1 Pediatric Pain Management in the Emergency Setting SECOND EDITION 2013 EMSC 2013 Illinois Emergency Medical Services for Children is a collaborative program between the Illinois Department of Public Health and Loyola University Health System 2 EMSC 2013 Hyperlinks Throughout this module hyperlinks to resources are underlined and in a different color font. 3 EMSC 2013 Illinois EMSC Illinois Emergency Medical Services for Children (EMSC) is a collaborative program between the Illinois Department of Public Health and Loyola University Health System, aimed at improving pediatric emergency care within our state. Since 1994, the Illinois EMSC Advisory Board and several committees, organizations and individuals within EMS and pediatric communities have worked to enhance and integrate: Pediatric education Practice standards Injury prevention Data initiatives 4 EMSC 2013 Illinois EMSC The goal of Illinois EMSC is to ensure that appropriate emergency medical care is available for ill and injured children at every point along the continuum of care. 5 EMSC 2013 Disclaimer • Illinois EMSC has worked to ensure that all information presented is accurate and congruent with current practice as of the date of publication. Please note, the information does not serve as a substitute for existing policies and procedures. These guidelines may be modified at the discretion of the healthcare provider. • This educational activity’s planners have indicated they have no bias or conflict of interest. 6 EMSC 2013 Citation An electronic version of this document is available on the Illinois EMSC Web site: www.luhs.org/emsc • All training materials are considered under public domain, and can be utilized to conduct similar educational programs provided there is appropriate acknowledgement of the source of these materials. • Suggested Citation: Pediatric Pain Management in the Emergency Setting, Illinois Emergency Medical Services for Children, 2013. 7 EMSC 2013 Acknowledgements • Pediatric Pain Module Revision Workgroup Ellen Goldsworthy RN, APN, CEN Clinical Nurse Specialist, Emergency Services Swedish American Hospital, Rockford, Illinois Christine Kennelly RN, MS, CCRN Educator, Illinois EMSC Maywood, Illinois Michele Habich DNP, APN/CNS, CPN Pediatric Clinical Nurse Specialist, Central DuPage Hospital, Winfield, Illinois Kirk Schubert PharmD Emergency Medicine Swedish American Hospital, Rockford, Illinois Gina Hardy RN Nurse Manager Bright Star, Elmwood Park, Illinois • Illinois EMSC Advisory Board • Illinois EMSC Facility Recognition Committee • Illinois EMSC Quality Improvement Subcommittee 8 EMSC 2013 Exclusion • Pediatric procedural sedation and analgesia (PSA) is not within the scope of this module. • PSA references are provided at the conclusion of this module in Appendix A. 9 EMSC 2013 Objectives At the conclusion of this module, the learner will be able to: 1. Discuss current pediatric pain management 2. Improve application of evidence-based pediatric pain management interventions 3. Dispel common myths 4. Support development of pediatric pain policies and protocols 5. Facilitate quality improvement in the pediatric pain process 10 EMSC 2013 Table of Contents • Introduction • Pediatric Pain Physiology • Pediatric Pain Management ▫ Pediatric Pain Assessment ▫ Teamwork in Pain Management ▫ Interventions Non-pharmacologic Interventions Pharmacologic Interventions • Pediatric Pain Quality Monitoring • Appendices 11 EMSC 2013 12 EMSC 2013 Children and emergency care • Of the almost 129 million visits to the ED in 2009, children 0-17 years accounted for 28 million or 22% of visits.1 22% • Pain management is a significant challenge in Emergency Medical Services (EMS) and Emergency Department (ED) care settings. • Research shows continued under treatment in pre-hospital and ED settings.2-7 13 EMSC 2013 Recognize painful pediatric presentations Used with permission from Illinois EMSC Used with permission from Illinois EMSC 14 EMSC 2013 Anticipate painful pediatric events Blood draw Immunization or vaccination IV start Laceration repair Lumbar puncture Fracture reduction 15 EMSC 2013 Which regulatory agencies guide pain management? Food and Drug Administration (FDA) State Board of Health Drug Enforcement Administration (DEA) State Professional Regulation Boards for Medicine, Nursing, and Pharmacy 16 EMSC 2013 What other organizations guide pain management? • Global Health Authorities ▫ World Health Organization (WHO) • Accreditation and Certifying Organizations ▫ Det Norske Veritas Healthcare Inc. (DNV) ▫ Healthcare Facilities Accreditation Program (HFAP) ▫ The Joint Commission (TJC) 17 EMSC 2013 Which professional organizations guide pain management? American Society for Pain Management in Nursing American Medical Association Emergency Nurses Association (ENA) (ASPMN) (IASP) (AMA) National Association of Emergency Medical System Physicians (NAEMSP) American Academy of Pediatrics (AAP) American College of Emergency Physicians (ACEP) International Association for the Study of Pain Pain management National Association of Emergency Medical Technicians (NAEMT) 18 EMSC 2013 Guidance from AAP, ACEP, ENA NAEMPS and NAEMT and others8 • Guidelines for the Care of Children in the Emergency Department states that EDs serving children should have among other things: ▫ Policies, procedures and protocols that include patient assessment, reassessment and documentation ▫ Pediatric pain competencies related to assessment and treatment ▫ Pain scale and assessment tools appropriate for age ▫ Quality Improvement/Performance Improvement (QI/PI) plan that includes Pediatric-specific indicators The collection and analysis of the data to discover variances A process for improvement based on the data A process for evaluating the success of this plan 19 EMSC 2013 Principles to optimize pain management Evaluate using assessment and self report Recognize that children are at high risk for inadequate pain management Guide management with evidence based assessment and treatment Develop analgesic protocols using multidisciplinary teams Support pain management with clinical resources and education Offer both nonpharmacologic and pharmacologic interventions Initiate analgesia early; even in the absence of a diagnosis Provide individualized discharge instruction This triangle contains summarized selections from Optimizing the Treatment of Pain in Patients with Acute Presentations9 of the core principles promoted by ASPMN, ENA, ACEP and APS. Consider referral to case manager, pain team or center for palliative care 20 EMSC 2013 Summary • Children comprise a significant proportion of the ED population, and frequently present with pain • Many organizations offer guidelines to improve pain management in the emergency setting • Illinois EMSC is providing this module to improve pain management in the emergency setting 21 EMSC 2013 22 EMSC 2013 Four pain myths 1. Babies can’t feel pain 2. Children don’t remember pain 3. Children can’t have chronic pain 4. Getting used to pain is part of growing up It’s time to give up the