NST11 Spring 2025 Assignment 3
Multiple Choice
1. In the fall of 2024, the California Department of Fish and Wildlife issued a warning to delay
opening the Dungeness crab fishing in parts of northern California. This was likely due to
a.​ Red tide warnings in that area
b.​ Brevetoxin
c.​ Domoic Acid
d.​ Histamine
2. Which of the following is not a source of Alflatoxin B1 exposure?
a.​ Peanuts
b.​ Potato
c.​ Wheat
d.​ Milk
3. What does ADI stand for?
a.​ Acceptable Daily Intake
b.​ Accepted Dose Intake
c.​ Actual Daily Intake
d.​ Acceptable Dose Intensity
4. Polychlorinated biphenyls disrupt thyroid hormone function in all of the following ways except
a.​ Inhibit conversion of T4 to T3
b.​ Promote thyroid hormone breakdown in the liver
c.​ Reduce the ability of thyroid hormone to bind transport proteins
d.​ Directly bind to thyroid tissue causing apoptosis
Please answer true or false and correct the questions that are false
5. Orange B and Citrus Red No. 2 are restricted for specific uses
6. FD&C Blue No.1 is the most toxic color additive
7. Scombriod fish can accumulate histamine in their muscle tissue which is toxic to humans
when eaten
8. Amanita phalloides causes hallucinations and is an agonist of the 5-HT2A serotonin receptor
Short Answer
9. You are suffering from migraines and your doctor prescribes you Ergomar. What is the active
ingredient in this medication and what is the mechanism of action?
10. You are planning a trip to Japan! There are so many exciting and interesting foods to try and
you are interested in trying fugu. What organism does fugu originate from and why is its
preparation important?
11. Calculate an ADI for Brevetoxin in adult humans. The NOAEL in mice is 500µg/kg based on
an acute (short-term) exposure study. Make sure to write the ADI with the correct units.
12. Define GRAS and then name 3 common food additives that are GRAS
13. Please draw a diagram of how BPA causes PPARy activation at the cellular level and
describe what the downstream effects are.