Learning Objectives • Convince you that efforts to improve nutrition in the ICU are worthwhile • Familiarize you with the recommendations of the Canadian Critical Care Nutrition Clinical Practice Guidelines • Make you aware of current nutrition practices in ICUs in your own geographic region and throughout the world • Enable you to identify gaps between guideline recommendations and current practices in ICUs • Provide tools to begin to narrow that GAP! EN Intake kcal Underlying Pathophysiology Of Critical Illness Prescribed Engergy 2000 1800 1600 1400 1200 1000 800 600 400 200 0 Energy Received From Enteral Feed Caloric Debt 1 3 5 7 9 11 13 15 17 19 21 Days Caloric debt associated with: Longer ICU stay Days on mechanical ventilation Complications Mortality Rubinson CCM 2004; Villet Clin Nutr 2005; Dvir Clin Nutr 2006; Petros Clin Nutr 2006 • Point prevalence survey of nutrition practices in ICU’s around the world conducted Jan. 27, 2007 • Enrolled 2772 patients from 158 ICU’s over 5 continents • Included ventilated adult patients who remained in ICU >72 hours Hypothesis • There is a relationship between amount of energy and protein received and clinical outcomes (mortality and # of days on ventilator) • The relationship is influenced by nutritional risk • BMI is used to define chronic nutritional risk What Study Patients Actually Rec’d • Average Calories in all groups: – 1034 kcals and 47 gm of protein Result: • Average caloric deficit in Lean Pts: – 7500kcal/10days • Average caloric deficit in Severely Obese: – 12000kcal/10days Relationship Between Increased Calories and 60 day Mortality BMI Group P-value Odds 95% Ratio Confidence Limits Overall 0.76 0.61 0.95 0.014 <20 0.52 0.29 0.95 0.033 20-<25 0.62 0.44 0.88 0.007 25-<30 1.05 0.75 1.49 0.768 30-<35 1.04 0.64 1.68 0.889 35-<40 0.36 0.16 0.80 0.012 >=40 0.63 0.32 1.24 0.180 Legend: Odds of 60-day Mortality per 1000 kcals received per day adjusting for nutrition days, BMI, age, admission category, admission diagnosis and APACHE II score. Relationship of Caloric Intake, 60 day Mortality and BMI 60 BMI All Patients < 20 20-25 25-30 30-35 35-40 >40 Mortality (%) 50 40 30 20 10 0 0 500 1000 1500 Calories Delivered 2000 Relationship Between Increased Energy and Ventilator-Free days Adjusted 95% CI BMI Group P-value Estimate LCL UCL Overall 3.5 1.2 5.9 0.003 <20 2.8 -2.9 8.5 0.337 20-<25 4.7 1.5 7.8 0.004 25-<30 0.1 -3.0 3.2 0.958 30-<35 -1.5 -5.8 2.9 0.508 35-<40 8.7 2.0 15.3 0.011 >=40 6.4 -0.1 12.8 0.053 Legend: # of VFD per 1000 kcals received per day adjusting for nutrition days, BMI, age, admission category, admission diagnosis and APACHE II score. Effect of Increasing Amounts of Calories from EN on Infectious Complications Multicenter observational study of 207 patients >72 hrs in ICU followed prospectively for development of infection for increase of 1000 cal/day, OR of infection at 28 days Heyland Clinical Nutrition 2010 Effect of Increasing Amounts of Protein from EN on Infectious Complications Multicenter observational study of 207 patients >72 hrs in ICU followed prospectively for development of infection for increase of 30 gram/day, OR of infection at 28 days Heyland Clinical Nutrition 2010 Relationship between increased nutrition intake and physical function (as defined by SF-36 scores) following critical illness Multicenter RCT of glutamine and antioxidants (REDOXS Study) First 364 patients with SF 36 at 3 months and/or 6 months Model * Estimate (CI) P values PHYSICAL FUNCTIONING (PF) at 3 months 3.2 (-1.0, 7.3) P=0.14 ROLE PHYSICAL (RP) at 3 months 4.2 (-0.0, 8.5) P=0.05 (A) Increased energy intake for STANDARDIZED PHYSICAL COMPONENT 1.8 (0.3, 3.4) SCALE (PCS) at 3 months P=0.02 PHYSICAL FUNCTIONING (PF) at 6 months 0.8 (-3.6, 5.1) P=0.73 ROLE PHYSICAL (RP) at 6 months 2.0 (-2.5, 6.5) P=0.38 STANDARDIZED PHYSICAL COMPONENT 0.70 (-1.0, 2.4) P=0.41 SCALE (PCS) at 6gram/day, months increase of 30 OR of infection at 28 days Heyland Unpublished Data Mechancially Vent’d patients >7days (average ICU LOS 28 days) Faisy BJN 2009;101:1079 Permissive Underfeeding (Starvation)? 