fairy tales Used with permission from Microsoft 23 EMSC 2013 Anatomic components related to pain transmission10,11 • • • • • • • • • Chemical mediators Nociceptors A delta fibers C fibers Dorsal horn of the spinal cord Thalamus Limbic system Cerebral cortex Endorphins All components are present by 24 weeks gestation12 Illinois EMSC 2013 EMSC 2013 24 24 25 EMSC 2013 Newborn pain physiology review • Newborns : • have functional peripheral and central nervous system structures at birth • perceive pain whether premature or full-term • lack descending inhibitory neurotransmitters until about 3 months of age 12 • feel pain more intensely until those transmitters develop13 Used with permission from Microsoft 26 EMSC 2013 Pain has metabolic effects • Increased release of ▫ Catecholamines ▫ Glucagon ▫ Corticosteroids • The catabolic state induced by acute pain may be more damaging to infants and young children due to their higher metabolic rates and lower nutritional reserves than adults10 • Increased morbidity and mortality was demonstrated in infants having surgical procedures when pain was not controlled 14 27 EMSC 2013 Why are there differences between pain in individuals?12 • The pain experience does not reflect a simple one-to-one relationship between tissue damage and pain • Pain is a personal experience • If pain were hardwired, each noxious stimulus would elicit the same response and same intensity every time in every person Subsequent pain interventions Physical factors Previous pain experiences 28 EMSC 2013 Creation of a pain memory15,16 Recurrent pain17-21 Undertreated pain Developmental factors Past experience Temperament Pain memory Coping Developmental age 29 EMSC 2013 Increased fear of medical procedures Restricted social and athletic activities from chronic pain22 Higher pain ratings than others with a similar condition Behavioral Effects Missed school days from chronic pain22 More anxious infant, toddler and preschooler Recounting of pain nightmares Behavioral effects of pain memories16 30 EMSC 2013 Summary • Pain perception is a neurologic phenomena • Infants have nervous system components present and functioning at birth; inhibitory neurotransmitters mature at about 3 months • Repeated pain experiences can have long term consequences on the child 31 EMSC 2013 32 EMSC 2013 33 EMSC 2013 Elements of pain assessment23 Assess physiologic parameters Perform behavioral observation Question the child Use standardized assessment tool 34 EMSC 2013 Assess physiologic parameters • Heart rate, blood pressure, respirations • Perform a focused physical exam • Children with acute pain may have:15,24 Consider pain as the 5th vital sign.19 Tachycardia Tachypnea Hypertension Oxygen desaturation Dilated pupils Flushing, pallor • Children with chronic pain may not have altered vital signs 35 EMSC 2013 Elements of pain assessment Assess physiologic parameters Perform behavioral observation Question the child Use standardized assessment tool 36 EMSC 2013 Perform behavioral observation: Myth: All 13,24,25 infant babies cry at their health care visit Facial Expression • Bulged brow • Tightly shut eyes • Nasolabial furrow, • Stretched mouth • Taut tongue10 Note: • Facial expression • Extremity activity and tone • Guarding, splinting • Position and tone • Irritability, crying • Poor feeding • Poor sleep quality Used with permission from Microsoft 37 EMSC 2013 Perform behavioral observation: toddler26 Myth: Don’t worry, he always cries Used with permission from Microsoft Note: • Anger • Tantrums, regression • Facial expression • Extremity activity and tone • Guarding, splinting • Position of comfort • Irritability, crying • Poor eating and sleep quality • Restless or unusually quiet 38 EMSC 2013 Perform behavioral observation: preschooler10,26 Used with permission from Illinois EMSC Myth: Pain builds character Note: • Stalling/delaying • Magical thinking explanations • Behavioral regression • Facial expression, grimacing • Extremity activity and tone • Guarding, splinting • Position of comfort • Irritability, anxiety • Change in appetite or sleep quality 39 EMSC 2013 Perform behavioral observation: school-ager and adolescent10 Note: • Stalling/delaying • Flat affect • Facial expression • Extremity activity and tone • Guarding, splinting • Position of comfort • Irritability, anxiety • Change in appetite or sleep quality Used with permission from Illinois EMSC Myth: Children who are playing, can’t be in much pain 40 EMSC 2013 Perform behavioral observation: special needs child Used with permission from Microsoft Note: • Facial expression, grimacing • Extremity activity and muscle tone • Guarding, splinting • Position of comfort • Irritability, anxiety • Behavioral regression • Change in appetite or sleep quality 41 EMSC 2013 Elements of pain assessment Assess physiologic parameters Perform behavioral observation Question the child Use standardized assessment tool 42 EMSC 2013 Question the child about pain8,23 Consider: • The child’s primary language • Words, or phrases suggested by the parent/caregiver • The child’s developmental level Best practice: Adapt the interview questions to obtain a complete pain history. Explore: • Location • Duration • Quality of pain • Precipitating factors • Effect on daily activities • Pain relief measures • Previous pain experiences Best practice: Self–report of pain is the most accurate. 43 EMSC 2013 Question the toddler and pre-schooler10,13,26,27 • Ask the parent/caregiver what the child’s words for pain are • Using the child’s words for pain, ask: • • • • Where it hurts What it feels like The child to point directly to where it hurts If the child is unable to respond, ask the parent/caregiver to interview the child Best practice: Avoid comments that lead a child to believe that denying pain is a preferred behavior. 44 EMSC 2013 Question the school age and adolescent child:10 • • • • • • • Do you have pain? Where is the pain? How long have you had it? Describe what kind of pain it is Has it changed? What makes it better or worse? How does the pain impact your daily life? • Have you had pain in the past? Used with permission from Illinois EMSC Best Practice: Interview an adolescent in private, away from parent or peer. 28 45 EMSC 2013 Questioning the special needs child29 • Adapt the questioning and communication to the child’s ability to understand and respond • Ask the parent/caregiver to describe: • The child’s cognitive level and communication abilities • Pain-related behaviors • Effective calming and soothing measures Remember, questions should explore pain: • • • • • • • Location Duration Quality Precipitating factors Effect on daily activities Relief measures Previous pain experiences 46 EMSC 2013 Why might children not disclose that they’re in pain?10,15 • Hoping to avoid painful treatment • Fear of being sick • Fear of healthcare professionals • Protecting their parents/caregiver • Avoiding hospitalization • Wanting to return to desired activities ▫ Sports ▫ Social events ▫ School Used with permission from Illinois EMSC 47 EMSC 