Objectives
1. Analyze how changes in the environment will impact the
interactions of subcellular structures (organelles), each of which
possess specialized functions and provide essential functions for the
eukaryotic cell.
2. Predict the interactions between subcellular organelles.
3. Construct explanations and resolutions based on scientific evidence
as to how interactions of subcellular structures provide essential
functions.
The Problem
Jason Hornbuckle is not a happy little boy. For the past 12 hours, he has
complained of pain when he swallows, has a headache, and has vomited
twice. His mother decides to take him to the pediatrician. Upon
examining Jason, the doctor finds that Jason’s pharynx, tonsils and uvula
are swollen and red, he has a fever, and has enlarged lymph nodes.
A complete blood count is performed on a sample of Jason’s blood
reveals that he has leukocytosis, an increased number of white blood
cells, due to an increase in the number of neutrophils. A throat swab
taken indicates an infection by beta-hemolytic streptococci.
As a neutrophil, how will your organelles respond and what role will
you play in the resolution of this bacterial infection.
Speakers List
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
Overall
Speaker
Unmoderated Caucus
Moderated Caucus
Overall
Speaker
Jason Hornbuckle: Health Update 2:30pm
Jason Hornbuckle’s temperature is rising. Over the past hour, his fever
has risen to 108°C, well past what is considered safe. As a result of his
elevated fever, Jason is becoming agitated and confused.
Moreover, recent blood samples indicate that the infection is no longer
confined to his pharynx, tonsils and uvula, but has spread through his
bloodstream and now a systemic infection. His elevated levels of the
cytokine IL-1β indicate that his immune system has boosted its
inflammatory response, thus causing his elevated temperature.
As a neutrophil, how will your organelles respond and what role will
you play in the resolution of this bacterial infection.
Unmoderated Caucus
Moderated Caucus
Overall
Speaker
Jason Hornbuckle: Health Update 3:00pm
Jason Hornbuckle’s has become unresponsive and can no longer
respond to verbal or physical cues. The elevated temperature.
Jason’s IL-1β levels continue to increase to dangerous levels, threatening
to lead to sepsis, a whole-body inflammatory state which results in
blood poisoning. Doctor’s have begun administering beta-blockers to
try and slow the effects of IL-1β. However, this IL-1β inhibitor is a
competitive inhibitor and accordingly its effects can be overcome by an
increase in the amount of substrate. If Jason’s IL-1β levels continue to
rise, the medication will have no effect.
As a neutrophil, how will your organelles respond and what role will
you play in the resolution of this bacterial infection.
Unmoderated Caucus
Moderated Caucus
Overall
Speaker
Jason Hornbuckle: Health Update 3:20pm
Jason Hornbuckle’s has passed out and entered a coma as a result of his
prolonged elevated temperature.
Jason’s IL-1β levels have overcome the effect of the IL-1β inhibitors, and
the elevated levels of IL-1β has activated the inflammasome – a
multiprotein complex that activates the apoptosis pathway. As a result
of the activity of the inflammasome and entering a state of sepsis,
Jason’s tissues and organs are beginning to fail as the cells begin
undergoing programmed cell death.
As a neutrophil, how will your organelles respond and what role will
you play in the resolution of this bacterial infection.
Unmoderated Caucus
Moderated Caucus
Overall
Speaker
The Solution?
The United Organelles has moved to a vote, and the delegates have
voted to accept a resolution.
The dias will now deliberate to determine whether or not this resolution
represents an appropriate response to Jason’s bacterial infection and
condition.
Resolution
Accepted
Resolution
Denied
Cured!
In addition to your work, Jason is also treated with phenoxylmethyl for 5
days. After three days of treatment, Jason’s temperature has returned to
normal and he has made an eventful recovery.
Death
Despite your best efforts, Jason’s bacterial infection could not be
cleared. After reaching a temperature of 108°F, Jason became agitated
and confused, and shortly thereafter entered a coma . Additionally,
Jason’s whole body entered a systemic inflammatory state, known as
sepsis, which resulted in blood poisoning resulting in organ dysfunction
and failure.
Organelle Delegations: HBio Lab 1
Organelle
Delegation
Student 1
Student 2
Student 3
Nucleus
Grace A.
Starkwan B.
KieshaK.
Smooth ER
Nyjeera A.
Serron B.
Rough ER
Tiye W.
Darian M.
Marcus D.
Golgi Apparatus
Ebony F.
Timothy F.
Kelechi A.
Cell Membrane
Michelle K.
Tatyana W.
Mitochondria
Kayla M.
Kaitlin B.
Lysosomes
Prince U.
Aquill R.
Alicia Y.
Organelle Delegations: HBio Lab 2
Organelle
Delegation
Student 1
Student 2
Student 3
Nucleus
Edward A.
Reinaldo C.
Dalila D.
Ribosomes
Sally A.
Amir B.
Karla C.
Smooth ER
Jonathan A.
Jessica D.
Tiaja H.
Rough ER
Janeris H.
Shanice M.
Sandra O.F.
Golgi Apparatus
Terrell H.
Nicole M.
Cristina T.
Cell Membrane
Charisma L.
Safiyyah M.
Camari S.
Mitochondria
Nicole R.
Sierra S.
Michelle Y.
Lysosomes
Eboni C.
Hannah J.
Simani B.
Jennifer C.
Central Vacuole
Chijoke U.
Bria W.
Al-Tiyanah W.
Organelle Delegations: HBio Lab 3
Organelle
Delegation
Student 1
Student 2
Nucleus
Ixhon A.
Timothy W.
Ribosomes
Tyrique D.
Ramon W.
Rough ER
Daree F.
Christian I.
Golgi Apparatus
Shykiia M.
Dominant W.
Cell Membrane
Andres M.
Andrew R.
Mitochondria
Anjel P.
CJ N.
Lysosomes
Tanasjwa S.
Yemi O.
Student 3
Stephanie C.