Hydrophilic PU foam BIOPOL GLOBAL CO., LTD. BIOPOL GLOBAL CO., LTD. Ⅰ. Company Overview Vision We pursue the innovative technology based society for human. We pursue the person who develops the innovative technology. We are aiming to make commitment to the public welfare of the human society. We believe that the technology is a creation and creation needs to be based upon understanding of the human being. Our product stem to the belief that contribution for human. Therefore, we are proudly produce our product for better society, better life of human, better health of human being. We are focusing on developing revolutionary technology based product in wound care industry. We have confidence in ourselves to become a leading company in global wound care market and It will be happening in the near future with your close hand. Here and Now, We create the future !! BIOPOL GLOBAL CO., LTD. Ⅰ. Company Overview History - Oct. 2002 : Export contracted MEDIFOAM to Singapore, Malaysia and Indonesia (US$ 7.5 Million) - Sep. 2002 : Prime Minister (Gold) awarding in INO tech-show 2002 (Ministry of Government Administration and Home Affairs) - Jun. 2002 : Export contracted MEDIFOAM to China (US$ 10,000,000) - May. 2002 : Established BIOPOL GLOBAL CO., LTD. for the Exclusive Overseas Sales - Mar. 2002 : Applied for FDA registration - Mar. 2002 : CE 0120, ISO 9001 and EN 46001 Mark certified - Nov. 2001 : Certified as INNO-BIZ Company (Small and Medium Business Administration) - Oct. 2001 : Began to sell Medifoam® series - Jun. 2001 : Contracted ILDONG Pharmaceutical Co., Ltd. for the Exclusive Domestic Sales - May. 2001 : Own factory completed and began to produce Medifoam® series - Nov. 2000 : Venture company certified (Small and Medium Business Administration) - Sep. 2000 : Completed the development of Medifoam series and began to produce samples - Aug. 2000 : Established Biopol Co., Ltd. - Nov. 1996 : Began to develop Medifoam® series BIOPOL GLOBAL CO., LTD. Ⅰ. Company Overview Future Business < First step > MEDIFOAM MEDIFOAM B MEDIFOAM 2 MEDIFOAM A EPICARE ULTRASORB Moist bandage Applicable Products Occlusive and/or Moist Wound Dressing Medical Skin Polymer Bio Engineering < Second step> Pharmacy < Third step> Biocompatible Material Cultured Skin Chitin/Chitosan Occlusive Dressing Drug Delivery System Etc. BIOPOL GLOBAL CO., LTD. Ⅱ. Product Comparison Clinical & Economical differences Other products Low thermal insulation Less absorption capacity of exudates Dry environment cause delayed cure High vulnerability of Infection Adhesive on wound surface High cost of production High price Frequent change of gauze BIOPOL MEDIFOAM High thermal insulation Twice better absorption of body fluid and blood Moisture wound environment Preventing bacteria’s proliferation Protecting from infection Non-adhesive on wound surface Decreasing of scar and no pain Saving cost of production General to open surgical wound Low price Wound contact layer’s micro pores size is even much smaller than the cell, 20m. It protects epithelial growth into the pore. It is a highly advanced technology that eventually leads patients feel no pain with much much less scar. Biopsy, toxicity and clinical tests which conducted by “Seoul National University” and other major hospitals testified that the MEDIFOAM has much better quality effects than any other company’s wound care products existing in the world currently BIOPOL GLOBAL CO., LTD. Ⅱ. Product Comparison Gauze dressing’s main problem a beginning Exudates gauze b Escher Low protected skin Ground substance c d Change gauze Moving cell below the dried skin Cell comes out with