NERVOUS SYSTEM
12 CRANIAL NERVES
Cranial Nerves
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Twelve pairs of cranial nerves emerge
from the inferior surface of the brain. All
of these nerves, except the vagus nerve,
pass through the foramina of the skull to
innervate structures in the head, neck,
and facial region.
The cranial nerves are designated both
by name and by Roman numerals,
according to the order in which they
appear on the inferior surface of the
brain. Most of the nerves have both
sensory and motor components. Three
of the nerves are associated with the
special senses of smell, vision, hearing,
and equilibrium and have only sensory
fibers. Five other nerves are primarily
motor in function but do have some
sensory fibers for proprioception. The
remaining four nerves consist of
significant amounts of both sensory and
motor fibers.
Acoustic neuromas are benign fibrous
growths that arise from the balance
nerve, also called the eighth cranial
nerve or vestibulocochlear nerve. These
tumors are non-malignant, meaning that
they do not spread or metastasize to
other parts of the body. The location of
these tumors is deep inside the skull,
adjacent to vital brain centers in the brain
stem. As the tumors enlarge, they
involve surrounding structures which
have to do with vital functions. In the
majority of cases, these tumors grow
slowly over a period of years. In other
cases, the growth rate is more rapid and
patients develop symptoms at a faster
pace. Usually, the symptoms are mild
and many patients are not diagnosed
until some time after their tumor has
developed. Many patients also exhibit no
tumor growth over a number of years
when followed by yearly MRI scans.
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CN I - OLFACTORY (CEREBRUM)
SENSORY OF OLFACTION OR SMELL.
CN II - OPTIC (CEREBRUM) SENSORY OF
VISION.
CN III - OCCULOMOTOR (MIDBRAIN)
MOTOR OF EYE MOVEMENT, EYELID
ELEVATION, PUPILLARY CONTRACTION,
LENS ACCOMODATION.
CN IV - TROCHLEAR (MOTOR MIDBRAIN)
EYE MOVEMENT.
CN V - TRIGEMINAL (PONS) SENSORYFACIAL SENSATION AND TONGUE
MOVEMENT ANTERIOR 2/3. MOTOR PART
FOR MASTICATION OR BITING AND
CHEWING.
CN VI- ABDUCENS (PONTOMEDULLARY
REGION) MOTOR- EYE MOVEMENT.
CN VII- FACIAL ( PONTOMEDULLARY)
SENSORY FOR TASTE BUT ONLY 2/3 OF
TONGUE. MOTOR FOR FACIAL
EXPRESSION, EYE CLOSSING,
SALIVATION OR PRODUCING SALIVA AND
LACRIMATION OR TEARS SECRETION.
CN VIII- VESTIBULOCOCHLEAR,
AUDITORY (PONTOMEDULLARY REGION)
SENSORY FOR BALANCE AND HEARING
CN IX- GLOSSOPHARYNGEAL (MEDULLA
OBLONGATA) “Glosso meaning TONGUE”
“Pharyng meaning Pharynx or Throat”.
SENSORY FOR SENSATION/SALIVATION
POSTERIOR 4/3 PHARYN SECRETION.
MOTOR FOR SWALLOWING, SALIVATION.
CN VI- ABDUCENS (PONTOMEDULLARY
REGION) MOTOR- EYE MOVEMENT.
CN VII- FACIAL ( PONTOMEDULLARY)
SENSORY FOR TASTE BUT ONLY 2/3 OF
TONGUE. MOTOR FOR FACIAL
EXPRESSION, EYE CLOSSING,
SALIVATION OR PRODUCING SALIVA AND
LACRIMATION OR TEARS SECRETION.
CN VIII- VESTIBULOCOCHLEAR,
AUDITORY (PONTOMEDULLARY REGION)
SENSORY FOR BALANCE AND HEARING
CN IX- GLOSSOPHARYNGEAL (MEDULLA
OBLONGATA) “Glosso meaning TONGUE”
“Pharyng meaning Pharynx or Throat”.
