Mr Basim Matti FRCS London
Dr Peter Everts PhD Eindhoven, Holland
Mr Matti 31 Patients
Data Set as of 1st November 2011
PRP
PRP is an autologous blood product
with a high concentration of platelets.
The platelets produce a cocktail of
Cytokines and Growth Factors, which trigger
and accelerate the regeneration of tissues.
PRP
It is concentration of human platelets in
a small volume of plasma measured > than
1,000,000 platelets /mm³ = 4-6x the normal
Normal value of platelet concentration in
whole blood
150,000-400,000mm³
Aim Of PRP Therapy
Regeneration of collagen and Elastine
fibres
Prevention of collagen degradations
Rejuvenation of the skin
Wound healing principles
Platelet physiology
Platelet activation
Growth Factors
Platelet Rich Plasma Concentration
of Growth Factors
 PDGR – 130 times
Platelet derived Growth Factor
 TGF beta – 80 times
Transforming Growth Factor-beta.
 VEGF – 11 times
Vascular Endothelial Growth Factor
 IGF 1 Insulin like Growth Factor, HGF
Hepatocyte GF, Basic Fibroplasten GF
How Growth Factor Works
Areas for injection
Injection sites
into dermal layer
and dermal
junction
Seishin Institute
Japan.
• >12,000 patients undergone PRP
Therapy
Hyaluronic
Acid
PRP
• “NEW PRP Skin Regeneration
Therapy,
•three to five times richer in
platelets than conventional PRP
therapy
•inject platelet-rich plasma
containing white blood cells. “
http://www.saiseiiryou.com
Source: Seishin Institute Japan
Cytomedix Angel System
Enclosed Point of Care System
Automatic collection of PRP
Peripheral blood Platelet
level 276.000mm³
Dense Platelet
concentration
2.750.000mm ³ using
Angel™ System
Other Test Tube systems
Our PRP Technique
52ml blood draw
8mls citrate ACD-A
Angel processing 18 minutes
PRP yield 2mls highly concentrated
average 12.2 x baseline platelets
Add 4mls platelet poor plasma
= 6mls PRP injected with platelet
concentration >850.000mm³
 >3-4 x baseline platelet concentration
Video: Procedure 56secs www.youtube/avancemedical/final_edit_5th_November
Our Experience: Cohort n31
Pre
Post
8 wks
Source: Sclafani A.P. (2010) Platelet
Rich Fibrin Matrix for improvement of
deep naso-labial folds . Journal of
Cosmetic Dermatology , Vol.9: 66-71
Sclafani A.P. (2011) Safety, Efficacy and Utility of Platelet Rich Fibrin Matrix ARCH Facial Plastic Surgery
Published on line Feb 2011 doi:10.1001/archfacial.2011.3
Sclafani A.P. (2009) Applications of Platelet Rich Safety, Fibrin Matrix in Facial Plastic Surgery Facial Plastic
Surgery Vol 25 No. 4
Patient Questionnaire
Key questions:
Improvement in tone of skin
Improvement in texture of skin
Reduction in lines
Improved ‘glow’ or radiance of the skin
Volumetric improvement ????
PATIENT SURVEY
Respondents 21 patients
19% (4 patients) see no difference
81% (17 patients) see and feel a difference
in skin tone and texture.
42.86% (9 patients) state they see a marked
improvement in skin tone, texture and
reduction of lines.
38.1% (8 patients) extremely satisfied with
the results.
Age Distribution
Number of patients 31n
15
10
5
Number of patients
0
< 40yrs
4050yrs
5160yrs
>61 yrs
Further Research
Number & intervals of treatments
Longevity of treatment
Combination therapies
Micro needling
Mesotherapy
Ultrasound
Cost of treatment
Is it worth it?
THANK YOU
barbados meating
Thank you