2013 Elements of pain assessment Assess physiologic parameters Perform behavioral observation Question the child Use standardized assessment tool 48 EMSC 2013 Choosing a standardized assessment tool • Choose an appropriate tool based on the: ▫ ▫ ▫ ▫ Child’s age Cognitive ability and language Condition Institutional preference • Use the same pain scale throughout the hospital experience ▫ Document the use of a differing scale, if changed • Educate the child/parent/caregiver about the use of the scale 49 EMSC 2013 Assessment Tools: Birth - 6 months Measurement Scale Description Neonatal Infant Pain Scale (NIPS) Behavioral scale. NIPS assesses facial expression, cry, breathing patterns, movement of arms and legs, and state of arousal 30 Age range: Preterm and full term neonates Neonatal Pain Assessment and Sedation Scale (N-PASS) Age range: Preterm and full term neonates Neonatal Facial Coding System (NFCS) Age range: 32 weeks gestation to 6months CRIES Age range: 32 weeks gestation to 6 months Behavioral and physiologic scale. N-PASS assesses vital signs (heart rate, respiratory rate, blood pressure, and oxygen saturation), extremity tone, facial expression, behavior state, and crying irritability 24,25,30,31 Facial muscle group movement, brow budge, eye squeeze, nasolabial furrow, open lips, stretch mouth lip purse, taut tongue, and chin quiver32 Behavioral and physiologic scale. Each of five categories is scored from 0 to 2: crying; requires O2 for saturation above 95%; increased vital signs (arterial pressure and heart rate); expression—facial; and sleeplessness30,33 50 EMSC 2013 Assessment Tools: Infant and older (non-verbal children) Measurement Scale Description Revised Faces, Legs, Activity, Cry, and Consolability (r-FLACC) Behavioral scale. Assesses behaviors including: face, legs, arms, cry, and consolability. The revised scale includes behaviors most consistently associated with pain in children with cognitive impairments as well as parentidentified unique behaviors specific to their child. Note: rFLACC contains the same core components as the original FLACC therefore the revised scale is still appropriate for non-cognitively impaired children.15,29,34 Age range: Two months to three years, critically ill, cognitively impaired children, and those children older than three years of age unable to utilize a self-report scale. Non Communicating Children’s Pain Checklist (NCCPC-R) Age range: 3-19 years (with cognitive impairment) 30 items that assess seven dimensions: vocal, eating/sleeping, social, facial, activity, body/limb, and physiologic signs35 51 EMSC 2013 Assessment Tools: 3 years and older Measurement Scale Description Wong Baker Faces Self-report scale. Consists of 6 cartoon faces ranging from a very happy smiling face depicting no pain to a tearful sad face depicting worst pain. Note: there are a variety of modified faces scales. Please refer to specific references for those alternative face scales.36-38 Age range: 3 years and older Oucher Age range: 3 -12 years Self-report tool consisting of a vertical numerical scale and a photographic scale with expressions of “hurt” to “no hurt.” Utilizes actual pictures of children’s faces to estimate pain intensity.37,39,40 52 EMSC 2013 Assessment Tools: 8 years and older10 Measurement Scale Description Visual Analogue Scale (VAS) Self-report scale. Consists of pre-measured vertical or horizontal line, where the ends of the line represent extreme limits of pain intensity. There are many versions of the VAS in the literature (some with anchor terminology, presence or absence of divisions along the line, units of measurement, length, and layout). Requires understanding of numbers, addition and subtraction.37,41,42 Self-report scale. Eleven point scale. Children are asked to rate their pain using numbers with 0 representing the least amount of pain and 10 the worst amount of pain. Requires understanding of numbers, addition and subtraction 40 Age range: 8 years and older Verbal Numeric Scale (VNS)/ Numeric Rating Scale (NRS) Age range: 8 years and older 53 EMSC 2013 Pain score as a measure of effectiveness15,43 • Children are more than their score alone ▫ May have distress or anxiety ▫ May not have recovered functionally ▫ Pain score meaning and response to treatment are complex Reassessment should include all assessment elements not just a pain score. • In a pain study of young children postoperatively,* they had difficulty distinguishing between ▫ Pain ▫ Nausea ▫ Anxiety *It is not known if the above is true in the ED setting 54 EMSC 2013 Pain score interpretability15,43 • Interpretability = clinical meaningfulness of the pain score • Compares pain scores with pain categories ▫ Mild, moderate and severe vs. 0-10 score • Studies show pain scores overlap when categorized ▫ An individual child’s pain score may or may not be equivalent to mild/moderate/severe or satisfaction with pain relief ▫ Variability in perceptions of pain relief makes pain score interpretation difficult ▫ Girls tended to be satisfied with pain relief at higher scores than boys 55 EMSC 2013 Summary • Self-report of pain is the most reliable • Understanding developmental differences is critical in assessing pain and understanding children’s behavior • Pain score meaning and response to treatment are complex processes • Pain reassessment includes all the assessment elements, not just the pain score 56 EMSC 2013 57 EMSC 2013 Collaborate as pain team members ▫ ▫ ▫ ▫ ▫ ▫ ▫ ▫ Child Parent/Caregiver EMS staff Nurse APN Physician Pharmacist Child Life Specialist 58 EMSC 2013 Child Life Specialist20 • Child Life Specialist - specially trained to provide developmental, educational, and therapeutic interventions for children and their families in the healthcare setting ▫ Provide psychosocial preparation for tests, surgeries, and other procedures. ▫ Facilitate medical play using special dolls, stuffed animals and medical equipment to prepare children for what they are going to hear, see, and feel in honest, yet soft and relatable language ▫ Reduce overall anxiety to help prevent a negative medical experience20 59 EMSC 2013 Promote family-centered care44 • Integrate family-centered care into practice ▫ Treat all with respect ▫ Communicate with unbiased information ▫ Encourage patient and family participation in the individualized plan of care, including pain management • Family-centered care leads to improved ▫ Health outcomes ▫ Patient satisfaction ▫ Provider satisfaction 60 EMSC 2013 Promote pediatric patient safety • Team members: ▫ Share information to define the plan of care ▫ Implement evidence based approaches to reduce errors9 Identify the patient Collect allergy information Document weight taken in kilograms Best Practice: Weigh the patient on a kilogram only scale.8,45 61 EMSC 2013 Team Communication Discuss and document ▫ Allergies ▫ Physiologic data ▫ Weight8,45 ▫ Previous pain history ▫ Pain scale used ▫ Child’s pain rating ▫ Anticipated painful procedures ▫ Proposed interventions Used with permission from Microsoft 62 EMSC 2013 Pain