187 critically ill patients Tertiles according to ACCP recommended levels of caloric intake Highest tertile (>66% recommended calories) vs. Lowest tertile (<33% recommended calories) in hospital mortality Discharge from ICU breathing spontaneously Middle tertile (33-65% recommended calories) vs. lowest tertile Discharge from ICU breathing spontaneously Krishnan et al Chest 2003 Optimal Amount of Calories for Critically Ill Patients: Depends on how you slice the cake! • Objective: To examine the relationship between the amount of calories administered and mortality using various sample restriction and statistical adjustment techniques and demonstrate the influence of the analytic approach on the results. • Design: Prospective, multi-institutional audit • Setting: 352 Intensive Care Units (ICUs) from 33 countries. • Patients: 7,872 mechanically ventilated, critically ill patients who remained in ICU for at least 96 hours. Heyland Crit Care Med 2011 (in press) Optimal Amount of Calories for Critically Ill Patients: Depends on how you slice the cake! • Sample restriction approaches have included limiting analyzed patients to those: 1. 2. 3. • In the ICU for at least 96 hours, In the ICU at least 96 hours prior to progression to exclusive oral feeding and Eliminating days after progression to exclusive oral feeding from the calculation of nutrition intake. Statistical adjustment approaches have included using regression techniques to adjust for: 1. 2. 3. ICU length of stay (LOS), Evaluable nutrition days and Relevant baseline patient characteristics or some combination thereof. Heyland Crit Care Med 2011 (in press) Association between 12 day average caloric adequacy and 60 day hospital mortality A. In ICU for at least 96 hours. Days after permanent progression to exclusive oral feeding are included as zero calories* B. In ICU for at least 96 hours. Days after permanent progression to exclusive oral feeding are excluded from average adequacy calculation.* Unadjusted Adjusted C. In ICU for at least 4 days before permanent progression to exclusive oral feeding. Days after permanent progression to exclusive oral feeding are excluded from average adequacy calculation.* >2/3 Unadjusted >2/3 Adjusted 1/3-2/3 Unadjusted 1/3-2/3 Adjusted D. In ICU at least 12 days prior to permanent progression to exclusive oral feeding* 0.4 0.6 0.8 1.0 1.2 1.4 1.6 Odds ratios with 95% confidence intervals Adjusted for evaluable days and covariates,covariates include region (Canada, Australia and New Zealand, USA, Europe and South Africa, Latin America, Asia), admission category (medical, surgical), APACHE II score, age, gender and BMI. Association Between 12-day Caloric Adequacy and 60-Day Hospital Mortality Quality Improvement Target More is Better! If you feed them (better!) They will leave (sooner!) ICU patients are not all created equal…should we expect the impact of nutrition therapy to be the same across all patients? Trophic vs. Full enteral feeding in critically ill patients with acute respiratory failure • Single center study of 200 mechanically ventilated patients • Trophic feeds: 10 ml/hr x 5 days Rice CCM 2011;39:967 Trophic vs. Full enteral feeding in critically ill patients with acute respiratory failure No difference between groups! Didn’t measure infection nor physical function Rice CCM 2011;39:967 Trophic vs. Full enteral feeding in critically ill patients with acute respiratory failure • • • • • Average age 51 Few comorbidities Average BMI 29 All fed within 24 hrs (benefits of early EN) Average duration of study intervention 5 days No effect in young, healthy, overweight patients who have short stays! Large multicenter trial of this concept (EDEN study) by ARDSNET just finished ICU patients are not all created equal…should we expect