THE GASTRIC CARCINOMA Prof. Faisal Ghani Siddiqui FCPS; PGDip-bioethics; MCPS-HPE Preamble • Epidemiology • Aetiologic factors • Pathology • Clinical features • Investigations • Treatment Adenocarcinoma -Epidemiology • Incidence in USA/western Europe • Leading cause of death in Asia/Eastern Europe • Elderly • Blacks • Low SE status What causes Gastric Cancer? Gastric Cancer • Pernicious anaemia • Blood group A • Family history of gastric cancer Gastric Cancer Diet • • • • • • High fat diet Pickled, preserved food Tobacco Fresh fruit and vegetables Vitamin C Regular aspirin Gastric Cancer Genetic Mutations • Deletion or suppression of p53 • Overexpression of COX-2 • CDH1 Gastric Cancer Pre-malignant Conditions • Polyps • Atrophic gastritis • Benign gastric ulcer • Gastric ramnant H.Pylori infection Superficial gastritis Atrophic gastritis Intestinal metaplasia Dysplasia Cancer Gastric Cancer Pathology Malignant Neoplasms of the Stomach Primary Adenocarcinoma (94%) Lymphoma (4%) Malignant GIST (1%) Haematogenous spread Breast Malignant melanoma Direct invasion Pancreas; Liver; colon; ovary Gastric Cancer Gross Appearance Polypoid Fungating Ulcerative Scirrhous Gastric Cancer Histology –Lauren Classification Intestinal Diffuse Unclassified Gastric Cancer TNM staging Tis T1 T2 T3 T4 Intaepithelial tumour Tumour invades LP or submucosa Tumour invades muscularis propria or subserosa Tumour penetrates serosa without invasion of adjacent structures Tumour invades adjacent structures Gastric Cancer TNM staging N0 No regional lymph node metastases N1 N2 Metastasis in 1 to 6 regional lymph nodes Metastasis in 7 to 15 regional lymph nodes N3 Metastasis in more than 15 regional lymph nodes Gastric Cancer TNM staging M0 No distant metastasis M1 Distant metastasis Gastric Cancer Clinical Manifestations Symptoms • Weight loss • Decreased food intake • Abdominal pain • Nausea, vomiting and bloating • Acute GI bleeding • Chronic GI bleeding • Dysphagia Trousseau’s syndrome (thrombophlebitis) Acanthosis Nigracans Clinical Signs • Cervical, supraclavicular and axillary lymphadenopathy • Pleural effusion • Aspiration pneumonitis • Abdominal mass • Sister Joseph’s nodule • Ascites • Rectal shelf of Blumer Rudolph Virchow Gastric Cancer Diagnostic Evaluation Prompt upper endoscopy if … • New onset of dyspepsia >45 years • Dyspepsia with alarm symptoms (weight loss, anaemia, recurrent vomiting, bleeding) • Dyspepsia & family h/o gastric carcinoma Preoperative Staging • Abdominal / pelvic CT scanning • Endoscopic ultrasound (EUS) – Depth of the tumour – Enlarged perigastric/coeliac lymph nodes Gastric Cancer Treatment Surgical Resection & Adequate Lymphadenectomy is the only curative treatment except • Metastases • Co-morbid Surgical Resection • Resection of tumour • Grossly negative margin of at least 5 cms • Partial gastrectomy • Confirmed on frozen section • En block resection of adjacent involved organs Extent of Gastrectomy • Radical subtotal gastrectomy (Distal tumour) • Total gastrectomy (Proximal tumour) Lymphadenectomy • D1: stations 3-6 • D2: stations 1,2, 7,8 and 11 • D3: stations 9, 10 and 12 Survival benefit to adjuvant radio-chemotherapy is marginal in patients who have undergone adequate resection In gross unresectable, metastatic tumour Role of palliative chemotherapy is uncertain