assessment, intervention, reassessment, and disposition process Assessment Reassessment46 • Assess for pain at triage • Explain assessment to child and parent • Determine intervention needed • Explain intervention • Document Interventions •Timing is determined by the intervention chosen • Document intervention(s) • Document instruction provided • Continue to reassess after each intervention until discharge Disposition •Home •Admission •Surgery •Transfer 63 EMSC 2013 Patient discharge Create a written discharge pain plan: Used with permission from Illinois EMSC 1. Review ongoing treatment at home 2. Discuss what to do if pain worsens 3. Arrange follow up with primary care provider 4. Consider referral to case manager, pain specialist/service, or palliative care team for chronic pain conditions 5. Document instructions reviewed and given 64 EMSC 2013 Summary • A multidisciplinary team approach should be accessible to every child in the ED • Effective pain management requires: ▫ Team communication ▫ Attention to patient safety ▫ Adherence to family-centered care principles • Pain reassessment is an ongoing team process throughout the child’s hospitalization 65 EMSC 2013 66 EMSC 2013 Pain interventions that alter peripheral transmission of pain47 Transmission Point Peripheral transmission of pain impulses ▫ Reduce tissue injury ▫ Alter blood flow to area ▫ Reduce swelling ▫ Inhibit prostaglandin production Transmission Altering Interventions Non-pharmacologic Splinting Immobilization Skin stimulation Application of heat and cold Touch Pharmacologic Administer non -steroidal anti-inflammatory drugs (NSAIDs) Ibuprofen, Ketorolac Administer local anesthetic agent Lidocaine Applied to site of injury Applied regionally 67 EMSC 2013 Pain interventions that alter spinal cord transmission of pain47 Transmission Point Spinal cord : ▫ Block by activating large fibers and preventing nociceptive transmission ▫ Block by binding opioid receptors in the spinal cord ▫ Decrease release of neurotransmitters ▫ Interrupt the descending input from the brain Transmission Altering Interventions Non-pharmacologic Skin stimulation Massage Acupuncture Application of heat and cold Touch Pharmacologic Epidural analgesia Intrathecal analgesia Opioids 68 EMSC 2013 Pain interventions that alter receptor site transmission of pain47 Transmission Point Receptor sites throughout the body and the brain ▫ ▫ ▫ Increase stimuli to the brain Increase blood flow to targeted areas, decreases pain chemicals Increase endorphins Transmission Altering Interventions Non-pharmacologic Distraction Imagery Relaxation Biofeedback Pharmacologic Systemic opioids 69 EMSC 2013 70 EMSC 2013 Non-pharmacologic intervention categories20,27,28 Child’s Support Group Developmental interventions ED environment 71 EMSC 2013 Child’s sources of support Parent/ Caregiver Friend(s) Previous experience 72 EMSC 2013 Environmental resources20,28 Music TV Room amenities Toys, books, games 73 EMSC 2013 Non-pharmacologic Interventions13,20,28,48 • Non-pharmacologic and pharmacologic methods can work together effectively • Educate and encourage the parent/caregiver to participate in non-pharmacologic techniques • Distraction • Passive distraction: child is engaged without any effort on their part • Active distraction: child participates in an activity 74 EMSC 2013 Non-pharmacologic measures infants13,28 • • • • Swaddling Holding Rocking Sucking ▫ Sucrose pacifier49 ▫ Non-nutritive sucking • • • • Dim lighting Music Picture reading Toys ▫ Key chains ▫ Rattles ▫ Blocks 75 EMSC 2013 Non-pharmacologic measures toddlers13,28 • • • • • Provide distraction with music Provide a pacifier Provide light touch or massage Try repositioning, splinting Apply cold or hot pack • • • • • Offer play with blocks Drawing with crayons and paper Encourage picture reading Encourage singing Blowing bubbles 76 EMSC 2013 Non-pharmacologic measures – pre-schoolers13,28 • • • • • • Provide a calm environment Apply cold or hot pack Provide a position of comfort Provide light touch or massage Suggest music or TV to entertain Coach child through the ED process and/or procedures • • • • • • Draw in coloring books Play with puzzles Look at or read storybooks Encourage singing or storytelling Hold cold or hot pack Engage in distracting conversation 77 EMSC 2013 Non-pharmacologic measures – school age child13,28,50 • Provide a calm environment • Suggest new positions for comfort • Suggest music, TV • Read books • Coach child through the ED process and/or procedures • Share jokes • Provide light touch or massage • Hold cold or hot pack • Demonstrate relaxation techniques such as breathing exercises • Use squeeze balls • Encourage conversation about favorite things • Play with electronic tablet/wireless internet device 78 EMSC 2013 Non-pharmacologic measures adolescent13,28,51 • Apply cold or hot pack • Suggest repositioning or positions of comfort • Encourage talking about favorite places or activities • Provide light touch or massage • Listen to music • Read • Visit with friend • Use telephone access • Coach about ED processes and procedures • Discuss preferred relaxation techniques • Demonstrate relaxation techniques, if unfamiliar • Use squeeze balls • Encourage making choices • Play with electronic games or tablets 79 EMSC 2013 Summary • The child’s age, cognitive abilities, the type of pain, and the environment, must be considered when selecting a non-pharmacologic intervention • Parental presence is a significant supportive mechanism for children • Parent/caregiver and child benefit from instruction specific to the use of non-pharmacologic techniques in pain management 80 EMSC 2013 81 EMSC 2013 Pharmacologic pediatric pain management barriers20 Used with permission from Microsoft 82 EMSC 2013 Incorporate evidence-based pharmacologic pain interventions48 • Provide analgesia for children with abdominal pain prior to the surgical consult • Apply topical anesthetics prior to IV insertions, blood draws and laceration repairs • Provide pain medication for children in triage with a pain rating greater than 6 out of 10 • Provide pressure to IM site before giving injections • Provide anesthetic ear drops for ear pain • Use lidocaine as a diluent if giving IM ceftriaxone • Use buffered lidocaine for local anesthesia 83 EMSC 2013 Topical anesthetics52-54 AGENT L.M.X.4® (Lidocaine 4%) INDICATION DOSE/ROUTE For external use for pain Apply externally relief of minor cuts, scrapes, burns, sunburn, insect bites, and minor skin irritations TIME ONSET/ DURATION Onset 20-30 minutes MAXIMUM DOSE Externally 3-4 times per day Duration 60 minutes Apply in area less than 100cm2 for children less than 10 kg Apply in area less than 600cm2 for children between 10 and 20 kg LET Lidocaine Epinephrine Tetracaine (gel or liquid) Wound repair (non-mucosal) Per pharmacy protocol Topical 4% Lidocaine 1:2,000 Epinephrine 0.5% Tetracaine Onset 10 minute Duration 30-60 minute 3 ml (not to exceed maximal Lidocaine dosage of 3-5 mg/kg) COMMENTS Advantages For use in children 2 years and older