Cell injury p.1
SYLLABUS:
Robbins and Cotran, Pathologic Basis of
Disease, Chapter:
Cellular Responses to Stress and Toxic
Insults: Adaptation, Injury, and Death
excluding:
hypertrophy
hyperplasia
metaplasia
necrosis
apoptosis
cellular aging
Cell injury p.1
15
Lipofuscin storage in myocardial cells
7929/09 Lipomatous (adipose) atrophy of the
pancreas
17
Liver steatosis
22
Hyaline degeneration of the fibrous
tissue
20
Calcification
3520/10
Gout (gouty tophus)
Lipofuscin storage in myocardial cells
- cardiomyocytes containing yellowish-brown
intracytoplasmatic granules in a perinuclear
location
(candle flame shape)
Lipofuscin storage in myocardial cells
(hematoxylin only)
Lipofuscin storage in myocardial cells
Lipomatous atrophy of the pancreas
- replacement of the pancreatic acini by
adipose tissue
- large areas of total adipose atrophy
isolating islands of Langerhans
- dilated pancreatic ducts and periductal
fibrosis
Lipomatous atrophy of the pancreas
Lipomatous atrophy of the pancreas
Lipomatous atrophy of the pancreas
Liver steatosis
(paraffin block, H&E):
-clear vacuolar spaces within hepatocytes
(accumulated triglycerides were dissolved and
removed from cells during the tissue
processing)
(frozen tissue sample, Sudan III):
-vacuoles with orange-stained substance (fat)
(.ppt demonstration only, no slides during the microscopy lab)
Liver steatosis
Liver steatosis
Liver steatosis
(paraffin block, H&E):
-clear vacuolar spaces within hepatocytes
(accumulated triglycerides were dissolved and
removed from cells during the tissue
processing)
(frozen tissue sample, Sudan III):
-vacuoles with orange-stained substance (fat)
Liver steatosis (Sudan III)
Liver steatosis (Sudan III)
Hyaline degeneration of the fibrous tissue
- thick, eosinophilic collagen fibers
- few fibroblasts
Hyaline degeneration of the fibrous tissue
Hyaline degeneration of the fibrous tissue
Calcification
basophilic calcium deposits within the artery wall
Calcification
Calcification
(empty areas within the calcium deposits are artifacts)
Gout (gouty tophus)
- clusters of pale-staining monosodium urate
crystals surrounded by macrophages, lymphocytes
and large foreign body giant cells
Gout (gouty tophus)
Gout (gouty tophus)
Gout (gouty tophus)