WHAT IS VITAMIN D?
Vitamin D is classified as a fat
soluble vitamin
There are two important groups of this
compound in humans:

Vitamin D2 (Ergocalciferol)

Vitamin D3 (Cholecalciferol)
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Uses of Vitamin D
• Regulates calcium uptake:
Liver converts cholecalciferol into calcidiol
kidney converts calcidiol to calcitriol
Transported to intestinal tract, triggering the production of
Calcium uptake proteins.
• Suppresses abnormal cell growth
• Stimulates immunity and prevents the development of autoimmune
diseases.
• Regulates the release of renin; citing its role in the cardiovascular
system
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Deficiency of vitamin D
Prevalence of vitamin D deficiency is 30-50% in
the general population.
Following disorders are the consequences resulting
from this deficiency:
•
Osteoporosis and other bone abnormalities
•
Hip and vertebral fractures
•
Hypertension
•
Congestive heart failure
•
Autoimmune diseases
•
Chronic muscle aches
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Diagnostic values
Serum concentration of 25(OH)D3 are used as
diagnostic markers for Vitamin D
• Normal levels are 30-60 ng/ml
• Concentrations < 12-20 ng/ml are considered deficient
• Levels > 60 ng/ml are considered toxic to the body.
Recommended daily intake of vitamin D is 600-800 IU
Remember that 100 IU = 1ng/ml
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Sources of Vitamin D
Food source:
Very little food contains adequate amounts of vitamin D. The
flesh of certain fatty fish ( salmon, tuna) and cod liver oil is a good source.
Small amounts are also found in cheese , beef liver and egg yolks.
Sun Exposure:
Exposure to sunlight manufactures Vitamin D3 through our
skin, that’s why this vitamin is also known as the “sunshine vitamin”.
Dietary supplements:
Dietary supplements come in both forms of vitamin D.
Research has shown D2 to have lesser potency and short duration of
action, rendering it half as effective as D3
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Introducing…D-Sorb™
A wide range of vitamin D-3
potencies using the patented
VESIsorb® colloidal droplet
technology
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D-Sorb™ in both Liquid
Droplets and Solid Dosage Forms
•Droplets
A) 500 IU Vit. D*/drop (1drop = 25mg)
B) 2'000 IU Vit. D*/drop (1drop = 25mg) *as D3 plus Pre-D3
•Available in various potencies from 500IU to 15,000IU of D-3
per capsule and capsule sizes and D-3 potency can be
customized
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Vitamin D Bioavailability & VESIsorb (I)
•Enhanced solubilization of Vitamin D3 by VESIsorb®
...”Body Ready”...
Vitamin D3, like Coenzyme Q10, is a poorly water-soluble compound. Thus,
enhanced solubilization of Vitamin D3 within the GI fluid by VESIsorb® may
improve its oral bioavailability.
•Fat/food independent absorption
The absorption of Vitamin D3, like the one of other poorly water-soluble
vitamins, is dependent on food respectively fat. Like other solubilizing delivery
system VESIsorb can reduce this food/fat effects and hence may provide
more reproducible Vitamin D3 plasma levels.
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Vitamin D Bioavailability & VESIsorb (II)
•MCT
Vitamin D3 dissolved in medium-chain triglycerides (MCT) produced a 4.25
times greater increase in serum 25(OH)D levels than an ethanol vehicle.
Reference: Maalouf et al. J. Clin. Endocrinol. Metab. 93:2693-2701, 2008
Remember: MCT is a main ingredients of D-Sorb/VESIsorb®
•Improved lymphatic absorption
Vitamin D3 absorption is associated with lymphatic transport. Reference:
Cuiné JF et al. Pharmaceutical Research, 24:748-757, 2007
DSorb/VESIsorb formulation contains ingredients that are known to increase
the lymphatic transport capacity
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