over-the-counter (OTC) availability Risks Discuss use with physician in children under 2 years old. Advantages No physical wound distortion, painless application, decreased repair time, non-cocaine containing anesthetic Risks Not for use over end arteriole locations 84 EMSC 2013 AGENT INDICATION EMLA (2.5% Lidocaine 2.5% Prilocaine) Dermal analgesic (intact skin) (for children > 3 months age) AGE/DOSE/ROUTE 3-12 months (and >5 kg) maximum area covered 20 cm2 TIME ONSET/ DURATION Onset 60 minutes MAXIMUM DOSE 2 gm* Duration 3-4 hour 1-6 years (and >10 kg) maximum area covered 100 cm2 10 gm* 7-12 years (and >20 kg) maximum area covered 200 cm2 20 gm* topical/transdermal (cover area with occlusive dressing) NOTE: *Dosages are guidelines to avoid systemic toxicity in patients with normal intact skin and with normal renal and hepatic function COMMENTS Advantages Painless application, patient compliance, decreased repair time Risks Methemoglobinemia, contact dermatitis Maximum application time not to exceed 4 hours (If a patient does not meet the minimum weight requirement, the maximum total dose should be restricted to that which corresponds to the patient’s weight) 85 EMSC 2013 Topical anesthetics52-55 AGENT Pain-Ease® INDICATION Cooling intact skin and mucus membranes and minor open wounds DOSE/ROUTE Spray for 4-10 seconds from a distance of 8-18 cm TIME ONSET/ DURATION MAXIMUM DOSE Onset- immediate When skin turns white Duration- a few seconds, up to a minute COMMENTS Advantages Quick acting Risks Skin freezing may create hypopigmentation especially in dark pigment skin Viscous Lidocaine Foley catheter and nasogastric tube insertion; intubation 2%- 4% topical jelly Onset 2-5 min Duration 30-60 min 3-5 mg/kg Advantages Comfort of insertion, lubrication for insertion 10% spray NOTE: Not recommended for teething children or young children who cannot expectorate. Risks Hematoma, painful, bleeding at site, absorption can cause systemic toxicity. 86 EMSC 2013 Infiltrative anesthetics52-55 AGENT Infiltrative Lidocaine INDICATION Vascular access; needle insertion procedures DOSE/ROUTE Subcutaneous 1% Lidocaine with epinephrine TIME ONSET/ DURATION Onset 4-10 minutes Duration 90-120 minutes 0.5% Lidocaine with epinephrine 1% or 0.5% plain Lidocaine J-Tip® Jet injector of 1% buffered Lidocaine Vascular access, needle insertion procedures 0.2 ml subcutaneous MAXIMUM DOSE Immediate 7mg/kg to a maximum of 500 mg COMMENTS Advantages Rapid onset, longer duration Risks 4.5 mg/kg to a maximum of Hematoma, bleeding at 300 mg site; absorption can cause systemic toxicity Additional dosing after maximum reached, may occur after 2 hours. One application per site Advantages Needleless Risks Not for preterm infants; neonates; patients with blood disorders; or in children receiving chemotherapy or blood thinners. 87 EMSC 2013 Pharmacologic pain approaches and interventions56 By mouth By the ladder Pharmacologic Pain Management By the child By the clock 88 EMSC 2013 By mouth56 By mouth • Promote use of least invasive, most effective agent • IV route is reserved for moderate to severe pain • Avoid intramuscular route Used with permission from Microsoft 89 EMSC 2013 By the clock By the clock56 • Promote pain relief with timely and routine dosing • Start with a dose that matches both the pain assessment findings and pain score • Titrate dose upward if relief is inadequate Used with permission from Microsoft • Modify intervals between doses in the presence of moderate and severe pain 90 EMSC 2013 By the child By the child20,55,56 • Incorporates the child’s ▫ ▫ ▫ ▫ ▫ Used with permission from Illinois EMSC Developmental status Cultural influences Religious concerns Personal preferences Previous pain experiences 91 EMSC 2013 By the ladder WHO Pain Ladder56,57 • Originally created for guiding cancer pain treatment • Uses a three-step ladder • Uses least invasive administration route to provide needed analgesic • Recommends use of adjuvants to manage side effects, minimize fear, and enhance pain relief Used with permission. Cancer Pain Relief and Palliative Care in Children. World Health Organization 1998. 92 EMSC 2013 Mild pain agents52-54 NON-OPIOID Acetaminophen (APAP)‡ INDICATION Mild pain DOSE/ROUTE* MAX DOSE 10 - 15 mg/kg 75 mg/kg/day Every 4-6 hr COMMENTS Advantages Minimal adverse effects on GI tract or renal function Risks Liver toxicity PO, PR NOTE: ‡ All doses of combination products limited by APAP content to 75 mg/kg Ibuprofen (Motrin®, Advil®) Mild pain 5 - 10mg/kg Every 6-8 hr PO 40 mg/kg/day Advantages Inhibits prostaglandin-induced nociception Risks Nausea, vomiting, ulcers, platelet dysfunction, liver toxicity 93 EMSC 2013 Moderate pain agents52-54 NON-OPIOID Ketorolac (Toradol®) DOSE/ROUTE* INDICATION Moderate - severe pain 0.25 mg – 1 mg/kg every 6 hr MAX DOSE 30 mg every 6 hr IV, IM* PO for patients > 50 kg COMMENTS Advantages Effective alternative to opioids for treatment of moderate to severe pain Risks Bleeding diathesis; hyperkalemia; depression of renal function; and hepatotoxicity NOTE: Do not use with other NSAIDs. NOTE: Meperidine (Demerol®) is not recommended due to its potential for prolonged side effects from active metabolites, lowered seizure threshold, and renal insufficiency. *IM routes not recommended as first line treatment. 94 . EMSC 2013 Moderate pain agents52-54 OPIOIDS§ Codeine/APAP with Codeine DOSE/ROUTE* INDICATION Mild - moderate pain 0.5 - 1mg/kg of Codeine ONSET 1-2 hr DURATION 4-6 hr MAX DOSE 60 mg/dose Every 4-6 hr PO COMMENTS Advantages Rapid onset action, minimal respiratory depression orally Risks Nausea, vomiting, constipation, respiratory depression, hypotension, bradycardia, CNS depression NOTE: Codeine is ineffective in 1/3 of patients. NOTE: Ibuprofen has provided equivalent pain relief when compared to codeine alone or acetaminophen with codeine. 58,59 95 EMSC 2013 Moderate pain agents52-54 OPIOIDS Hydrocodone (+ APAP: Lortab® Vicodin®) INDICATION DOSE/ROUTE* Mild 0.1 - 0.2 mg/kg of moderate pain Hydrocodone ONSET 30 min DURATION 3 - 4 hr MAX DOSE Limited by APAP component Every 4-6 hr (+APAP: Percocet®) Moderate severe pain 0.05 - 0.15 mg/kg of Oxycodone 15 min 3 - 4 hr 10 mg every 4-6 hr Every 4-6 hr PO (immediate release formula) Advantages Oral medication, moderately rapid onset Risks Dizziness, sedation, nausea, vomiting, constipation PO Oxycodone COMMENTS NOTE: Generally not recommended in children less than 6 years of age. Advantages Oral medication, moderately rapid onset Risks CNS depression, respiratory depression, hypotension, bradycardia, nausea 96 EMSC 2013 Severe pain • Use high potency analgesics ▫ Morphine ▫ Fentanyl ▫ Hydromorphone Myth: Children can become easily addicted if given narcotics • Intractable pain may require: ▫ Nerve block, epidural or patient controlled analgesia (PCA)60 97 EMSC 2013 Intranasal Fentanyl • Intranasal administration is helpful in meeting pain relief for long bone fractures.61,62 Used with permission from Illinois EMSC 98 EMSC 2013 Severe pain52-54 OPIOIDS Fentanyl (Sublimaze®) DOSE/ROUTE* INDICATION