
University Press.
Werkboek Kinderlongziekten (pp. 275-280).
Werkboek Kinderlongziekten (pp. 265-269). Amsterdam: VU
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Rottier, B.L. & Pijnenburg, M.W.H. (2012). Longtransplantatie. In R. van Gent, P. Merkus, M. Pijnenburg
& B. Rottier (Eds.), Werkboek Kinderlongziekten (pp. 377-380). Amsterdam: VU University Press.
Tiddens, H.A.W.M., Berger-Hartog, O. & Klein, W.W. (2012). Beeldvormend onderzoek. In R. van Gent,
P. Merkus, M. Pijnenburg & B. Rottier (Eds.),
VU University Press.
Werkboek Kinderlongziekten (pp. 127-138). Amsterdam:
Tiddens, H.A.W.M. & Graniel, K. (2012). Monitorizacion de la efectacion pulmonar mediante tecnicas de imagen. In A. Salcedo Posadas, S. Gartner, R.M. Giron Moreno & M.D. Garcia Novo (Eds.), Tratadoe de
Fibrosis Quistica . Aval Cientifico.
Book Editorship
Gent, R. van, Merkus, P.J.F.M., Pijnenburg, M.W.H. & Rottier, B.L. (Eds.). (2012). Werkboek
Kinderlongziekten.
Amsterdam: VU University Press.
Journal Editorship/Refereeship
Vrijlandt, E.J.L.E. & Jongste, J.C. de (Eds.). (2009).
Tijdschrift voor Kindergeneeskunde, 77 (6).
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EMC OR-01-58-01 - Applied social and forensic psychiatry
Programme (brief description)
This research programme comprises applied social and forensic psychiatry.
Since 2007, the Research Center O3 (a collaboration between mental health organisations in the
Rijnmond region, the municipal health center and the department of Psychiatry) carries out studies in the field of public mental health. The main aim of the research center is to study difficult to engage populations with severe mental illness in the public domain as well as in the mental health services domain. This includes studies related to public mental health issues such as social breakdown and self neglect, and help seeking behaviour (using the Rijnmond Case
Register data), effects of different organisational models for assertive outreach, interventions to increase compliance with treatment, the epidemiology and prevention of involuntary admissions and coercive measures in psychiatry and victimisation of psychiatric patients. Populations studied include the general population, and outpatient in inpatient patients with severe mental illness. A strong focus is on developing and testing new interventions, especially for difficult to engage patients with severe mental illness.
Within the forensic psychiatric research, determinants of violent behaviour, persistent delinquency in adolescents, treatment effects, and the epidemiology of criminality in combination with mental health care are studied. Diagnosis, treatment and risk profiling are the main areas of research in forensic psychiatry. The group has two main themes in this field, the development of criminal careers for juvenile and adult offenders and psychiatric determinants of violent behaviour, with special interest for the translation of empirical research findings into clinical practice. By means of a multidisciplinary approach, psychotic offenders, antisocial personality disordered patients and psychopaths are discriminated regarding the start of their offending behaviour related to the onset of their mental disorder and regarding psychiatric precursors of violence. Results should lead to a better indication and programming of forensic psychiatric treatment. Special attention is given to the complexity of sexual offending, as a phenomenon limited to adolescence, persistent adult offending with or without other non-sexual offenses, and the specific influence of cognitive distorsions on sexual offending. The focus of our research group is on how this subtype differs from other subtypes within sex offenders with respect to psychiatric disorders. Further studies are directed at the role of attachment problems and personality disorders in domestic violence offenders.
Key Figures
Department Sp1 Sp2 Sp3 Sp4 SpTot T1 T2 T3 Ttot IS FS OP Ptot psychiatry 5,95 5,95
Total 0 0 0 5,95 5,95 3 0 0 3 23 1 14 41
Thesis
Dongen, J.D.M. van (2012, december 04). Pathways to violence in schizophrenia.
Prom./coprom.: Prof.Dr. H.J.C. van Marle & Dr. N.M.L. Buck.
Georgieva, I.V. (2012, juni 14).
EUR (256 pag.).
Coercive interventions during inpatient psychiatric care.
pag.). Prom./coprom.: Prof.dr. C.L. Mulder.
EUR (171
Article/Letter to the editor
Beekman, A.T.F., Os, J. van, Marle, H.J.C. van & Harten, PN van (2012). Stagering en profilering van psychiatrische stoornissen. Tijdschrift voor Psychiatrie, 54 profilering: hervorming van diagnostiek.
(11), 915-920.
Beekman, A.T.F., Os, J. van, Marle, H.J.C. van & Harten, PN van (2012). Themanummer stagering en
Tijdschrift voor Psychiatrie, 54 , 913-914.
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Buck, N.M.L., Leenaars, P.E.M., Emmelkamp, P.M.G. & Marle, H.J.C. van (2012). Expaining the relation between insecure attachment and partner abuse; The role of personality characteristics. Journal of
Interpersonal Violence .
Buck, N.M.L., Leenaars, EPEM, Emmelkamp, P.M.G. & Marle, H.J.C. van (2012). Explaining the
Relationship Between Insecure Attachment and Partner Abuse: The Role of Personality Characteristics.
Journal of Interpersonal Violence, 27 (16), 3149-3170.
Buck, N.M.L., Cima, M., Lancel, M. & Marle, H.J.C. van (2012). On the explanation of the hostile attributional bias: traumatic experiences, schemas, and migrant status. Journal of Aggression,
Maltreatment and Trauma, 21 (2), 223-236.
Dekker, J.A. & Marle, H.J.C. van (2012). Amnesie als excuus voor verantwoordelijkheid. Ethiek en
Maatschappij, 14 (3), 39-50.
Dongen, J.D.M. van, Buck, N.M.L. & Marle, H.J.C. van (2012). Delusional distress partly explains the
Psychiatry Research, relation between persecutory ideations and inpatient aggression on the ward.
200 (2-3), 779-783.
Dongen, J.D.M. van, Buck, N.M.L. & Marle, H.J.C. van (2012). The role of ideational distress in the relation between persecutory ideations and reactive aggression. Criminal Behaviour and Mental Health,
22 (5), 350-359.
Dongen, J.D.M. van, Buck, N.M.L. & Marle, H.J.C. van (2012). The role of ideational distress in the relation between persecutory ideations and reactive aggression. Criminal Behaviour and Mental Health .
Drozdek, B, Kamperman, A.M., Bolwerk, N, Tol, WA & Kleber, RJ (2012). Group Therapy With Male
Asylum Seekers and Refugees With Posttraumatic Stress Disorder A Controlled Comparison Cohort
Study of Three Day-Treatment Programs. Journal of Nervous and Mental Disease, 200
EARLY INTERVENTION IN PSYCHIATRY, 6 (4), 415-422.
(9), 758-765.
Georgieva, I.V., Vesselinov, R & Mulder, C.L. (2012). Early detection of risk factors for seclusion and restraint: a prospective study.
Georgieva, I.V., Mulder, C.L. & Whittington, R. (2012). Evaluation of behavioral changes and subjective distress after exposure to coercive inpatient interventions.
Psychiatric Quarterly, 83 (1), 1-13.
Tijdschrift voor Psychiatrie, 54
BMC Psychiatry, 12
(2), 179-183.
(54).
Georgieva, I.V., Mulder, C.L. & Wierdsma, A.I. (2012). Patients' Preference and Experiences of Forced
Medication and Seclusion.
Goethals, K.R. & Marle, H.J.C. van (2012). Routine outcome monitoring in de forensische psychiatrie: een lang verhaal in het kort.
Hempel, I.S., Buck, N.M.L., Goethals, K.R. & Marle, H.J.C. van (2012). Unraveling Sexual Associations in
Contact en Noncontact Child Sex Offenders using the Single Category-Implicit Association Test. SEXUAL
ABUSE-A JOURNAL OF RESEARCH AND TREATMENT .
Hussaarts, P, Roozen, H.G., Meyers, RJ, Wetering, B.J.M. van de & McCrady, BS (2012). Problem Areas
Reported by Substance Abusing Individuals and Their Concerned Significant Others. American Journal on Addictions, 21 (1), 38-46.
Jochems, E.C., Mulder, C.L., Dam, A van, Duivenvoorden, H.J., Scheffer, SCM, Spek, W.J. van der &
Feltz-Cornelis, C.M. van der (2012). Motivation and treatment engagement intervention trial
(MotivaTe-IT): the effects of motivation feedback to clinicians on treatment engagement in patients with severe mental illness. BMC Psychiatry, 12 (209).
Kortrijk, HE, Mulder, C.L., Drukker, M., Wiersma, D. & Duivenvoorden, H.J. (2012). Duration of assertive community treatment and the interpretation of routine outcome data. Australian & New
Zealand Journal of Psychiatry, 46 (3), 240-248.
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Kortrijk, HE, Mulder, C.L., Gaag, M. de & Wiersma, D. (2012). Symptomatic and functional remission and its associations with quality of life in patients with psychotic disorder in Assertive Community
Treatment teams. Comprehensive Psychiatry, 53 (8), 1174-1180.
Marle, H.J.C. van (2012). De stagering met profielen in de forensisch psychiatrische delictanalyse.
Tijdschrift voor Psychiatrie, 54 (11), 973-978.
Marle, H.J.C. van (2012). Het onlosmakelijke geweld in de psychiatrie. Redactioneel.
Psychiatrie, 54 (5), 405-407.
Tijdschrift voor
Mulder, C.L. & Kortrijk, HE (2012). De invloed van de duur van behandeling op het interpreteren van
ROM-metingen bij ACT. Tijdschrift voor Psychiatrie, 54 (2), 191-196.
Mulder, E.A., Vermunt, J., Brand, E., Bullens, R. & Marle, H. van (2012). Recidivism in subgroups of serious juvenile offenders: Different profiles, different risks? Criminal Behaviour and Mental Health,
22 (2), 122-135.
Osse, R.J., Fekkes, D., Tulen, J.H.M., Wierdsma, A.I., Bogers, A.J.J.C., Mast, R.C. van der & Hengeveld,
M.W. (2012). High Preoperative Plasma Neopterin Predicts Delirium After Cardiac Surgery in Older
Adults. Journal of American Geriatrics Society, 60 (4), 661-668.
Post, L., Visch, I, Mulder, C., Schoevers, R, Dekker, J. & Beekman, A. (2012). Factors associated with higher risks of emergency compulsory admission for immigrants: A report from the ASAP study.
International Journal of Social Psychiatry, 58 (4), 374-380.
Post, L.F.M. van der, Mulder, C.L., Peen, J, Visch, I, Dekker, J. & Beekman, A.T.F. (2012). Social
Support and Risk of Compulsory Admission: Part IV of the Amsterdam Study of Acute Psychiatry.
Psychiatric Services, 63 (6), 577-583.
Post, L.F.M. van der, Mulder, C.L., Bernardt, CML, Schroevers, RA, Beekman, A.T.F. & Dekker, J.J.M.
(2012). Inbewaringstelling als uitkomst; de Amsterdam Study of Acute Psychiatry. Tijdschrift voor
Psychiatrie, 54 (4), 317-327.
Staring, A.B.P., Blaauw, E. & Mulder, C.L. (2012). The Effects of Assertive Community Treatment
Including Integrated Dual Diagnosis Treatment on Nuisance Acts and Crimes in Dual-Diagnosis
Patients. Community Mental Health Journal, 48
Termorshuizen, F., Wierdsma, A.I., Visser, E.G., Drukker, M., Sytema, S., Laan, W., Smeets, HM &
Selten, J.P. (2012). Psychosis and suicide risk by ethnic origin and history of migration in the
Netherlands. Schizophrenia Research, 138
(2), 150-152.
(2-3), 268-273.
Vruwink, F.J., Noorthoorn, EO, Nijman, H.L.I., VanDerNagel, JEL, Hox, JJ & Mulder, C.L. (2012).
Archives of Psychiatric Nursing, Determinants of Seclusion After Aggression in Psychiatric Inpatients.
26 (4), 307-315.
Vruwink, F.J., Mulder, C.L., Noorthoorn, EO, Uitenbroek, D. & Nijman, H.L.I. (2012). The effects of a nationwide program to reduce seclusion in the Netherlands.
Vugt, MD van, Kroon, H, Delespaul, PAEG & Mulder, C.L. (2012). Consumer-Providers in Assertive
Community Treatment Programs: Associations With Client Outcomes.
477-481.
BMC Psychiatry, 12 (231).
Psychiatric Services, 63 (5),
Wierdsma, A.I. & Kamperman, A.M. (2012). Reactie op `contact met de jeugd-ggz is een zaak van culturele en sociaaleconomische verschillen¿: antwoord.
Tijdschrift voor Psychiatrie, 54 , 845.
Tijdschrift voor Psychiatrie, 54 (1), 102-103.
Wierdsma, A.I. (2012). Reactie op `Inbewaringstelling als uitkomst; de Amsterdam Study of Acute
Psychiatry¿.
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Wierdsma, A.I., Driessen, G.A.M., Smeets, H.M. & Visser, E (2012). Regionale verschillen in nazorg bij inbewaringstelling. Tijdschrift voor Psychiatrie, 54 , 777-783.
Part of book - Abstract
Goethals, K. & Marle, H.J.C. van (2012). ROM in de forensische psychiatrie: werk voor pioniers. In C.L.
Mulder (Ed.),
Psychiatrie.
ROM, handreiking voor de psychiater (pp. 65-68). Utrecht: Nederlandse Vereniging voor
Marle, H.J.C. van (2012). Forensic Psychotherapy in the Netherlands and the Essence of Psychiatric
TBS-detention. In T.I. Oei & M.S. Groenhuijsen (Eds.), Progression in Forensic Psychiatry; About
Boundaries (pp. 187-198). Deventer: Kluwer.
Boekbespreking
Marle, H.J.C. van (2012). [Bespreking van het boek Probleemgeoriënteerd denken in de ggz: juridische dilemma's. Een praktijkboed voor de opleiding en de kliniek.
