The monitoring and evaluation (M&E) of Egypt's "100 Million Healthy Lives" initiative, especially concerning child health services, involves systematic processes to track progress and outcomes through multi-phase screenings, data collection, and analysis. This M&E structure is designed to ensure transparency, continuous improvement, and responsiveness to public health needs. 1. Data Collection and Screening: For child health, the initiative conducts genetic screenings for newborns in two stages. Initial screenings occur in Ministry of Health facilities, followed by a broader rollout in university hospitals, private nurseries, and health units. Blood samples are collected from infants and analyzed at the Egyptian Center for Disease Control (ECDC), ensuring uniformity in data handling and prompt action for detected genetic conditions. This phased approach allows for consistent tracking of screening numbers, coverage rate, and disease incidence rates 2. Progressive Targeting and Scaling: To measure and expand its reach, the initiative employs a phased expansion plan that adapts based on ongoing results. In the early stages, it focuses on immediate health concerns like congenital diseases in infants, then broadens to cover chronic diseases across other age demographics. The Ministry of Health reports updates on the number of screenings conducted and any emerging health trends, which helps to evaluate and adjust the program’s efficacy in real-time 3. Outcome Reporting and Recognition: Egypt’s achievements under the initiative, such as being declared Hepatitis C-free by WHO, highlight the impact of data-driven health policies. WHO’s acknowledgment indicates that M&E processes are recognized internationally, reinforcing their effectiveness. Regular updates, like the high number of screenings and specific disease reductions, are shared with stakeholders and the public, increasing accountability and support. . 4. Performance Metrics: The initiative sets measurable health indicators, such as the number of diseases screened, the number of newborns and adults examined, and specific outcomes in chronic disease management. By evaluating these metrics, health officials gain insight into service coverage, success rates, and areas needing more resources or strategy adjustments. This data is essential for refining policies, redirecting resources, and enhancing healthcare accessibility nationwide. On June 21, 2024, Egypt's Minister of Health and Population, Khaled Abdul Ghafar, announced that approximately 454,879 infants had been screened through a presidential program focused on early genetic disease detection. This campaign, part of the "100 Million Healthy Lives" initiative launched on July 13, 2021, aims to support a healthier generation by identifying genetic conditions early. In the initiative's first phase, 19 specific genetic conditions are screened in premature infants within Ministry-affiliated hospital nurseries. According to the ministry’s spokesperson, Hossam Abdel Ghaffar, the second phase expands the screenings to newborns in nurseries nationwide, covering university and private hospitals and various health units. Soad Abdel Meguid, head of the healthcare and nursing sector, specified that these screenings include conditions like congenital hypothyroidism, cystic fibrosis, and phenylketonuria, among others. Blood samples from infants' heels are collected and analyzed at the Egyptian Centre for Diseases and Control (ECDC), as explained by Abdel-Razek Through these M&E practices, the "100 Million Healthy Lives" initiative leverages reliable health data to track its impact, inform policy, and maintain transparency as it strives toward creating a healthier, disability-free generation in Egypt. Resources: EgyptToday Egypt Independent World Bank Group Egyptian Gazette .