Chapter 1: Introductory Concepts Definition of Anatomy and Physiology: Anatomy refers to structure; physiology refers to function. Levels of Organization: Chemical, cellular, tissue, organ, organ system, and organismal. Homeostasis: o Definition: Maintenance of a stable internal environment. o Components: Receptor, control center, effector. o Feedback Mechanisms: Negative (stabilizing) vs. Positive (amplifying). Directional Terms: Superior/inferior, anterior/posterior, medial/lateral, proximal/distal, superficial/deep. Body Planes and Cavities: o Planes: Sagittal, coronal, transverse. o Cavities: Dorsal (cranial, spinal) and ventral (thoracic, abdominopelvic). Chapter 2: Basic Biochemistry Atoms and Molecules: Structure of an atom (protons, neutrons, electrons). Chemical Bonds: Ionic, covalent, and hydrogen bonds. Organic Molecules: o Carbohydrates: Monosaccharides, disaccharides, polysaccharides. o Lipids: Triglycerides, phospholipids, steroids. o Proteins: Amino acids, primary/secondary/tertiary/quaternary structures. o Nucleic Acids: DNA and RNA. Enzymes: Biological catalysts, factors affecting enzyme activity. pH and Buffers: o pH scale (0-14): Acidity and alkalinity. o Role of buffers in maintaining homeostasis. Chapter 3: Cellular Structure and Function Cell Theory: Basic unit of life. Cell Membrane: Phospholipid bilayer, membrane proteins, selective permeability. Organelles and Their Functions: o Nucleus: DNA storage, control center. o Mitochondria: Energy production (ATP). o Ribosomes: Protein synthesis. o Endoplasmic Reticulum: Rough (protein production), smooth (lipid synthesis). o Golgi Apparatus: Packaging and transport. o Lysosomes/Peroxisomes: Waste breakdown. o Cytoskeleton: Shape, support, movement. Transport Mechanisms: o Passive: Diffusion, osmosis, facilitated diffusion. o Active: Pumps, endocytosis, exocytosis. Cell Division: o Mitosis: Phases (prophase, metaphase, anaphase, telophase). o Cytokinesis: Division of the cytoplasm. Chapter 4: Tissue Types Four Tissue Types: o Epithelial: Covering, lining, glandular. o Connective: Support, protection, storage (bone, cartilage, blood). o Muscle: Skeletal, cardiac, smooth. o Nervous: Neurons and neuroglia. Characteristics of Epithelial Tissue: o Cellularity, polarity, avascularity, regeneration. Connective Tissue Components: o Fibers: Collagen, elastin, reticular. o Cells: Fibroblasts, macrophages, adipocytes. Types of Muscle Tissue: o Skeletal: Voluntary, striated. o Cardiac: Involuntary, striated, intercalated discs. o Smooth: Involuntary, non-striated. Chapter 5: The Integumentary System Functions: Protection, thermoregulation, sensation, vitamin D synthesis. Layers of Skin: o Epidermis: Stratified squamous epithelium, keratinized. o Dermis: Connective tissue, blood vessels, nerve endings. o Hypodermis: Subcutaneous fat layer. Skin Appendages: Hair, nails, sweat glands (eccrine/apocrine), sebaceous glands. Skin Repair and Healing: Inflammation, proliferation, remodeling. Chapter 6: The Skeletal System Functions: Support, protection, movement, mineral storage, blood cell formation. Bone Structure: o Compact bone: Osteons, lamellae, central canals. o Spongy bone: Trabeculae, marrow spaces. Bone Cells: Osteoblasts, osteocytes, osteoclasts. Bone Development: o Intramembranous ossification: Flat bones. o Endochondral ossification: Long bones. Axial vs. Appendicular Skeleton: o Axial: Skull, vertebral column, thoracic cage. o Appendicular: Limbs, girdles. Chapter 7: The Muscular System Muscle Functions: Movement, posture, heat production. Muscle Anatomy: o Structure: Muscle fibers, myofibrils, sarcomeres. o Sliding Filament Theory: Actin, myosin interaction. Muscle Contraction: o Neuromuscular junction: Role of acetylcholine. o ATP and calcium ions in contraction. Types of Muscle Contractions: Isometric vs. isotonic. Major Muscle Groups: Biceps, triceps, quadriceps, hamstrings, etc. Chapter 10: The Nervous System Divisions of the Nervous System: o Central (CNS): Brain and spinal cord. o Peripheral (PNS): Cranial and spinal nerves. o Autonomic (ANS): Sympathetic and parasympathetic. Neuron Structure: Dendrites, axon, soma. Neuroglia Cells: Astrocytes, oligodendrocytes, Schwann cells. Action Potential: Resting potential, depolarization, repolarization. Reflex Arc: Sensory neuron, interneuron, motor neuron. Chapter 11: Special Senses Types of Senses: o General: Touch, temperature, pain. o Special: Vision, hearing, taste, smell, equilibrium. Vision: o Eye anatomy: Retina, lens, cornea, optic nerve. o Photoreceptors: Rods (low light), cones (color). Hearing: o Ear anatomy: Outer, middle, inner (cochlea, semicircular canals). o Mechanism of hearing: Sound waves to neural impulses. Taste and Smell: o Chemoreceptors: Taste buds, olfactory receptors. o Connection to limbic system. Equilibrium: Role of vestibular apparatus.