Psychosocial Treatment for Severe and Persistent Mental Illness Greg Horn Appalachian State University Spring 2008 Overview SPMI and schizophrenia Impact on family and social functioning Epidemiology and etiology Medication Social Skills Training Family interventions and psychoeducation Empirical support Severe and persistent mental illness (SPMI) Serious mental illness (SMI) Defined by Federal regulations referring to mental disorders that interfere with some area of social functioning – One-year prevalence 5.4 % (NIMH) Severe and persistent mental illness (SPMI) - severe impairment over time – One-year prevalence 2.6% (NIMH) No standardized criteria Experts agree it involves: – Diagnostic severity – Degree of disability – Duration of problem Relies on assessment of overall functioning, Brief Psychotic Rating Scale-Extended (BPRS-E) (Burlingame et al., 2006) – Thought-disturbance, pos Sx – Anxiety-Depression – Withdrawal – neg Sx – Hostile – suspicious, paranoid – Activity / mania Current or previous GAF of 40 or less Due to schizophrenia, psychotic disorders, bipolar disorder, Major depressive disorder, panic disorder, obsessive-compulsive disorder Definitions vary by state Schizophrenia: Diagnostic criteria • Characteristic Sx, 2 or more for 1 month • Delusions • Hallucinations • Disorganized speech • Grossly disorganized or catatonic behavior • Negative Sx • Note: Only one is required if delusions are bizarre or hallucinations consist of a voice keeping up a running commentary on the person’s behavior or thought, or two or more voices conversing with each other • Social / occupational dysfunction Duration: Continuous signs for at least 6 months Schizoaffective and mood disorder exclusion Substance / general medical condition exclusion Pervasive developmental disorder: Additional diagnosis of schizophrenia if prominent delusions or hallucinations (DSM-IV-TR) Schizophrenia subtypes Paranoid type: Preoccupation of 1 or more delusions or frequent auditory hallucinations Disorganized type, all 3: – Disorganized speech – Disorganized behavior – Flat or inappropriate affect Catatonic, at least 2: – Immobility – Excessive activity – Extreme negativism - motiveless resistance – Peculiarities – Echolalia or echopraxia Catatonic type takes precedence, then disorganized, then paranoid Undifferentiated type Residual type (DSM-IV-TR) Epidemiology Prevalence – – – Gender differences – Women • More affective Sx, paranoid delusions, & hallucinations • Better prognosis, attenuates with age – Men • Negative Sx – flat affect, avolition, social withdrawal Higher rate in urban areas – Deprivation – Neighborhood composition – Ethnic composition Populations – Occurs at similar rates across ethnic groups (Mueser & McGurk, 2004) – Higher for some populations • African Caribbeans living in UK – Culturally insensitive? One-year - 1.3% (NIMH) Among adults .5 – 1.5% Slightly higher in men (DSM-IV-TR) Onset – – – Early and late onsets do occur, but they are rare Men: late teens, early 20s Women: late 20s, early 30s • Late onset is more common (DSM-IV-TR) (www.schizophrenia.com) Etiology: Genetics www.schizophrenia.com Etiology: Early environment Odds ratio is determined by comparing the odds of each group to the odds of the average person with no family history of schizophrenia www.schizophrenia.com Biopsychology and anatomy The Dopamine Theory (positive Sx) – Reserpine, extrapyramidal side effects (EPS) and Parkinson’s – Amphetamines and cocaine – Haloperidol and D2 receptors The Glutamate Theory (positive and negative Sx) – N-methyl-D-aspartate (NMDA), a glutamate receptor is compromised – Complex behaviors – Neural pathways Small differences in brain anatomy – – – – – Fluid-filled ventricles are larger Cerebral cortices are smaller Lower gray matter volume Less or more metabolic activity Different distribution of brain cells (Mueser & McGurk, 2004) Features of SPMI interfere with social and family functioning Isolation Disturbances in eating and sleeping cycles Poor insight: A product of disease rather than a coping mechanism Violence No higher then general population 10% commit suicide 20%-40% attempt Low life expectancy (DSM-IV-TR) Comorbidity – – Panic disorder OCD Victimization Homelessness and housing Psychotic symptoms Motivational factors Affective states Stigmatization Cigarette smoking (88%, Hughes et al., 1986) Comprehensive treatment Combination of optimal medication and targeted psychosocial treatment Psychoeducation – – – – Symptoms Medication and importance of adherence Treatment and strategies Relapse prevention Family involvement – Education – Ongoing contact with treatment team (Lehman et al., 2003) Psychosocial Treatment Behavioral and psychosocial – Social skills training – Family interventions – Cognitive-behavioral psychotherapy – Supported employment – Assertive community treatment – Token