SENSORY FOR SENSATION/SALIVATION
POSTERIOR 4/3 PHARYN SECRETION.
MOTOR FOR SWALLOWING, SALIVATION.
in turn, consist of various tissues, including
nerve, blood, and connective tissue. Together
these carry out the complex activities of the
nervous system.
The various activities of the nervous system can
be grouped together as three general,
overlapping functions:
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Sensory
Integrative
Motor
Millions of sensory receptors detect changes,
called stimuli, which occur inside and outside
the body. They monitor such things as
temperature, light, and sound from the external
environment. Inside the body, the internal
environment, receptors detect variations in
pressure, pH, carbon dioxide concentration, and
the levels of various electrolytes. All of this
gathered information is called sensory input.
Sensory input is converted into electrical signals
called nerve impulses that are transmitted to the
brain. There the signals are brought together to
create sensations, to produce thoughts, or to
add to memory; Decisions are made each
moment based on the sensory input. This is
integration.
Introduction to the Nervous System
- The nervous system is the major controlling,
regulatory, and communicating system in the
body. It is the center of all mental activity
including thought, learning, and memory.
Together with the endocrine system, the nervous
system is responsible for regulating and
maintaining homeostasis. Through its receptors,
the nervous system keeps us in touch with our
environment, both external and internal.
Like other systems in the body, the nervous
system is composed of organs, principally the
brain, spinal cord, nerves, and ganglia. These,
Based on the sensory input and integration, the
nervous system responds by sending signals to
muscles, causing them to contract, or to glands,
causing them to produce secretions. Muscles
and glands are called effectors because they
cause an effect in response to directions from
the nervous system. This is the motor output or
motor function.
Nerve Tissue
Although the nervous system is very complex,
there are only two main types of cells in nerve
tissue. The actual nerve cell is the neuron. It is
the "conducting" cell that transmits impulses and
the structural unit of the nervous system. The
other type of cell is neuroglia, or glial, cell. The
word "neuroglia" means "nerve glue." These
cells are nonconductive and provide a support
system for the neurons. They are a special type
of "connective tissue" for the nervous system.
Neurons
Neurons, or nerve cells, carry out the
functions of the nervous system by conducting
nerve impulses. They are highly specialized and
amitotic. This means that if a neuron is
destroyed, it cannot be replaced because
neurons do not go through mitosis. The image
below illustrates the structure of a typical
neuron. Each neuron has three basic parts: cell
body (soma), one or more dendrites, and a
single axon.
impulses relative to the central nervous system.
Afferent, or sensory, neurons carry impulses
from peripheral sense receptors to the CNS.
They usually have long dendrites and relatively
short axons. Efferent, or motor, neurons transmit
impulses from the CNS to effector organs such
as muscles and glands. Efferent neurons usually
have short dendrites and long axons.
Interneurons, or association neurons, are
located entirely within the CNS in which they
form the connecting link between the afferent
and efferent neurons. They have short dendrites
and may have either a short or long axon.
Neuroglia
Neuroglia cells do not conduct nerve impulses,
but instead, they support, nourish, and protect
the neurons. They are far more numerous than
neurons and, unlike neurons, are capable of
mitosis.
Axon
An axon may have infrequent branches
called axon collaterals. Axons and axon
collaterals terminate in many short branches or
telodendria. The distal ends of the telodendria
are slightly enlarged to form synaptic bulbs.
Many axons are surrounded by a segmented,
white, fatty substance called myelin or the
myelin sheath. Myelinated fibers make up the
white matter in the CNS, while cell bodies and
unmyelinated fibers make the gray matter. The
unmyelinated regions between the myelin
segments are called the nodes of Ranvier.