Moderate severe pain ONSET DURATION 1-2 mcg/kg/dose IV (administer over 3-5 minutes) 1-2 min IV 30-60 min IV IN (divide dose equally between each nostril) 10 min IN 60 min IN IM* 7-15 min IM 1-2 hr IM NOTE: IN route should not be used in patients with facial trauma. *IM routes not recommended as first line treatment. MAX DOSE COMMENTS 1-3 mcg/kg/dose Advantages Rapid onset, short duration, potent analgesic; preferred medication for renal patients Risks Respiratory depression, apnea may precede alteration of consciousness chest wall rigidity if given too rapidly 99 EMSC 2013 Severe pain52-54 OPIOIDS Morphine (Roxanol®) INDICATION Moderate severe pain DOSE/ROUTE* 0.2 - 0.5 mg/kg IV, SC, IM* ONSET 5-15 min DURATION 3-4 hr MAX DOSE 15 mg Every 4-6 hr 0.1 - 0.2 mg/kg PO (immediate release formula) Every 2-4 hr Advantages Moderately rapid predictable onset. Significant role for patients who need prolonged pain control (e.g., fracture reduction, multiple trauma, sickle cell disease) Risks Respiratory depression, hypotension, bradycardia, CNS depression NOTE: Avoid in children with renal failure. *IM routes not recommended as first line treatment. COMMENTS 100 EMSC 2013 Severe pain52-54 OPIOIDS Hydro-morphone (Dilaudid®) INDICATION Severe pain DOSE/ROUTE* 0.015 mg/kg IV ONSET DURATION Almost immediately 2-4 hr Up to 30 min 4-5 hr Every 4 hr 0.03 - 0.08 mg/kg PO Every 4 hr MAX DOSE COMMENTS 0.015 mg/kg/dose Advantages Rapid onset; less pruritis Every 4 hr than morphine Risks Respiratory depression, CNS depression, sedation 101 EMSC 2013 Use of adjuvants46 Coanalgesics Drugs to combat side effects • • • • • • • • Antidepressants Anticonvulsants Corticosteroids Sedative/hypnotics Anti-emetics Antihistamines Psychostimulants Neuroleptics Remember, children have difficulty distinguishing between pain, nausea and anxiety. 102 EMSC 2013 Summary • Pharmacologic approaches include: by mouth, by the clock, by the child and by the ladder • The least invasive, best match for the severity of pain is the preferred analgesic choice • Integrating evidence-based pharmacologic interventions provides effective pain management 103 EMSC 2013 104 EMSC 2013 Quality monitoring63,64,65 • Activities to evaluate care • Selected by organizations to: ▫ Ensure quality care ▫ Monitor outcomes of care ▫ Respond to outcomes that are below acceptable standards ▫ Identify and promote best practices 105 EMSC 2013 Tools that support quality63,64,65 • • • • • • Multidisciplinary committee work Policy Procedure Guidelines, pathways, frameworks, protocols Ongoing staff training Safety culture 106 EMSC 2013 Practice improvement terminology65 • Quality control ▫ A set of activities whose purpose is to guarantee that all quality requirements are being met. The organization monitors processes and provides solutions to performance problems to achieve this purpose. • Quality of care, treatment, and services ▫ The degree to which care, treatment, or services for individuals and populations increases the likelihood of desired health outcomes. This includes the appropriateness, efficacy, efficiency, timeliness, accessibility, and continuity of care; and the safety of the care environment. • Guideline, practice parameter, protocol description ▫ An evidence-based document about best practice processes, developed by consensus opinion of experts, for evaluating and/or treating a patient, who has a specific symptom, condition, or diagnosis. • Policy ▫ A principle or method that is developed for the purpose of guiding decisions and activities related to care, treatment, and services. 107 EMSC 2013 Elements of pediatric pain guideline, protocol, policy, and order sets • Evidence-based • Age of target population • Expected behaviors by role ▫ Assessment AAP, ASPMN and ENA endorsed 9,20 Initiation Reassessment ▫ Actions to take when a specific symptom, condition or diagnosis are present45 108 EMSC 2013 Tools to improve the timeliness of interventions • Create with multidisciplinary consensus •Musculoskeletal pain •Ear pain •Eye pain • Determine format •Algorithm Practice Guideline Algorithm Quality monitors Policy and procedure ▫ Based on facility preferences • Review and revise at specified intervals • Allow comparison between the care standard and the actual care provided •Audit tool #1 •Audit tool #2 •Policy and Procedure 109 Rapid Cycle Model66 EMSC 2013 What are we trying to accomplish? Setting Aims How will we know that a change is an improvement? Establishing Measures What changes can we make that will result in improvement? Selecting Changes Example: Improving pain reassessment, of children less than 15 years old, prior to disposition Example: 90% of discharge pediatric medical records have a reassessment documented prior to disposition Examples: Post pain scale in patient area Offer education or competency Change order set Seek solutions through debriefing of pain cases Evaluating Changes Act Study Plan Do Example: Review and analyze the data after implementing one of the above changes 110 EMSC 2013 Rapid Cycle Improvement Model Setting Aims What are we trying to accomplish ? Improvement requires setting aims. The aim should be time-specific and measurable and define the specific population of patients that will be affected. 111 EMSC 2013 Rapid Cycle Improvement Model Establishing Measures How will we know a change is an improvement? Use quantitative measures to determine if specific changes actually lead to an improvement. 112 EMSC 2013 Rapid Cycle Improvement Model What changes can we make that will result in an improvement ? All improvement requires making changes, but not all changes result in improvement. Identify the changes that most likely will lead to improvement. 113 EMSC 2013 Rapid Cycle Improvement Model Act Plan Study Do The Plan-Do-Study-Act (PDSA) cycle is used for testing change in an actual setting, by planning it, doing it, checking the results, and acting on what is learned. 114 EMSC 2013 Summary • Quality monitoring should be incorporated into your facility’s pain management program • Quality monitoring is a multidisciplinary process • Organizations improve the care process by utilizing tools to standardize care • The Rapid Cycle Improvement model provides a framework for improving care quality by testing changes in care for effectiveness 115 EMSC 2013 Thank you Used with permission from Illinois EMSC 116 EMSC 2013 Appendix A: PSA reference list 1. American College of Emergency Physicians. The use of pediatric sedation and analgesia. Ann Emerg Med. 2008;52(5):595-596. 2. Atkinson P, Chesters A, Heinz P. Pain management and sedation for children in the emergency department. BMJ. 2009;339:b4234. 3. Babl FE, Mandrawa C, O'Sullivan R, Crellin D. Procedural pain and distress in young children as perceived by medical and nursing staff. Paediatr Anaesth. 2008;18(5):412-419. 4. Bhatt M, Currie GR, Auld MC, Johnson DW. Current practice and tolerance for risk in performing procedural sedation and analgesia on children who have not met fasting guidelines: A Canadian survey using a stated preference discrete choice experiment. Acad Emerg Med. 2010;17(11):1207-1215. 