the impact of nutrition therapy to be the same across all patients? RCT Level of Evidence that More EN= Improved Outcomes RCTs of aggressive feeding protocols Results in better protein-energy intake Associated with reduced complications and improved survival Taylor et al Crit Care Med 1999; Martin CMAJ 2004 Meta-analysis of Early vs Delayed EN Reduced infections: RR 0.76 (.59,0.98),p=0.04 Reduced Mortality: RR 0.68 (0.46, 1.01) p=0.06 www.criticalcarenutrition.com More (and Earlier) is Better! If you feed them (better!) They will leave (sooner!) Objectives of International Survey Quality Improvement • To determine current nutrition practice in the adult critical care setting (overall and subgroups) • Illuminate gaps between best practice and current practice • To identify nutrition practices to target for quality improvement initiatives Generate New Knowledge • To determine factors associated with optimal provision of nutrition • To determine what nutrition practices are associated with best clinical outcomes History of International Surveys • 3 previous surveys in Canada – 2001, 2003, 2004 – N > 50 • Extended to other countries – Focus on North America in 2007 (n=167) – Focus on Australasia in 2008 (n=169) – Focus back on North America in 2009 (n=172) • 2011, Focus on Latin America Methods Eligibility Criteria • ICU Site – >8 beds – Availability of individual with knowledge of clinical nutrition to collect data • Patient – In ICU > 72 hours – Mechanically ventilated within 48 hours Methods • Prospective observational cohort study • Start date: 16th September 2009 • Aim 20 consecutive patients – Min 8 pts • Data included: – Hospital and ICU demographics – Patient baseline information (e.g. age, admission diagnosis, APACHE II) – Baseline Nutrition Assessment – 12 days Daily Nutrition data (e.g. type of NS, amount NS received) – 60 day hospital outcomes (e.g. mortality, length of stay) Web based Data Capture System Benchmarking Individual ICUs compared to: •Canadian Clinical Practice Guidelines •All ICUs •ICUs from same geographic region Early vs Delayed Nutrition Intake • Recommendations: Based on 8 level 2 studies, we recommend early enteral nutrition (within 24-48 hrs following resuscitation) in critically ill patients. Time to Initiation of EN (hrs) 120 100 80 Site Maximum Minimum Median 60 40 20 0 Your site All sites Sister sites Who participated in 2009? : 157 ICUs Canada: 32 Europe: 14 USA: 63 Mexico: 2 Brazil:1 Colombia:5 Peru:1 Venezuela:1 Latin America: 10 Italy: 2 UK: 7 Ireland: 2 Norway: 1 Switzerland: 1 Czech Republic: 1 Asia: 16 China: 1 Taiwan: 1 India: 10 Iran : 1 Japan: 1 Singapore: 2 Australia & New Zealand: 22 ICU Characteristics Characteristics Total (n=157) Hospital Type Teaching Non-teaching Size of Hospital (beds) Mean (Range) ICU Structure Open Closed Other Size of ICU (beds) Mean (Range) Designated Medical Director Presence of Dietitian(s) FTE Dietitians (per 10 beds) Mean (Range) 116 (73.9%) 41 (26.1%) 503 (50, 1500) 49 (31.2%) 104 (66.2%) 4 (2.6%) 19 (6, 64) 149 (94.9%) 145 (92.4%) 0.4 (0.0, 1.7) Patient Characteristics Characteristics Total n=3028 Age (years) Median [Q1,Q3] 61 [48, 73] Sex Female Male 1215 (40.1%) 1813 (59.9%) Medical Surgical: Elective Surgical: Emergency 1952 (64.5%) 366 (12.1%) 710 (23.4%) Admission Category BMI (kg|m2) Median [Q1, Q3] 26.0 [22.8, 30.8] Median [Q1, Q3] 22 [17, 28] Apache II Score Presence of ARDS Yes 413 (13.6%) Outcomes at 60 days Characteristics Length of Mechanical Ventilation (days) Median [Q1, Q3] Length of ICU Stay (days) Median [Q1, Q3] Length of Hospital Stay (days) Median [Q1,Q3] Patient Died (within 60 days) Yes Total n=2948 7.2 [3.3, 15.2] 10.3 [5.9, 19.8] 18.9[10.4, 36.7] 738(24.7%) We strongly recommend the use of enteral nutrition over parenteral nutrition Type of Artificial Nutrition PN Only 6% EN+PN 13% EN Only 71% None 10% n=3028 patients Use of EN Only 100 73.6% 93.9% 90 80 % ICU days 70 62.2% 