Syphilis
主讲人：叶茜

制作人：
陈永 冯斌 时迎斌
张伟强 孙景福
陈娜 徐平 周强
于晓宁 叶茜
Syphilis


There are more than
70,000 new cases of
syphilis（梅毒） each
year .
Syphilis, chronic and
slowly progressive, is
the third most common
sexually transmitted
disease.
Spirochetes
 Gram negative bacteria
 long, thin, helical and motile
 Axial filaments - (a form of flagella) are the locomotory organelles
• found between the peptidoglycan layer and
outer membrane and running parallel to them
T.Pallidum
Mechanism
The antibodies result
from tissue injury,
with autoimmunity
developing to self
components.
Transmission
 T. pallidum is generally transmitted by
genital/genital contact.
 Transmission in utero or during birth can also
occur.
It can also be transmitted through
blood transfusion
.
Congenital syphilis
Blood Transfusion

The main
manifestation

Fever
Robeola
Symptoms like secondary
stage of syphilis


Pathogenic process

Primary syphilis

Secondary syphilis

Tertiary syphilis
Primary syphilis



After initial infection
hard chancre present.
Mainly seen in outer
genital organ.
Last for 4 to 8 weeks.
Secondary syphilis



The organisms has penetrate and
systemically spread during this
time period.
The patient has flu-like symptoms
with secondary lesion particularly
affecting the skin(2-10 weeks later)
Mainly in trunk and limbs.
Secondary Syphilis
Secondary Syphilis
Common features
of primary and secondary syphilis



In these two stages large
numbers of T. Pallidum
often present.
Strong infection , weak
damage.
Self-limited
Tertiary syphilis



The final stage is tertiary syphilis ( after
several years later).
As the disease progresses immunity
controls the bacterial replication and
few organisms are seen.
Main manifestation are chronic
granuloma and tissue necrosis.
Tertiary Syphilis
Tertiary Syphilis
Diagnosis(1)



The organisms are often present in
sufficient numbers in exudates
detected by dark field microscopy.
The actively motile organisms
appears brightly lit against the dark
backdrop.
The FTA-ABS（荧光密螺旋体抗体吸收
试验) is often used.
Diagnosis(2)
1. Serological methods are usually
used to detect syphilis.
2. Screening methods are based on
detecting serum antibodies to cardiolipin
in patients (including VDRL test).
3.VDRL and RPR are also widely
used.
Therapy

No vaccine exists, but
antibiotic therapy
(usually penicillin G)
is usually highly
effective.
That is all .
Thank you!