]. Tijdschrift voor Psychiatrie, 54 , 664-664.
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EMC OR-01-59-01 - Epidemiology and biology of oral and maxillofacial tissues
Programme (brief description)
Experimental research
1.Effects of hyperbaric oxygen therapy on the viability of irradiated head and neck tissues and on tumor development. In a mouse model the role of hyperbaric oxygen is examined in order to prevent the negative side effects of radiotherapy of the hard and soft tissues in the head and neck region. In addition the effects of hyperbaric oxygen on the growth and metastatic potential of (irradiated) tumors are studied.
2.Bone tissue engineering. The process of bone formation by mesenchymal stem cells (MSCs) is studied in relevant models in order to create new therapies for large bone defects.
Clinical research
1.Craniofacial anomalies. Robin sequence and hemifacial microsomia are rare congenital craniofacial disorders with unclear prevalence of obstructive sleep apneu (OSA). Patients are monitored in order to identify subgroups for early surgery to overcome the OSA. Cleft is the most frequent craniofacial anomaly. Outcomes of cleft treatment, surgical aspects and patient satisfaction are addressed.
2.Orthognatic surgery. Maxillary and mandibular (distraction) widening. In a prospective clinical study the outcomes of combined orthodontic-surgical treatments are evaluated.
3.Trauma. In a prospective randomized clinical trial two materials for reconstruction of orbital wall fractures are explored: autogenous bone from the iliac crest is compared with titanium.
Epidemiology
The Generation R Study is a prospective cohort study that is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health. In
2012 the project ¿focus on 9¿ has started with involvement of our Department.
1.Facial 3D. Quantitative facial measurements will be extracted from 3D images and linked to the available genome-wide SNP markers. The role of various determinants on facial development will be investigated.
2.Orthodontic needs/looks. The child¿s perception of facial/orthodontic looks and oral function is measured by questionnaires and related to objective orthodontic need measured by 3D facial images.
Key Figures
Department oral and maxillofacial surgery
Sp1 Sp2 Sp3 Sp4 SpTot T1 T2 T3 Ttot IS FS OP Ptot
3,05 2,7 5,75
Total 3,05 0
Article/Letter to the editor
0 2,7 5,75 0 0 0 0 12 3 1 16
Badarne, O., Koudstaal, M.J., Elswijk, J.F.A. van & Wolvius, E.B. (2012). Odontogenic maxillary sinusitis based on overextension of root canal filling material. Nederlands Tijdschrift Tandheelkunde, 119 (10),
480-483.
Djasim, U.M., Spiegelberg, L., Wolvius, E.B. & Wal, K.G.H. van der (2012). A hyperbaric oxygen chamber for animal experimental purposes. International Journal of Oral and Maxillofacial Surgery,
41 (2), 271-274.
Gijt, J.P. de, Wal, K.G.H. van der, Kleinrensink, G.J., Smeets, JBJ & Koudstaal, M.J. (2012). Introduction of the "Rotterdam mandibular distractor" and a biomechanical skull analysis of mandibular midline distraction. British Journal of Oral & Maxillofacial Surgery, 50 (6), 519-522.
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Gijt, J.P. de, Vervoorn, C.J., Wolvius, E.B., Wal, K.G.H. van der & Koudstaal, M.J. (2012). Mandibular midline distraction: A systematic review. Journal of Cranio-Maxillofacial Surgery, 40 (3), 248-260.
Hundepool, A.C., Willemsen, M.A.P., Koudstaal, M.J. & Wal, K.G.H. van der (2012). Open reduction versus endoscopically controlled reconstruction of orbital floor fractures: a retrospective analysis.
International Journal of Oral and Maxillofacial Surgery, 41 (4), 489-493.
Molendijk, J., Wal, K.G.H. van der & Koudstaal, M.J. (2012). Surgical treatment of frontal sinus fractures: the simple percutaneous reduction revised. International Journal of Oral and Maxillofacial
Surgery, 41 (10), 1192-1194.
Nout, E., Bezooijen, J.S. van, Koudstaal, M.J., Veenland, J.F., Hop, W.C.J., Wolvius, E.B. & Wal, K.G.H. van der (2012). Orbital change following Le Fort III advancement in syndromic craniosynostosis:
Quantitative evaluation of orbital volume, infra-orbital rim and globe position. Journal of
Cranio-Maxillofacial Surgery, 40 (3), 223-228.
Nout, E., Bannink, N., Koudstaal, M.J., Veenland, J.F., Joosten, K.F.M., Poublon, R.M.L., Wal, K.G.H. van der, Mathijssen, I.M.J. & Wolvius, E.B. (2012). Upper airway changes in syndromic craniosynostosis patients following midface or monobloc advancement: Correlation between volume changes and respiratory outcome. Journal of Cranio-Maxillofacial Surgery, 40 (3), 209-214.
Ongkosuwito, E.M., Goos, J.A.C., Wattel, E, Wal, K.G.H. van der, Adrichem, L.N.A. van & Neck, J.W. van
(2012). Assessment of Volumetric Changes With a Best-Fit Method in Three-Dimensional
Stereophotograms. and cause.
Cleft Palate-Craniofacial Journal, 49 (4), 472-476.
Plomp, R.G., Bredero-Boelhouwer, H.H., Joosten, K.F.M., Wolvius, E.B., Hoeve, L.J., Poublon, R.M.L. &
Mathijssen, I.M.J. (2012). Obstructive sleep apnoea in Treacher Collins syndrome: prevalence, severity
International Journal of Oral and Maxillofacial Surgery, 41 (6), 696-701.
Plomp, R.G., Joosten, K.F.M., Wolvius, E.B., Hoeve, L.J., Poublon, R.M.L., Montfort, C.A.G.M. van,
Bredero-Boelhouwer, H.H. & Mathijssen, I.M.J. (2012). Screening for obstructive sleep apnea in treacher-collins syndrome. Laryngoscope, 122 (4), 930-934.
Pluijmers, B.I., Koudstaal, M.J., Wolvius, E.B. & Wal, K.G.H. van der (2012). Custom-made intraoral mandibular distraction as treatment for neonatal airway obstruction. International Journal of Oral and
Maxillofacial Surgery, 41 (2), 186-191.
Spiegelberg, L., Djasim, U.M., Neck, J.W. van, Wolvius, E.B. & Wal, K.G.H. van der (2012). The effects of heparan sulphate mimetic RGTA-OTR4120 on irradiated murine salivary glands. Journal of Oral
Pathology & Medicine, 41 (6), 477-483.
Tan, J., Simonsz, H.J. & Koudstaal, M.J. (2012). Oogtrauma bij kinderen; meer dan een blauw oog.
Nederlands Tijdschrift voor Geneeskunde, 156 .
Veneman, W., Metselaar, R.M., Koudstaal, M.J. & Wal, K.G.H. van der (2012). Osteoradionecrosis of the external auditory canal: three cases involving.
1022-1026.
Journal of Laryngology and Otology, 126
The Frequency of Le Fort I Osteotomy in Cleft Patients.
160-166.
(10),
Voshol, I.E., Wal, K.G.H. van der, Adrichem, L.N.A. van, Ongkosuwito, E.M. & Koudstaal, M.J. (2012).
Cleft Palate-Craniofacial Journal, 49 (2),
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EMC OR-01-60-01 - Diagnosis and treatment of disorders of the posterior segment and strabismus
Programme (brief description)
Studies of cornea, uveal melanoma, macular diseases and strabismus
Ways are sought to prolong the survival of corneal grafts by local modulation of the immune response. Therefore, cellular and humoral immunity is examined in experimental corneal allograft rejection.
In a prospective and retropspective study of uveal melanoma patients the relation between chromosomal abnormalities and survival are analysed with molecular biology techniques. The detection of these chromosomal abnormalities in fine needle biopsies is validated with fluorescent in-situ hybridisation in collaboration with the Universities of Sheffield and Liverpool.
Target genes like p16, p73 and pten are investigated. In a prospective study the control rate and complication rate is studied in uveal melanoma patients treated by stereotactic radiotherapy.
The pathogenesis of age-related macular degeneration (AMD) was studied in een group of very old. Macaque monkeys. Molecular mechanisms that causes senescence in the retiina, apoptosis and the expression of somatostatine receptor 2A are studied. Somatostatin receptor binding may inhibit angiogenesis in AMD. A pilot study was performed with octreotide treatment for the control of subfoveal choroidal neovascularisation in AMD in men. A two-center prospective randomized masked trial is intitiated to investigate its clinical effect. The study of the effect of adjuvant hormonal treatment in surgery for macular holes is ongoing.
The study of strabismus consists of three multicenter and cohort studies: Together with the
University of Heidelberg a study is organised to address the question whether children with congenital strabismus should be operated early or late, involving 54 European clinics
(1992-2002). A second randomized study is organised that compares the two surgical techniques that are most commonly used in congenital strabismus, in 9 German and 4 Dutch clinics
(1997-2002). A new microelectronic device has been developed that measures compliance in patch wearing in children with amblyopia; a cohort study has been initiated to measure compliance in the treatment of amblyopia.
Key Figures
Department Sp1 Sp2 Sp3 Sp4 SpTot T1 T2 T3 Ttot IS FS OP Ptot ophthalmology 2,2 0,62 3,22 0,3 6,34 pathology
Total
Thesis
0,89 0,89
2,2 0,62 3,22 1,19 7,23 2 0 0 2 48 9 0 59
Hillenaar, T. (2012, november 15). In vivo confocal microscopy; expanding horizons in corneal imaging.
EUR. Prom./coprom.: Prof. Dr. J.C. van Meurs.
Tjiam, A.M.L. (2012, november 21). Effective detection and treatment of amblyopia: addressing noncompliance.
EUR. Prom./coprom.: Prof. Dr. G. van Rij & Prof. Dr. H.J. Simonsz.
Article/Letter to the editor
Baas, DC, Ho, L., Tanck, M.W.T., Fritsche, LG, Merriam, JE, Slot, R van 't, Koeleman, B.P.C., Gorgels,
T.G.M.F., Duijn, C.M. van, Uitterlinden, A.G., Jong, P.T.V.M. de, Hofman, A., Brink, J.B., Vingerling, J.R.,
Klaver, C.C.W., Dean, M, Weber, BHF, Allikmets, R., Hageman, G.S. & Bergen, A.A.B. (2012).
Multicenter cohort association study of SLC2A1 single nucleotide polymorphisms and age-related macular degeneration. Molecular Vision, 18 (72), 657-674.
Bhargava, M, Ikram, M.K. & Wong, TY (2012). How does hypertension affect your eyes? Journal of
Human Hypertension, 26 (2), 71-83.
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Bosch, T. van den, Beek, J.G.M. van, Vaarwater, J.W.C., Verdijk, R.M., Naus, N.C., Paridaens, A.D.A.,
Klein, A. de & Kilic, E. (2012). Higher Percentage of FISH-Determined Monosomy 3 and 8q Amplification in Uveal Melanoma Cells relate to Poor Patient Prognosis. Investigative Ophthalmology & Visual
Science, 53 (6), 2668-2674.
Burke, TR, Fishman, GA, Zernant, J, Schubert, C, Tsang, SH, Smith, R.T., Ayyagari, R, Koenekoop, RK,
Umfress, A, Ciccarelli, ML, Baldi, A, Iannaccone, A, Cremers, F.P.M., Klaver, C.C.W. & Allikmets, R.
(2012). Retinal Phenotypes in Patients Homozygous for the G1961E Mutation in the ABCA4 Gene.
Investigative Ophthalmology & Visual Science, 53 (8), 4458-4467.
Cheung, CY, Thomas, GN, Tay, W, Ikram, M.K., Hsu, W, Lee, M.L. van der, Lau, QP & Wong, TY (2012).
Retinal Vascular Fractal Dimension and Its Relationship With Cardiovascular and Ocular Risk Factors.
American Journal of Ophthalmology, 154 (4), 663-674.
Cheung, CY, Lamoureux, EL, Ikram, M.K., Sasongko, M.B., Ding, J, Zheng, Y, Mitchell, P., Wang, J.J. &
Wong, TY (2012). Retinal vascular geometry in Asian persons with diabetes and retinopathy. Journal of
Diabetes Science and Technology, 6 (3), 663-674.
Cheung, CYL, Ikram, M.K., Sabanayagam, C & Wong, TY (2012). Retinal Microvasculature as a Model to
Study the Manifestations of Hypertension. Hypertension, 60 (5), 1094-+.
Ding, J, Cheung, CY, Ikram, M.K., Zheng, YF, Cheng, CY, Lamoureux, EL, Tai, ES, Subramaniam, T &
Wong, TY (2012). Early Retinal Arteriolar Changes and Peripheral Neuropathy in Diabetes. Diabetes
Care, 35 (5), 1098-1104.
Ding, J, Ikram, M.K., Cheung, CY & Wong, TY (2012). Retinal vascular calibre as a predictor of incidence and progression of diabetic retinopathy. CLINICAL AND EXPERIMENTAL OPTOMETRY, 95 (3), 290-296.
Eijk, A.C. van der, Dankelman, J, Schutte, S., Simonsz, H.J. & Smit, B.J. (2012). An observational study to quantify manual adjustments of the inspired oxygen fraction in extremely low birth weight infants.
Acta Paediatrica, 101 (3), E97-E104.
Ganteris-Gerritsen, E, Ugahary, LC, Jansen, J., Mulder, P.G.H., Cohen, A.F. & Meurs, J.C. van (2012).
SIX MONTHS TREATMENT WITH IBOPAMINE IN PATIENTS WITH HYPOTONY AFTER VITREORETINAL
SURGERY FOR RETINAL DETACHMENT, UVEITIS OR PENETRATING TRAUMA. Retina. The Journal of
Retinal and Vitreous Diseases, 32 (4), 742-747.