gauze BIOPOL GLOBAL CO., LTD. Ⅱ. Product Comparison Comparison Test – Explanation of each graph 1. Absorption Capacity (g/cm3) To measure the water absorptive of sample, pre-weighed dry sample was immersed in distilled water for 24h. After the bulk water was removed by placing the absorbent paper, the weight of wet sample was measured. The procedure was repeated with 5 different pieces of same foam. Then, the water absorptive was determined according to the following equation : Water absorptive (g/cm3) = {(Ws – Wd) / Wd} X density (g/cm3) where Ws = weight of water absorbed sample Wd = weight of dry sample 2. MVTR (Moisture Vapor Transmission Rate, g/m2/day) ASTM E96-95 (CaCl2 or Desiccant Method) was used to determine MVTR by measuring the rate of change of mass in a CaCl2 filled test dish on which the dressing was mounted. The test dishes (maximum of five) were placed on a platform within an incubator set at 37±0.5℃ and maintained at a relative humidity of 85±2% using a water. Periodic weightings determine the rate of water vapor movement through the specimen into the desiccant. MVTR was calculated at a given time interval by the following method. MVTR = {( m / Δt ) X 24} / A (g/m2/day) where m = mass of water absorbing over the specified time interval (g) Δt = time interval (h) and A = the effective transfer area. 3. Price The price of the products, except MEDIFOAM, was investigated from “Yahoo Shopping” site. All of the price based on 10cmX10cm size product and divided from standard price, MEDIFOAM. BIOPOL GLOBAL CO., LTD. Ⅱ. Product Comparison Comparison Test 2.MVTR 1.Absorption Capacity 1400 2.4 1500 1.5 2 1.5 1.5 1200 1200 770 1000 2 0.8 g/m /day g/cm3 2.5 1 500 0.5 0 Medifoam Allevyn Biatain Seasorb 0 Medifoam Allevyn Biatain Seasorb BIOPOL GLOBAL CO., LTD. Ⅱ. Product Comparison Comparison Test 3.Price (10cmX10cm) 1.33 1.50 4.Tensile Strength 1.26 0.4 0.97 1.00 0.3 0.25 0.18 kgf/cm 2 1.00 0.33 0.50 0.12 0.2 0.1 0.00 Medifoam Allevyn Biatain Seasorb 0 Medifoam Allevyn Biatain Seasorb BIOPOL GLOBAL CO., LTD. Ⅲ. Product Information Product Line-Up – Foam type Dressing Products Product Names Medifoam • • • • • Medifoam B Thickness : 3, 5, 7, 10mm Size : 12 classes (5cmX5cm, 5cmX10cm, 10cmX10cm, 10cmX20cm, 10cmX30cm etc) • Over full thickness second degree burns– Antibiosis and debridment • Absorption of excessive exudates and blood Medifoam F Thickness : 1∼2 mm Size : variable • Adhesive film attached to Medifoam N • Relatively small site and exudate wound • Surgical wound Medifoam C Thickness : 1∼2 mm Size : various size • Adhesive non-woven fabric attached to Medifoam (Foam Dressing) Indications Thickness : 1, 2, 3, 5mm Size : 13 classes (5cmX5cm, 10cmX10cm, 10cmX20cm, 20cmX20cm, 5cmX7cm etc) Medifoam® Series Structure of Product Wide and large amount exudates Superficial second degree burns Ulcers • Abrasions Donor site Skin graft site or general wound BIOPOL GLOBAL CO., LTD. Ⅲ. Product Information Product Line-Up – Foam type Dressing Products Product Names Indications Thickness : 2, 3, 5mm Size : 2 classes (5×5㎝, 10×10㎝) • Modified of Medifoam • Catheter and tube fixation, and protection of drainage hole Medifoam D Thickness : 3∼5 mm Size : various size • Modified of Medifoam A •Used for absorbing exudates from connecting parts of inner and outer body due to pore and preventing bacterial infection • Used with Ilizarov, used with catheter and tubes Medifoam A Thickness : 1∼3 mm Size : various size • Spread adhesive on MEDIFOAM • Pressure sore • Surgical wound • Skin graft site Medifoam T Medifoam® Series (Foam Dressing) Structure of Product BIOPOL GLOBAL CO., LTD. Ⅲ. Product