economy social learning intervention (Lehman et al., 2003) Domain specific – Psychoeducation improves knowledge of mental illness – Behavioral tailoring improves medication adherence as prescribed – Relapse prevention reduces rates of symptom relapses and rehospitalizations – Cognitive-behavioral coping skills training reduces the severity and distress of persistent symptoms (Mueser et al., 2002) What is recovery? Development of new meaning and purpose Short-term and long-term relief Social successes and personal accomplishment Personal meaning is critical Self-confidence and self-efficacy Self-concept beyond the illness Enjoyment and pleasure in daily activities Sense of well-being, hope, and optimism Gain mastery of their symptoms Improvement coping with stresses of daily life (Mueser et al., 2002) Types of pharmacotherapy Traditional medication – Stelazine, flupenthixol, loxipine, perphenazine, chlorpromazine, haldol, and prolixin Second generation – Aripiprazole, clozaril, geodon, risperdal, seroquel, zyprexa, Both old and new medications can help All can have side effects depending on the person and the type of medication Schizophrenia medication treatment www.schizophrenia.com Limitations to medication Not a cure They don’t always work Can take many years to find an optimal drug Side effects Adherence and compliance Expensive – Assistance programs for those who are eligible (Taylor, 2003) What is Social Skills Training (SST) Behaviorally based instruction, modeling, corrective feedback and contingent social reinforcement aimed to improve social competence through: – Social skills – Self-care – Independent living skills Characteristics – – – – – Highly interactive Structured Systematic Educational Incremental approach to skills acquisition Advantage: SST provides a useful format of teaching in which other skills can be inserted (Heinssen et al., 2000; Lehman et al., 2004) Components of social skills Expressive skills – Speech content – Paralinguistic features – Nonverbal behaviors Receptive behaviors – Attention to and interpretation of cues – Emotion recognition Interactive behaviors – Response timing – Use of social reinforcers – Turn taking Situational factors – Social “intelligence” (Bellack et al., 2004) Theoretical basis for SST Social skills model (Mueser, 1998) – – – Specific social skills make up general social competence Skills are learned or learnable Social incompetence is a result of: • • • – Reinforcement, shaping, overlearning Social learning theory (Bandura, 1969) – Social skills training can improve social competence Operant conditioning (Skinner, 1938, 1953) – A lack of required social skills Using a social skill at the inappropriate time Performing socially inappropriate behaviors Modeling, generalization Stress-vulnerability model (Zubin & Spring, 1977) – – – – – Perceived severity of the life event stressor Perception of the stressfulness of the load The capacities of the individual in dealing with the stressful event Coping efforts exerted in dealing with the stressful situation Vulnerability of the individual Multi-method, multi-rater assessment of social functioning Comprehensive clinical interview – Attention to social deficits • Specific situations • Probable source • Observation of current behavior – General question followed by specific questions: • Can you remember the last time you had an argument with someone at home/ where you live? – When was that? – Can you describe the situation for me? – What exactly did you say? – Social Functioning Interview • • • • Role functioning, past and present Problematic social situations Personal goals Social skills strengths and weaknesses (Bellack et al., 2004) Multi-method, multi-rater assessment of social functioning Assessment tools – Social Behavior Schedule (informant) • – Katz Adjustment Scale (self & informant) • – Social withdrawal, interpersonal functioning , prosocial activities, recreation, level of independence, level of dependence, and employment Social-Adaptive Functioning Evaluation (designed for geriatrics, but can be used for low functioning individuals with schizophrenia) • – Self-care, social contact, appropriateness of communication, social responsibility, & social turbulence Social Functioning Scale (self & informant) • – Role functioning, household chores, finances, family relationships, social leisure, friendships and dating Life Skills Profile (informant) • – Social behavior, leisure time, social participation Social Adjustment Scale-II, client and family versions • – Ability to converse, social comfort and appropriateness, degree of social contact and personal strife Self-care, impulse control, basic social behaviors, social engagement, participation in treatment Independent Living Skills Survey (self & informant) • Self-care, care of personal possessions, money management, use of public transportation (Pratt & Mueser, 2002) Multi-method, multi-rater assessment of social functioning Observation – Informal • • • • • • • Looking down Whispering Tangential speech Rapport Positive response Verbal and nonverbal skills Situation appropriate behavior – Direct • Social skills checklist • Role-play test • Maryland Assessment of Social Competence (MASC) Interviewing significant others – Environment • Supportive • Social reinforcement • Model appropriate behavior – Conflict – Clinician seeks objective, specific reports (Bellack et al., 2004) On-going assessment From sessions – Goals, dates, skills, number of role-plays – Attention & cooperation Evaluating effectiveness of specific social skills – Interviewing about certain situations – Informal observation – Obtaining perspective of significant others – Observation of role-play test Homework – Brief description of what took place – Self-rating of effectiveness – Assignment descriptions – Due dates – Name of leader who assigned homework – Date, time, and location that the skill was practiced (Bellack et al., 2004) Logistics: Established before first session Format Pacing Group composition Location Group size Session duration Evaluation procedures Timing Group duration (Bellack et al., 2004) Attendance Important due to hierarchical nature – Simple to complex skills Emphasize attendance – Promote the view that attendance is a key component to their treatment – Strategies to encourage attendance • Reward with money, increased privileges, recreational opportunities, food, time with staff, or tokens (used to buy goods at a hospital or clinic) (Pratt & Mueser, 2002) Group leadership Can be paraprofessional Competent leadership style is necessary Co-leaders Consistent Supervision (Pratt & Mueser, 2002) Preparing clients for group meetings 15 to 30 minutes with each client Build rapport Orient client to social skills training (rationale) Screen clients who are not ready – If not, stay in contact Both co-leaders should meet the client together Set goals for the group – If they cannot, prompt them – If goals are too ambitious, don’t discourage • Help the client to break it down into manageable steps (Bellack et al., 2004) Goals related to social skills deficits Problems in social functioning Possible goal for social skills training No friends, social isolation To start conversation on a regualr basis Lack of interest in leisure activities To participate in at least one form of recreation Gives in to unreasonable demands To refuse inappropriate requests Becomes physically aggressive when angry To express anger appropriately Speaks in a monotone To vary voice tone and expression Speech is delusional and tangential To stay on the converstional topic Makes frequent demands To make positive requests of others (Bellack et al., 2004) Break goals into smaller steps Goal Possible steps to achieve goal Make friends 1. Start a conversation with one person at work 2. Attend the next social event at the dropin center 3. Introduce self to one person per week Shop for clothes independently 1. Choose one item of clothing to purchase 2. Shop with the assistance of a relative 3. Establish size needed, approximate price 4. Select item for purchase (Bellack et al., 2004) Breaking down goals (cont.) Goal Possible steps to achieve goal Respond effectively to criticism from employer 1. Use reflective listening when receiving supervisory feedback 2. Ask clarifying questions to obtain more information 3. Request suggestions for improvement Use public transportation to all locations 1. Obtain schedule for buses stopping nearby 2. Choose a relatively close destination that does not require transferring buses 3. Ask friend to accompany on first trip (Bellack et al., 2004) Implementation Steps 1. Establish a rationale for the skill 2. Discuss the steps of the skill 3. Perform role-play exercises 4. Assign homework 5. Use generalization strategies Presentation style – Slowly – Repetitively in small “chunks” – Positive reinforcement – Gradually combining simple behaviors to complex sequences (Bellack et al, 2004) Step 1: Establish a rationale Elicit reasons for learning the skill from group participants – Helps them to take greater ownership – “Why might it be be helpful to be able to start a conversation with somebody?” Provide additional reasons Emphasize relevance of learning skill to achieving important life goals (Bellack et al., 2004) Step 2: Discuss the steps of the skill Display the steps of the skill on the board or poster Explain each step Elicit reasons for and importance of each step from group participants Provide additional reasons not provided by group participants (Bellack et al., 2004) Step 3: Role-play exercises Plan in advance Value Description of scenario Leaders model Participants identify steps Participants evaluate effectiveness (Bellack et al., 2004) Step 3: Role-play exercises Understanding of roles and expectations Elicit a volunteer Others participants observe the volunteer Elicit positive feedback Redirect (Bellack et al., 2004) Step 3: Role-play Provide additional positive feedback Offer one suggestion Encourage repetition Elicit and provide additional positive feedback Use supplementary modeling, discrimination modeling, and coaching, if necessary (Bellack et al., 2004) Step 4: Assign homework Completed in a natural environment Value of practicing skills in real-life situations Tailor assignments to match level of mastery Identification of when, where, how and with whom Review homework at the beginning of the next session (Bellack et al., 2004) Step 5: Use generalization strategies Staff at treatment facility Invite indigenous community supports Regular meetings Choosing which skills to teach Depends on the group – – – – – Age Severity Types of symptoms Social deficits Environment Basic skills are typically taught in all cases Categories of curricula Basic social skills Conversation skills Assertiveness Conflict management Communal living Friendship and dating Health maintenance Vocational/ work Coping skills for drug and alcohol use Basic social skills Expressing positive feelings Making requests Listening to others Expressing unpleasant feelings They are taught in this order They are building blocks for other skills Help clients feel comfortable with the process of social skills training (Bellack et al., 2004) Curriculum menus: Anger management Expressing unpleasant feelings Leaving stressful situations Responding to untrue accusations Expressing angry feelings Disagreeing with another’s opinion without arguing Responding to unwanted advice Guidelines for using skill sheets Each social skill has its own skill sheet Provides a framework for learning the skill Leaders can tailor the skill sheets to meet the needs of the clients – It is not necessary to use any of the suggested role-plays provided – Leaders can make role-plays more relevant to the lives of the clients (Bellack et al., 2004) Follow the model Go step by step May be a struggle for new leaders Experienced leaders may stray Maintain positive communication style Use checklists to ensure adherence to the model (Bellack et al., 2004) Example lesson plan: Anger management Session 1 – Generate a list of early warning signs and solutions – Discussion Session 2 – Generate a list of coping strategies for dealing with angry feelings – Discussion Example lesson plan Session 3 – Introduce the skill Leaving Stressful Situations. – Leaders model and then practice with each group member, tailoring the scenes to specific experiences. – Assign homework Session 4 – Review homework – Continue with the skill Leaving Stressful Situations. – Group members practice the skill with each other, using role-play scenes that are relevant to their experiences. – Assign homework Session 5 – Review homework – Finish with the skill Leaving Stressful Situations. – Leaders practice the skill with each member while increasing the difficulty of the role-play scene. – Assign homework Continue down the curriculum menu at an appropriate pace When the curriculum breaks down Teach problem solving – Steps • • • • • • Define the problem Use brainstorming to generate possible solutions Identify the advantages and disadvantages to each solution Select the best solution or combination Plan how to carry out the solution Follow up on the plan at a later time – Use same format (rationale, role-play, etc.) – More complicated, so may take more time than other skills Develop a new curriculum Common problems Poor attendance Cognitive difficulties Responding to psychotic symptoms Distractibility Disruptions Social withdrawal/Low level of participation (Bellack et al., 2004) General principles in dealing with problems Keep communication brief and to the point Be consistent in maintaining structure and holding group at same time and in same place Praise efforts and small steps toward improvement Teach and review basic skills frequently (Bellack et al., 2004) Highlights of empirical support Improves targeted skills and social adjustment in general (Chambon & Marie-Cardine, 1998) Simple and complex behaviors (Heinssen et al., 2000) Retention up to 1 year after treatment (Eckman et al., 1992) Protective role - less anxiety, less stress (Heinssen et al., 2000) Effective across severity (Heinssen et al., 2000) Little impact on level of psychopathology or relapse rates (Liberman et al., 1998) Males acquire more skills than females (Mueser et al., 1990) Females have higher skills scores at baseline (Mueser et al., 1995) Empirical support of SST Purpose: Compare two-year community functioning between psychosocial occupational therapy and SST Participants: Eighty-four medicated men with schizophrenia were randomly assigned to OT or SST