Kids First Saskatchewan November 2010 The First ‘R” Relationships: How Love Builds Brains Jean Clinton BMus MD FRCP(C) McMaster University and Children’s Hospital Department of Psychiatry and Behavioural Neurosciences Offord Centre for Child Studies Kids First Saskatchewan November 2010 Kids First Saskatchewan November 2010 The Wisdom of the Elders Consider the interest of the next 7 generations when decisions are being made Kids First Saskatchewan November 2010 Masai Greeting: How are the children? Kids First Saskatchewan November 2010 What is our VALUES DRIVEN question and conversation? Who won the hockey game last night?? What about those Blue Jays? Kids First Saskatchewan November 2010 The Child “To the doctor, the child is a typhoid patient; to the playground supervisor, a first baseman; to the teacher, a learner of arithmetic. At times, he may be different things to each of these specialists, but too rarely is he a whole child to any of them.” From the 1930 report of The White House Conference on Children and Youth Kids First Saskatchewan November 2010 What is the world we want to see? What we believe about children informs our view…and our language. Child as empty vessel? Or Child as Powerful ,resourceful, creative co-learner and creator Develop normally or function to the best of ability? Fix the problem…..or promote activity and what can be? WHAT IS OUR IMAGE OF THE CHILD? Kids First Saskatchewan November 2010 Adapted from Loris Malaguzzi How are the Children? Kids First Saskatchewan November 2010 UNICEF REPORT CARD 2007 “The true measure of a nation’s standing is how well it attends to its children-their health and safety, their material security, their education and socialization, and their sense of being loved, valued and included in the families and societies into which they are born.” Kids First Saskatchewan November 2010 Unicef Innocenti Report 2007 Unicef Report :Canada Material Well Being Health and Safety Educational Well being Family and Peer Relationships Behaviours and Risks Subjective well being 6 13 2 18 SWEDEN SWEDEN BELGIUM ITALY 17 15 SWEDEN 1 NETHERLANDS 1 12/21 Overall Unicef Innocenti Report 2007 Kids First Saskatchewan November 2010 1 1 1 1 Reaching For the Top Report. We are doing poorly compared to other OECD countries(29 total) 21st in child well being, including mental health 22nd in PREVENTABLE childhood injury and deaths 27th in childhood obesity Kids First Saskatchewan November 2010 National Advisor Report March 2008 03-080 The Founder’s Network Experience-Based Brain Development in the early years of life sets neurological and biological pathways that affect: Health Learning Behaviour Kids First Saskatchewan November 2010 Why do we care about brain? You are your brain. BUT Your brain is not just produced by your genes. Your brain is sculpted by a lifetime of experiences . The most important time in brain development is the first few years of life. Kids First Saskatchewan November 2010 Kolb The Brain Matters The human brain is the organ responsible for everything we do. It allows us to laugh, walk, love, talk. For each of us, our brain is a reflection of our experiences. The brain is an environmental organ. It reflects our environment. Adapted from Bruce Perry Kids First Saskatchewan November 2010 Time Magazine from the MEHRI Neuroscience lab Kids First Saskatchewan November 2010 Hamilton Regional Child Wefare Conference September 2010 Nature/ Nurture No longer a debate Environment leaves its mark on our genome and can modulate future gene expression in a sometimes heritable fashion The study of how environment leaves its footprint on the genome falls into the domain of Epigenetics Dr Robin Gibb U of Lethbridge Kids First Saskatchewan November 2010 Hamilton Regional Child Wefare Conference September 2010 Children’s Mental Health Is… Developing the capacity to: Experience, regulate, and express emotions • Form close interpersonal relationships • Explore the environment and learn • Child mental health = healthy social and emotional development. Zero to Three Kids First Saskatchewan November 2010 BRAIN PLASTICITY Connections are formed and altered by experience But, not done