Information Product Line-Up – Other type dressing Products Epicare ( Film Dressing ) Ultrasorb ( Nonwoven fabric Dressing ) Product Names Structure of Product Indications Epicare ‘N’ Thickness : 45㎛ Size : various size • Wounds with little exudates • Wounds which need observation • 1st and 2nd pressure sore Epicare ‘S’ Thickness : 55㎛ Size : various size • High absorbency Epicare ‘N’ • Wounds with little exudates • Wounds which need observation • 1st and 2nd pressure sore Epicare ‘IV’ Thickness : 40㎛ Size : various size • IV fixation Thickness : 1∼5 mm • Suitable for all kinds of wounds Ultrasorb BIOPOL GLOBAL CO., LTD. Ⅲ. Product Information Product Line-Up – Other type dressing Products Product Names Non-sticking to wound Dressing Other Application Dressing with Chitin/ Chitosan Wounds Sealing Adhesive Dressing Structure of Product Thickness : 1∼3mm • Moist Dressing, No scars Thickness : 1∼3 mm Size : Expected • Antibacterial,Enhancing effectiveness of wound healing, Added adhesiveness, Able to absorb exudates, Sealing, Non-sticking to wound Thickness : 1∼5 mm • Antibacterial, Enhancing effectiveness of wound healing Indications • Minor abrasion • Fixing catheter • Sealing Ilizarov • Sealing other wounds • Bedsore and ulcer BIOPOL GLOBAL CO., LTD. Ⅲ. Product Information MEDIFOAM MEDIFOAM is an advanced wound dressing made by highly absorbent polyurethane which has very unique structure. It provides the best moisture wound healing environment resulted from both excellent absorption capability and moisture permeability for exudates. And it is never non-adherent on the wound surface. The protection layer is made by PU film which has minimal micro pore structure. This structure protects bacterial invasion and maintain the optimal MVTR and releases the absorbed exudates properly. The absorption layer is composed of PU foam which has higher absorption capability as almost 1,000%. It makes to absorb and hold the exudates from wound surface. MEDIFOAM absorption capability is far superior than other dressings. Especially, It provides perfect moisture wound environment continuously by holding the absorbed exudates. The wound contact layer is PU membrane which supports to absorb the exudates smoothly and it prevents adherence of dressing on wound surface. BIOPOL GLOBAL CO., LTD. Ⅲ. Product Information Medifoam Medifoam B Medifoam A Protection Layer Protection Layer Absorption Layer Absorption Layer Absorption Layer Wound Contact Layer Adhesive Coated Layer Thickness : 1, 2, 3, 5mm Thickness : 3, 5, 7, 10mm Thickness : 1∼3 mm Size : 13 classes Size : 12 classes Size : Various size • Wide and exudative wounds • Superficial second degree burns • Ulcers • Abrasions • Donor site • Skin graft and general wounds • Over full thickness second degree burns – Antibiosis and debridment • wounds which need high absorbency • Pocket and cavity wounds • Adhesive coated type of Medifoam • Ulcers • Pressure sores • Surgical wounds • Donor site • Skin graft and general wounds BIOPOL GLOBAL CO., LTD. Ⅲ. Product Information MEDIFOAM’s Structure & Characteristics Protection Layer Let the absorbed exudate out and protects the wound surface from possible infection. MVTR : 800~1,200g/㎡/day Absorption Layer Has the high absorbency (Swelling ratio :1,000∼1,500%) and maintaining the best environment for wound healing Wound Contact Layer Absorbing exudates and maintains the moist wound healing environment, and does not stick to wound surface. BIOPOL GLOBAL CO., LTD. Ⅲ. Product Information Properties of MEDIFOAM Body Temperature(℃)* Hydrocolloid Type Film Type Hydrogel Type 30 ∼ 32℃ 30 ∼ 32℃ 30 ∼ 32℃ Swelling Ratio(%)** 90 0 400 MVTR (g/㎡/day) Characteristics 0 1. It keeps moist environment and maintains healing environment of low acidity. - Stimulates granulation and epithelialization 2. Not suitable for infected wounds 480 1. Visibility – eases viewing of wounds 2. It keeps moist environment. 