Gaining Efficiencies in
Pharmaceutical
Operations
Pfizer’s Green Journey
ISPE
September 12, 2013
Overview
 Global Interest in Environmental
Sustainability
 Gaining Efficiency through Environmental
Sustainability
Healthcare’s Greenhouse Gas Emissions
 Healthcare roughly 3-5% of global GHG emissions
 United States healthcare roughly 8-12% of country GHG emissions
ERM estimate
 Total global health expenditure US$ 6.5 Trillion
WHO Global Health Expenditure Atlas, 2012
 Current population roughly 7.1 Billion
United Nations
NHS SDU
 Sustainable Development
Unit set up in 2008
 Working across the health
sector in England
 To develop organisations,
people, tools, policy and
research which will
enable organisations to
promote sustainable
development, to mitigate
and to adapt to climate
change.
Healthcare Impacts - Direct & Supply Chain
X ~35%
Direct
State of Green Business 2013,
GreenBiz
UK NHS Footprint – Scope 3 Emissions
 NHS Industry partnership developed Product
Life Cycle Accounting Standard
 Aimed to support consistent quantification of
the carbon footprint of pharmaceutical
products and medical devices
NHS SDU
GHG Protocol
UK NHS Footprint 2010
US Health Care Greenhouse Gas Emissions
Estimates of Greenhouse Gas Emissions from US Health Care
Sector
Administrative/Insurance
Home Healthcare
Scientific Research
Nondurable and Durable Equipment
Other Professional
Nursing Homecare
Structures/equipment
Physician/Dental Service
Prescription Drugs
Hospital
0%
TOTAL GLOBAL WARMING POTENTIAL
FOR US HEALTHCARE
800 MMTCO2 Eq
5%
10%
15%
20%
25%
30%
* Based on National Expenditures 2007
Published in JAMA
November 11, 2009 Vol. 302, No. 18 pp 1970-71
35%
40%
45%
External Reporting – disclosure to investors
Carbon Disclosure Project Score
•
NEW PROPOSAL Sustainability
Accounting Standards
Board (SASB) provides
sustainability accounting
standards for use by
publicly-listed
corporations in the U.S.
in disclosing material
sustainability issues for
the benefit of investors
and the public
Bloomberg Maplecroft Climate Innovation Index
• Maplecroft Climate Innovation Index (CII) Benchmark is a
composite index professionally traded on Bloomberg
terminals – weighted in index based upon score.
• Companies rated based on their performance in climaterelated innovation and carbon management.
8
Green Procurement Trends in Healthcare
The Present
• Institutional Tenders
• Group Procurement Programs
Emerging
• The Sustainability Consortium (WalMart)
• Swedish National Pharmaceutical
Strategies
The Future
• Green Government Procurement
Programs
Overview
 Global Interest in Environmental
Sustainability
 Gaining Efficiency through Environmental
Sustainability
Pfizer’s Green Journey – Expanding beyond fence lines
Build on
Achievements
Report on
Progress
Gain Recognition
as a Leader
Reach Beyond
Our
Boundaries
Working throughout Product Lifecycle
Manufacturing
& Packaging
Engaging with Customers
Partnering Across Supply Chain
Responsible
Supply Chain
Initiatives
• Supplier Survey
• Capacity building
Delivery to
Manufacturing
Colleagues
Suppliers &
Ingredients
Understanding
Customer
Requirements
• Procurement
• Tenders
Delivery to
Customers
Use & Disposal
11
Pfizer’s Green Journey – Keeping it On Track
Our Strategies
Reduce Impact
Improve
Efficiency
Greener
Products
Our Delivery Platforms
Plants
Our Objectives
Reduce energy, water, waste in internal supply chain
Partners
Products
Promote green practices across our supply chain
Deliver “greener” products and processes
Reduced
Environmental
Impact
Reduced Use of
Scarce Resources
Operational
Efficiency / Savings
Valued Products
Engage
Colleagues
Public Outreach
and Reporting
Embed
Sustainability
People
Promote and enable green practices
Public
Share our accomplishments
Environmental Sustainability Council
Energy
Waste
Our Value Pillars
Water
Enhanced
Relationships
Improved Rankings
& Reputation
Sustainability
Culture
Pfizer’s Green Journey – Company Footprint
Pfizer is on a Green Journey
Publish company environmental KPIs alongside
financial performance metrics in annual report
• Integrated report to shareholders includes:
• Greenhouse Gas Footprint
• Waste Generated
• Water Withdrawal
http://www.pfizer.com/investors/financial_reports/annual_reports/2012/performance.jsp
Gaining Efficiency – Site Operations
Achieved 5-yr Public Goal to Reduce Greenhouse Gas
Emissions by 20% after only 4 years
• Second time since 2000 that Pfizer has achieved its
target of cutting GHG emissions.
