Introduction to
meta-analysis in
Review Manager (RevMan).
Ewelina Rogozinska
CT Data Assistant/Researcher
Women's Health Research Unit
The systematic review process
Formulate
research
question
Further selection of
primary studies
using inclusion
criteria
Extract data
Design
search
strategy
Search
bibliographic
databases
Retrieve papers
Identify possible
papers from
titles/abstracts
Quality
appraisal
Synthesis
Formulate research /
policy conclusions
Session overview
1. Brief introduction
• What do we use RevMan for?
• Setting up RevMan file
2. Practical part
•
Adding studies
•
Add outcome
•
Data entry
•
Conducting meta-analysis
•
Add new comparison
•
Introducing subgroups
•
Generating plots and graphs
Introduction to meta-analysis in RevMan
Ewelina Rogozinska
Working with RevMan
•
Review Manager (RevMan) - software used for preparing and maintaining
Cochrane Reviews.
•
You can use RevMan for protocols and full reviews.
•
It is most useful when you have formulated the question for the review
and allows you to:
•
prepare the text,
•
build the tables showing the characteristics of studies and the comparisons in
the review,
•
•
add study data,
•
perform meta-analyses and
•
present the results graphically.
It can be downloaded from Cochrane web page http://ims.cochrane.org/revman
Tasks
1.
Add two new studies: Mardones 2007 and Zhou 2012
2.
Add new outcome ‘Birth weight (g)’ under comparison ‘Fish oils’ and specify:
•
Type of data: continuous
•
Analysis model: random
•
Effect measure: mean difference
•
Analysis details: totals and subtotals
•
Graph details
3.
To outcome ‘Birth weight (g)’ add studies: Mardones 2007 and Zhou 2012
4.
Transfer earlier extracted data for birth weight from these two studies
Introduction to meta-analysis in RevMan
Ewelina Rogozinska
Tasks
5.
6.
7.
Create new comparison ‘Diet and fish oils’ and specify:
•
Type of data: dichotomous
•
Stat method: Mantel-Haenszel
•
Analysis model: random
•
Effect measure: Risk Ratio
•
Analysis details: totals and subtotals
•
Graph details: scale 10.0
Add studies and create two subgroups:
•
First: diet
•
Second: fish oils
For outcome ‘Pre-eclampsia (PET)’ generate:
•
Forest plot;
•
Funnel plot
•
Risk of bias graph
Introduction to meta-analysis in RevMan
Ewelina Rogozinska