3. Prevents bedsore, used for protecting the skin. 4. Not suitable for infected wounds 300 1. It keeps moist environment . 2. Its mechanical property weakens after absorbing exudates. BIOPOL GLOBAL CO., LTD. Ⅲ. Product Information Properties of MEDIFOAM Body Temperature(℃)* Polyurethane Foam Type MEDIFOAM 33 ∼ 35℃ 33 ∼ 35℃ Swelling Ratio(%)** 710 1,000 ∼ 1,500 MVTR (g/㎡/day) 1,800 1,000 ∼ 2,500 Characteristics a. It can be used for wounds with excessive exudates b. It sticks to the wound if it is applied for more than 3 days. a. It keeps moist environment. b. It prevents forming of scars and facilitates epitheialization. c. It can be used for wounds with excessive exudates. d. It doesn’t stick to the wound surface e. It provides the ideal healing environment ※ Note) - Pig skin experiment results by Lock, - Calculation : Swelling Ratio (%) = (Ws-Wd)/Wd ×100 - Moisture Vapor Transfer Rate(MVTR) : Tested according to the KS M – 6886 testing method, 37℃ - 85% RH BIOPOL GLOBAL CO., LTD. Ⅲ. Product Information Cell Toxicity Test Dressing Progress Time Control ( x 104) 1 day MEDIFOAM Variants(U.K) 25.75 92% 4% 2 days 25.3 81% 0% 3 days 24.5 64% - 5 days 7.63 72% - ※ Note) - The test was performed by using the ISO 10993-5 Test method and % indicates live cells. - Initial seeding(3T3 cell) was set as 2x104/cm2 BIOPOL GLOBAL CO., LTD. Ⅲ. Product Information Clinical Test (1) (1) Seoul National University Hospital (Prof. Min, K. W.) – refer to photos and appendix1 ※ Half Side Test between MEDIFOAM and ALLEVYN (Smith & Nephew) was performed. ※ 32 patients participated. ※ Average age : 41.7 Contents Unit Medifoam ALLEVYN Period Days 9.37 12.62 Healing effect Points 5.37 4.16 Technical evaluation Points 4.84 4.16 Side effect Times 1 7 Infection Times 0 0 Scar Marks Minor Severe Validation Superior Inferior Remarks Maximum scale of 6 points BIOPOL GLOBAL CO., LTD. Ⅲ. Product Information Test 1) Femoral region : Wound surface applied and the result 7days later (Left: Smith & Nephew’s ALLEVYN Right : MEDIFOAM) 7days later Test 2) Femoral region : Donor site applied and the result 4days later (Above : Medifoam, Below : Smith & Nephew’s ALLEVYN ) 4days later BIOPOL GLOBAL CO., LTD. Ⅲ. Product Information Clinical Test (2) (2) Hankang Sungshim Hospital (Prof. Kim,J.H) – refer to photos and appendix2 ※ Comparison test between Medifoam and Vaseline gauze was performed. ※ 70 patients participated. Contents Medifoam Vaseline Gauze 9.7 14.5 Scar marks Minor Severe Sharp pains Non Severe 0 7 Superior Inferior Period Infection Validation Unit Day Person Remarks BIOPOL GLOBAL CO., LTD. Ⅲ. Product Information Test 1) The femoral region : Wound Surface applied and the result as time passed (Above : Medifoam, Below : Vaseline gauze) BIOPOL GLOBAL CO., LTD. Ⅲ. Product Information Test 2) The femoral region : Wound Surface applied and the result as time passed (Above : Medifoam, Below : Vaseline gauze) BIOPOL GLOBAL CO., LTD. Ⅲ. Product Information Clinical Trials (Seoul National University Hospital) Ex. 1) Femoral region : Wound Surface & Dressing (Left: Smith & Nephew’s ALLEVYN , Right : Medifoam-5T) 3 days 7 days(1) 7 days(2) BIOPOL GLOBAL CO., LTD. Ⅲ. Product Information Clinical Trials (Seoul National University Hospital) Ex.2) 2mm thickness MEDIFOAM – Applied on the scar face ① ② ③ ④ 6 days 9 days BIOPOL GLOBAL