Pretreatment: A psychiatrist blind to psychosocial treatment prescribed antipsychotics as he would ordinarily Treatment: Twelve hours per week for six months – Both groups received subsequent case management community follow-up for 18 months – SST focused on • Basic conversation skills • Leisure and recreational skills • Skills for medication management • Sx management skills (Liberman et al., 1998) Empirical support SST group had significantly better independent living skills and lower levels of stress OT SST Mean F p Personal possessions 2.97 11.54 4.81 0.03 Food preparation 4.71 9.89 3.76 0.05 Money management 3.03 11.78 4.64 0.03 Life distress 0.17 -0.20 5.45 0.02 (Liberman et al., 1998) What is a family intervention? Home visits Behavioral strategies The aim: To mprove the family's ability to cope with a members' severe mental illness. Techniques include: – Active learning through guided practice – Therapist demonstration – Role-play – Homework – Coaching – Psychoeducation Format – Group (family) setting – 60 to 75 min sessions – 9 months to 3 years – Repeated practice among family members – Similar to social skills training (Falloon, 2002) Theoretical assumptions Improved communication in families alleviates stresses of reintegration Strength of the family is one of the greatest natural resources Families can be the target of blame (i.e., genetics, bereavement, separation/divorce) Family care extends beyond the confines of the family home Improvements in telecommunications and transportations Family = intimate social network, not necessarily a biological family (Falloon, 2002) Clinical strategies Assessment of functioning of the family unit Education about specific disorders Communication training Structured problem-solving training Specific cognitive-behavioral strategies Home-based crisis intervention Variability of approaches (Falloon, 2002) Assessment What is the vulnerability, stress, and problem-solving capacity of the family unit? – Camberwell Family Interview • Expressed Emotion Index – – – – Critical remarks (high interrater reliability) Hostility (low) Emotional overinvolvement (high) Warmth and positive remarks (low) (Swedish sample; Orhagen & d’Elia, 1991) – What are each family members goals? – Problem analysis for each family member • What triggers a family argument? • What increases or decreases the intensity of agitated behavior? • What happens when a person experiences rejection while attempting to develop a friendship? (Falloon, 2002) Family psychoeducation First few sessions Handouts are provided Stress-vulnerability model Revision of education, when necessary – A stressor is emerging Recognition of early warning signs Checklists are available, though it is best to determine an individual’s idiosyncratic warning signs (Falloon, 2002) Communication training (CT) Goal: Facilitate the ability of the family unit to conduct its own problemsolving discussions CT enhances – – – – Specificity Positive reinforcement of progress Prompting behavior change w/out coercion Empathy Method – Repeated practice among family members – Similar to social skills training • Role-play • Homework Family members do not have social deficits, but optimal communication will make life easier living with someone who is vulnerable to a stresssensitive disorder (Falloon, 2002) Structured problem-solving training Goal: Enhance the problem-solving efficiency of the family unit Steps – Define the problem or goal – List alternative solutions – Evaluate the consequences of proposed solutions – Choose the optimal solution – Make a plan – Review and evaluate implementation Therapist assists to convene at least weekly Therapist avoids getting personally involved or offering solutions (Falloon, 2002) Cognitive-behavioral strategies Use when family is struggling to think of a solution of their own – Operant reinforcement – Desensitization – Cognitive restructuring – Strategies to address sexual dysfunction Integrate into problem-solving process (Falloon, 2002) Empirical support for family interventions Purpose: To compare the efficacy of family management and patientoriented therapy on family functioning Constructs assessed: family burden, family coping, psychotic symptoms, social behavior Two groups randomly assignment – Experimental: community management based on family support (n=18) – Control: Patient-oriented treatment with supplementary family support (n=18) Family management treatment – Twenty-three weekly sessions of behavioral family therapy – Two additional sessions of family education about schizophrenia (Falloon, & Pederson, 1985) Empirical support for family interventions Sessions were conducted at family residences Results: People in the family management group reported significantly less: – Disruption of activities – Physical and mental health problems – Subjective burden (Falloon, & Pederson, 1985)