until at least ageKids First Saskatchewan November 2010 24+years… 19 Proliferation Migration- how cells grow where cells go Subtle changes in the neurotransmittershow the cells communicate Many parts of the brain are affected Kids First Saskatchewan November 2010 The Hamilton Task Force on FASD 905 527-3823 x267 20 13 weeks Kids First Saskatchewan November 2010 Kids First Saskatchewan November 2010 Dr Robin Gibb U of Lethbridge 04039 Two Neurons Axon RECIPIENT NEURON Synapse SIGNALSENDING NEURON Dendrite Kids First Saskatchewan November 2010 Founders Network KidsUniversity. First Saskatchewan November 2010 C.A. (1999) Change and continuity in neurobehavioral Graphic courtesy of Center on the Developing Child at Harvard Originally published in Nelson, development: lessons from the study of neurobiology and neural plasticity. Infant Behavior and Development, Volume 22(4) 415-429. Cited in InBrief: The Science of Early Childhood Development, presentation summary from the National Symposium on Early Childhood Science and Policy, Cambridge, MA, June 2008. PLASTICITY Babies highly attuned to their environment Massive synaptic growth in first two years Pruning starts at 8months Pruning regulated by emotional interactions with caregivers From “The First Idea” Greenspan and Shanker Kids First Saskatchewan November 2010 04-212 SERVE AND RETURN Sound Vision Smell Touch Proprioception Taste Kids First Saskatchewan November 2010 Neal Halfon From Aitken and Trevarthen Kids First Saskatchewan Law November 2010 Ontario Collaborative Federation September 2010 27 A Citizen and Competent from Birth Amazing Talents of the Newborn ; Johnson & Johnson Paediatric Institute Kids First Saskatchewan November 2010 Brain Cells develop connections over the first 2 years Kids First Saskatchewan November 2010 Then they are sculpted actively for the rest of your life! Kids First Saskatchewan November 2010 02-002 Estimated Cumulative Difference in Language Experiences by 4 Years of Age Million 50 Professional 40 Working-class 30 20 10 Welfare 0 0 12 24 36 Age of child in months Kids First Saskatchewan November 2010 48 Cumulative Vocabulary (Words) Disparities in Early Vocabulary Growth 1200 600 College Educated Parents Working Class Parents Welfare Parents 200 16 mos. 24 mos. Child’s Age (Months) Kids First Saskatchewan November 2010 Source: Hart & Risley (1995) Slide by The National Scientific Council on the Developing Child 36 mos. ‘Sensitive periods’ in earlyBinocular vision Central auditory system brain development Habitual ways of responding Language Emotional control Symbol Peer social skills Relative quantity High Low 0 1 2 Kids First Saskatchewan November 2010 3 Years 4 5 6 7 Harvard Centre on the Developing Child Kids First Saskatchewan November 2010 USE IT OR LOSE IT ! The more a system, or set of brain cells is activated, the more that system changes in response. The stronger the repetitions the stronger the memory. Kids First Saskatchewan November 2010 Brain Development Maturation Occurs from Back to Front of the Brain Images of Brain Development in Healthy Youth (Ages 5 – 20) Blue represents maturing of brain areas Source: Gogtay, Giedd, et al., 2004.Kids First Copyright © 2004 The National Academy of Sciences, USA Gogtay, N., Giedd, J.N., et al. (2004) Dynamic mapping of human cortical development during childhood through early adulthood Saskatchewan November 2010 Proceedings of the National Academy of Sciences, 101 (21), 8174 – 8179 Brain Plasticity Incidental Finding in 55 year old man Kids First Saskatchewan November 2010 Brain Plasticity Kids First Saskatchewan November 2010 02-066 The Fear Response Visual Thalamus Visual Cortex Amygdala Scientific Kids First Saskatchewan November 2010 American The Hidden Mind, 2002, Volume 12, Number 1 Hippocampus Amygdala Kids First Saskatchewan November 2010 Kids First Saskatchewan November 2010 Stress is NUTS Novelty, Unpredictability, Threat to the ego, Sense of loss of control Dr Sonia Lupien Centre for Studies on Human Stress Kids First Saskatchewan November 2010 03-002 Emotional Stimulus Amygdala + Hippocampus + Hypothalamus - - PVN Cortisol Cortisol CRF PIT ACTH Adrenal Cortex Kids First