BLOOD NET - Update
Montreal, 2011
BLOOD NET
• Name change from TRICKS
• Pediatric Blood Research Network
– BLOOD NET
• Formed 2-3 years ago as subgroup of PALISI
– Meet 4 X yr
– 47 members
• Unfunded – Self Funded Network
BLOOD NET – Research Focus
• How blood becomes dysfunctional with critical
illness
– RBC vasoregulation
– Hemostasis
• How transfusion may affect outcomes
– Storage Lesion
– Immunology/infection risk
BLOOD NET Goals
• Support/Perform Multidisciplinary Blood Related
Research in Critically Ill Children
– Development
• Encourage/Motivate/stimulate ideas
• Study Design/Methods
• Identify Funding Sources
– Completion
• Site recruitment
– Analysis
• Data Analysis and Manuscript preparation
BLOOD NET-Leadership
• Steering Committee
– Phil Spinella (Chair), Marisa Tucci (Vice-Chair),
Jacques Lacroix, Marie Steiner, Allan Doctor,
Cassandra Josephson
• Scientific Review Committee
– Steering Committee
– Christopher Silliman, Neil Blumberg, Philip Norris,
Mark Hall
BLOOD NET Sub-Groups
• Transfusion Outcomes
– Tucci and Spinella
• Transfusion Immunology
– Mark Hall
• Thrombosis and Coagulation Monitoring
– Sheila Hanson
– Marie Steiner
– Vince Faustino
BLOOD NET Productivity
• 7 Manuscripts
• 9 Studies in development/ongoing
• 10 million – extramural funding
Manuscripts Published
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Cholette JM , et al. Washing blood cells transfused in open heart surgery reduces postoperative inflammation and transfusion requirements: Results of a prospective, randomized
controlled trial. In Press
Cholette JM, et al. Children with single-ventricle physiology do not benefit from higher
hemoglobin levels post cavopulmonary connection: results of a prospective, randomized,
controlled trial of a restrictive versus liberal red-cell transfusion strategy. Pediatr Crit Care
Med. 2011 Jan;12(1):39-45
Spinella PC, Dressler A, Tucci M, Carroll CL, Sanchez R, Hume H, Sloan S, Lacroix J. Survey of
Transfusion Policies at US and Canadian Children’s Hospitals in 2008 and 2009. Transfusion. E
pub 2010 May 28.
France Gauvin, Philip C. Spinella, Jacques Lacroix, Ghassan Choker, Thierry Ducruet, Oliver
Karam, Paul C. Hébert, James S. Hutchison, Heather A. Hume, Marisa Tucci. Association
between length of storage of transfused red blood cells and multiple organ dysfunction
syndrome in pediatric intensive care patients. Transfusion. E pub 2010 Apr 30.
Karam O, Tucci M, Bateman ST, Ducruet T, Spinella PC, Randolph AG, Lacroix J. Association
between length of storage of red blood cell units and outcome of critically ill children. Crit
Care. 2010 Apr 8;14(2):R57.
Transfusion Outcomes Group
• ARMS and MARS
– Mechanistic & Repository Studies to Age of Blood RCTs (ABLE and RESTORE)
– 1 RO1, 2 DOD grants, supplemental $ via TMH network ($10M in funding)
• Blood Conservation Implementation
– York/Doctor/Spinella
• Survey of Plasma Transfusion Practice Patterns
– Oliver Karam
Transfusion Outcomes Group
• Transfusion epidemiology and impact of interaction
between blood products
– Jacques Lacriox, Marisa Tucci & Helen Trottier
• Transfusion Outcomes Data Platform
– Hanson and Spinella
• ABC study (Tucci/Spinella/Lacroix)
– CIHR proposal submitted Sept 2011
– IND FDA approved Oct 2011
– RO1 to NHLBI Feb 2012
Transfusion Outcomes Group
• Efficacy of Blood Conservation Program in Spinal
Surgery
– Nabil Hassan
• Role of vWF and ADAMTS13 in surgical blood loss.
– Surrender Rajasekaran
Transfusion Immunology
• Transfusion and storage duration effect on monocyte
and T-cell function
– Hall and Muszinsky
• EBV Transmission via Transfusion to HSCT patients
– Helen Trottier
• Transfusion Associated Microchimerism - R21
– Spinella
Thrombosis and Coagulation Monitoring
• Incidence and outcomes for catheter related
DVT
– Faustino (Completed)
• Post thrombotic syndrome in children with CHD
post cath
– Faustino (Partial funding by AHA)
• Thromboprophylactic Prevalence (PROTRACT)
– Faustino
– Prospective Observational Practice Study
– 70 International Centers
Thrombosis and Coagulation
Monitoring
• Incidence of ASA resistance in cardiac surgery pts
– Truong/Spinella
• COAgulation in Sepsis and Trauma (COAST) Study
– Incidence of hypercoagulation in Sepsis and Trauma patients
– Hanson/Steiner/Spinella
• Anticoagulation effectiveness according to clot
strength (TEG)
– Spinella
BLOOD NET Extramural Activities
• NIH/NHLBI Transfusion Brach
– Comparative effectiveness symposium
– RBC age mechanism and clinical trials symposium
• Best Pharmaceutical for Children’s Act (BCPA)
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Society for Advancement of Blood Management
Norwegian Navy Blood Research Program
US Army Blood Research Program
Industry Sponsored Trials
– Alternative Plasma Products, WBC/pathogen inactivation
BLOOD NET
– It’s an Offer You Can’t Refuse
spinella_p@kids.wustl.edu
marisa.tucci@recherche-ste-justine.qc.ca