SLA Pipeline Town Hall Meeting Christine Blazynski PhD Sr. Vice-President Product Development An informa business www.citeline.com Integrated and Enterprise-Wide Services TrialTrove Clinical Trials Intelligence Global Coverage Of Clinical Trials Design and Status Pipeline / Pharmaprojects Drug Intelligence World’s foremost collection of All Drugs In Development From Bench To Market clinical trials, investigators, sites, drugs & analysis SiteTrove Investigator / Site Selection Investigators And Sites Based Upon Direct Trials Experience TrialPredict Trials Timing / Benchmarking Citeline Analytics Mapping the Competition Drug: Tykerb (Lapatinib) Disease: Breast Cancer Adjuvant and Neoadjuvant Therapy 2004 Map Date: 2005 2006 Competitive Development Map 2007 2008 2009 2010 2011 2012 2013 2014 Visualization of Clinical Development Programs 6/23/07 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Adjuvant Lap (+ AC,Doxo,Pac,Tras), 0/I/II/III, TA109, #65110 Phase II Lap, I/II/III, TA3000, TEACH, (#56312) Phase III Biomarker/Tox Biomarker/SE, PGX Lap (4-arm trial), I/II, TA8000, ALTTO, (#45399) EI, Biomarker/SE, PGX Lap (+/vs Tras, + AC,Doxo), I/II, #55823 Neoadjuvant Phase II Lap, II/III/IV, TA22-55, #33321 Biomarker/SE Lap (+ Pac,Surg), III/IV, PGX AA50/TA60, #29064 Lap (+ Ab), I/II/III, TA30, #50405 Lap, II/III, #51923 Biomarker/SE Biomarker/SE Lap, I/II/III, TA150, #52438 Citeline Proprietary Prediction of Trials Enrollment Timing Lap, I/II/III, TA120, Biomarker/SE #45628 Lap (+ AC,Doc,Doxo), II/III, TA71, #60281 PGX Lap (+/vs Tras, + Chemo), II/III, TA120, #63895 Lap (+/vs Let), II/III, TA91, #63171 Phase III Biomarker/SE Biomarker/SE Lap (+/vs Tras, + Pac), I/II, TA450, NEO-ALTTO, (#53035) Biomarker/SE, PGX PGX Lap (+/vs Tras, +AC,Doxo), II/III, TA522, #71240 An informa business NeoAdjuvant and Adjuvant Phase II Lap +Tras (+ AC,Doxo,Pac,Surg), 0/I/II/III, TA100, #70768 Biomarker/Tox www.citeline.com Depth and Breadth of Citeline Data 150 countries covered 180+ disease areas in TrialTrove/ >1000 in Pipeline ☐ 222 therapeutic categories in Pipeline 250+ analysts and editors 18,000 data sources >4,000 companies developing therapeutics >46,000 drugs ☐ Over 30 years of history >120,000 interventional trials >250,000 investigator profiles An informa business www.citeline.com Citeline’s Drug Intelligence One centralized database of drug information Deep integration with Citeline’s clinical development offerings An informa business www.citeline.com Pharmaprojects Legacy pipeline database ☐ PJB publications Thirty-one continual years of tracking drug development ☐ Print 3rd party electronic distributer delivery ☐ Updated once weekly CD ROM Web Trends data from 1995 through 2010 An informa business www.citeline.com Pipeline Continually updated/real-time Clean, simple, user-friendly interface Customized alerts, saved searches, and share search Unlimited research support Search criteria expanded over time All fields export or disease-focused export Integration with TrialTrove, SiteTrove and TrialPredict An informa business www.citeline.com Export Options An informa business www.citeline.com An informa business www.citeline.com Recent Enhancements ☐ Hierarchical mechanism search ☐ Addition of biosimilars/biogenerics ☐ Company country HQ search and research focus ☐ Delivery route/medium/technology search ☐ Advanced search [phase 1] ☐ Automatic search for trials from multiple drug results ☐ Search by latest change date or range An informa business www.citeline.com Pipeline An informa business www.citeline.com Planned Enhancements ☐ Advanced Search: nested booleans, ability to move search terms, edit operators within and between categories ☐ NCE search ☐ Search by chemical name ☐ Search by originator OR licensee ☐ Trial reporting: tabular view ☐ Dashboard reporting An informa business www.citeline.com 700 Pipeline Users by Job Function 600 500 400 300 200 100 0 An informa business www.citeline.com Citeline’s Drug Intelligence One centralized database of drug information Drug, company data to meet all business development needs An informa business www.citeline.com Citeline - MedTrack An MedTrack joined Citeline in late March 2011. As of April 6: ☐ 21,326 companies ☐ 107,199 drugs (not all unique; includes generics) ☐ 1,556 drug delivery technologies ☐ 55,758 deals ☐ 642 indications ☐ 615,114 searchable news releases ☐ 142,525 management bios ☐ 481,558 searchable SEC documents MedTrack V2 migration continues Planning for initial integration between products just starting but clear synergies exist Need for market research and focus groups……… will you help? informa business www.citeline.com