Saskatchewan November 2010 LeDoux, Synaptic Self Amygdala and Hippocampus Kids First Saskatchewan November 2010 00-058 Cortisol can be bad for the brain Hippocampus high sterol levels cause loss of dendrites and cell death Frontal brain attention deficits Kids First Saskatchewan November 2010 05-212 Limbic HPA Pathway - Stress Cortisol – Over Production Behaviour (ADHD, violence), depression, diabetes, malnutrition, cardiovascular disease, memory, immune system, drug and alcohol addiction Cortisol – Under Production Chronic fatigue syndrome, fibromyalgia, immune system (autoimmune disorders) rheumatoid arthritis, allergies, asthma Kids First Saskatchewan November 2010 Anterior Cingulate Cortex Kids First Saskatchewan November 2010 Cortisol & Brain Development Cortisol affects the parts of the brain that regulate stress store memory Are involved in planning and executing complex functions Are involved in language Kids First Saskatchewan November 2010 PFC AMYGDALA A: Positive emotional state, flow through amygdala to PFC and better memory test results. B: Stressed state: No passage of information to PFC & lower memory testing short and long-term. (Hamman,et al. Cognitive Kids First Saskatchewan November 2010 Hamilton Regional Child Wefare Conference September 2010 Neuroscience.) Children’s Stress Pathway “Children’s number one fear is PUBLIC HUMILIATION. They will do anything to belong”. “If a child is not sure if they are going to be embarrassed or humiliated they can’t learn” Mary Gordon Kids First Saskatchewan November 2010 Still Face Experiment Kids First Saskatchewan November 2010 Self-Regulation SR is the ability to manage emotions and behaviour independently Is considered by some to be a central organizing feature of human development Most mental illnesses can be thought of as a problem of self-regulation Babies learn to self-regulate from their caregiving experiences Kids First Saskatchewan November 2010 Self regulation Kids First Saskatchewan November 2010 Hamilton Regional Child Wefare Conference September 2010 Maternal Stress Affects HPA axis in offspring Can alter susceptibilty to later disease/ drug taking Affects males more than females Kids First Saskatchewan November 2010 Maternal style Mothering has a lifelong influence on health of offspring Passed on from generation to generation via epigenetics Kids First Saskatchewan November 2010 05-056 Individual differences in stress reactivity of the adult are determined by maternal behaviour during infancy HIGH LG LOW LG Development of Stress Reactivity Modest Stress Reactivity Reduced Risk for Disease Increased Stress Reactivity Increased Risk for Heart Disease, Type II Diabetes, Alcoholism, Affective Disorders, Brain Aging, etc. Kids First Saskatchewan November 2010 M. Szyf 05-057 Is maternal care the mediator of these effects on hippocampal (GR(17) promoter methylation? ADOPTION/CROSS FOSTERING STUDIES Biological Mother Adoptive Mother LOW LOW HIGH HIGH Kids First Saskatchewan November 2010 M. Szyf 05-059 Rats – Gene Methylation Cytosine-Methylation 1.2 0.8 Licking Low 0.4 Licking High 0 Embryo Day 20 Birth Pup Day 6 Day 1 Kids First Saskatchewan November 2010 Age Weaning Adult Day 21 Day 90 M. Szyf Serotonin Gene, Experience, and Depression 03-089 Depression Risk .70 Age 26 SS S = Short Allele L = Long Allele .50 SL .30 LL No Abuse Moderate Abuse Severe Abuse Kids First Saskatchewan November 2010 Early Childhood A. Caspi, Science, 18 July 2003, Vol 301. Nature/ Nurture No longer a debate Environment leaves its mark on our genome and can modulate future gene expression in a sometimes heritable fashion The study of how environment leaves its footprint on the genome falls into the domain of Epigenetics Dr Robin Gibb U of Lethbridge Kids First Saskatchewan November 2010 Hamilton Regional Child Wefare Conference September 2010 Perinatal Depression Kids First Saskatchewan November 2010 Perinatal Depression For decades the medical profession believed the increased hormones in pregnancy protected women from becoming depressed. In the late 70's and 80's researchers discovered that many of the women who experienced depression after the birth of their child