5. Bhatt M, Kennedy RM, Osmond MH, et al. Consensus-based recommendations for standardizing terminology and reporting adverse events for emergency department procedural sedation and analgesia in children. Ann Emerg Med. 2009;53(4):426435.e4. 6. EMSC Panel on Critical Issues in the Sedation of Pediatric Patients in the Emergency Department. Ann Emerg Med. 2008;51(4):378-399.e57. 7. Green SM, Roback MG, Kennedy RM, Krauss B. Clinical practice guideline for emergency department ketamine dissociative sedation: 2011 update. Ann Emerg Med. 2011;57(5):449-461. 8. McDonnell WM, Guenther E, Larsen LF, Schunk J. The reimbursement gap: Providing and paying for pediatric procedural sedation in the emergency department. Pediatr Emerg Care. 2009;25(11):797-802. 117 EMSC 2013 Appendix B: Module references 1. HCUP Nationwide Emergency Department Sample (NEDS). Healthcare Cost and Utilization Project (HCUP). 2007, 2008, 2009. Agency for Healthcare Research and Quality, Rockville, MD. Web site. http://www.hcup-us.ahrq.gov/nedsoverview.jsp. Accessed 7/12/2012. 2. Alexander J, Manno M. Underuse of analgesia in very young pediatric patients with isolated painful injuries. Ann Emerg Med. 2003;41(5):617-622. 3. Probst BD, Lyons E, Leonard D, Esposito TJ. Factors affecting emergency department assessment and management of pain in children. Pediatr Emerg Care. 2005;21(5):298-305. 4. Drendel AL, Brousseau DC, Gorelick MH. Pain assessment for pediatric patients in the emergency department. Pediatrics. 2006;117(5):1511-1518. 5. Rogovik AL, Rostami M, Hussain S, Goldman RD. Physician pain reminder as an intervention to enhance analgesia for extremity and clavicle injuries in pediatric emergency. J Pain. 2007;8(1):26-32. 6. Dong L, Donaldson A, Metzger R, Keenan H. Analgesic administration in the emergency department for children requiring hospitalization for long-bone fracture. Pediatr Emerg Care. 2012;28(2):109-114. 7. Galinski M, Picco N, Hennequin B, Raphael V, Ayachi A, Beruben A, Lapostolle F, Adnet F. Out-of-hospital emergency medicine in pediatric patients: prevalence and management of pain. American Journal of Emergency Medicine.2011;29:1062–1066. 8. American Academy of Pediatrics, Committee on Pediatric Emergency Medicine, American College of Emergency Physicians, Pediatric Committee, Emergency Nurses Association Pediatric Committee. Joint policy statement-guidelines for care of children in the emergency department. Pediatrics. 2009;124(4):1233-1243. 118 EMSC 2013 Appendix B: Module references 9-16 9. Emergency Nurses Association, American Society for Pain Management Nursing. Optimizing the treatment of pain in patients with acute presentations . Emergency Nurses Association Web site. http://www.ena.org/SiteCollectionDocuments/Position%20Statements/Pain_Mgmt_pol.pdf. Updated July 2009. Accessed 1/3/2012. 10. Franck L, Greenberg C, Stevens B. Acute pain in children: Pain assessment in infants and children. Pediatr Clin North Am. 2000;47(3):487. 11. Fitzgerald A, Anand KJS. Development Neuroanatomy and Neurophysiology of pain. In: Schecter NL, Berde CB, Yaster M, eds. Pain in infants, children, and adolescents. Baltimore: Williams and Wilkins; 1993:11. 12. Helms JE, Barone CP. Physiology and treatment of pain. Critical Care Nurse. 2008;2008(28):38. 13. Illinois Emergency Medical Services for Children (EMSC), ed. Pediatric pain management in the emergency department educational module, August 2002; 2002. 14. Anand KJS, Phil D, Hickey PR. Halothane-morphine compared with high-dose sufentanil for anesthesia and postoperative analgesia in cardiac surgery. The New England Journal of Medicine. 1992;326(1):1. 15. Drendel, A , Kelly, BT, Ali, S. Pain Assessment for Children Overcoming Challenges and Optimizing Care. Pediatr Emerg Care. 2011;27(8):773. 16. von Baeyer CL, Marche TA, Rocha EM, Salmon K. Children's memory for pain: Overview and implications for practice. Journal of Pain. 2004;5(5):241-249. 119 EMSC 2013 Appendix B: Module references 17-24 17. Taddio A, Goldbach M, Ipp M, Stevens B, Koren G. Effect of neonatal circumcision on pain responses during vaccinations of boys. The Lancet. 1995;345:291. 18. Grunau R, Whitfield M, Petrie J. Pain sensitivity and temperament in extremely low-birth-weight premature toddlers and pre-term and fullterm controls. Pain. 1994;58:341. 19. APS press room. American Pain Society Web site. www.ampainsoc.org/. Accessed November 14, 2012. 20. Fein J, Zempsky W, Cravero J, Committee on the Pediatric Emergency Medicine and Section on Anesthesiology and Pain Medicine. Relief of pain and anxiety in pediatric patients in emergency medical systems. Pediatrics. 2012;130(5):11/13/2012. 21. Child, Adolescent & "Catch-up" Immunization Schedules Details For Health Care Professionals Web site. http://www.cdc.gov/vaccines/schedules/hcp/child-adolescent.html. Updated June 2012. Accessed 8/2/2012. 22. Perquin CW, Hunfeld JAM, Hazebroek-Kampschreurc AAJM, et al. Insights in the use of health care services in chronic benign pain in childhood and adolescence. Pain. 2001;94:205. 23. Emergency Nurses Association. Pediatric procedural pain management. ENA Position Statement Web site. http://www.ena.org/about/position/position/Pages/Default.aspx. Published 12/2010. Updated 2010. Accessed 3/20/2012. 24. Hummel P, Puchalski M, Greech S, Weiss M. Clinical reliability and validity of the N-PASS: Neonatal pain, agitation and sedation scale with prolonged pain. Journal of Perinatology. 2008;28(1):55. 120 EMSC 2013 Appendix B: Module references 25-32 25. Hummel P, Van Dijk M. Pain assessment: Current status and challenges. Seminars in Fetal Neonatal Medicine. 2006;11(4):237. 26. Oakes LL. Compact Clinical Guide to Infant and Child Pain Management: an Evidence based Approach for Nurses. New York: Springer; 2011. 27. Stanford EA, Chambers CT, Craig KD. A normative analysis of the development of pain-related vocabulary in children. Pain. 2005;114:278. 28. Srouji R, Ratnapalan S, Schneeweiss S. Pain in children: Assessment and non-pharmacological management. International Journal of Pediatrics. 2010;474838. 29. Voepel-Lewis T, Merkel S, Tait A, Trzcinka A, Malviya S. The reliability and validity of the face, legs, activity, cry, consolability observational tool as a measure of pain in children with cognitive impairment. Anesthesia & Analgesia. 2002;95:1224. 30. Spasojevic S, Bregun-Doronjski A. A simultaneous comparison of four neonatal pain scales in clinical settings . Journal of Maternal-Fetal & Neonatal Medicine. 2011;24(4):590. 31. Hummel P, Lawlor-Klean P, Weiss M. Validity and reliability of the N-PASS assessment tool with acute pain. Journal of Perinatology. 2010;30(7):474. 32. Ahola Kohut S, Pillai Riddell R. Does the neonatal facial coding system differentiate between infants experiencing painrelated and non-pain-related distress? Journal of Pain. 2009;10(2):214. 121 EMSC 2013 Appendix B: Module references 33-41 33. Krechel S, Bildner J. CRIES: A new neonatal postoperative pain measurement score– initial testing of validity and reliability. Paediatric Anaesthesia. 