66.7% 60 50 40 30 20 9.8% 10 0 Canada n=17567 patients days Australia and New Zealand USA Europe Latin America Asia Total Use of PN Only 50 45 40 38.6% % ICU days 35 30 25 20 15 10.0% 10 8.7% 6.6% 5 0.6% 0 Canada n=2294 patients days Australia and New Zealand USA Europe Latin America Asia Total Role of Supplemental PN We recommend that parenteral nutrition not be started at the same time as enteral nutrition. In the patient who is not tolerating adequate enteral nutrition, there are insufficient data to put forward a recommendation about when parenteral nutrition should be initiated. Practitioners will have to weigh the safety and benefits of initiating PN in patients not tolerating EN on an individual case-by-case basis. We recommend that PN not be started in critically ill patients until all strategies to maximize EN delivery (such as small bowel feeding tubes, motility agents) have been attempted. Use of EN + PN 80 72.2% 70 % ICU days 60 50 40 30 20 10 11.7% 4.4% 2.7% 0.3% 0 Canada n=1157 patients days Australia and New Zealand USA Europe Latin America Asia Total EN in Combination with PN % of patients received motility agents before PN started % received motility agents before PN started 100 90 80 70 63.2 60 50 34.6 40 30 21.4 20 10 0 Canada Australia and New Zealand USA Europe Latin America Asia Total We recommend early enteral nutrition (within 24-48 hrs following admission) in critically ill patients Timing of Initiation of EN 168 Time to Initiation of EN (hours) 144hrs 144 120 96 72 50hrs 48 41hrs 30hrs 24 9hrs 0 Canada Australia and New Zealand USA Europe Latin America Asia Total An evidence based feeding protocol should be considered as a strategy to optimize delivery of enteral nutrition Use of a Feeding Protocol Characteristics Total n=157 Feeding Protocol Yes Gastric Residual VolumeThreshold Mean (range) Algorithms included in Protocol Motility agents Small bowel feeding Withholding for procedures HOB Elevation Other 129 (82.2%) 240 (50, 500) 90 (72.6%) 69 (55.6%) 69 (55.6%) 117 (94.4%) 19 (15.3%) In critically ill patients who experience feed intolerance (high gastric residual volumes, emesis) the use of a motility agent and small bowel feeding tubes are recommended Strategies to Optimize EN Delivery: Motility Agents 100.0 100 90 86% % patients with HGRV 80 67% 70 60 46% 50 40 30 20 10 0.0 0 Canada Australia and New Zealand USA Europe Latin America Asia Total Strategies to Optimize EN Delivery: Small Bowel Feeding 100 100 90 % patients with HGRV 80 70 60 44% 50 40 30 20 12% 10 2% 0 0 Canada Australia and New Zealand USA Europe Latin America Asia Total Composition of EN and Pharmaconutrient Supplementation recommendations Arginine-supplemented formulas Recommend NOT be used Glutamine supplementation Enteral should be considered in burn and trauma Parenteral strongly recommended in PN pts Fish oil enriched formula Recommended in ARDS Combined vitamins and trace elements Should be considered Polymeric Recommend Use of EN Formula and Pharmaconutrients Arginine-supplemented formulas 8.2%(0.0%-94.7%) Glutamine supplementation (All) 5.9%(0.0%-95%) Fish oil enriched formula (ARDS) 18.9% (0.0%-100%) Selenium Supplementation (All) 3.1% (0.0%-100%) Polymeric 85.9% (0.0%-100.%) We recommend that hyperglycemia (blood sugars >10mmol/l) be avoided Blood Glucose >10 mmol/l 40 35 % patient-days 30 25 20 15.2 13.1 15 8.7 10 5 0 Canada Australia and New Zealand USA Europe Latin America Asia Total Overall Performance Adequacy of Nutrition Support = Calories received from EN + appropriate PN+Propofol Calories prescribed Overall Performance: Kcals 120 87% % received/prescribed 100 80 58% 60 40 6.8% 20 0 1 2 3 4 5 6 7 8 9 10 11 ICU Day Mean of All Sites Best Performing Site Worst Performing Site 12 Failure Rate % patients who failed to meet minimal quality targets (80% overall energy adequacy) % patients not achieve minimum of 80% over stay in ICU 100 89.0 90 80 81.1 83.8 79.4 78.2 83.6 