were depressed in pregnancy. Today we know that 10 % of women will experience depression during pregnancy. Kids First Saskatchewan November 2010 Perinatal psychiatric disorders are a leading cause of maternal morbidity and mortality Parental mental illness may pose the first adverse life event for a child Depression transmits across the generations Kids First Saskatchewan November 2010 Perinatal Depression: Prevalence Depression is among the most common of health disorders in women (1 in 4 lifetime) 10% during pregnancy 12-16% postpartum It is a recurrent disorder Kids First Saskatchewan November 2010 The Problem: Under-Detection & UnderTreatment The diagnosis is made in only 0.8% of childbearing women Most receive inadequate treatment Compliance substantial maternal/infant morbidity Kids First Saskatchewan November 2010 Edinburgh Postnatal Depression Scale Brief, easy to use screening instrument comprising 10 questions Can improve the awareness of healthcare providers and aid in the early detection of postpartum depression Kids First Saskatchewan November 2010 Risks Of Untreated Depression During Pregnancy: The Mother Postpartum depression Exposure to additional medication Drug, alcohol, tobacco use Poor self-care, nutrition, sleep Noncompliance with prenatal care Obstetrical complications Pre-eclampsia Negative effect on bonding Suicide Kids First Saskatchewan November 2010 Prenatal and Postpartum Depression in Dads A recent study by James Paulson and Sharnail Bazemore from the Virginia Medical School, Norfolk, VA, published in the Journal of the American Medical Association, throws new light on this interesting issue. Notes: http://www.ncbi.nlm.nih.gov/pubmed/20483973 Kids First Saskatchewan November 2010 Paternal Depression the average rate of paternal depression in the antenatal period (during pregnancy) was abour 10% but increased to about 25% during the 3 to 6-month postpartum period (after birth). Kids First Saskatchewan November 2010 Paternal Depression it is important to also be wary of mood disorders in expecting and new fathers (especially if the mother has mood problems), but these mood disorders in fathers may need to be addressed. Kids First Saskatchewan November 2010 Impact on child paternal depression may have substantial emotional, behavioral and developmental effects on the infant. prevention, screening and interventions for depression should likely be focused on the couple rather than on the individual parent. Kids First Saskatchewan November 2010 Kids First Saskatchewan November 2010 What is Attachment? Kids First Saskatchewan November 2010 What is Attachment? An affectional bond or tie between an infant and his/her mother figure Kids First Saskatchewan November 2010 What is Attachment? Bowlby’s Attachment Theory proximity-maintaining behaviours for protection in balance with exploration system “secure base” “Attachment & Loss” (1969) Kids First Saskatchewan November 2010 Internal Working Models Early relationship experiences create internal representations of the self in relation to the attachment figure and the world Influence expectations of significant others (Bowlby, 1988) Kids First Saskatchewan November 2010 What is not attachment? Other parental roles: Teacher Playmate Physical caregiver (Bowlby, 1988) Kids First Saskatchewan November 2010 Ainsworth’s Strange Situation Procedure Mary Ainsworth (1978) Laboratory measure of attachment based on internal working model theory i.e., infant’s attachment strategy is based on expectation of how the caregiver is likely to behave Kids First Saskatchewan November 2010 Ainsworth’s Strange Situation Procedure Infant & Mother (stranger enters) infant, mother, stranger (mother leaves) infant, stranger (mother returns, stranger leaves) infant & mother (FIRST REUNION) (mother leaves) infant alone (stranger returns) infant & stranger (mother returns) infant & mother (SECOND REUNION) (Ainsworth et al., 1978) Kids First Saskatchewan November 2010 Video Kids First Saskatchewan November 2010 Attachment Classifications Secure Insecure – Avoidant Ignores or avoids mother upon reunion History of predictably unavailable or unresponsive caregiving Insecure – Resistant Settles easily with mother upon reunion History of consistently responsive caregiving Difficulty settling upon reunion History of inconsistent, unpredictable caregiving Insecure – Disorganized Odd behaviour, confusion, fear upon reunion History of abuse/neglect Kids First Saskatchewan November 2010 Developmental Implications of Insecure Attachment Increased Social withdrawal Aggression towards peers Parent-child conflict Behaviour problems Decreased Persistence with challenging tasks Cognitive problem-solving competence Mental health Physical health Kids First Saskatchewan November 2010 What Influences Attachment? Mother Responsiveness Her own childhood experiences Personality Depression Stress – parenting, life events Marital satisfaction, social support Infant Unique characteristics Reactivity to environment and people Special needs (e.g., premature, developmentally delayed) Kids First Saskatchewan November 2010 What’s a parent to do? Get peer support! Get rid of the “ghosts in the nursery” family, friends, join a group or early years centre - -get counseling (family doctor, local infant development program, hospital or mental health centre, or Employee Assistance Program) Education books (e.g., Sears, Leach) videos (e.g., A Simple Gift) - home study (e.g., the Parent Kit) courses (e.g., Right from the Start) Have fun! Kids First Saskatchewan November 2010 - Developmental Implications of Insecure Attachment Increased Social withdrawal Aggression towards peers Parent-child conflict Behaviour problems Decreased Persistence with challenging tasks Cognitive problem-solving competence Mental health Physical health Kids First Saskatchewan November 2010 TEMPERAMENT “A child’s first and most natural way of reacting to the world around him” Kids First Saskatchewan November 2010 Thomas and Chess TEMPERAMENT INTENSITY How strong are your child’s emotional reactions?Does he laugh and cry loudly and energetically or softly and mildly? PERSISTENCE If your child is involved in an activity and you tell her to stop,does she stop easily or fight to continue? Kids First Saskatchewan November 2010 Raising your Spirited Child: Mary Sheedy Kurcinka SENSITIVITY How aware is your child of slight noises,emotions and differences in temperature,taste and texture? Does he react easily to certain foods,tags in clothing,irritating noises,or your stress? PERCEPTIVENESS Does your child notice people, colors,noises, and objects around her?Does she frequently forget to do what you asked because something else has caught her attention? Kids First Saskatchewan November 2010 Raising your Spirited Child: Mary Sheedy Kurcinka ADAPTABILITY How quickly does your child adapt to changes in his schedule or routine? How does he cope with surprises? REGULARITY Is your child quite regular about eating times,sleeping times,amount of sleep needed, and other bodily functions? ENERGY Is your child always on the move and busy or quiet and quiescent? Does he need to run, jump, and use his whole body in order to feel good? Raising your Spirited Child: Mary Sheedy Kurcinka Kids First Saskatchewan November 2010 FIRST REACTION What is your child’s first reaction when she is asked to meet people, try a new activity or idea,or go someplace new? MOOD How much of the time does your child feel happy and content compared with serious, analytical, or cranky? Kids First Saskatchewan November 2010 TEMPERAMENT CONSTELLATIONS EASY DIFFICULT SLOW TO WARM Kids First Saskatchewan November 2010 GOODNESS OF FIT Healthy functioning and development occurs when there is a goodness of fit (compatibility) between the capacities and characteristics of the individual and the demands and expectations of the environment. Kids First Saskatchewan November 2010 Thomas and Chess TODDLERS CREED If I want it ,it’s mine If I give it to you, and change my mind later, it’s mine If I had it a little while ago, it’s mine If it’s mine it will never belong to anyone else, no matter what. If we are building something together, all the pieces are mine. If it looks like mine, it is mine If it breaks, it’s yours Kids First Saskatchewan November 2010 00-046 Evening Cortisol Levels Increase with Months of Orphanage Rearing * -0.2 -0.4 -0.6 -0.8 *linear trendline -1 -1.2 0 10 20 30 40 Kids First November 2010Rearing Months ofSaskatchewan Orphanage 50 05-046 The Founders’ Network Secure Attachment Buffers Cortisol Response to Threatening Events Change in Salivary Cortisol 0.35 0.3 0.25 Secure Attachment Insecure Attachment 0.2 0.15 0.1 0.05 0 -0.05 -0.1 HIGH LOW Kids First Saskatchewan November 2010 Fearful Responses to Stimuli Gunnar (1996). 