Gasten, A.C., Ramdas, W.D., Broer, L., Koolwijk, L.M.E. van, Ikram, M.K., Jong, P.T.V.M. de, Aulchenko,
Y.S., Wolfs, R.C.W., Hofman, A., Rivadeneira, F., Uitterlinden, A.G., Oostra, B.A., Lemij, H.G., Klaver,
C.C.W., Jansonius, N.M., Vingerling, J.R. & Duijn, C.M. van (2012). A Genetic Epidemiologic Study of
Candidate Genes Involved in the Optic Nerve Head Morphology. Investigative Ophthalmology & Visual
Science, 53 (3), 1485-1491.
Hoehn, R, Zeller, T, Verhoeven, V.J.M., Grus, F, Adler, M., Wolfs, R.C.W., Uitterlinden, A.G., Castagne,
R, Schillert, A, Klaver, C.C.W., Pfeiffer, N & Mirshahi, A (2012). Population-based meta-analysis in
Caucasians confirms association with COL5A1 and ZNF469 but not COL8A2 with central corneal thickness. Human Genetics, 131 (11), 1783-1793.
Ikram, M.K., Mitchell, P., Klein, R., Sharrett, AR, Couper, DJ & Wong, TY (2012). Age-Related Macular
Degeneration and Long-Term Risk of Stroke Subtypes. Stroke, 43 (6), 1681-1683.
Ikram, M.K., Cheung, CY, Wong, TY & Chen, CPLH (2012). Retinal pathology as biomarker for cognitive impairment and Alzheimer's disease.
917-922.
Journal of Neurology Neurosurgery and Psychiatry, 83 (9),
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Jong, P.T.V.M. de, Chakravarthy, U., Rahu, M., Seland, J, Soubrane, G, Topouzis, F, Vingerling, J.R.,
Vioque, J, Young, I & Fletcher, AE (2012). Associations between Aspirin Use and Aging Macula Disorder
The European Eye Study. Ophthalmology, 119 (1), 112-118.
Kilic, E. & Kuijpers, R.W.A.M. (2012). Transconjunctivale micro-incisie-vitrectomie; veilig alternatief voor de conventionele vitrectomie. Nederlands Tijdschrift voor Geneeskunde, 156 in the diagnosis of malignant melanoma.
.
Klein, A. de, Koopmans, A.E. & Kilic, E. (2012). Multicolor FISH with improved sensitivity and specificity
Expert Review of Molecular Diagnosis, 12 (7), 683-685.
Kongyai, N, Pathanapitoon, K, Sirirungsi, W, Kunavisarut, P, Groot-Mijnes, JDF de & Rothova, A. (2012).
Infectious causes of posterior uveitis and panuveitis in Thailand. Japanese Journal of Ophthalmology,
56 (4), 390-395.
Koolwijk, L.M.E. van, Ramdas, W.D., Ikram, M.K., Jansonius, N.M., Pasutto, F, Hysi, PG, Macgregor, S,
Janssen, SF, Hewitt, AW, Viswanathan, AC, Brink, J.B., Hosseini, SM, Amin, N., Despriet, D.D.G.,
Willemse-Assink, JJM, Kramer, R, Rivadeneira, F., Struchalin, M, Aulchenko, Y.S., Weisschuh, N, Zenkel,
M, Mardin, CY, Gramer, E, Welge-Lussen, U, Montgomery, GW, Carbonaro, F, Young, TL, Bellenguez, C,
McGuffin, P, Foster, PJ, Topouzis, F, Mitchell, P., Wang, J.J., Wong, TY, Czudowska, M.A., Hofman, A.,
Uitterlinden, A.G., Wolfs, R.C.W., Jong, P.T.V.M. de, Oostra, B.A., Paterson, AD, Mackey, DA, Bergen,
A.A.B., Reis, A., Hammond, CJ, Vingerling, J.R., Lemij, HG, Klaver, C.C.W. & Duijn, C.M. van (2012).
Common Genetic Determinants of Intraocular Pressure and Primary Open-Angle Glaucoma. PLoS
Genetics, 8 (5).
Koolwijk, L.M.E. van, Ramdas, W.D., Amin, N., Despriet, D.D.G., Vingerling, J.R., Lemij, HG, Oostra,
B.A., Klaver, C.C.W., Aulchenko, Y.S. & Duijn, C.M. van (2012). Linkage and association analyses of glaucoma related traits in a large pedigree from a Dutch genetically isolated population (vol 48, pg 802,
2011). Journal of Medical Genetics, 49 (3), 220-220.
Kunavisarut, P, Sirirungsi, W, Pathanapitoon, K & Rothova, A. (2012). Clinical Manifestations of Human
Immunodeficiency Virus-Induced Uveitis. Ophthalmology, 119 (7), 1455-1459.
Li, LJ, Cheung, CYL, Ikram, M.K., Gluckman, P, Meaney, MJ, Chong, YS, Kwek, K, Wong, TY & Saw, SM
(2012). Blood Pressure and Retinal Microvascular Characteristics During Pregnancy Growing Up in
Singapore Towards Healthy Outcomes (GUSTO) Study.
Obstetrics and Gynecology, 120
Hypertension, 60
(3), 627-635.
(1), 223-230.
Li, LJ, Ikram, M.K., Cheung, CYL, Lee, Y.S., Lee, LJ, Gluckman, P, Godfrey, KM, Chong, YS, Kwek, K,
Wong, TY & Saw, SM (2012). Effect of Maternal Body Mass Index on the Retinal Microvasculature in
Pregnancy.
Marcus, MW, Muskens, R.P.H.M., Ramdas, W.D., Wolfs, R.C.W., Jong, P.T.V.M. de, Vingerling, J.R.,
Hofman, A., Stricker, B.H.C. & Jansonius, N.M. (2012). Antithrombotic Medication and Incident
Open-Angle Glaucoma. Investigative Ophthalmology & Visual Science, 53
Marcus, MW, Muskens, R.P.H.M., Ramdas, W.D., Wolfs, R.C.W., Jong, P.T.V.M. de, Vingerling, J.R.,
Hofman, A., Stricker, B.H.C. & Jansonius, N.M. (2012). Corticosteroids and Open-Angle Glaucoma in the
Elderly A Population-Based Cohort Study. Drugs & Aging, 29
(7), 3801-3805.
(12), 963-970.
Muller, K., Naus, N.C., Nowak, P.J.C.M., Schmitz, P.I.M., Pan, C. de, Santen, C.A. van, Marijnissen, JP,
Paridaens, DA, Levendag, P.C. & Luyten, G.P.M. (2012). Fractionated stereotactic radiotherapy for uveal melanoma, late clinical results. Radiotherapy and Oncology, 102 (2), 219-224.
Ong, SY, Cheung, CY, Li, X., Lamoureux, EL, Ikram, M.K., Ding, J, Cheng, CY, Haaland, BA, Saw, SM,
Venketasubramanian, N, Chen, CPL & Wong, TY (2012). Visual Impairment, Age-Related Eye Diseases, and Cognitive Function The Singapore Malay Eye Study. Archives of Ophthalmology, 130 (7), 895-900.
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Ossewaarde-van Norel, A., Camfferman, L.P. & Rothova, A. (2012). Discrepancies Between Fluorescein
Angiography and Optical Coherence Tomography in Macular Edema in Uveitis. American Journal of
Ophthalmology, 154 (2), 233-239.
Ossewaarde-van Norel, A. & Rothova, A. (2012). Imaging methods for inflammatory macular edema.
International Ophthalmology Clinics, 52 (4), 55-66.
Peachey, NS, Ray, TA, Florijn, R, Rowe, LB, Sjoerdsma, T, Contreras-Alcantara, S, Baba, K, Tosini, G,
Pozdeyev, N, Iuvone, PM, Bojang, P, Pearring, JN, Simonsz, H.J., Genderen, M van, Birch, DG,
Traboulsi, EI, Dorfman, A, Lopez, I, Ren, HN, Goldberg, AFX, Nishina, PM, Lachapelle, P, McCall, MA,
Koenekoop, RK, Bergen, A.A.B., Kamermans, M & Gregg, RG (2012). GPR179 Is Required for
Depolarizing Bipolar Cell Function and Is Mutated in Autosomal-Recessive Complete Congenital
Stationary Night Blindness. American Journal of Human Genetics, 90 (2), 331-339.
Ramdas, W.D., Wolfs, R.C.W., Hofman, A., Jong, P.T.V.M. de, Vingerling, J.R. & Jansonius, N.M.
(2012). Author Response: Incident Open-Angle Glaucoma and Ocular Perfusion Pressure. Investigative
Ophthalmology & Visual Science, 53 (1), 150-151.
Ramdas, W.D., Wolfs, R.C.W., Kiefte- de Jong, J.C., Hofman, A., Jong, P.T.V.M. de, Vingerling, J.R. &
Jansonius, N.M. (2012). Nutrient intake and risk of open-angle glaucoma: the Rotterdam Study.
European Journal of Epidemiology, 27 (5), 385-393.
Riemens, A, Stoyanova, E, Rothova, A. & Kuiper, J.W. (2012). Cytokines in tear fluid of patients with ocular graft-versus-host disease after allogeneic stem cell transplantation. Molecular Vision, 18 (85),
797-802.
Roefs, A.M.J., Tjiam, A.M.L., Looman, C.W.N., Simonsz-Toth, B., Fronius, M, Felius, J, Simonsz, H.J. &
Loudon, S.E. (2012). Comfort of wear and material properties of eye patches for amblyopia treatment and the influence on compliance. Strabismus, 20 (1), 3-10.
Schrijvers, E.M.C., Buitendijk, G.H.S., Ikram, M.K., Koudstaal, P.J., Hofman, A., Vingerling, J.R. &
Breteler, M.M.B. (2012). Retinopathy and risk of dementia The Rotterdam Study.
Strabismus, 20 (1), 42. eyelid ectropion in cutis laxa: a paraneoplastic process in multiple myeloma.
Neurology, 79 (4),
365-370.
Simonsz, H.J. (2012). Occlusion dose monitor available for electronic recording of compliance in patch wearing for amblyopia.
Slingerland, N.W.R., Sonneveld, P., Hollander, J.C. den & Bleyen, I. (2012). Marked bilateral lower
Orbit, 31 (3), 174-176.
Smailhodzic, D, Klaver, C.C.W., Klevering, B.J., Boon, CJF, Groenewoud, JMM, Kirchhof, B, Daha, M.R.,
Hollander, A.I. & Hoyng, C.B. (2012). Risk Alleles in CFH and ARMS2 Are Independently Associated with
Systemic Complement Activation in Age-related Macular Degeneration.
339-346.
Ophthalmology, 119 (2),
Sobrin, L, Ripke, S, Yu, Y., Fagerness, J, Bhangale, TR, Tan, PL, Souied, EH, Buitendijk, G.H.S.,
Merriam, JE, Richardson, AJ, Raychaudhuri, S, Reynolds, R, Chin, KA, Lee, A. Y., Leveziel, N, Zack, DJ,
Campochiaro, P, Smith, R.T., Barile, GR, Hogg, RE, Chakravarthy, U., Behrens, TW, Uitterlinden, A.G.,
Duijn, C.M. van, Vingerling, J.R., Brantley, MA, Baird, PN, Klaver, C.C.W., Allikmets, R., Katsanis, N,
Graham, RR, Ioannidis, JPA, Daly, M.J. & Seddon, J.M. (2012). Heritability and Genome-Wide
Association Study to Assess Genetic Differences between Advanced Age-related Macular Degeneration
Subtypes. Ophthalmology, 119 (9), 1874-1885.
Sofat, R, Casas, JP, Webster, AR, Bird, A.C., Mann, SS, Yates, J.R.W., Moore, AT, Sepp, T., Cipriani, V,
Bunce, C, Khan, JC, Shahid, H, Swaroop, A, Abecasis, G, Branham, KEH, Zareparsi, S, Bergen, AA,
Klaver, C.C.W., Baas, DC, Zhang, K, Chen, YH, Gibbs, D., Weber, BHF, Keilhauer, CN, Fritsche, LG,
Lotery, A, Cree, AJ, Griffiths, HL, Bhattacharya, SS, Chen, LL, Jenkins, SA, Peto, T, Lathrop, M,
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Leveillard, T, Gorin, M.B., Weeks, DE, Ortube, MC, Ferrell, RE, Jakobsdottir, J, Conley, YP, Rahu, M.,
Seland, JH, Soubrane, G, Topouzis, F, Vioque, J, Tomazzoli, L, Young, I, Whittaker, J., Chakravarthy,
U., Jong, P.T.V.M. de, Smeeth, L, Fletcher, A & Hingorani, AD (2012). Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype. International Journal of Epidemiology, 41 (1), 250-262.
Springelkamp, H., Lee, K, Ramdas, W.D., Vingerling, J.R., Hofman, A., Klaver, C.C.W., Sonka, M,
Abramoff, MD & Jansonius, N.M. (2012). Optimizing the Information Yield of 3-D OCT in Glaucoma.
Investigative Ophthalmology & Visual Science, 53 (13), 8162-8171.
Steensel, L. van, Paridaens, A.D.A., Meurs, M. van, Hagen, P.M. van, Bosch, W.A. van den, Kuijpers,
R.W.A.M., Drexhage, H.A., Hooijkaas, H. & Dik, W.A. (2012). Orbit-Infiltrating Mast Cells, Monocytes, and Macrophages Produce PDGF Isoforms that Orchestrate Orbital Fibroblast Activation in Graves'
Ophthalmopathy. Journal of Clinical Endocrinology and Metabolism, 97 (3), E400-E408.
Steensel, L. van, Hooijkaas, H., Paridaens, A.D.A., Bosch, W.A. van den, Kuijpers, R.W.A.M., Drexhage,
H.A., Hagen, P.M. van & Dik, W.A. (2012). PDGF Enhances Orbital Fibroblast Responses to TSHR
Stimulating Autoantibodies in Graves' Ophthalmopathy Patients. Journal of Clinical Endocrinology and
Metabolism, 97 (6), E944-E953.