77.8 70 60 50 40 30 20 10 0 Canada Australia and New Zealand USA Europe Latin America Asia Total Where can we do better? • Inadequate EN delivery – timing of initiation of EN – feeding protocols – small bowel feeding and motility agents • Optimize Pharmaconutrition – use of glutamine, antioxidants, omega-3 FFA. • Tighten (not tight) glycemic control How to Change? CPGs to bedside Guidelines Bedside Dissemination and Implementation Strategies Special JPEN Issue Dedicated to KT • Knowledge Translation (KT) – describes the process of moving evidence learned from clinical research and summarized in CPGs to its incorporation into clinical and policy decision-making. – defined as “a dynamic and iterative process that includes synthesis, dissemination, exchange and ethically-sound application of knowledge to improve the health of patients, provide more effective health services and products and strengthen the health care system.” – Knowledge transfer, knowledge exchange, research utilization, implementation science, dissemination, and diffusion are other terms that have been used interchangeably to describe the same concept. Nov 2010, Available online at www.criticalcarenutrition.com Understanding Adherence to Guidelines in the ICU: Development of a Comprehensive Framework CPG Characteristics ADHERENCE Patient Characteristics Implementation Process Provider Intent Institutional Factors Provider Characteristics - Profession -Critical care expertise -Educational background -Personality Hospital characteristics -Structure - Processes -Resources -Patient Case-mix Knowledge Attitudes ICU characteristics Familiarity -Structure - Processes -Resources - Patient Case-mix -Culture Awareness Agreement Outcome expectancy Motivation Self-efficacy Jones N, Suurdt J, Ouellette-Kuntz H, Heyland DK In resuscitated, hemodynamically stable patients, other aspects of patient care take… 50.0 No or not enough feeding pumps on the unit. 48.6 Enteral formula not available on the unit. 46.9 Delays and difficulties in obtaining small bowel access in patients not tolerating… 43.1 No or not enough dietitian coverage during weekends and holidays. 42.4 No feeding tube in place to start feeding. 41.4 Delay in physicians ordering the initiation of EN. 40.7 Non-ICU physicians (i.e. surgeons, gastroenterologists) requesting patients not be… 37.8 Delays in initiating motility agents in patients not tolerating enteral nutrition. 37.2 The current national guidelines for nutrition are not readily accessible. 35.2 Waiting for the dietitian to assess the patient. 34.0 Feeding being held too far in advance of procedures or operating room visits. 31.3 No feeding protocol in place to guide the initiation and progression of enteral… 31.0 Fear of adverse events due to aggressively feeding patients. 29.9 The language of the recommendations of the current national guidelines for… 29.0 Nurses failing to progress feeds as per the feeding protocol. 29.0 Not enough time dedicated to education and training on how to optimally feed… 28.0 Not enough dietitian time dedicated to the ICU during regular weekday hours. 27.8 Not enough nursing staff to deliver adequate nutrition. 23.4 Current feeding protocol is outdated. 23.4 Current scientific evidence supporting some nutrition interventions is inadequate to… 21.3 Lack of agreement among ICU team on the best nutrition plan of care for the patient. 