Suggested guidelines for appropriate patient selection for patients undergoing Accelerated Partial Breast Irradiation at DMC. Tonya Echols Cole, MD Patient Evaluation • Multidisciplinary; before surgery – Breast Surgeon – Radiation Oncologist – Medical Oncologists Types of APBI • Interstitial • Intraoperative – Electron – 50 Kv • Balloon cavitary – Mammosite – Contura – Savi • External Beam – 3D conformal – IMRT Current Guidelines- Old • • • • • ASBS - 2005 ABS - 2007 European Collaborative Group - 2009 ACRO - 2008 ASTRO- 2009 Additional Studies • At least 5 randomized trials – Short follow-up – Outdated or nonstandard technique – Lack of power • At least 41 non randomized trials – Many with at least 10 year follow-up Clinical Trial Results • ASBS Mammosite Registry Trial – 44 month follow-up on first 400 cases. – Cancer specific survival of 100% – Local recurrence rate between 0-2.65% • DCIS Phase II Clinical Study – 15 month follow-up on 100 patients – 3% local recurrence rate ACCELERATED PARTIAL BREAST RADIATION RECURRENCE RATE STUDY (QI 2013 4-6) TONYA ECHOLS COLE, MD & TERRI RICHARDSON, RHIA,CTR Retrospective review of 330 analytic cases of breast cancer treated with accelerated partial breast irradiation from 2006 to present • 330 APBI procedure • 72% (239) were invasive • 28% (91) were DCIS Recurrences • • • • • 14 total recurrences ( 4.2%) 7 Local (2.1%) 3 Regional (0.9%) 4 Distant (1.2%) Median time to recurrence was 53 months Local Recurrences 7 local recurrences 2.1% recurrence rate All patients were >50 yrs. old All tumors <3cm 3 were DCIS or 3/91 or 3.3% 2 of the 3 did not take Tamoxifen (pt. refusal or medically contraindicated.) All were ER+ 4 were invasive 4/239 or 1.7% 1 was triple negative 2 were triple + Regional Recurrences • 3 regional recurrences 3/330 ( 0.9%) – All invasive cancer <3cm – All >60 yrs. old – 2 were triple -, 1ER+, Her2+ – All had 3 lymph nodes examined Distant recurrences • 4 Distant recurrences 4/330 (1.2%) • 75% ¾ were invasive – All >50 yrs. old – All tumors <3cm – All were ER+ • All received hormonal therapy • 1 received chemotherapy • 25% (1/4) DCIS – Was ER - Conclusions • Local recurrence rates for patients treated with accelerated partial breast radiation therapy at DMC are comparable to published data. • There was no group or subset found to be at increased risk of recurrence. Acceptable • • • • • • • Age > 50 Size < 3 cm Histology ER Margins LVI Nodal status All invasive subtypes and DCIS Positive or negative Negative Not present negative Not acceptable Outside of a clinical Trial • Node positive • Tumors > 3cm including DCIS • Extensive LVSI • Neoadjuvant chemo • Age <45 • Multicentric • Microscopically multifocal >3cm • EIC > 3cm • Margins + • Nodal surgery- not performed. • BRCA + Future Directions • Recommendations should be updated annually as new results from prospective randomized trials are released.