Tan, J., Simonsz, H.J. & Koudstaal, M.J. (2012). Oogtrauma bij kinderen; meer dan een blauw oog.
Nederlands Tijdschrift voor Geneeskunde, 156 .
Thiadens, A.A.H.J., Phan, TML, Zekveld-Vroon, RC, Leroy, BP, Born, L.I. van den, Hoyng, C.B., Klaver,
C.C.W., Roosing, S, Pott, JWR, Schooneveld, MJ van, Moll-Ramirez, N van, Genderen, MM van, Boon,
CJF, Hollander, A.I., Bergen, A.A.B., Baere, E De, Cremers, F.P.M. & Lotery, AJ (2012). Clinical Course,
Genetic Etiology, and Visual Outcome in Cone and Cone-Rod Dystrophy.
819-826.
(2012). Cone-rod dystrophy can be a manifestation of Danon disease.
Ophthalmology, 119 (4),
Thiadens, A.A.H.J., Slingerland, N.W.R., Florijn, RJ, Visser, G.H., Riemslag, F.C. & Klaver, C.C.W.
Graefes Archive for Clinical and
Experimental Ophthalmology, 250 (5), 769-774.
Tjiam, A.M.L., Holtslag, G., Vukovic, E., Asjes-Tydeman, W.L., Loudon, S.E., Borsboom, G.J.J.M.,
Koning, H.J. de & Simonsz, H.J. (2012). An Educational Cartoon Accelerates Amblyopia Therapy and
Improves Compliance, Especially among Children of Immigrants.
Melanoma Research, 22
Ophthalmology, 119
(1), 30-37.
(11), 2393-2401.
Vaarwater, J.W.C., Bosch, T. van den, Mensink, H.W., Kempen, CMG van, Verdijk, R.M., Naus, N.C.,
Paridaens, A.D.A., Bruggenwirth, H.T., Kilic, E. & Klein, A. de (2012). Multiplex ligation-dependent probe amplification equals fluorescence in-situ hybridization for the identification of patients at risk for metastatic disease in uveal melanoma.
Ven, JPH van de, Boon, CJF, Fauser, S, Hoefsloot, LH, Smailhodzic, D, Schoenmaker-Koller, F,
Klevering, B.J., Klaver, C.C.W., Hollander, A.I. & Hoyng, C.B. (2012). Clinical Evaluation of 3 Families
With Basal Laminar Drusen Caused by Novel Mutations in the Complement Factor H Gene. Archives of
Ophthalmology, 130 (8), 1038-1047.
Verhoeven, V.J.M., Hysi, PG, Saw, SM, Vitart, V, Mirshahi, A, Guggenheim, JA, Cotch, MF, Yamashiro, K,
Baird, PN, Mackey, DA, Wojciechowski, R, Ikram, M.K., Hewitt, AW, Duggal, P, Janmahasatian, S, Khor,
C.C., Fan, Q, Zhou, X., Young, TL, Tai, ES, Goh, LK, Li, YJ, Aung, T, Vithana, E, Teo, YY, Tay, W, Sim, X,
Rudan, I, Hayward, C, Wright, AF, Polasek, O, Campbell, H, Wilson, JF, Fleck, BW, Nakata, I,
Yoshimura, N, Yamada, R, Matsuda, F, Ohno-Matsui, K, Nag, A, McMahon, G, Pourcain, B St, Lu, Y.,
Rahi, JS, Cumberland, PM, Bhattacharya, S, Simpson, CL, Atwood, LD, Li, XH, Raffel, LJ, Murgia, F,
Portas, L, Despriet, D.D.G., Koolwijk, L.M.E. van, Wolfram, C, Lackner, KJ, Tonjes, A, Magi, R,
Lehtimaki, T, Kahonen, M, Esko, T, Metspalu, A, Rantanen, T, Parssinen, O, Klein, BE, Meitinger, T,
Spector, T.D., Oostra, B.A., Smith, AV, Jong, P.T.V.M. de, Hofman, A., Amin, N., Karssen, L.C.,
Rivadeneira, F., Vingerling, J.R., Eiriksdottir, G, Gudnason, V, Doring, A, Bettecken, T, Uitterlinden,
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A.G., Williams, C., Zeller, T, Castagne, R, Oexle, K, Duijn, C.M. van, Iyengar, SK, Mitchell, P., Wang,
J.J., Hohn, R, Pfeiffer, N, Bailey-Wilson, JE, Stambolian, D, Wong, TY, Hammond, CJ & Klaver, C.C.W.
(2012). Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium. Human Genetics, 131 (9), 1467-1480.
Walsh, S., Wollstein, A.D., Liu, F., Chakravarthy, U., Rahu, M., Seland, JH, Soubrane, G, Tomazzoli, L,
Topouzis, F, Vingerling, J.R., Vioque, J, Fletcher, AE, Ballantyne, K.N. & Kayser, M. (2012). DNA-based eye colour prediction across Europe with the IrisPlex system. Forensic Science International: Genetics,
6 (3), 330-340.
Yau, JWY, Rogers, SL, Kawasaki, R, Lamoureux, EL, Kowalski, JW, Bek, T, Chen, SJ, Dekker, J.M.,
Fletcher, A, Grauslund, J, Haffner, S, Hamman, RF, Ikram, M.K., Kayama, T, Klein, B.E.K., Klein, R.,
Krishnaiah, S, Mayurasakorn, K, O'Hare, JP, Orchard, TJ, Porta, M, Rema, M, Roy, MS, Sharma, T,
Shaw, J., Taylor, H, Tielsch, JM, Varma, R, Wang, J.J., Wang, NL, West, S., Xu, L., Yasuda, M., Zhang,
XZ, Mitchell, P. & Wong, TY (2012). Global Prevalence and Major Risk Factors of Diabetic Retinopathy.
Diabetes Care, 35 (3), 556-564.
Yodmuang, T, Rothova, A., Kunavisarut, P & Pathanapitoon, K (2012). Vogt-Koyanagi-Harada Disease in Thailand. Ocular Immunology and Inflammation, 20
Degeneration: Results up to 7 Years.
(6), 419-422.
Zeeburg, E.J.T. van, Maaijwee, K.J.M., Missotten, T.O.A.R., Heimann, H & Meurs, J.C. van (2012). A
Free Retinal Pigment Epithelium-Choroid Graft in Patients With Exudative Age-Related Macular
American Journal of Ophthalmology, 153 (1), 120-127.
Part of book - Abstract
Rothova, A. (2012). What is the risk of blindness due to uveitis in patients treated with monotherapy? In
C.S. Foster, D. Opremchak & D. Hinkle (Eds.),
(pp. 33-35). Thorofare: Slack Incorporated.
Curbside Consultation in Uveitis; 49 Clinical Questions
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EMC OR-01-61-01 - Optimalising respiratory, circulatory and metabolic functions for improved (wound)healing after trauma and operation and infection in intensive care patients
Programme (brief description)
Intensive care is an indispensible health care provision. Mortality rates and morbidity typically are high.
Every aspect of this specialism is continuously subject to new developments and views and opinions are subject to rapid changes. The developments are characterised by their multidisciplinarity and technological nature. Recovery of intensive care patients requires optimal gas exchange and supply of nutrients to the tissues. The research efforts in a broader sense are aimed at technological improvements for optical tissue characterization for diagnosis and guidance of clinical procedures, non-invasive blood analysis, patient monitoring and rapid diagnosis of clinically relevant microorganisms for optimal patient treatment and infection control.
Journal Editorship/Refereeship
Bigio, I.J., Müller, G.J., Puppels, G.J., Steiner, R.W. & Svanberg, K. (Eds.). (2000).
Progress in
Biomedical Optics and Imaging, 1 (32).
Mahadevan-Jansen, A. & Puppels, G.J. (Eds.). (2000).
1 (12).
Progress in Biomedical Optics and Imaging,
Puppels, G.J. (Ed.). (2002).
Journal of Raman Spectroscopy, 33 (7).
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EMC OR-01-62-02 - Otorhinolaryngology and head & neck surgery
Programme (brief description)
General
Can we improve early detection of disease?
Do prognostic models improve the quality of health care?
Head and neck cancer
Can we identify the role of organ-sparing strategies in head and neck cancer?
Do modern optical imaging and molecular biology add to the current diagnostic armamentarium?
What are key factors in optimal palliation of head neck cancer patients?
How can we improve Quality of Life in head and neck cancer?
Audiology/otology
Can we adequately describe epidemiology of hearing loss and can we identify etiological factors?
Can we improve diagnostics in hearing loss and central auditory processing disorders?
How can we effectively evaluate and optimise the result of Cochleair Implantation?
Speech
Is the Lidcombe programme for early stuttering intervention more (cost-)effective than the
Demands and Capacities Model based treatment (Dutch standard) ?
Can risk factors for a Speech Sound Disorder (SSD) in preterm children at age 4 be identified? Is a short, parent based speech intervention programme for preterm children with a SSD at 2 years of age effective?
Tissue engineering
Find methods to repair large tissue defects after oncologic surgery.
Key Figures
Department Sp1 Sp2 Sp3 Sp4 SpTot T1 T2 T3 Ttot IS FS OP Ptot orthopaedics 0,22 otorhinolaryngology 9,19 0,19 0,37
0,22
9,75
Total
Thesis
9,41 0,19
Datema, F.R. (2012, juni 22).
Dr. R.J. Baatenburg de Jong.
0 0,37 9,97 2 0 0
Survival prediction in head and neck cancer.
2 41 5 4 52
EUR. Prom./coprom.: Prof.
Hellingman, C.A. (2012, januari 27). Finetuning cartilage tissue engineering by applying principles from embryonic development.
EUR (168 pag.). Prom./coprom.: Prof. Dr. R.J. Baatenburg de Jong & Prof. Dr.
G.J.V.M. van Osch.
Octrooi
Metselaar, R.M. (). Smartphone camera adaptor. no PCT/NL2012/050786.
Narcisi, R., Berge, D. ten & Osch, G.J.V.M. van (). Stimulation of Wnt and FGF increase cartilage yield by
MSCs. no 61/641,963.
Article/Letter to the editor
Al-Mamgani, A., Rooij, P.H.E. van, Sewnaik, A., Tans, L. & Hardillo, J.A.U. (2012). Adenoid cystic carcinoma of parotid gland treated with surgery and radiotherapy: Long-term outcomes, QoL assessment and review of the literature. Oral Oncology, 48 (3), 278-283.
Al-Mamgani, A., Monserez, D., Rooij, P.H.E. van, Verduijn, G.M., Hardillo, J.A.U. & Levendag, P.C.
(2012). Highly-conformal intensity-modulated radiotherapy reduced toxicity without jeopardizing outcome in patients with paranasal sinus cancer treated by surgery and radiotherapy or
(chemo)radiation. Oral Oncology, 48 (9), 905-911.
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Al-Mamgani, A., Rooij, P.H.E. van, Verduijn, G.M., Meeuwis, C.A. & Levendag, P.C. (2012). Long-term
Outcomes and Quality of Life of 186 Patients With Primary Parotid Carcinoma Treated With Surgery and
Radiotherapy at the Daniel den Hoed Cancer Center. International Journal of Radiation Oncology
Biology Physics, 84 (1), 189-195.
Al-Mamgani, A., Mehilal, R., Rooij, P.H.E. van, Tans, L., Sewnaik, A. & Levendag, P.C. (2012). Toxicity, quality of life, and functional outcomes of 176 hypopharyngeal cancer patients treated by
(Chemo)radiation: The impact of treatment modality and radiation technique.
1789-1795.
Laryngoscope, 122 fat pad of patients with end-stage osteoarthritis inhibits catabolic mediators in cartilage.
(8),
Bastiaansen-Jenniskens, Y.M., Clockaerts, S.B.F., Feijt, C., Zuurmond, AM, Stojanovic-Susulic, V, Bridts,
C, Clerck, L De, DeGroot, J., Verhaar, J.A.N., Kloppenburg, M & Osch, G.J.V.M. van (2012). Infrapatellar
Annals of the
Rheumatic Diseases, 71 (2), 288-294.
Beek, N.A.M.E. van der, Verschuure, J., Reuser, A.J.J., Ploeg, A.T. van der, Doorn, P.A. van & Poublon,
R.M.L. (2012). Hearing in adults with Pompe disease.
335341.
Journal of Inherited Metabolic Disease, 35 ,
Buul, G.M. van, Villafuertes, E, Bos, P.K., Waarsing, J.H., Kops, N., Narcisi, R., Weinans, H.H., Verhaar,
J.A.N., Bernsen, M.R. & Osch, G.J.V.M. van (2012). Mesenchymal stem cells secrete factors that inhibit inflammatory processes in short-term osteoarthritic synovium and cartilage explant culture.
Osteoarthritis and Cartilage, 20 (10), 1186-1196.
Cals, F.L.J., Hellingman, C.A., Koevoet, J.L.M., Baatenburg de Jong, R.J. & Osch, G.J.V.M. van (2012).
Effects of transforming growth factor-ss subtypes on in vitro cartilage production and mineralization of human bone marrow stromal-derived mesenchymal stem cells. Journal of Tissue Engineering and
Regenerative Medicine, 6 (1), 68-76.
Clockaerts, S.B.F., Osch, G.J.V.M. van, Bastiaansen-Jenniskens, Y.M., Verhaar, J.A.N., Glabbeek, F Van,
Meurs, J.B.J. van, Kerkhof, J.M., Hofman, A., Stricker, B.H.C. & Bierma-Zeinstra, S.M.A. (2012). Statin use is associated with reduced incidence and progression of knee osteoarthritis in the Rotterdam study.
Annals of the Rheumatic Diseases, 71 (5), 642-647.
Coenraad, S. (2012). Hoofd-halscarcinoom. Huisarts en Wetenschap, 12 , 572.
Datema, F.R., Moya, A., Krause, P, Back, T., Willmes, L, Langeveld, T, Jong, RJB de & Blom, H.M.