CO., LTD. Ⅲ. Product Information Animal Test 1week The wound has reduced to 55% of the beginning 2weeks The wound has reduced to 25% of the beginning Beginning 1 week later 2 weeks later 2weeks The wound has reduced to 50% of the beginning BIOPOL GLOBAL CO., LTD. Ⅲ. Product Information MEDIFOAM B MEDIFOAM B is a porous, single layered and hydrophilic polyurethane foam dressing which fulfill many requirements. It has higher handling capacity(~ 1,500%) and provide perfect moisture wound healing environment by not allowing maceration of the wound or the peri-skin. It does not adhere to the wound surface and it does not release any particle or toxic component into the wound site. MEDIFOAM B is very comfortable on the skin and provides both excellent cushioning and protecting effects on the wound surface. BIOPOL GLOBAL CO., LTD. Ⅲ. Product Information MEDIFOAM B Absorption Layer ▶ Easy to apply and conform to body contours and flexes with movement ▶ Leave no particles on the wound surface due to the great mechanical properties ▶ High absorption and retention of body fluid and blood Ex.1) Clinical trials of MEDIFOAM B BIOPOL GLOBAL CO., LTD. Ⅲ. Product Information MEDIFOAM B † Usage 1) Covering Usage (Burns) ① Disinfect the wound site ② Cover with MEDIFOAM B ③ Fix the MEDIFOAM B with the secondary dressing 2) Filling Usage (Cavity wound) ① Disinfect the wound site ② Fill the MEDIFOAM B in the cavity ③ Cover and fix with the secondary dressing over the wound BIOPOL GLOBAL CO., LTD. Ⅲ. Product Information MEDIFOAM B † Physical Properties BIOPOL GLOBAL CO., LTD. Ⅳ. Appendix Appendix 1 THE EFFECTS OF MEDIFOAM(HYDROPHILIC POLYURETHANE FOAM) DRESSING IN SPLIT THICKNESS SKIN DONOR SITE By Young oh Park, M.D., Kyung won Min, M.D. Department of Plastic and Reconstruction Surgery, College of Medicine, Seoul National University, Seoul, Korea The purpose of our study is to evaluate the effects of occlusive wet dressing by using hydrophilic polyurethane foam, MEDIFOAM ®, in the management of donor sites of split thickness skin graft. The outer layer of MEDIFOAM ® is made of a polyurethane film, which is impermeable to water and microorganisms. It provides moist wound environment and effective bacterial barrier. The middle layer is polyurethane foam, absorption layer. It’s swelling ratio is 1020% and the layer contains wound healing promoters. Inner layer is polyurethane film, which has micro pores whose size are below 20㎛. It protects to epithelial growth into the pore. Ⅳ. Appendix We perform half side test to compare MEDIFOAM ® to Allevyn(the hydrocellular dressing materials). We parted STSG donor site into Allevyn ® dressing site, and MEDIFOAM ® dressing site in random fashion. This study was performed in Seoul National University Hospital from April 2001 till August 2001 with 32 patients, who need to skin graft. We investigated about pain, comfort, healing, and time for complete healing. The MEDIFOAM ® dressed site had less pain, more comfortable, easier handling and more rapid wound healing. The average healing time of MEDIFOAM is 9.3751.930 days and AHD is 12.625 1.862 days(p<0.001) So we conclude that occlusive dressing with MEDIFOAM ® is an effective dressing method in split thickness skin graft donor site, and we expect that it is also effective dressing material in many other wounds. BIOPOL GLOBAL CO., LTD. Ⅳ. Appendix Appendix 2 THE TREATMENT OF DONOR SITES WOUND USING FOAM DRESSING MATERIAL By Jong hyun Kim, M.D., Youb nam Koong, M.D., Dong kun Kim, M.D., Yoon kyu Park, M.D. Department of Surgery, College of Medicine, Hallym University, Seoul, Korea Backgrounds ; Foam dressings are nonlinting