In the peripheral nervous system, the myelin is
produced by Schwann cells. The cytoplasm,
nucleus, and outer cell membrane of the
Schwann cell form a tight covering around the
myelin and around the axon itself at the nodes
of Ranvier. This covering is the neurilemma,
which plays an important role in the
regeneration of nerve fibers. In the CNS,
oligodendrocytes produce myelin, but there is no
neurilemma, which is why fibers within the CNS
do not regenerate.
Functionally, neurons are classified as afferent,
efferent, or interneurons (association neurons)
according to the direction in which they transmit
Tumors
Schwannomas are benign tumors of the
peripheral nervous system which commonly
occur in their sporadic, solitary form in otherwise
normal individuals. Rarely, individuals develop
multiple schwannomas arising from one or many
elements of the peripheral nervous system.
Commonly called a Morton's Neuroma, this
problem is a fairly common benign nerve growth
and begins when the outer coating of a nerve in
your foot thickens. This thickening is caused by
irritation of branches of the medial and lateral
plantar nerves that results when two bones
repeatedly rub together.
Organization of the Nervous System
Although terminology seems to indicate
otherwise, there is really only one nervous
system in the body. Although each subdivision of
the system is also called a "nervous system," all
of these smaller systems belong to the single,
highly integrated nervous system. Each
subdivision has structural and functional
characteristics that distinguish it from the others.
The nervous system as a whole is divided into
two subdivisions: the central nervous system
(CNS) and the peripheral nervous system
(PNS).
regulates involuntary or automatic functions, it is
called the involuntary nervous system.
The Central Nervous System
The Central Nervous System
The brain and spinal cord are the organs of the
central nervous system. Because they are so
vitally important, the brain and spinal cord,
located in the dorsal body cavity, are encased in
bone for protection. The brain is in the cranial
vault, and the spinal cord is in the vertebral
canal of the vertebral column. Although
considered to be two separate organs, the brain
and spinal cord are continuous at the foramen
magnum.
The CNS consists of the brain and spinal cord,
which are located in the dorsal body cavity. The
brain is surrounded by the cranium, and the
spinal cord is protected by the vertebrae. The
brain is continuous with the spinal cord at the
foramen magnum. In addition to bone, the CNS
is surrounded by connective tissue membranes,
called meninges, and by cerebrospinal fluid.
The Peripheral Nervous System
There are three layers of meninges around the
brain and spinal cord. The outer layer, the dura
mater, is tough white fibrous connective tissue.
The middle layer of meninges is arachnoid,
which resembles a cobweb in appearance, is a
thin layer with numerous threadlike strands that
attach it to the innermost layer. The space under
the arachnoid, the subarachnoid space, is filled
with cerebrospinal fluid and contains blood
vessels. The pia mater is the innermost layer of
meninges. This thin, delicate membrane is
tightly bound to the surface of the brain and
spinal cord and cannot be dissected away
without damaging the surface.
The organs of the peripheral nervous system
are the nerves and ganglia. Nerves are bundles
of nerve fibers, much like muscles are bundles
of muscle fibers. Cranial nerves and spinal
nerves extend from the CNS to peripheral
organs such as muscles and glands. Ganglia
are collections, or small knots, of nerve cell
bodies outside the CNS.
The peripheral nervous system is further
subdivided into an afferent (sensory) division
and an efferent (motor) division. The afferent or
sensory division transmits impulses from
peripheral organs to the CNS. The efferent or
motor division transmits impulses from the CNS
out to the peripheral organs to cause an effect or
action.
Finally, the efferent or motor division is again
subdivided into the somatic nervous system and
the autonomic nervous system. The somatic
nervous system, also called the somatomotor or
somatic efferent nervous system, supplies motor
impulses to the skeletal muscles. Because these
nerves permit conscious control of the skeletal
muscles, it is sometimes called the voluntary
nervous system. The autonomic nervous
system, also called the visceral efferent nervous
system, supplies motor impulses to cardiac
muscle, to smooth muscle, and to glandular
epithelium. It is further subdivided into
sympathetic and parasympathetic divisions.