(2012). NOVEL HEAD AND NECK CANCER SURVIVAL ANALYSIS APPROACH: RANDOM SURVIVAL
FORESTS VERSUS COX PROPORTIONAL HAZARDS REGRESSION. Head & Neck-Journal for the Sciences and Specialties of the Head and Neck, 34 (1), 50-58.
Franken, M.C.J.P., Laroes, E. & Putker, D. (2012). Stotterende kinderen behandelen volgend de
Logopedie en Phoniatrie , 24-29. RESTART-DCM werkwijze: een leidraad.
Gelder, C.M. van, Capelle, C.I. van, Ebbink, B.J., Nugteren, I. van, Hout, J.M.P. van den, Hakkesteegt,
M.M., Doorn, P.A. van, Coo, I.F.M. de, Reuser, A.J.J., Gier, H.H.W. de & Ploeg, A.T. van der (2012).
Facial-muscle weakness, speech disorders and dysphagia are common in patients with classic infantile
Pompe disease treated with enzyme therapy. Journal of Inherited Metabolic Disease, 35 (3), 505-511.
Gierman, LM, Ham, F. van der, Koudijs, A, Wielinga, PY, Kleemann, R, Kooistra, T, Stoop, R,
Kloppenburg, M, Osch, G.J.V.M. van, Stojanovic-Susulic, V, Huizinga, TW & Zuurmond, AM (2012).
Metabolic Stress-Induced Inflammation Plays a Major Role in the Development of Osteoarthritis in Mice.
Arthritis & Rheumatism, 64 (4), 1172-1181.
Hellingman, C.A., Koevoet, W & Osch, G.J.V.M. van (2012). Can one generate stable hyaline cartilage from adult mesenchymal stem cells? A developmental approach. Journal of Tissue Engineering and
Regenerative Medicine, 6 (10), e1-e11.
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Hooff, SR van, Leusink, FKJ, Roepman, P, Jong, RJB de, Speel, E.J.M., Brekel, M.W.M. van den,
Velthuysen, M.L.F. van, Diest, P.J. van, Es, RJJ van, Merkx, MAW, Kummer, JA, Leemans, C.R.,
Schuuring, E., Langendijk, J.A., Lacko, M, Herdt, M.J. de, Jansen, JC, Brakenhoff, R.H., Slootweg, P.J.,
Takes, R.P. & Holstege, FCP (2012). Validation of a Gene Expression Signature for Assessment of
Lymph Node Metastasis in Oral Squamous Cell Carcinoma. Journal of Clinical Oncology, 30 (33),
4104-4110.
Keereweer, S., Kerrebijn, J.D.F., Al-Mamgani, A., Sewnaik, A., Jong, RJB de & Meerten, E. van (2012).
Chemoradiation for advanced hypopharyngeal carcinoma: a retrospective study on efficacy, morbidity and quality of life. European Archives of Oto-Rhino-Laryngology, 269
Keereweer, S., Mol, IM, Vahrmeijer, A.L., Driel, PBAA van, Jong, RJB de, Kerrebijn, J.D.F. & Lowik,
C.W.G.M. (2012). Dual wavelength tumor targeting for detection of hypopharyngeal cancer using near-infrared optical imaging in an animal model.
(3), 939-946.
International Journal of Cancer, 131 (7), 1633-1640.
Keereweer, S., Sterenborg, H.J.C.M., Kerrebijn, J.D.F., Driel, PBAA van, Jong, RJB de & Lowik,
C.W.G.M. (2012). IMAGE-GUIDED SURGERY IN HEAD AND NECK CANCER: CURRENT PRACTICE AND
FUTURE DIRECTIONS OF OPTICAL IMAGING. Head & Neck-Journal for the Sciences and Specialties of the Head and Neck, 34 (1), 120-126.
Keereweer, S., Kerrebijn, J.D.F., Mol, IM, Mieog, JSD, Driel, PBAA van, Jong, RJB de, Vahrmeijer, A.L. &
Lowik, C.W.G.M. (2012). Optical imaging of oral squamous cell carcinoma and cervical lymph node metastasis.
1002-1008.
Head & Neck-Journal for the Sciences and Specialties of the Head and Neck, 34 (7),
Keereweer, S., Appel, I.M. & Hoeve, L.J. (2012). Subglottic stenosis in Shwachman-Diamond syndrome
- Is there a link? International Journal of Pediatric Otorhinolaryngology, 76
Keereweer, S., Mol, IM, Kerrebijn, J.D.F., Driel, PBAA van, Xie, BW, Jong, RJB de, Vahrmeijer, A.L. &
Lowik, C.W.G.M. (2012). Targeting integrins and enhanced permeability and retention (EPR) effect for optical imaging of oral cancer. Journal of Surgical Oncology, 105
(10), 1531-1532.
(7), 714-718.
Keereweer, S., Hutteman, M, Kerrebijn, J.D.F., Velde, C.J.H. van de, Vahrmeijer, A.L. & Lowik,
C.W.G.M. (2012). Translational Optical Imaging in Diagnosis and Treatment of Cancer. CURRENT
PHARMACEUTICAL BIOTECHNOLOGY, 13 (4), 498-503.
Leusink, FKJ, Es, RJJ van, Bree, R. de, Jong, RJB de, Hooff, SR van, Holstege, FCP, Slootweg, P.J.,
Brakenhoff, R.H. & Takes, R.P. (2012). Novel diagnostic modalities for assessment of the clinically node-negative neck in oral squamous-cell carcinoma. Lancet Oncology, 13 (12), E554-E561.
Loon, Y. van, Sjogren, EV, Langeveld, TPM, Baatenburg de Jong, R.J., Schoones, JW & Rossum, MA van
(2012). Functional outcomes after radiotherapy or laser surgery in early glottic carcinoma: A systematic review. Head & Neck-Journal for the Sciences and Specialties of the Head and Neck, 34 (8), 1179-1189.
Melle, M.L. van, Mandl, E.W., Kops, N., Koevoet, J.L.M., Verhaar, J.A.N. & Osch, G.J.V.M. van (2012).
An Osteochondral Culture Model to Study Mechanisms Involved in Articular Cartilage Repair. Tissue
Engineering part C-Methods, 18 (1), 45-53.
Narcisi, R., Signorile, L., Verhaar, J.A.N., Giannoni, P & Osch, G.J.V.M. van (2012). TGF beta inhibition during expansion phase increases the chondrogenic re-differentiation capacity of human articular chondrocytes. Osteoarthritis and Cartilage, 20 (10), 1152-1160.
Narcisi, R., Signorile, L, Verhaar, J.A.N., Giannoni, P & Osch, G.J.V.M. van (2012). TGFbeta-depletion during expansion enhances chondrogenesis of human chondrocytes. Journal of Tissue Engineering and
Regenerative Medicine, 6 , 59-59.
Nout, E., Bannink, N., Koudstaal, M.J., Veenland, J.F., Joosten, K.F.M., Poublon, R.M.L., Wal, K.G.H. van der, Mathijssen, I.M.J. & Wolvius, E.B. (2012). Upper airway changes in syndromic craniosynostosis
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< back to index patients following midface or monobloc advancement: Correlation between volume changes and respiratory outcome. Journal of Cranio-Maxillofacial Surgery, 40 (3), 209-214.
Plomp, R.G., Bredero-Boelhouwer, H.H., Joosten, K.F.M., Wolvius, E.B., Hoeve, L.J., Poublon, R.M.L. &
Mathijssen, I.M.J. (2012). Obstructive sleep apnoea in Treacher Collins syndrome: prevalence, severity and cause. International Journal of Oral and Maxillofacial Surgery, 41
Laryngoscope, 122 (4), 930-934.
(6), 696-701.
Plomp, R.G., Joosten, K.F.M., Wolvius, E.B., Hoeve, L.J., Poublon, R.M.L., Montfort, C.A.G.M. van,
Bredero-Boelhouwer, H.H. & Mathijssen, I.M.J. (2012). Screening for obstructive sleep apnea in treacher-collins syndrome.
Schroeff, M.P. van der, Steyerberg, E.W., Wieringa, M.H., Langeveld, A.P.M., Molenaar, J & Jong, RJB de (2012). PROGNOSIS: A VARIABLE PARAMETER. DYNAMIC PROGNOSTIC MODELING IN HEAD AND
NECK SQUAMOUS CELL CARCINOMA. Head & Neck-Journal for the Sciences and Specialties of the Head and Neck, 34 (1), 34-41.
Sewnaik, A., Keereweer, S., Al-Mamgani, A., Baatenburg de Jong, R.J., Wieringa, M.H., Meeuwis, C.A. &
Kerrebijn, J.D.F. (2012). High complication risk of salvage surgery after chemoradiation failures. Acta
Oto-Laryngologica, 132 (1), 96-100.
Spek, I.L. van der, Franken, M.C.J.P. & Weisglas-Kuperus, N. (2012). Language Functions in
Preterm-Born Children: A Systematic Review and Meta-analysis. Pediatrics, 129 (4), 745-754.
Spoor, M., Nagtegaal, A.P., Ridwan, Y, Zuiderveen Borgesius, C.H., Alphen, B. van, Pluijm, I. van der,
Hoeijmakers, J.H.J., Frens, M.A. & Borst, J.G.G. (2012). Accelerated loss of hearing and vision in the
DNA-repair deficient Ercc1(delta/-) mouse.
Cells Tissues Organs, 195
Mechanisms of Ageing and Development, 133
(3), 185-196.
(2-3), 59-67.
Tra, W.M.W., Neck, J.W. van, Hovius, S.E.R., Osch, G.J.V.M. van & Perez-Amodio, S (2012).
Characterization of a Three-Dimensional Mucosal Equivalent: Similarities and Differences with Native
Oral Mucosa.
Uitdehaag, M.J., Velden, L.A. van der, Boer, M.F. de, Spaander, M.C.W., Steyerberg, E.W., Kuipers, E.J.,
Siersema, P.D. & Pruijn, J.F.A. (2012). Recordings of consultations are beneficial in the transition from curative to palliative cancer care: A pilot-study in patients with oesophageal or head and neck cancer.
European Journal of Oncology Nursing, 16 (2), 109-114.
Veneman, W., Metselaar, R.M., Koudstaal, M.J. & Wal, K.G.H. van der (2012). Osteoradionecrosis of the external auditory canal: three cases involving.
1022-1026.
Journal of Laryngology and Otology, 126 (10),
Verseijden, F., Sluijs, SJP, Neck, J.W. van, Hofer, S.O.P., Hovius, S.E.R. & Osch, G.J.V.M. van (2012).
Comparing Scaffold-Free and Fibrin-Based Adipose-Derived Stromal Cell Constructs for Adipose Tissue
Engineering: An In Vitro and In Vivo Study. constructs after implantation in nude mice.
Cell Transplantation, 21 (10), 2283-2297.
Verseijden, F., Sluijs, S.J. van, Neck, J.W. van, Hofer, S.O.P., Hovius, S.E.R. & Osch, G.J.V.M. van
(2012). Vascularization of prevascularized and non-prevascularized fibrin-based human adipose tissue
Journal of Tissue Engineering and Regenerative Medicine,
6 (3), 169-178.
Vijven, J.P.J. van, Luijsterburg, P.A.J., Verhagen, A.P., Osch, G.J.V.M. van, Kloppenburg, M &
Bierma-Zeinstra, S.M.A. (2012). Symptomatic and chondroprotective treatment with collagen derivatives in osteoarthritis: a systematic review. Osteoarthritis and Cartilage, 20
Vos, F.Y.F.L. de, Sewnaik, A., Wilt, J.H.W. de, Smid, E.J., Bakker, M.A. den & Meerten, E. van (2012).
COMBINED THERAPY FOR THYROID SQUAMOUS CELL CARCINOMA.
Sciences and Specialties of the Head and Neck, 34 (1), 131-134.
(8), 809-821.
Head & Neck-Journal for the
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Werf, F. van der, Reits, D, Metselaar, M. & Zeeuw, C.I. de (2012). Long-Term Effect of Prednisolone on
Functional Blink Recovery after Transient Peripheral Facial Motor Paralysis. Otolaryngology and Head and Neck Surgery, 146 (3), 448-454.
Xie, BW, Mol, IM, Keereweer, S., Beek, ER van, Que, I., Snoeks, TJA, Chan, A.M., Kaijzel, EL & Lowik,
C.W.G.M. (2012). Dual-Wavelength Imaging of Tumor Progression by Activatable and Targeting
Near-Infrared Fluorescent Probes in a Bioluminescent Breast Cancer Model. PLoS One, 7 (2).
Part of book - Abstract
Baatenburg de Jong, R.J. (2012). Prognosis of recurrent head and neck cancer. In M. Ang & K. Ang
(Eds.), Head and neck recurrence
Baatenburg de Jong, R.J. (2012). Psychosocial aspects of recurrent head and neck cancer. In M. Ang &
K. Ang (Eds.),
. --: Thieme.
Head and neck recurrence . Amersfoort: Thieme.
Hoeve, L.J., Rottier, B.L. & Rijn, P. van (2012). Farynx, larynx, trachea en stem. In kinderlongziekten (pp. 46). Amsterdam: VU university press.
Wedrkboek
Hoeve, L.J. (2012). Gehoor en oren. In Richtlijn behandeling Turner syndroom in Nederland .
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EMC OR-01-65-03 - Addiction research
Programme (brief description)
What is the prevalence and incidence of drug use, alcohol consumption and other lifestyles and addiction? Which factors are the determinants of lifestyles and addiction? What are the consequences of lifestyles and addiction in terms of health, quality of life, environment (a.o. nuisance). What is the quality, efficiency of addiction care, prevention and policy? What is the interaction of lifestyles and addiction with society.