1995;5:53. 34. Malviya S, Voepel-Lewis T, Burke C, Merkel S, Tait A. The revised FLACC observational pain tool: Improved reliability and validity for pain assessment in children with cognitive impairment. Pediatric Anaesthesia. 2006;16(3):258. 35. Breau L, Finley G, McGrath P, Camfield C. Validation of the non-communicating children’s pain checklist-postoperative version. Anesthesiology. 2002;96(3):528. 36. Garra G, Singer AJ, Taira BR, et al. Validation of the Wong-Baker FACES pain rating scale in pediatric emergency department patients. Acad Emerg Med. 2010;17(1):50-54. 37. Stinson J, Kavanagh T, Yamada J, Gill N, Stevens B. Systematic review of the psychometric properties, interpretability and feasibility of self-report pain intensity measures for use in clinical trials in children and adolescents. Pain. 2006;125(12):143. 38. Wong D, Baker C. Pain in children: Comparison of assessment scales. Pediatric Nursing. 1988;14(1):9. 39. Beyer J, Denyes M, Villarruel A. The creation, validation, and continuing development of the Oucher: A measure of pain intensity in children. Journal of Pediatric Nursing. 1992;7(5):335. 40. Luffy R, Groves S. Examining the validity, reliability, and preference of three pediatric pain measurement tools in African American children. Pediatric Nursing. 2003;23(1):54. 41. Bailey B, Bergeron S, Gravel J, Daoust R. Comparison of four pain scales in children with acute abdominal pain in a pediatric emergency department. Academic Emergency Medicine. 2007;14(5):S90. 122 EMSC 2013 Appendix B: Module references 42-50 42. Shields B, Cohen D, Harbeck-Weber C, Powers J, Smith G. Pediatric pain measurement using a visual analogue scale: A comparison of two teaching methods. Clinical Pediatrics. 2010;42:227. 43. Voepel-Lewis T. Commentary pain assessment and decision making: Have we missed the mark? Special Interest Group on Pain in Childhood, International Association for the Study of Pain. 2011;13(1):1. 44. Committee on the Future of Emergency Care in the United States Health System. Emergency Care for Children: Growing Pains. Washington, DC: The National Academies Press, 2007 45. Emergency Nurses Association. Weighing pediatric patients in kilograms. Emergency Nurses Association Position Statement Web site. http://www.ena.org/SiteCollectionDocuments/Position%20Statements/WeighingPedsPtsinKG.pdf. Published August 2012. Updated March 2012. Accessed 8/24/2012. 46. Hockenberry M, Wilson D, eds. Wong’s Nursing Care of Infants and Children 8th ed. St. Louis: Mosby; 2007. 47. Copstead LC, Banasik J. Pathophysiology. Vol 12. 4th ed. Canada: Elsevier; 2010:900. 48. Kleiber C, Jennissen C, McCarthy AM, Ansley T. Evidence-based pediatric pain management in emergency departments in a rural state. The Journal of Pain. 2011;12(8):900. 49. Curtis SJ, Jou H, Ali S, Vandermeer B, Klassen T. A randomized controlled trial of sucrose and/or pacifier as analgesia for infants receiving venipuncture in a pediatric emergency department. BMC Pediatr. 2007;7:27. 50. Chambers CT, Taddio A, Uman LS, McMurty CM, HELPinKIDS Team. Psychological interventions for reducing pain and distress during routine childhood immunizations: A systematic review. Clinical Therapeutics. 2009;31(Supplement B):S77. 123 EMSC 2013 Appendix B: Module references 51-59 51. Uman LS, Chambers CT, McGrath PJ, Kisely SR. Psychological interventions for needle-related procedural pain and distress in children and adolescents. Cochrane Database of Systematic Reviews. 2006;2006(4):CD005179. 52. Lacy C, ed. Drug Information Handbook. 21st ed. Lexi-Comp; 2012. 53. Young TE, ed. Neofax. 24th ed. Raleigh NC: Thomson Reuters; 2011. 54. Gunn VL, Nechyba C, eds. Harriet Lane Handbook. 16th ed. St. Louis; 2002. 55. Jennissen C, Kleiber C, Ryan A, Pediatric Pain management and Prevention. 1st Edition. University of Iowa; 2011. 56. McGrath PA. Development of the World Health Organization guidelines on cancer pain relief and palliative care in children. J Pain Symptom Manage. 1996;12(2):87-92. 57. World Health Organization, ed. Cancer Pain Relief and Palliative Care in Children. Geneva: World Health Organization; 1998. 58. Clark E, Plint AC, Correll R, Gaboury I, Passi B. A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma Pediatrics. 2007;119(3):460. 59. Friday JH, Kanegaye JT, McCaslin I, Zheng A, Harley JR. Ibuprofen provides analgesia equivalent to acetaminophen-codeine in the treatment of acute pain in children with extremity injuries: A randomized clinical trial. Acad Emerg Med. 2009;16(8):711716. 124 EMSC 2013 Appendix B: Module references 59-66 60. Vargas-Schaffer G. Is the WHO analgesic ladder still valid? Twenty-four years of experience. Can Fam Physician. 2010;56(6):514. 61. Holdgate A, Cao A, Lo KM. The implementation of intranasal fentanyl for children in a mixed adult and pediatric emergency department reduces time to analgesic administration. Acad Emerg Med. 2010;17(2):214-217. 62. Borland M, Jacobs I, King B, O'Brien D. A randomized, controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department. Ann Emerg Med. 2007;49(3):335-340. 63. Thomas DO. Implementing the IOM recommendations for improving pediatric emergency care in your emergency department: Start from where you are! Journal of Emergency Nursing. 2010 36(4),375–378. 64. The Joint Commission. (2008, April 11). Preventing pediatric medication errors. Sentinel Event Alert, (39). http://www.jointcommission.org/assets/1/18/SEA_39.PDF. Accessed 10/1/2012. 65. 2012 The Joint Commission . Standards Manual Content, Glossary Web site. https://e-dition.jcrinc.com/MainContent.aspx. Published 2012. Updated 2012. Accessed 9/4/2012. 66. Taylor JA, Crowe VL. Rapid cycle change sells itself. Journal for Healthcare Quality. 1999;21(5):4-7. 125 EMSC 2013 Appendix C: Electronic sites American Academy of Pediatrics www.aap.org/en-us/professional-resources/Pages/Professional-Resources.aspx American College of Emergency Physicians www.acep.org/ www.ama-assn.org/ama/pub/education-careers/continuing-medicaleducation.page? American Medical Association American Pain Society American Society for Pain Management in Nursing www.ampainsoc.org/ Det Norske Veritas Healthcare, Inc http://dnvaccreditation.com/pr/dnv/default.aspx Drug Enforcement Administration www.justice.gov/dea/index.shtml Emergency Nurses Association www.ena.org/ Food and Drug Administration www.fda.gov/ForHealthProfessionals/default.htm www.aspmn.org/ 126 EMSC 2013 Appendix C: Electronic sites Healthcare Facilities Accreditation Program http://www.hfap.org/ Illinois Emergency Medical Services for Children www.luhs.org/emsc International Association for the Study of Pain www.iasp-pain.org/ National Association of Emergency Medical System Physicians http://www.naemsp.org/Pages/default.aspx National Association of Emergency Medical Technicians http://www.ems1.com/partners/national-association-of-emergency-medicaltechnicians-(naemt) The Joint Commission http://www.jointcommission.org World Health Organization www.who.int/en