Because the autonomic nervous system
Meninges
Meningiomas are tumors of the nerve tissue
covering the brain and spinal cord. Although
meningiomas are usually not likely to spread,
physicians often treat them as though they were
malignant to treat symptoms that may develop
when a tumor applies pressure to the brain.
Brain
The brain is divided into the cerebrum,
diencephalons, brain stem, and cerebellum.
Cerebrum
The largest and most obvious portion of the
brain is the cerebrum, which is divided by a
deep longitudinal fissure into two cerebral
hemispheres. The two hemispheres are two
separate entities but are connected by an
arching band of white fibers, called the corpus
callosum that provides a communication
pathway between the two halves.
Each cerebral hemisphere is divided into five
lobes, four of which have the same name as the
bone over them: the fontal lobe, the parietal
lobe, the occipital lobe, and the temporal lobe. A
fifth lobe, the insula or Island of Reil, lies deep
within the lateral sulcus.
Diencephalon
The diencephalons is centrally located and is
nearly surrounded by the cerebral hemispheres.
It includes the thalamus, hypothalamus, and
epithalamus. The thalamus, about 80 percent of
the diencephalons, consists of two oval masses
of gray matter that serve as relay stations for
sensory impulses, except for the sense of smell,
going to the cerebral cortex. The hypothalamus
is a small region below the thalamus, which
plays a key role in maintaining homeostasis
because it regulates many visceral activities.
The epithalamus is the most dorsal portion of
the diencephalons. This small gland is involved
with the onset of puberty and rhythmic cycles in
the body. It is like a biological clock.
Brain Stem
The brain stem is the region between the
diencephalons and the spinal cord. It consists of
three parts: midbrain, pons, and medulla
oblongata. The midbrain is the most superior
portion of the brain stem. The pons is the
bulging middle portion of the brain stem. This
region primarily consists of nerve fibers that
form conduction tracts between the higher brain
centers and spinal cord. The medulla oblongata,
or simply medulla, extends inferiorly from the
pons. It is continuous with the spinal cord at the
foramen magnum. All the ascending (sensory)
and descending (motor) nerve fibers connecting
the brain and spinal cord pass through the
medulla.
Cerebellum
The cerebellum, the second largest portion of
the brain, is located below the occipital lobes of
the cerebrum. Three paired bundles of
myelinated nerve fibers, called cerebellar
peduncles, form communication pathways
between the cerebellum and other parts of the
central nervous system.
Ventricles and Cerebrospinal Fluid
A series of interconnected, fluid-filled cavities
are found witihn the brain. These cavities are
the ventricles of the brain, and the fluid is
cerebrospinal fluid (CSF).
Spinal Cord
The spinal cord extends from the foramen
magnum at the base of the skull to the level of
the first lumbar vertebra. The cord is continuous
with the medulla oblongata at the foramen
magnum. Like the brain, the spinal cord is
surrounded by bone, meninges, and
cerebrospinal fluid.
The spinal cord is divided into 31 segments with
each segment giving rise to a pair of spinal
nerves. At the distal end of the cord, many
spinal nerves extend beyond the conus
medullaris to form a collection that resembles a
horse's tail. This is the cauda equina. In cross
section, the spinal cord appears oval in shape.
The spinal cord has two main functions:
Serving as a conduction pathway for impulses
going to and from the brain. Sensory impulses
travel to the brain on ascending tracts in the
cord. Motor impulses travel on descending
tracts.
Serving as a reflex center. The reflex arc is the
functional unit of the nervous system. Reflexes
are responses to stimuli that do not require
conscious thought and consequently, they occur
more quickly than reactions that require thought
processes. For example, with the withdrawal
reflex, the reflex action withdraws the affected
part before you are aware of the pain. Many
reflexes are mediated in the spinal cord without
going to the higher brain centers.