Key Figures
Department Sp1 Sp2 Sp3 Sp4 SpTot T1 T2 T3 Ttot IS FS OP Ptot addiction research 0,79 5 5,79
Total 0,79 0
Article/Letter to the editor
0 5 5,79 0 0 0 0 9 2 28 39
Garretsen, H.F.L., Audenaerdt, M.J., Goor, L van de, Roeg, D, Sar, R.M. van der, Schoenmakers, T.M. &
Mheen, H. van de (2012). Social and epidemiological research on alcohol: developments in the research agenda between 1983 and 2010. The Kettil Bruun Society in the past decades. International journal of alcohol and drug research, 1 (1), 95.
Garretsen, H.F.L. & Mheen, H. van de (2012). Zoeken naar de balans tussen volkgezondheid en openbare orde. MGV online .
Genugten, L. van, Empelen, P. van, Boon, B., Borsboom, G., Visscher, T & Oenema, A. (2012). Results from an Online Computer-Tailored Weight Management Intervention for Overweight Adults:
Randomized Controlled Trial. Journal of Medical Internet Research, 14 (2).
Harakeh, Z, Sonneville, L de, Eijnden, R.J.J.M. van den, Huizink, A.C., Reijneveld, S.A., Ormel, J.,
Verhulst, F.C., Monshouwer, K. & Vollebergh, W.A.M. (2012). The Association Between Neurocognitive
Functioning and Smoking in Adolescence: The TRAILS Study.
Addiction Biology, 17
Computers in Human Behavior, 28
(5), 934-947.
Neuropsychology, 26
(2), 465-472.
(5), 541-550.
Heuvel, A van den, Eijnden, R.J.J.M. van den, Rooij, A.J. van & Mheen, D. van de (2012). Meeting online contacts in real life among adolescents: The predictive role of psychosocial wellbeing and internet-specific parenting.
Littel, M., Berg, I. van den, Luijten, M., Rooij, A.J. van, Keemink, L. & Franken, I.H.A. (2012). Error processing and response inhibition in excessive computer game players: an event-related potential study.
Meerkerk, G.J. (2012). Tijd voor een deflatie van het begrip verslaving? Verslaving, 8 (1), 68-70.
Rodenburg, G., Kremers, S.P.J., Oenema, A. & Mheen, D. van de (2012). Associations of Children's
Appetitive Traits with Weight and Dietary Behaviours in the Context of General Parenting. PLoS One,
7 (12).
Rodenburg, G., Oenema, A., Kremers, S.P.J. & Mheen, D. van de (2012). Parental and child fruit consumption in the context of general parenting, parental education and ethnic background. Appetite,
58 (1), 364-372.
Rooij, A.J. van, Zinn, MF, Schoenmakers, T.M. & Mheen, D. van de (2012). Treating Internet Addiction
With Cognitive-Behavioral Therapy: A Thematic Analysis of the Experiences of Therapists. International
Journal of Mental Health & Addiction, 10 (1), 69-82.
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Rooij, A.J. van, Schoenmakers, T.M., Eijnden, R.J.J.M. van den, Vermulst, A.A. & Mheen, D. van de
(2012). Video Game Addiction Test: Validity and Psychometric Characteristics. Cyberpsychology,
Behavior and Social Networking, 15 (9), 507-511.
Rooij, A.J. van, Zinn, MF, Schoenmakers, T.M. & Mheen, H. van de (2012). ). Het behandelen van
Verslaving, 8 (4), 37-52. internetverslaving met cognitieve gedragstherapie.
Rooij, A.J. van, Duijn, L. van, Frielink, N., DeFuentes-Merillas, L. & Schoenmakers, T.M. (2012). C-VAT:
Clinical Video game Addiction Test. Een diagnostisch instrument voor het herkennen van gameverslaving in de klinische praktijk. TOKK. Tijdschrift voor Orthopedagogiek, Kinderpsychiatrie en
Klinische Kinderpsychologie .
Rooij, A.J. van & Mheen, H. van de (2012). Internet- en online gameverslaving. Bijblijven. Cumulatief
Geneeskundig Nascholingssysteem, 28 (10), 12-19.
Rooij, A.J. van, Schoenmakers, T.M., Eijnden, R.J.J.M. van den & Mheen, H. van de (2012). Online video gameverslaving: verkenning van een nieuw fenomeen. TSG, 90 (7), 421-427.
Rooij, A.J. van (2012). Recensie Wilskracht - Baumeister and Tierney [Book review: Willpower].
Verslaving, 8 (3), 76-77.
Schoenmakers, T.M., Hellman, M, Nordstrom, B & Holst, R (2012). ). Bestaat online-gameverslaving?
Een crossdisciplinaire benadering. Verslaving, 8 (4), 4-15.
Schoenmakers, T.M. (2012). K. Schelleman-Offermans (2012). Growing up getting drunk; development and prevention of adolescent alcohol use. Academisch Proefschrift, Universiteit Maastricht. (Bespreking van proefschrift. MGV, 67
Snelleman, M. (2012). Zorg voor Rotterdamse zwerfjongeren met ernstige problematiek: goed op weg en hoe nu verder? TSG, 3
, 389-390.
, 157-158.
Teunissen, HA, Spijkerman, R., Schoenmakers, T.M., Vohs, Kathleen D. & Engels, R.C.M.E. (2012). The
Effect of Self-Control on Attentional Bias for Alcohol Cues in Male Heavy Drinkers.
Social Psychology, 42 (3), 776-792.
Journal of Applied
Wits, E., Mheen, H. van de, Snoek, A & Stel, J. van der (2012). Kwetsbare groepen jeugdigen en problematisch middelengebruik: visie en interventiematrix. Verslaving, 8 (1), 3-21.
Part of book - Abstract
Barendregt, C. & Mheen, H. van de (2012). Some contextual aspects of Dutch policy on psychoactive substances. In Reflections on the concept of coherency for a policy on psychoactive substances and beyond (pp. 75-88). Strasbourg: Pompidou Group of the counsil of Europe.
Jansz, J & Rooij, A.J. van (2012). ). The Perils and Pleasures of Playing Videogames. In W Stol & R Leukfeldt
(Eds.), Cyber safety: An introduction (pp. 227-235). The Hague: Eleven International Publishing.
Mheen, H. van de & Brink, W van den (2012). Verslavingszorg. In JP Mackenbach & K Stronks (Eds.),
Volksgezondheid en gezondheidszorg . Amsterdam: Reed Business.
Report
Duijn, L. van & Wits, E. (2012). Evaluatie van de werkwijze en resultaten van het LSOVD-groepswerk.
Rotterdam: IVO.
Hammink, A, Altenburg, M & Schrijvers, C.T.M. (2012). De Sociale gevolgen van verslaving. Een state of the art studie naar verstoring van sociale relaties, schooluitval, dakloosheid, schulden en huiselijk geweld als gevolg van alcohol- of drugsverslaving.
Rotterdam: IVO.
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Hammink, A & Schrijvers, C.T.M. (2012). Middelengebruik en gokken onder jongeren en volwassenen met een licht verstandelijke beperking in de regio Rotterdam. Aard, omvang, zorgbehoeften en huidig zorgaanbod.
Rotterdam: IVO.
Hammink, A & Schrijvers, C.T.M. (2012). Preventie van GHB gebruik in Nederland. Onderzoek naar de kenmerken van GHB gebruikers, in het bijzonder van hangjongeren en thuisgebruikers.
Rotterdam:
IVO.
Hammink, A & Wits, E. (2012).
Rotterdam: IVO.
Procesevaluatie van de gedragsinterventie Alcohol en Geweld.
Loth, C., Wits, E., Jong, C de & Mheen, H. van de (2012). RIOB. Richtlijn
Opiaatonderhoudsbehandeling: Herziene versie.
Amersfoort: Resultaten Scoren.
Meerkerk, G.J. & Schoenmakers, T.M. (2012). ). Hoe harder hoe beter? Een onderzoek naar de relatie tussen het kijken naar online pornografie en het optreden van tolerantie- en sensitisatie-effecten voor seksuele stimuli.
Rotterdam: IVO.
Meerkerk, G.J. & Schoenmakers, T.M. (2012).
Voorthuizen 2012.
Rotterdam: IVO.
Cliënttevredenheid verslavingskliniek SolutionS Center in
Rooij, A.J. van & Meerkerk, G.J. (2012). Gameadviesopmaat.nl: Bezoek in de eerste maanden [Personal game advice website: the statistics.
Rotterdam: IVO.
Rooij, A.J. van, Duijn, L. van, Frielink, N., DeFuentes-Merillas, L. & Schoenmakers, T.M. (2012). Klinisch
Assessment instrument voor Videogameverslaving. Een diagnostisch instrument voor het herkennen van gameverslaving in de klinische praktijk.
Rotterdam: IVO/Stichting Volksbond.
Snoek, A, Wits, E. & Meulders, W. (2012). Patiëntenfolder Angststoornissen en problemen met verslavende middelen.
Amersfoort: Resultaten Scoren.
Snoek, A, Wits, E. & Meulders, W. (2012). Richtlijn Middelenmisbruik of -afhankelijkheid en angststoornissen. Addendum bij de MDR Angststoornissen.
Amersfoort: Resultaten Scoren.
Straaten, B. van, Laan, J van der, Schrijvers, C.T.M., Boersma, SM, Maas, M., Wolf, J & Mheen, H. van de (2012).
Veldhuis, L. & Schrijvers, C.T.M. (2012).
Profiel van daklozen in de vier grote steden.
Rotterdam/Nijmegen: IVO.
Naar een integrale aanpak van genotmiddelengebruik door cluster 4 leerlingen van het Voorgezet Speciaal Onderwijs. Een kortdurend onderzoek in het kader van
Klein maar Fijn.
Rotterdam: IVO.
Wits, E., Choenni, V. & Duijn, L. van (2012). Verslavingsreclassering voor jongeren met middelenproblematiek. Ontwikkeling van een landelijk, eenduidig aanbod van advies, toezicht en gedragsinterventies.
Rotterdam: IVO.
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EMC OR-01-74-01 - Philosophy of Medicine
Programme (brief description)
Are the obese the lepers of modern time? When is suffering unbearable? Is it okay to enhance one¿s memory by taking a pill? Can doctors still do the best for individual patients in health care systems organised by market principles? Is there an obligation to donate a kidney to one¿s close ones? Just some examples of questions we are working on now.
In our research the following themes play a central role:
Ethics and individual responsibility for health
Ethics, beauty and appearance
Ethics and fiction
Ethics and paediatrics
Ethics and technology assessment and professional morality
Ethics and transplantation
These are the themes that we have been working on for at least 5 years. More recent subjects we are working on are: medical decisions regarding the end of life, neuroethics and ethical aspects of pandemics.
We work in interdisciplinary contexts we; are not afraid of practical solutions, but also fascinated by underlying fundamental ethical issues. We strive for international cooperation, particularly via our EU projects, but we also participate in the Dutch debate.
Key Figures
Department medical ethics and filosophy of medicine
Sp1 Sp2 Sp3 Sp4 SpTot T1 T2 T3 Ttot IS FS OP Ptot
1,11 3,6 0,22 4,93 medical history 4,16 3,2 7,36
Total 5,27 6,8
Inaugurale rede
0 0,22 12,29 0 0 0 0
Schermer, M.H.N. (2012). Van genezen naar verbeteren?
Article/Letter to the editor
. Rotterdam: ErasmusMC.
7 3 31 41
Asscher, E.C.A., Bolt, L.L.E. & Schermer, M.H.N. (2012). Wish-fulfilling medicine in practice: a qualitative study of physician arguments. Journal of Medical Ethics, 38 (6), 327-331.
Boer, J. de, Blijderveen, G., Dijk, G. van, Duivenvoorden, H.J. & Williams, M. (2012). Implementing structured, multiprofessional medical ethical decision-making in a neonatal intensive care unit. Journal of Medical Ethics, 38 , 596-601.
Bunnik, E.M., Schermer, M.H.N. & Janssens, A.C.J.W. (2012). The role of disease characteristics in the ethical debate on personal genome testing. BMC MEDICAL GENOMICS, 5
Bunnik, E.M. (2012). Erfelijk risico goed te verzekeren.
Dijk, G. van (2012). Camera¿s en de SEH: een ongelukkig huwelijk.
Dijk, G. van (2012). De complexe werkelijkheid van morele problemen.
.
Medisch Contact, 67
KNMG .
(48), 2728-2730.
Dijk, G. van (2012). De complexe werkelijkheid van morele problemen. reflectie .
Dijk, G. van (2012). Goede zorg en de levenseindekliniek.
Medisch Contact, 49 (07).
Nieuwsbrief week van de
Medisch Contact , 2430.
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Dijk, G. van (2012). His Body, His Choice. The European, 8 .
Dijk, G. van (2012). Jongensbesnijdenis steeds meer omstreden. Katholiek Nieuwsblad, 12
Dijk, G. van (2012). Verplichte anticonceptie geen wapen tegen kindermishandeling.
(6).
KNMG .
Dijk, G. van (2012). Zelfbeschikking: recht op hulp bij zelfdoding?
Ethiek, 22 (2), 40-41.
Tijdschrift voor Geneeskunde en
Everdingen, J.J.E. van & Meulenberg, F.A.E.M. (2012). Geurvertoon.
Dermatologie & Venereologie, 1 , 33-35.
Nederlands Tijdschrift voor
Kaptein, A.A., Lyons, C.C., Pearson, A.S., Geest, S van der, Haan, J., Meulenberg, F.A.E.M. & Smyth,
J.M. (2012). Storying Stories. Medical Education Development, 2 , 24-26.