02-050 Development and Cortisol Levels 1.3 Low SES Medium SES High SES 1.1 0.9 0.7 0.5 6 8 Age Kids First Saskatchewan November 2010 10 05-047 Children in Poorer Quality Childcare Show Rises in Cortisol Over the Day Quality of Childcare 2.0 1.0 0.0 -1.0 -0.4 -0.2 0.0 Kids First Saskatchewan November 2010 Rise in Cortisol 0.2 0.4 Dettling (2000). 05-063 Averaged Cortisol (log10) Daycare Quality & Cortisol Levels (Individual Needs) 0.6 Unsatisfactory 0.5 High Quality Satisfactory 0.4 AM Kids First Saskatchewan November 2010 Time of Sampling PM Sims et al. 2005. 05-064 Averaged Cortisol (log10) Daycare Quality & Cortisol Levels (Treat Equitably) 0.6 Unsatisfactory 0.5 High Quality Satisfactory 0.4 AM Kids First Saskatchewan November 2010 Time of Sampling PM Sims et al. 2005. 00-045 Cortisol Levels in Romanian Adopted Children 6 Years Post Adoption Adopted < 4 months in orphanage Adopted > 8 months in orphanage Canadian Control 1 0.8 0.6 0.4 0.2 0 AM Noon Kids First Saskatchewan November 2010 PM Dr Megan Gunnar Social Relationships control cortisol levels in infants and young children. Children with secure attachments to their caregivers show stable cortisol levels. The key ingredient to buffering stress is sensitive, responsive, individualized care. It’s not separation from parents, but the experience in child care that triggers their stress responses. Kids First Saskatchewan November 2010 Research on Quality Treating children with respect Developing relationships with families Ensuring programmes focus on children feeling safe “ Kids First Saskatchewan November 2010 Hutchins and SIMS 2000 Research on Quality Meeting the individual needs of children Ensuring staff remain in their positions long enough to be able to develop and maintain relationships with children All of these dimensions of quality are fundamental to developing and maintaining strong relationships between caregivers and children “(Hutchins & Sims, 2000). “ Kids First Saskatchewan November 2010 Floor Time Stanley Greenspan’s Model Functional Emotional Scale Kids First Saskatchewan November 2010 Rates of Return to Human Development 03-074 Investment Across all Ages 8 6 Pre-school Programs Return Per $ 4 Invested School R Job Training 2 PreSchool 0 6 School Post School Kids First Saskatchewan November 2010 18 Age Carneiro, Heckman, Human Capital Policy, 2003 97-044 The Mismatch Between Opportunity and Investment Brain's "Malleability" Spending on Health, Education and Welfare 0 3 10 Age Kids First Saskatchewan November 2010 70 Impact on Health Kids First Saskatchewan November 2010 04-006 ECD Swedish Longitudinal Study and Adult Health Number of Adverse ECD Circumstances* 0 Adult Health 1 2 3 4 Odds - Ratios General Physical 1 1.39 1.54 2.08 2.66 Circulatory 1 1.56 1.53 2.91 7.76 Mental 1 1.78 2.05 3.76 10.27 * Economic, family size, broken family and family dissention Kids First Saskatchewan November 2010 Lundberg, Soc. Sci. Med, Vol. 36, No. 8, 1993 Life Course Problems Related to Early Life 2nd Decade • School Failure 3rd/4th Decade • Obesity 5th/6th Decade Old Age • Coronary Heart • Premature Disease Aging • Teen Pregnancy • Elevated Blood Pressure • Diabetes • Criminality • Depression Kids First Saskatchewan November 2010 • Memory Loss Risk Factors for Adult Heart Disease are Embedded in Adverse Childhood Experiences Odds Ratio 3.5 3 2.5 2 1.5 1 0.5 0 1 2 3 4 5,6 7,8 Kids First Saskatchewan November 2010 ACEs Source: Dong et al, 2004 Kids First Saskatchewan November 2010 SCENARIOS What we THINK…. Affects what we FEEL… Affects how we ACT…. Kids First Saskatchewan November 2010 112 “The Power of One” Collected all together is Massive Kids First Saskatchewan November 2010 Kids First Saskatchewan November 2010