Brain Tumor
Glioma refers to tumors that arise from the
support cells of the brain. These cells are called
glial cells. These tumors include the
astrocytoma's, ependymomas and
oligodendrogliomas. These tumors are the most
common primary brain tumors.
The Peripheral Nervous System
The peripheral nervous system consists of the
nerves that branch out from the brain and spinal
cord. These nerves form the communication
network between the CNS and the body parts.
The peripheral nervous system is further
subdivided into the somatic nervous system and
the autonomic nervous system. The somatic
nervous system consists of nerves that go to the
skin and muscles and is involved in conscious
activities. The autonomic nervous system
consists of nerves that connect the CNS to the
visceral organs such as the heart, stomach, and
intestines. It mediates unconscious activities.
blood vessels enclosed in its connective tissue
wrappings.
Spinal Nerves
Thirty-one pairs of spinal nerves emerge
laterally from the spinal cord. Each pair of
nerves corresponds to a segment of the cord
and they are named accordingly. This means
there are 8 cervical nerves, 12 thoracic nerves,
5 lumbar nerves, 5 sacral nerves, and 1
coccygeal nerve.
Each spinal nerve is connected to the spinal
cord by a dorsal root and a ventral root. The cell
bodies of the sensory neurons are in the dorsal
root ganglion, but the motor neuron cell bodies
are in the gray matter. The two roots join to form
the spinal nerve just before the nerve leaves the
vertebral column. Because all spinal nerves
have both sensory and motor components, they
are all mixed nerves.
Autonomic Nervous System
The autonomic nervous system is a visceral
efferent system, which means it sends motor
impulses to the visceral organs. It functions
automatically and continuously, without
conscious effort, to innervate smooth muscle,
cardiac muscle, and glands. It is concerned with
heart rate, breathing rate, blood pressure, body
temperature, and other visceral activities that
work together to maintain homeostasis.
Structure of a Nerve
A nerve contains bundles of nerve fibers, either
axons or dendrites, surrounded by connective
tissue. Sensory nerves contain only afferent
fibers, long dendrites of sensory neurons. Motor
nerves have only efferent fibers, long axons of
motor neurons. Mixed nerves contain both types
of fibers.
A connective tissue sheath called the
epineurium surrounds each nerve. Each bundle
of nerve fibers is called a fasciculus and is
surrounded by a layer of connective tissue
called the perineurium. Within the fasciculus,
each individual nerve fiber, with its myelin and
neurilemma, is surrounded by connective tissue
called the endoneurium. A nerve may also have
The autonomic nervous system has two parts,
the sympathetic division and the
parasympathetic division. Many visceral organs
are supplied with fibers from both divisions. In
this case, one stimulates and the other inhibits.
This antagonistic functional relationship serves
as a balance to help maintain homeostasis.
The afferent division of the peripheral nervous
system carries impulses to the CNS; the efferent
division carries impulses away from the CNS.
There are three layers of meninges around the
brain and spinal cord. The outer layer is dura
mater, the middle layer is arachnoid, and the
innermost layer is pia mater.
The spinal cord functions as a conduction
pathway and as a reflex center. Sensory
impulses travel to the brain on ascending tracts
in the cord. Motor impulses travel on descending
tracts.
NERVOUS SYSTEM DISORDER/DISEASES
Alzheimer's disease
Alzheimer’s disease is a type of dementia that
affects a person’s thinking, behavior and ability
to perform everyday tasks.
Alzheimer’s disease is associated with a
build-up of certain proteins and chemicals in the
brain, which leads to dementia symptoms that
worsen over time.
While Alzheimer’s disease is more common in
older Australians, it is not a normal part of
ageing.
There is no cure for Alzheimer’s disease, but
some medications and the learning of new
behaviors can help relieve symptoms and
improve quality of life.
See a doctor for a full assessment if you or
someone you care about experiences memory
loss, difficulty with familiar tasks or language, or
changes in mood or personality.
EPILEPSY
The symptom of epilepsy is seizures (fits).
