This is a Study About Some Sort of Glioblastoma Treatments or Imaging of
Brain Tumors
Author Name2, Author Name5
1Dept.
of Neurology, 2Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA
PURPOSE
To demonstrate the utility of whole brain graded functional diffusion maps (fDMs) as an biomarker for
monitoring brain tumor growth and invasion
INTRODUCTION
METHODS
 In neoplasms, a decrease in apparent diffusion coefficient
(ADC is believed to reflect an increase in tumor cellularity 1-6, and
an increase in ADC is believed to reflect necrosis or decreases in
cellularity as a result of successful cytotoxic treatment 2,7.
 Functional diffusion maps (fDMs) were developed to exploit
these principles on a voxel-wise basis and may be useful for
predicting response to chemotherapy and radiotherapy 8-11.
 Currently, traditional fDMs rely on a single threshold for
classifying voxels as significantly increasing or decreasing.
 We hypothesize that a graded fDM technique that stratifies
voxels into varying degrees of change, applied to the whole
brain may be useful for visualizing growing and invading tumor
with high sensitivity and specificity.
 In neoplasms, a decrease in apparent diffusion coefficient
(ADC is believed to reflect an increase in tumor cellularity 1-6, and
an increase in ADC is believed to reflect necrosis or decreases in
cellularity as a result of successful cytotoxic treatment 2,7.
 Functional diffusion maps (fDMs) were developed to exploit
these principles on a voxel-wise basis and may be useful for
predicting response to chemotherapy and radiotherapy 8-11.
 Currently, traditional fDMs rely on a single threshold for
classifying voxels as significantly increasing or decreasing.
 We hypothesize that a graded fDM technique that stratifies
voxels into varying degrees of change, applied to the whole
brain may be useful for visualizing growing and invading tumor
with high sensitivity and specificity.
RESULTS
 In neoplasms, a decrease in apparent diffusion coefficient
(ADC is believed to reflect an increase in tumor cellularity 1-6, and
an increase in ADC is believed to reflect necrosis or decreases in
cellularity as a result of successful cytotoxic treatment 2,7.
 Functional diffusion maps (fDMs) were developed to exploit
these principles on a voxel-wise basis and may be useful for
predicting response to chemotherapy and radiotherapy 8-11.
 Currently, traditional fDMs rely on a single threshold for
classifying voxels as significantly increasing or decreasing.
 We hypothesize that a graded fDM technique that stratifies
voxels into varying degrees of change, applied to the whole
brain may be useful for visualizing growing and invading tumor
with high sensitivity and specificity.
REFERENCES
Acknowledgements:
1
Sugahara, JMRI, 1999; 2 Lyng, MRM, 2000; 3 Chenevert, JNCI, 2000; 4 Hayashida,
AJNR, 2006; 5 Manenti, Radiol Med, 2008; 6 Gauvain, AJR, 2001; 7 Chenevert, Clin
Cancer Res, 1997; 8 Moffat, Proc Nat Acad Sci, 2005; 9 Moffat, Neoplasia, 2006; 10
Hamstra, JCO, 2008; 11 Hamstra, Proc Nat Acad Sci, 2005. 12 Ellingson, JMRI, 2010. 13
Stupp, NEJM, 2005.