CHEMICAL REGULATION CHEMICAL REGULATION • CHEMICAL SIGNALS COORDINATE BODY FUNCTIONS – HORMONE • A REGULATORY CHEMICAL THAT TRAVELS IN THE BLOOD FROM ITS PRODUCTION SITE AND AFFECTS OTHER SITES IN THE BODY – ENDOCRINE GLANDS • ORGANS THAT PRODUCE HORMONES – TARGET CELLS • CELLS THAT RESPOND TO A HORMONE CHEMICAL REGULATION • CHEMICAL SIGNALS COORDINATE BODY FUNCTIONS – NEUROSECRETORY CELL • SPECIALIZED NERVE CELL THAT, IN ADDITION TO CONDUCTING NERVE SIGNALS, MAKES AND SECRETES HORMONES – NEUROTRANSMITTERS • CHEMICALS THAT CARRY INFORMATION FROM ONE NERVE CELL TO ANOTHER, OR FROM A NERVE CELL TO ANOTHER KIND OF CELL THAT WILL REACT, SUCH AS A MUSCLE CELL OR AN ENDOCRINE CELL – LOCAL REGULATOR • SECRETED INTO THE INTERSTITIAL FLUID AND AFFECTS CELLS VERY NEAR THE POINT OF SECRETION • EXAMPLE: PROSTAGLANDINS CHEMICAL REGULATION • ENDOCRINE SYSTEM – THE BODY’S MAIN CHEMICAL-REGULATING SYSTEM – WORKS CLOSELY WITH THE NERVOUS SYSTEM CHEMICAL REGULATION CHEMICAL REGULATION CHEMICAL REGULATION • HORMONES AFFECT TARGET CELLS BY TWO MAIN SIGNALING MECHANISMS – STEROID HORMONES – NON-STEROID HORMONES CHEMICAL REGULATION • NON-STEROID HORMONES – HORMONE ATTACHES TO RECEPTOR ON CELL MEMBRANE; BINDING OCCURS OUTSIDE OF CELL – EX. EPINEPHRINE (A.K.A. ADRENALINE) – INITIATES A SIGNALTRANSDUCTION PATHWAY – ALWAYS MADE FROM AMINO ACIDS (PROTEIN BASED) • STEROID HORMONES – LIPIDS MADE FROM CHOLESTEROL – EX. TESTOSTERONE – HORMONE-RECEPTOR COMPLEX ACTS BY TURNING GENES ON OR OFF CHEMICAL REGULATION • HORMONES CAN BIND TO A VARIETY OF RECEPTORS – EPINEPRHINE CAUSES GLYCOGEN BREAKDOWN IN LIVER, BUT MUSCLE CONTRACTION IN HEART CELLS CHEMICAL REGULATION • OVERVIEW: THE VERTEBRATE ENDOCRINE SYSTEM – ENDOCRINE SYSTEM CONSISTS OF MORE THAN A DOZEN MAJOR GLANDS – PINEAL GLAND • OUTGROWTH OF BRAIN THAT SECRETES MELATONIN; NOT FULLY UNDERSTOOD – THYMUS • CLOSELY LINKED TO IMMUNE SYSTEM; STIMULATES T CELL DEVELOPMENT CHEMICAL REGULATION • THE HYPOTHALAMUS, CLOSELY TIED TO THE PITUITARY, CONNECTS THE NERVOUS AND ENDOCRINE SYSTEMS – HYPOTHALAMUS • MASTER CONTROL CENTER OF THE ENDOCRINE SYSTEM; PART OF THE BRAIN • ITS ENDOCRINE SIGNALS DIRECTLY CONTROLS THE PITUITARY GLAND CHEMICAL REGULATION • THE HYPOTHALAMUS, CLOSELY TIED TO THE PITUITARY, CONNECTS THE NERVOUS AND ENDOCRINE SYSTEMS – PITUITARY CONSISTS OF TWO DISTINCT PARTS • POSTERIOR PITUITARY – COMPOSED OF NERVOUS TISSUE, AN EXTENSION OF THE HYPOTHALAMUS; STORES AND SECRETES HORMONES MADE IN THE HYPOTHALAMUS CHEMICAL REGULATION • THE HYPOTHALAMUS, CLOSELY TIED TO THE PITUITARY, CONNECTS THE NERVOUS AND ENDOCRINE SYSTEMS – PITUITARY CONSISTS OF TWO DISTINCT PARTS • ANTERIOR PITUITARY – COMPOSED OF NON-NERVOUS, GLANDULAR TISSUE; SYNTHESIZES ITS OWN HORMONES CHEMICAL REGULATION CHEMICAL REGULATION • HYPOTHALAMUS AFFECTS THE PITUITARY IN TWO WAYS – RELEASING HORMONES • CAUSES THE ANTERIOR PITUITARY TO SECRETE HORMONES – INHIBITING HORMONES • CAUSES THE ANTERIOR PITUITARY TO STOP SECRETING HORMONES CHEMICAL REGULATION • HYPOTHALAMUS CONTROLS BODY TEMPERATURE BY – SECRETING TSH-RELEASING HORMONE (TRH) WHICH CAUSES – ANTERIOR PITUITARY TO SECRETE THYROIDSTIMULATING HORMONE (TSH) WHICH CAUSES – THRYOID TO SECRETE THYROXINE • THYROXINE INCREASES METABOLIC RATE, WARMING BODY CHEMICAL REGULATION • HYPOTHALAMUS/ POSTERIOR PITUITARY – ENDOCRINE FUNCTION INCLUDES • OXYTOCIN – CAUSES UTERINE MUSCLE CONTRACTION DURING CHILDBIRTH, MAMMARY GLANDS TO PUMP MILK • ANTI-DIURETIC HORMONE (ADH) – HELPS KIDNEY CELLS REABSORB WATER (COLLECTING DUCT OF THE NEPHRON) • ANTERIOR PITUITARY – THYROID-STIMULATING HORMONE (TSH) – ADRENOCORTICOTROPIC HORMONE (ACTH) – FOLLICLE-STIMULATING HORMONE (FSH) – LUTENIZING HORMONE (LH) – PROLACTIN – ENDORPHINS • NATURAL “OPIATE”; PAIN INHIBITOR / PLEASURE INDUCER CHEMICAL REGULATION • THE THYROID REGULATES DEVELOPMENT AND METABOLISM – THYROID GLAND • LOCATED JUST UNDER THE VOICE BOX • THYROXINE – HORMONE PRODUCED BY THYROID GLAND – CONTAINS 4 IODINE ATOMS CHEMICAL REGULATION • THE THYROID REGULATES DEVELOPMENT AND METABOLISM – HYPERTHYROIDISM • CAN LEAD TO OVERHEATING, PROFUSE SWEATING, HIGH BLOOD PRESSURE, WEIGHT LOSS, IRRITABILITY – HYPOTHYROIDISM • CAUSE WEIGHT GAIN, LETHARGY, INTOLERANCE TO COLD – GOITER • UNTREATED DIETARY DISORDER LEADS TO AN ENLARGEMENT OF THE THYROID; RESULTS FROM IODINE DEFICIENCY CHEMICAL REGULATION CHEMICAL REGULATION • HORMONES FROM THE THYROID AND PARATHYROIDS MAINTAIN CALCIUM HOMEOSTASIS – 4 PARATHYROID GLANDS EMBEDDED IN THE SURFACE OF THE THYROID CHEMICAL REGULATION • HORMONES FROM THE THYROID AND PARATHYROIDS MAINTAIN CALCIUM HOMEOSTASIS – CALCITONIC FROM THYROID – PARATHYROID HORMONE (PTH) FROM PARATHYROID • **ANTAGONISTIC