and absorbent. They vary in thickness and have a nonadherent layer that provides nontraumatic removal. Foams creates a moist environment and provide thermal insulation to the wound. General characteristics of dressings include ; nonadherent, may repel contaminants, easy to apply and remove, absorb light to heavy amounts of exudates, and may be used under compression. Foam dressings may be used as primary and secondary dressings for wounds with minimal moderate: or heavy drainage : as a primary dressing to provide adsorption and insulation; or as a secondary dressing for wounds with packing. They also may be used to absorb drainage around tubes. Foams may not be effective for wounds with dry Escher. They may macerate peri-wound skin if they become saturated. The purpose of this clinical study was to evaluate its efficacy as a donor-site dressing for thermally injured patients. Ⅳ. Appendix Methods ; We have analyzed 80 burned patients requiring split-skin graft. We covered one side of each donor site with hydrophilic polyurethane foam dressing. Medifoam® (Treatment group), the other half with Vaseline gauze (control group). All grafts were removed using a Zimmer dermatome set to cut at a thickness 0.005-0.010 inches. After hemostasis had been obtained, each donor site was covered with the polyurethane foam dressing and the Vaseline gauze. At 2 days postoperatively, the dressing were removed (first opening) and then the donor sites was observed daily until epithlization was complete, or until a complication developed that required discontinuance of the study. We examined donor site about epithelization, discharge, infection, scar formation, color and pain. Results ; Eighty patients had their donor sites heal without severe complication in a mean time (for complete healing) of 9.7 days for polyurethane foam areas, and 14.5 days for fine mesh Vaseline gauze dressings. In seven cases, superficial wound infection occurred in control group. Treatment group had more clean wound surface because of absorption of discharge, no hematoma, no infection, no pain. Treatment group were healed with evenly, homogenously, and hypopigmentation compared with control group. Conclusion ; Polyurethane foam dressing improved epidermal wound healing by providing a moist environment for enhanced epidermal cell migration and shortened the donor site healing time. BIOPOL GLOBAL CO., LTD. Ⅳ. Appendix Appendix 3 CE Mark EN 46001 ISO 9001 BIOPOL GLOBAL CO., LTD. Awards Korea Prime Minister (Gold) awarding in INOtech-Show2002 The Best of the Leading Venture Company BIOPOL GLOBAL CO., LTD. Comparison Test Comparison Test – Explanation of each graph 1) Fluid Handing Test (Water absorptivity (% or g/㎤)) - To measure the water absorption capability of sample, pre-weighed dry sample was immersed in distilled water for 24h. After the bulk water was removed by placing the absorbent paper, the weight of wet sample was measured. The procedure was repeated with 5 different pieces of same foam. Then, the water absorptivity was determined according to the following equation: Water absorptivity (%) = (WS - Wo) / Wo × 100 Water absorptivity (g/cm3) = (Ws - Wo)/WoⅩdensity (g/cm3) Where Ws = weight of water absorbed sample Wo = weight of dry sample 2) MVTR (Moisture Vapor Transmission Rate, g/㎡/day) - A ASTM E96-95 method (CaCl2 or Desiccant Method ) was used to determine MVTR by measuring the rate of change of mass in a CaCl2 filled test dish on which the dressing was mounted. The test dishes (maximum of five) were placed on a platform within an incubator set at 37±0.5℃ and maintained at a relative humidity of 85±2% using