Matas, AJ, Satel, S., Munn, S, Richards, JR, Tan-Alora, A, Ambagtsheer, FJAE, Asis, MDH, Baloloy, L,
Cole, E, Crippin, J, Cronin, D, Daar, AS, Eason, J, Fine, R, Florman, S, Freeman, R., Fung, J, Gaertner,
W, Gaston, R, Ghahramani, N, Ghods, A, Goodwin, M., Gutmann, T, Hakim, N, Hippen, B, Huilgol, A,
Kam, I, Lamban, A, Land, W, Langnas, A, Lesaca, R, Levy, G, Liquette, R, Marks, WH, Miller, C, Ona, E,
Pamugas, G, Paraiso, A, Peters, TG, Price, D, Randhawa, G, Reed, A., Rigg, K, Serrano, D, Sollinger, H,
Sundar, S, Teperman, L, Dijk, G. van, Weimar, W. & Danguilan, R (2012). Incentives for Organ
Donation: Proposed Standards for an Internationally Acceptable System. American Journal of
Transplantation, 12 (2), 306-312.
Meulenberg, F.A.E.M. (2012). Elegie voor dochter. Medisch Contact, 44
Meulenberg, F.A.E.M. & Everdingen, J.J.E. van (2012). Huid als honing.
, 2456.
Nederlands Tijdschrift voor
Dermatologie & Venereologie, 7 , 455.
Meulenberg, F.A.E.M. (2012). Illegale niertransplantaties in India. Medisch Contact, 36
Meulenberg, F.A.E.M. & Everdingen, J.J.E. van (2012). Kan door huid heen.
, 1961.
Nederlands Tijdschrift voor
Dermatologie & Venereologie, 8 , 505.
Meulenberg, F.A.E.M. & Everdingen, J.J.E. van (2012). Onderhuidse gelijkenis. voor Dermatologie & Venereologie, 10 , 631-632.
Nederlands Tijdschrift
Meulenberg, F.A.E.M. (2012). Reconstructie van een lijdenweg. Medisch Contact, 49
Meulenberg, F.A.E.M. & Everdingen, J.J.E. van (2012). Vanwege een tere huid.
, 2768.
Nederlands Tijdschrift voor Dermatologie & Venereologie, 5 , 323.
Pinxten, W.L.A., Denier, Y, Dooms, M, Cassiman, J.J. & Dierickx, K (2012). A fair share for the orphans: ethical guidelines for a fair distribution of resources within the bounds of the 10-year-old European
Orphan Drug Regulation. promotion.
Journal of Medical Ethics, 38 (3), 148-153.
Robroek, S., Vathorst, S. van de, Hilhorst, M.T. & Burdorf, A. (2012). Moral issues in workplace health
International Archives of Occupational and Environmental Health, 85 (3), 327-331.
Schoonen, H.M.H.J.D., Zee, B. van der, Wildschut, H.I.J., Beaufort, I.D. de, Wert, G.M.W.R. de, Koning,
H.J. de, Essink-Bot, M.L. & Steegers, E.A.P. (2012). Informing on prenatal screening for Down syndrome prior to conception. An empirical and ethical perspective.
Genetics Part A, 158A (3), 485-497.
American Journal of Medical
Vathorst, S. van de (2012). Discussie over ethische kwestie `plaatsing maagband¿,.
Tijdschrift voor voeding en diëtetiek, 7 (2), 29.
Nederlands
Vathorst, S. van de (2012). Is plaatsing maagband zinvol?,. Nederlands Tijdschrift voor voeding en diëtetiek .
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Vathorst, S. van de (2012). Ook palliatieve sedatie is belastend,. Pallium, 14 (3), 21-23.
Vathorst, S. van de (2012). Wie bepaalt wanneer de voeding van terminale patiënten wordt gestopt?
Nederlands Tijdschrift voor voeding en diëtetiek, 67 , 18.
Westra, A.E. & Vathorst, S. van de (2012). Weinig pijn bij neonaten met spina bifida, commentaar,.
Nederlands Tijdschrift voor Geneeskunde, 156 (30), 1208-1209.
Book - Monograph - Book Editorship
Beaufort, I.D. de & Meulenberg, F.A.E.M. (2012). Eyewitness in Erewhon Academic Hospital ¿ A medical-ethical soap serial.
Leeuwarden: Elikser Publishers.
Beaufort, I.D. de, Meulenberg, F.A.E.M. & Pinxten, W.L.A. (2012). ageing.
Zierikzee: Woordwinkel.
From fertile to fossil ¿ on ethics and
Everdingen, J.J.E. van & Meulenberg, F.A.E.M. (2012). Hemd en haar.
Overveen: Belvedere.
Part of book - Abstract
Bolt, L.L.E. (2012). 'Een minderjarige met suikerziekte¿. In W de Ruijter, A Hendriks & M Verkerk (Eds.),
Huisarts tussen individu en familie. Morele dilemma¿s in de huisartspraktijk (pp. 73-76). Assen: Van
Gorcum.
Meulenberg, F.A.E.M. (2012). Voorfwoord. In A.A. Kaptein (Ed.), de kunst . Zierikzee: De Woordwinkel.
Verhalen verhalen - ziektebeelden in
Schermer, M.H.N. & Bolt, I. (2012). What's in a name? ADHD and the grey area between treatment and enhancement. In J Savulescu, R ter Meulen & G Kahane (Eds.),
179-193). Chichester: Wiley-Blackwell.
Verkerk (Eds.),
Assen: Van Gorcum.
Enhancing human capacities
Schermer, M.H.N. (2012). Commentaar bij casus 19 `Telecare of tehuis?¿. In de Ruiter, Hendriks &
Huisarts tussen individu en familie. Morele dilemma¿s in de huisartsenpraktijk
(pp.
(pp. 94).
Schermer, M.H.N. (2012). De maakbare mens: een probleem in uw spreekkamer? In PJ Bindels (Ed.),
Ontwikkelingen in de geneeskunde . Rotterdam: ErasmusMC.
Schermer, M.H.N. (2012). Mensen beter maken, of betere mensen maken? Over enhancement en psychiatrie. In D Denys & G Meijnen (Eds.),
Amsterdam: De Tijdstroom.
Handboek psychiatrie en filosofie (pp. 258-268).
Book Editorship
Meulenberg, F.A.E.M. (Ed.). (2012). Mooie ontmoetingen in de zorg.
Den Haag/Leeuwarden:
ZonMw/Elikser.
Schermer, M.H.N. & Pinxten, W.L.A. (Eds.). (2012). Ethics, Health Policy and (Anti-) Aging: Mixed
Blessings.
Berlin: Springer Publishers.
Report
Heide, A. van der, Legemaate, J., Onwuteaka-Philipsen, B.D., Bolt, E., Bolt, L.L.E., Delden, H. van,
Geijteman, E.C.T., Snijdewind, M., Tol, D.G. van & Willems, D. (2012). Tweede evaluatie Wet toetsing levensbeëindiging op verzoek en hulp bij zelfdoding.
Den Haag: Zon MW.
Stukart, M.J., Olsthoorn-Heim, E.T.M., Vathorst, S. van de, Heide, A. van der, Tromp, K. & Klerk, C. de
(2012). Tweede evaluatie: wet medisch-wetenschappelijk onderzoek met mensen. Reeks evaluatie regelgeving: deel 30. Amsterdam ect.: MOAB488 Onderzoek en Advies, Amsterdam.
Amsterdam: Met recht.
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EMC OR-01-86-13 - Palliative and supportive care
Programme (brief description)
Palliative care aims to improve the quality of life of patients and their relatives in case of life-threatening disease. Because of the complexity of problems, multidisciplinary partnership is considered of utmost importance. When the underlying disease is still responsive to specific therapy, supportive care will be given to enhance the patient¿s quality of life by (symptomatic) treatment of concurrent disease- or therapy-induced complications. The research programme includes studies on the prevalence of symptoms and psychosocial problems in cancer patients at different stages during the course of disease, their needs and perceived quality of life and the development of clinical interventions to achieve symptom control in these patients. Specific attention is given to the development of effective interventions for chemotherapy-induced complications, medical and nurse-initiated interventions in pain and fatigue management, the use of a care pathway for the dying and end-of-life decisions.
Key Figures
Department Sp1 Sp2 Sp3 Sp4 SpTot T1 T2 T3 Ttot IS FS OP Ptot medical oncology 2,68 0,55 medical psychology & psychotherapy 0,2 neurology 0,06 public health 0,04 2,14
0,8 4,03
0,2
0,06
2,18
Total 2,98 2,69 0 0,8 6,47 1 0 0
Thesis
Oldenmenger, W.H. (2012, februari 15).
1 13 4 6 24
To be pain or not: research to improve cancer-related pain management.
EUR (150 pag.). Prom./coprom.: Prof. Dr. C.C.D. van der Rijt.
Article/Letter to the editor
Anquinet, L, Rietjens, J.A.C., Seale, C, Seymour, J., Deliens, L. & Heide, A. van der (2012). The Practice of Continuous Deep Sedation Until Death in Flanders (Belgium), The Netherlands, and the UK: A
Comparative Study.
Scales.
Journal of Pain and Symptom Management, 44
Arevalo, JJ, Brinkkemper, T, Heide, A. van der, Rietjens, J.A.C., Ribbe, M, Deliens, L., Loer, SA,
Zuurmond, WWA & Perez, R.S.G.M. (2012). Palliative Sedation: Reliability and Validity of Sedation
Journal of Pain and Symptom Management, 44
(1), 33-43.
(5), 704-714.
Broyl, A., Jongen, J.L.M. & Sonneveld, P. (2012). General Aspects and Mechanisms of Peripheral
Neuropathy Associated With Bortezomib in Patients With Newly Diagnosed Multiple Myeloma. Seminars in Hematology, 49 (3), 249-257.
Geijteman, G., Smorenburg, CH, Jong, M, Tijhaar, J., Heide, A. van der & Zuylen, L. van (2012).
Introductie van het Zorgpad Stervensfase in een algemeen ziekenhuis; ervaringen uit de praktijk.
Nederlands-Vlaams Tijdschrift voor Palliatieve Zorg, 1 , 4-11.
Kuip, E.J.M., Zandvliet, M.L., Mathijssen, R.H.J. & Rijt, C.C.D. van der (2012). Pharmacological and clinical aspects of immediate release fentanyl preparations: criteria for selection. EUROPEAN JOURNAL
OF HOSPITAL PHARMACY-SCIENCE AND PRACTICE, 19 (1), 38-40.
Lokker, M.E., Zuylen, L. van, Veerbeek, L., Rijt, C.C.D. van der & Heide, A. van der (2012). Awareness of dying: it needs words. Supportive Care in Cancer, 20 (6), 1227-1233.
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Oldenmenger, W.H., Lieverse, P.J., Janssen, P.J.J.M., Taal, W., Rijt, C.C.D. van der & Jager, A. (2012).
Efficacy of opioid rotation to continuous parenteral hydromorphone in advanced cancer patients failing on other opioids. Supportive Care in Cancer, 20 (8), 1639-1647.
Oldenmenger, W.H. & Rijt, C.C.D. van der (2012). Barriéres bij een adequate pijnbehandeling.
Oncologica, 4 , 21-24.
Oldenmenger, W.H. (2012). To be in pain or not: research to improve cancer-related pain management. Nederlands-Vlaams Tijdschrift voor Palliatieve Zorg, 12 , 30-34.
Onwuteaka-Philipsen, B.D., Stoppelenburg, A., Penning, C., Jong-Krul, GJF de, Delden, J.J.M. van &
Heide, A. van der (2012). Trends in end-of-life practices before and after the enactment of the euthanasia law in the Netherlands from 1990 to 2010: a repeated cross-sectional survey. Lancet (UK),
380 (9845), 908-915.
Raaf, P.J. de, Klerk, C. de, Timman, R., Hinz, A & Rijt, C.C.D. van der (2012). Differences in Fatigue
Experiences Among Patients With Advanced Cancer, Cancer Survivors, and the General Population.
Journal of Pain and Symptom Management, 44 (6), 823-830.
Raaf, P.J. de, Sleijfer, S., Lamers, C.H.J., Jager, A., Gratama, J.W. & Rijt, C.C.D. van der (2012).
Inflammation and fatigue dimensions in advanced cancer patients and cancer survivors. Cancer,
118 (23), 6005-6011.
Raijmakers, N.J.H., Zuylen, L. van, Costantini, M, Caraceni, A, Clark, JB, Simone, G De, Lundquist, G,
Voltz, R., Ellershaw, J.E. & Heide, A. van der (2012). Issues and needs in end-of-life decision making:
Palliative Medicine, 26 (7), 947-953. An international modified Delphi study.
Raijmakers, N.J.H., Zuylen, L. van & Heide, A. van der (2012). OPCARE9 work package 2-end-of-life decisions in Europe: shared experiences. European Journal of Palliative Care, 19 , 24-26.
Richardson, PG, Delforge, M., Beksac, M., Wen, P, Jongen, J.L.M., Sezer, O, Terpos, E, Munshi, N,
Palumbo, A, Rajkumar, SV, Harousseau, JL, Moreau, P, Avet-Loiseau, H, Lee, J.H. v.d., Cavo, M.,
Merlini, G, Voorhees, P, Chng, WJ, Mazumder, A, Usmani, S, Einsele, H, Comenzo, R., Orlowski, R,
Vesole, D, Lahuerta, JJ, Niesvizky, R, Siegel, D., Mateos, M.V., Dimopoulos, M, Lonial, S, Jagannath, S,
Blade, J., Miguel, J San, Morgan, G., Anderson, KC, Durie, BGM & Sonneveld, P. (2012). Management of treatment-emergent peripheral neuropathy in multiple myeloma. sedation at the end of life.
Leukemia, 26
Swart, S.J., Heide, A. van der, Zuylen, L. van, Perez, R.S.G.M., Zuurmond, WWA, Maas, P.J. van der,
Delden, J.J.M. van & Rietjens, J.A.C. (2012). Considerations of physicians about the depth of palliative
CMAJ. Canadian Medical Association Journal, 184
(4), 595-608.
(7), E360-E366.
Swart, S.J., Rietjens, J.A.C., Zuylen, L. van, Zuurmond, WWA, Perez, R.S.G.M., Maas, P.J. van der,
Delden, J.J.M. van & Heide, A. van der (2012). Continuous Palliative Sedation for Cancer and Noncancer
Patients. Journal of Pain and Symptom Management, 43
Swart, S.J., Heide, A. van der, Brinkkemper, T, Zuylen, L. van, Perez, R.S.G.M. & Rietjens, J.A.C.