19.3 10.0 15.0 20.0 25.0 30.0 35.0 40.0 45.0 50.0 55.0 60.0 65.0 70.0 75.0 80.0 85.0 90.0 Proportion that responded "important" or "very important" The Efficacy of Enhanced Protein-Energy Provision via the Enteral Route in Critically Ill Patients: The PEP uP Protocol! • • • • • • Different feeding options based on hemodynamic stability and suitability for high volume intragastric feeds. In select patients, we start the EN immediately at goal rate, not at 25 ml/hr. We target a 24 hour volume of EN rather than an hourly rate and provide the nurse with the latitude to increase the hourly rate to make up the 24 hour volume. Start with a semi elemental solution, progress to polymeric Tolerate higher GRV threshold (300 ml or more) Motility agents and protein supplements are started immediately, rather than started when there is a problem. A Major Paradigm Shift in How we Feed Enterally Heyland Crit Care 2010 Creating a Culture of Clinical Excellence in Critical Care Nutrition: The ‘Best of the Best’ Award Heyland DK, Heyland R, Jones N, Dhaliwal R, Day A Recognition and Reward Recognition a powerful motivator of human performance Determining the Best of the Best Determinant Overall Adequacy of EN plus appropriate PN % patients receiving EN % of patients with EN initiated within 48 hours % of patients with high gastric residual volumes (HGRV) receiving motility agents % of patients with HGRV receiving small bowel tubes % of patient glucose measurements greater than 10 mmol/L (excluding day 1; fewest is best) Rank all eligible ICUs by determinants Multiply ranking by weighting ICU with highest score is crowned ‘Best of the Best’ Weighting 10 5 3 1 1 3 Best of the Best Award • Eligible sites: Data on 20 critically ill patients Complete baseline nutrition assessment Presence of feeding protocol No missing data or outstanding queries Permit source verification by CCN • Awarded to ICU that demonstrate: Last year, 156 ICUs participated in an international audit of nutrition practices in critically ill patients. This year we want to take part. BEST OF THE BEST ADD HOSP LOGO KGH 2008 Please help us to improve our performance as it relates to nutrition in our ICU. Better nutrition therapy translates into reduced morbidity and improved survival. Highest ranking nutritional performance For more information, contact____________________ 2009 Best of the Best Of >200 ICUS competing Internationally TOP Performers 1. Instituto Neurologico de Antioquia, Medellin, Colombia 1. Royal Prince Alfred Hospital, Sydney, Australia 1. The Alfred, Melbourne, Australia Determinants to Top Performance What site and hospital characteristics are associated with top BOB ranking? (Best Rank=1rst thus a negative number is associated with a better ranking) Hospital/ICU characteristics** Ranking p values -3.0 0.61 +30.4 0.008 -7.9 0.22 India vs. Canada +32.7 0.08 Latin America vs. Canada 0.17 0.98 USA vs. Canada +30.4 <0.0001 -0.24 0.78 -0.89 0.89 -23.5 0.005 Region Australia and New Zealand vs. Canada China vs. Canada Europe and South Africa vs. Canada Hospital size (per 100 beds) ICU structure Closed vs. open or other Presence of Dietitian(s) Yes vs. No Heyland JPEN 2010 International Nutrition Survey 2011 Participate on May 11th 2011 Data on min 20 critically ill patients Complete baseline nutrition assessment No missing data or outstanding queries Permit source verification Last year, 156 ICUs participated in an international audit of nutrition practices in critically ill patients. This year we want to take part. BEST OF THE BEST ADD HOSP LOGO KGH 2008 Please help us to improve our performance as it relates to nutrition in our ICU. Better nutrition therapy translates into reduced morbidity and improved survival. Benchmarked Site Report Compare your performance to other ICUs Compare your performance to the Canadian CPGs Highlight gaps in practice and barriers to improving For more information, contact____________________ International Nutrition Survey 2011 Debriefing session with INS participants and other interested parties Today, 5 pm, SOLANA (1rst Floor, South Tower) Last year, 156 ICUs participated in an international audit of nutrition practices in critically ill patients. This year we want to take part. BEST OF THE BEST ADD HOSP LOGO KGH 2008 Please help us to improve our performance as it relates to nutrition in our ICU. Better nutrition therapy translates into reduced morbidity and improved survival. For more information, contact____________________