a water. Periodic weightings determine the rate of water vapor movement through the specimen into the desiccant. MVTR was calculated at a given time interval by the following method. MVTR = ( m / △t) · 24 / A (g/㎡/day) Where m = mass of water absorbing over the specified time interval (g) △t = time interval (h) and A = the effective transfer area. - MVTR were determined according to the ASTM Method E96-90, Procedure D (Inverted Cup Method). Evaporation of water through the test sample was monitored by measurement of loss of weight of the cup. The condition on the incubator were approximately 35±0.5 ℃ and 50±5% RH. BIOPOL GLOBAL CO., LTD. Comparison Test Comparison Test - Explanation of each graph 3) Vertical wicking rate (minutes) - The vertical wicking rate test measures the time taken for a colored test liquid from a reservoir to wick a vertical distance of 5cm through a test strip of foam of specified size when the test is performed at 37℃. 4) Vertical wicking absorbent distance (cm) - The vertical wicking absorbent distance test is carried out in conjunction with the vertical wicking rate test. Vertical wicking absorbent distance measures the vertical distance that is wicked to vertical section of the same standard size foam sample used in the vertical wicking rate test. Such a determination is generally made after the sample has been allowed to vertically wick test fluid to equilibrium. 5) Surface water absorbing rate in wound contact layer (sec) - Time for drop wetting (sec). BIOPOL GLOBAL CO., LTD. Gauze OpSite Tegaderm IV3000 Biofilm Comfeel DuoDerm Seasorb Curasorb Biatain Allevyn Medifoam B Medifoam Absorptivity(g/cm 2) Comparison Test Comparison Test (1) - Absorption Capability 2.5 2 1.5 1 0.5 0 BIOPOL GLOBAL CO., LTD. Comparison Test Comparison Test (2) - MTVR (= Moisture Vapor Transmission Rate, g/㎡/day) 4000 3000 2000 1000 OpSite Tegaderm IV3000 Comfeel DuoDerm Seasorb Kaltostat Curasorb Biatain Allevyn Medifoam B 0 Medifoam MVTR(g/m2/day) 5000 BIOPOL GLOBAL CO., LTD. Comparison Test 60 40 20 Gauze Biofilm Seasorb Kaltostat Curasorb Biatain Allevyn Medifoam B 0 Medifoam Vertical Wicking Rate(min) Comparison Test (3) - Vertical wicking rate (minutes) BIOPOL GLOBAL CO., LTD. Comparison Test 15 10 5 Gauze Biofilm Seasorb Kaltostat Curasorb Biatain Allevyn Medifoam B 0 Medifoam Vertical Wicking Absorbent Distance(cm) Comparison Test (4) - Vertical wicking absorbent distance (cm) BIOPOL GLOBAL CO., LTD. Gauze OpSite Tegaderm IV3000 Biofilm Comfeel DuoDerm Seasorb Kaltostat Curasorb Biatain Allevyn Medifoam B Medifoam Maximum Percent Strain(%) Comparison Test Comparison Test (5) – Maximum Percent Strain (%) 500 400 300 200 100 0 BIOPOL GLOBAL CO., LTD. Comparison Test Comparison Test (6) – Absorbing Rate in Wound Contact Layer (Sec) 580 560 40 30 20 10 Gauze Seasorb Kaltostat Curasorb Biatain Allevyn Medifoam B 0 Medifoam Absorbing Rate in Wound Contact Layer (sec) 600 BIOPOL GLOBAL CO., LTD. Gauze Opsite Tegaderm IV3000 Biofilm Comfeel DuoDERM Seasorb Kaltostat Curasorb Biatain Allevyn Medifoam B Medifoam 2 Tensile Strength(kgf/cm ) Comparison Test Comparison Test (7) – Tensile Strength (kgf/2gm) 13 12 6 5 4 3 2 1 0 BIOPOL GLOBAL CO., LTD. BIOPOL GLOBAL CO., LTD Add.: 1409, Hanseo Building, 11-11, Yeoido-dong, Yeongdeungpo-gu, Seoul, Korea 150-746 Tel. : 822 785 7270 Fax : 822 785 7279 H/page : http://www.biopolglobal.com E-mail : hchong@biopolglobal.com (H.C.Hong / President) jetaro@biopolglobal.com(Jetaro, Assist Man. In Overseas Sales ) s.young@biopolglobal.com (S.Young / Assist Man. In Overseas Sales ) Here and Now, We create the future !! BIOPOL GLOBAL CO., LTD.