(2012). Continuous palliative sedation until death: practice after introduction of the Dutch national guideline. BMJ Supportive & Palliative Care, 2
(2), 172-181.
(3), 256-263.
Taal, W., Rijn, J.M.W. van, Kros, J.M., Heuvel, I. van, Rijt, C.C.D. van der, Bromberg, J.E., Sillevis Smitt,
P.A.E. & Bent, M.J. van den (2012). Dose dense 1 week on/1 week off temozolomide in recurrent glioma: a retrospective study. Journal of Neuro-Oncology, 108 (1), 195-200.
Part of book - Abstract
Buiting, H.M., Delden, J.J.M. van, Rietjens, J.A.C., Onwuteaka-Philipsen, B.D., Bilsen, J, Fischer, S,
Lofmark, R, Miccinesi, G, Norup, M. & Heide, A. van der (2012). Withholding or withdrawing nutritional support at the end-of-life in six European countries. In VR Preedy (Ed.), Diet and Nutrition in Palliative
Care (pp. 231-242). CRC Press.
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Kuip, E.J. & Zuylen, L. van (2012). De stervende patient. In SM de Hosson, FJS Netters & CAHHVM
Verhagen (Eds.), Probleemgeoriënteerd denken in de palliatieve zorg
Tijdstroom uitgeverij.
(pp. 343-352). Utrecht: De
Report
Heide, A. van der, Stoppelenburg, A., Delden, H. van & Onwuteaka-Philipsen, B.D. (2012).
Sterfgevallenonderzoek 2010. Euthanasie en andere medische beslissingen rond het levenseinde.
Den
Haag: ZonMW.
Heide, A. van der, Legemaate, J. & Onwuteaka-Philipsen, B.D. (2012). Tweede evaluatie Wet toetsing levensbeëindiging op verzoek en hulp bij zelfdoding.
Den Haag: Zon MW.
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EMC OR-02-47-12 - Surgery, non-programme associated
Key Figures
Department Sp1 Sp2 Sp3 Sp4 SpTot T1 T2 T3 Ttot IS FS OP Ptot surgery 1,4 0,75 2,15
Total 1,4 0 0 0,75 2,15 0 0 0
Article/Letter to the editor
0 10 0 1 11
Deerenberg, E.B., Mulder, I.M., Grotenhuis, N., Ditzel, M., Jeekel, J. & Lange, J.F. (2012). Experimental study on synthetic and biological mesh implantation in a contaminated environment. British Journal of
Surgery, 99 (12), 1734-1741.
Deerenberg, E.B., Mulder, I.M., Ditzel, M., Slieker, J.C., Bemelman, W.A., Jeekel, J. & Lange, J.F.
(2012). Polyvinyl Alcohol Hydrogel Decreases Formation of Adhesions in a Rat Model of Peritonitis.
SURGICAL INFECTIONS, 13 (5), 321-325.
Ditzel, M., Deerenberg, E.B., Komen, N.A.P., Mulder, I.M., Jeekel, J. & Lange, J.F. (2012). Postoperative
Adhesion Prevention with a New Barrier: An Experimental Study.
187-193.
European Surgical Research, 48 (4),
Eker, H.H., Langeveld, H.R., Klitsie, P.J., Riet, M. van 't, Stassen, L.P.S., Weidema, W.F., Steyerberg,
E.W., Lange, J.F., Bonjer, H.J. & Jeekel, J. (2012). Randomized Clinical Trial of Total Extraperitoneal
Inguinal Hernioplasty vs Lichtenstein Repair A Long-term Follow-up Study.
256-260.
Techniques in Coloproctology, 16 (5), 363-368.
Archives of Surgery, 147 (3),
Gielens, M.P.M., Mulder, I.M., Harst, E. van der, Gosselink, M.P., Kraal, K.J., Teng, HT, Lange, J.F. &
Vermeulen, J. (2012). Preoperative staging of perforated diverticulitis by computed tomography scanning.
Goede, B. de, Klitsie, P.J., Lange, J.F., Metselaar, H.J. & Kazemier, G. (2012). Morbidity and mortality related to non-hepatic surgery in patients with liver cirrhosis; A systematic review. Best Practice &
Research in Clinical Gastroenterology, 26 (1), 47-59.
Ramshorst, G.H. van, Eker, H.H., Hop, W.C.J., Jeekel, J. & Lange, J.F. (2012). Impact of incisional hernia on health-related quality of life and body image: a prospective cohort study. American Journal of
Surgery, 204 (2), 144-150.
Sant, H.P. van t, Slieker, J.C., Hop, W.C.J., Weidema, W.F., Lange, J.F., Vermeulen, J. & Contant, CME
(2012). The influence of mechanical bowel preparation in elective colorectal surgery for diverticulitis.
Techniques in Coloproctology, 16 (4), 309-314.
Swank, H.A., Mulder, I.M., Chapelle, CF la, Reitsma, J.B., Lange, J.F. & Bemelman, W.A. (2012).
Systematic review of trocar-site hernia.
Surgery, 152 (5), 939-939.
British Journal of Surgery, 99 (3), 315-323.
Timmermans, L, Deerenberg, E.B., Kleinrensink, G.J., Lange, J.F. & Jeekel, J. (2012). Medieval times in surgery.
Part of book - Abstract
Boermeester, M.A. & Lange, J.F. (2012). Veiligheid en kwaliteit rondom operaties. In HG Gooszen (Ed.),
Leerboek voor chirurgie (pp. 23-34). Houten: Bohn Stafleu van Loghum.
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EMC OR-02-54-06 - Pediatrics, non-programme associated
Thesis
Betue, C.T.I. de (2012, september 06). Protein anabolism in critically ill children. Pathophysiological aspects and interventional challenges.
EUR (244 pag.). Prom./coprom.: Prof. Dr. D. Tibboel, Dr. N.E.P.
Deutz & Dr. K.F.M. Joosten.
Article/Letter to the editor
Betue, C.T.I. de, Verbruggen, S.C.A.T., Schierbeek, H., Chacko, S., Bogers, A.J.J.C., Goudoever, J.B. van & Joosten, K.F.M. (2012). Does a reduced glucose intake prevent hyperglycemia in children early after cardiac surgery? a randomized controlled crossover study. Critical Care, 16 , R176.
Bosch, G.E. van den, Merkus, P.J.F.M., Buysse, C.M.P., Boehmer, A.L.M., Verberne, A.A.P.H., Veen, L.N. van, Hop, W.C.J. & Hoog, M. de (2012). Risk factors for pediatric intensive care admission in children with acute asthma. Respiratory Care, 57 (9), 1391-1397.
Cock, RFW De, Allegaert, K., Schreuder, M.F., Sherwin, CMT, Hoog, M. de, Anker, J.N. van den, Danhof,
M & Knibbe, C.A.J. (2012). Maturation of the Glomerular Filtration Rate in Neonates, as Reflected by
Amikacin Clearance. Clinical Pharmacokinetics, 51 in children with syndromic craniosynostosis?
(2), 105-117.
Driessen, C., Mathijssen, I.M.J., Groot, MR De & Joosten, K.F.M. (2012). Does central sleep apnea occur
Respiratory Physiology & Neurobiology, 181 (3), 321-325.
Driessen, C., Veelen, M.L.C. van, Lequin, M.H., Joosten, K.F.M. & Mathijssen, I.M.J. (2012). Nocturnal ultrasound measurements of optic nerve sheath diameter correlate with intracranial pressure in children with craniosynostosis. Plastic and Reconstructive Surgery, 130 , 448e-451e.
Giessen, L.J. van der, Bakker, E.M., Joosten, K.F.M., Hop, W.C.J. & Tiddens, H.A.W.M. (2012).
Nocturnal oxygen saturation in children with stable cystic fibrosis.
1123-1130.
Pediatric Pulmonology, 47 ,
Grotel, M. van, Hoog, M. de, Krijger, R.R. de, Beverloo, H.B. & Heuvel-Eibrink, M.M. van den (2012).
Hypereosinophilic syndrome in children. besides propranolol.
Leukemia Research, 36
Janmohamed, S.R., Madern, G.C., Nieuwenhuis, K., Laat, P.C.J. de & Oranje, A.P. (2012). Evaluation of intra-lesional corticosteroids in the treatment of peri-ocular haemangioma of infancy: still an alternative
Pediatric Surgery International, 28
(10), 1249-1254.
, 393-398.
Janmohamed, S.R., Laat, P.C.J. de, Madern, G.C., Dorresteijn, E.M., Danser, A.H.J. & Oranje, A.P.
(2012). Treating hemangioma of infancy with beta-blockers: Is there really a risk of hypotension?
Journal of the American Academy of Dermatology, 67 (2), 315-316.
Koletzko, B., Cochat, P., Groot, R. de, Guys, J.M., Hazelzet, J.A., Lagae, L., Marlow, N. & Troncone, R.
(2012). Paediatric conferences: only a profit making enterprise? Acta Paediatrica, 101 validation of a neonatal intensive care parent satisfaction instrument.
, 1194-1195.
Latour, J.M., Duivenvoorden, H.J., Hazelzet, J.A. & Goudoever, J.B. van (2012). Development and
Pediatric Critical Care Medicine,
13 (5), 554-559.
Leeuwenburgh-Pronk, W.G., Smith, P.J., Vught, A.J. van, Lantos, JD, Tibboel, D., Hoog, M. de &
Buysse, C.M.P. (2012). A Baby With Meningococcemia and Septic Shock. Pediatrics, 130 (1), 134-138.
Nout, E., Bannink, N., Koudstaal, M.J., Veenland, J.F., Joosten, K.F.M., Poublon, R.M.L., Wal, K.G.H. van der, Mathijssen, I.M.J. & Wolvius, E.B. (2012). Upper airway changes in syndromic craniosynostosis patients following midface or monobloc advancement: Correlation between volume changes and respiratory outcome. Journal of Cranio-Maxillofacial Surgery, 40 (3), 209-214.
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Research Annual Report 2012

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Plaisier, A., Raets, M.M.A., Starre, C. van der, Roon, M., Govaert, P., Lequin, M.H., Heemskerk, A.M. &
Dudink, J. (2012). Safety of routine early MRI in pretem infants. Pediatric Radiology, 42 , 1205-1211.
Plomp, R.G., Bredero-Boelhouwer, H.H., Joosten, K.F.M., Wolvius, E.B., Hoeve, L.J., Poublon, R.M.L. &
Mathijssen, I.M.J. (2012). Obstructive sleep apnoea in Treacher Collins syndrome: prevalence, severity and cause. International Journal of Oral and Maxillofacial Surgery, 41
Laryngoscope, 122
BMJ Open, 2 , e000934.
(4), 930-934.
(6), 696-701.
Plomp, R.G., Joosten, K.F.M., Wolvius, E.B., Hoeve, L.J., Poublon, R.M.L., Montfort, C.A.G.M. van,
Bredero-Boelhouwer, H.H. & Mathijssen, I.M.J. (2012). Screening for obstructive sleep apnea in treacher-collins syndrome.
Posthumus, A.G., Alingh, C.W., Zwaan, C.M., Grootheest, K van, Hanff, L.M., Witjes, B.C.M., Jong, G.W. t & Hoog, M. de (2012). Adverse drug reaction-related admissions in paediatrics, a prospective single-cente study.
Snijdewind, I.J.M., Kampen, J.J.A. van, Fraaij, P.L.A., Ende, M.E. van der, Osterhaus, A.D.M.E. &
Gruters, R.A. (2012). Current and future applications of dries blood spots in viral disease management.
Antiviral Research, 93 , 309-321.
Starre, C. van der, Dijk, M. van & Tibboel, D. (2012). Real-time registration of adverse events in Dutch hospitalized children in general pediatric units: first experiences. European Journal of Pediatrics,
171 (3), 553-558.
Verbruggen, S.C.A.T., Landzaat, L.J., Reiss, I.K.M., Goudoever, J.B. van & Joosten, K.F.M. (2012).
Neonatology, 101 , Efficacy and safety of a tight glucose control protocol in citrically ill term neonates.
232-238.
Verhoeven, J.J., Koenraads, M., Hop, W.C.J., Brand, JB, Polder, MMV de & Joosten, K.F.M. (2012).
Baseline insulin/glucose ratio as a marker for the clinical course of hyperglycemic critically ill children treated with insulin. Nutrition, 28 (1), 25-29.
Verschoor, S.P., Nagel, B.C.H. van der, Sibbles, B.J. & Koch, B.C.P. (2012). Meconiumtest spoort alcoholische moeder op. Pharmaceutisch Weekblad, 40
Vet, N.J., Verlaat, C.W.M., Wildt, S.N. de, Tibboel, D. & Hoog, M. de (2012). Daily interruption of sedation in critically ill children. on midazolam therapy in children.
, 18-20.
Pediatric Critical Care Medicine, 13 (1), 122-122.
Vet, N.J., Hoog, M. de, Tibboel, D. & Wildt, S.N. de (2012). The effect of critical illness and inflammation
Pediatric Critical Care Medicine, 13 (1), E48-E50.
Zeerleder, S., Stephan, F., Emonts, M., Kleijn, E.D. de, Esmon, C.T., Varadi, K., Hack, C.E. & Hazelzet,
J.A. (2012). Circulatin nucleosomes and severety of illness in children suffering from meningococcal sepsis treated with protein C. sepsis treated with protein C.
Critical Care Medicine, 40
Zeerleder, S., Stephan, F., Emonts, M., Kleijn, E.D. de, Esmon, C.T., Varadi, K., Hack, C.E. & Hazelzet,
J.A. (2012). Circulatin nucleosomes and severity of illness in children suffering from meningococcal
Critical Care Medicine, 40
(12).
(12), 3324-3229.
Erasmus MC
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Research Annual Report 2012