HORMONES HORMONES THAT HAVE OPPOSITE EFFECTS CHEMICAL REGULATION • PANCREATIC HORMONES MANAGE CELLULAR FUEL – PANCREAS PRODUCES TWO HORMONES THAT PLAY A LARGE ROLE IN MANAGING THE BODY’S ENERGY SUPPLIES CHEMICAL REGULATION • PANCREATIC HORMONES MANAGE CELLULAR FUEL – INSULIN • LOWERS BLOOD-SUGAR LEVEL • PRODUCED BY ISLET CELLS – SPECIALIEZ CELLS OF PANCREAS – GLUCAGAON • RAISES BLOOD-SUGAR LEVEL BY BREAKING DOWN GLYCOGEN • PRODUCED BY ALPHA CELLS – SPECIALIZED CELLS OF PANCREAS CHEMICAL REGULATION • DIABETES IS A COMMON ENDOCRINE DISORDER – DIABETES MELLITUS • A SERIOUS HORMONAL DISEASE IN WHICH THE BODY CELLS ARE UNABLE TO ABSORB GLUOCSE FROM THE BLOOD • TYPE I (BORN WITH IT) – AUTOIMMUNE; IMMUNE SYSTEM ATTACKS AND KILLS BETA (ISLET ISLET CELLS) • TYPE II (DEVELOP IT LATER IN LIFE) – BODY CELLS FAIL TO RESPOND TO INSULIN • HYPOGLYCEMIA – OVERPRODUCTION OF INSULIN; BLOOD SUGAR LEVELS DROP TOO LOW AFTER A MEAL CHEMICAL REGULATION • THE ADRENAL GLANDS MOBILIZE RESPONSES TO STRESS – 2 ADRENAL GLANDS SITTING ATOP THE KIDNEYS – ADRENAL GLAND IS ACTUALLY TWO GLANDS IN ONE • ADRENAL MEDULLA • ADRENAL CORTEX CHEMICAL REGULATION • THE ADRENAL GLAND MOBILIZE RESPONSES TO STRESS – ADRENAL MEDULLA • INVOLVED IN FLIGHT-ORFLIGHT REFLX • PRODUCES EPINEPHRINE (ADRENALIN) AND NOR-EPINEPHRINE (NOR-ADRENALIN) CHEMICAL REGULATION • THE ADRENAL GLAND MOBILIZE RESPONSES TO STRESS – ADRENAL CORTEX • MORE LONG LASTING EFFECTS • ACTIVATED BY ACTH RELEASED BY ANTERIOR PITUITARY • SYNTHESIZES CORTICOSTEROIDS – 2 TYPES » MINERALOCORTICOIDS • CONTROL SALT AND WATER BALANCE » GLUCOCORTICOIDS • AID IN MOBILIZING CELLULAR FUEL • EX. CORTISONE LESSENS INFLAMMATORY RESPONSES, BUT WEAKENS IMMUNE SYSTEM CHEMICAL REGULATION • THE GONADS SECRETE HORMONES – GONADS • SEX GLANDS; SECRETE SEX HORMONES, IN ADDITION TO PRODUCING GAMETES • ESTROGENS – MAINTAIN THE FEMALE REPRODUCTIVE SYSTEM AND PROMOTE THE DEVELOPMENT OF SUCH FEMALE FEATURES AS SMALL BODY SIZE, HIGHER-PITCHED VOICE, BREASTS, AND WIDER HIPS • PROGESTINS – PRIMARILY INVOLVED IN PREPARING THE UTERUS TO SUPPORT THE EMBRYO • ANDROGENS – STIMULATE THE DEVELOPMENT AND MAINTENANCE OF THE MALE REPRODUCTIVE SYSTEM (EX. TESTOSTERONE) CHEMICAL REGULATION • SPEAKING OF THE REPRODUCTIVE ORGANS / GONADS…AND THE REPRODUCTIVE HORMONES…HOW DO BABIES GET MADE?? • THE REPRODUCTIVE SYSTEM IS NEXT!!!