• Result of more than 1500 energy conservation
projects
• Achieved $85M in annualized project savings
• Every dollar invested recovered within 2 years, on
average.
Gaining Efficiency - Processes
A Decade of Green Chemistry
Case Study: Lyrica (Pregabalin) – process changes
 Process 1 (2005-2006)
Classical chemistry, carbon based solvents. Used to launch the product
 Process 2 (2006-2010)
Enzymatic chemistry, all chemical processes use water as solvent
 Process 3 (2010-present)
Enzymatic process, all chemical processes use water as solvent. One key
by-product which was incinerated in process 2 is now recovered and
converted to high quality product, albeit with a relatively high energy
process
Solvent, reagent and energy reduction gives a saving of 3 million tonnes
of CO2 emissions. Or equivalent to 500,000 US cars off the road for a year.
Green Chemistry
- Finding a better alternative through solvent selection.
Strategy
Encourage selection of “better” solvents by evaluating
the following characteristics:
–
–
–
Worker Safety - carcinogenicity, mutagenicity, reprotoxicity, skin
absorption, skin sensitisation and toxicity
Process Safety – flammability, potential for high emissions, static
charge, potential for peroxide formation, odour issues.
Environmental and Regulatory Considerations – ecotoxicity, ground
water contamination potential, EHS regulatory restrictions, ozone
depletion potential, photo reactive potential
Opportunities Identified
Use of better alternative solvents makes it safer for
workers, processes and the environment, where possible.
Preferred Outcome
Take Away
Apply Simple Solvent Selection Scheme
Preferred
Water
Acetone
Ethanol
2-Propanol
1-Propanol
Ethyl Acetate
Isopropyl acetate
Methanol
MEK
1-Butanol
t-Butanol
Usable
Less Desirable
Pentane
Hexane(s)
Di-isopropyl ether
Diethyl ether
Dichloromethane
Dichloroethane
Chloroform
NMP
DMF
Pyridine
DMAc
Dioxane
Dimethoxyethane
Benzene
Carbon tetrachloride
Red Solvents
Better Alternative
Pentane
Heptane
Hexane(s)
Heptane
Di-isopropyl ether or ether
2-MeTHF or t-Butyl methyl ether
Dioxane or dimethoxyethane
2-MeTHF or t-Butyl methyl ether
Chloroform, dichloroethane
or carbon tetrachloride
DCM
DMF NMP or DMAc
Acetonitrile
Pyridine
Et3N (if pyridine used as base)
DCM (extractions)
EtOAc, MTBE, toluene, 2-MeTHF
DCM (chromatography)
EtOAc / Heptanes
Benzene
Toluene
Confidential and Internal use only. All content in this message is subject to works council and/or union consultations and other legal
requirements.
Gaining Efficiency – Product/Packaging
Formed Sustainable Packaging Team seeking
opportunities for reducing packaging weight,
optimizing designs, changing materials, and improving
pallet layouts
• Developed Green Package Design Checklist
• Thin gauging bottles and foils
• Eliminating extra PVC trays
• Eliminating inserts and individual cartons can
reduce overall packaging mass by 8%
• Smaller tablet that leads to less packaging
Summary
Continued Interest in Environmental Sustainability
Pfizer is on a Green Journey
•
Growing Interest in Environmental Sustainability
–
–
–
•
Gaining Efficiency through Environmental Sustainability
–
–
–
•
Institutions
Governments
Investors
Resource Efficiency – energy, water & waste
Process Chemistry
Green Packaging Design
Succinctly stated Environmental Sustainability –
It’s good for our environment,
It’s good for our communities,
It’s good for our business