These are episodes of changed electrical
activity in the brain and can vary a lot depending
on the part of the brain involved.
Seizures can cause symptoms like loss of
consciousness (passing out), unusual jerking
movements (convulsions) as well as other
unusual feelings, sensations and behaviors.
There are many different types of seizures.
Generalized seizures involve the whole brain
and so the whole body is affected. Focal
seizures involve only part of the brain.
Generalized tonic-clonic seizures
Previously known as 'grand mal seizures', these
types of seizures are the most well recognized.
The seizure starts with a sudden loss of
consciousness, the body then becomes stiff
followed by jerking of the muscles. Turning red
or blue, tongue-biting and loss of bladder control
are common. Confusion, drowsiness, memory
loss, headache and agitation can happen on
regaining consciousness.
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CAUSES OF EPILEPSY:
head injury or trauma
stroke or brain hemorrhage (bleed)
brain infection or inflammation, like
meningitis, encephalitis or a brain
abscess
brain malformations or tumors
brain diseases, like Alzheimer’s disease
chronic alcohol or drug use
high or low blood sugar and other
biochemical imbalances
PARKINSON’S DISEASE
Parkinson's disease is a disorder of the nervous
system. It results from damage to the nerve cells
that produce dopamine, a chemical that is vital
for the smooth control of muscles and
movement. Parkinson's disease mainly affects
people aged over 65, but it can come on earlier.
symptoms of Parkinson's disease
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Tremor or shaking, often when resting or
tired. It usually begins in one arm or
hand
Muscle rigidity or stiffness, which can
limit movement and may be painful
Slowing of movement, which may lead to
periods of freezing (inability to start
moving) and small shuffling steps
Stooped posture and balance problems
Loss of unconscious movements, such
as blinking and smiling
Difficulties with handwriting
Changes to speech, such as soft, quick
or slurred speech
Anxiety or depression
Loss of smell
Constipation
Lack of urinary control
Sleep disturbance
Fatigue
Impotence
Drop in blood pressure leading to
dizziness
Difficulty swallowing
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Sweating
brain, which can very quickly become life
threatening.
How is Parkinson's disease managed
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Levodopa, which replaces dopamine
Dopamine agonists, which copy the
function of dopamine
COMT inhibitors, which boost the
response of levodopa
MAO-B inhibitors, which help stop the
breakdown of dopamine in the brain
Anticholinergics to help with the tremor
Amantadine, which is used for people
who may have developed abnormal
movements (known as dyskinesia)
MIGRAINE
Migraines are severe headaches that typically
last for between 4 and 72 hours. Migraine
sufferers may experience nausea and vomiting
as well as sensitivity to light or sound. They also
frequently report throbbing pain that worsens
with normal activity.
Migraines are common and usually very painful.
There may be ways to prevent them, and there
are good treatments for them.
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CAUSES OF MIGRAINE:
Missing meals — this is the strongest
dietary trigger
Eating certain foods, such as cheese,
chocolate, citrus, red wine and food
additives (for example, monosodium
glutamate)
Altered sleep patterns — too much or too
little sleep
Changes in the weather
Hormonal changes, such as
menstruation, and the oral contraceptive
pill for women
Alcoholic drinks (especially red wine and
beer)
BRAIN ANEURYSM
A brain aneurysm, also known as a cerebral
aneurysm, is a bulge in an artery within the
brain. Many people have a brain aneurysm
without realizing it. If the aneurysm leaks or
bursts, however, it can cause bleeding on the
Brain aneurysms are quite common. Some
people are born with a weakness in an artery in
their brain; in other people, health conditions,
such as high blood pressure, atherosclerosis or
a head injury, cause the aneurysm. They are
more common in adults and in women, although
anyone can have a brain aneurysm.
Brain aneurysms can happen anywhere in the
brain, but they are most common in the major
arteries found along the base of the skull.
Saccular aneurysm: the most common type of
aneurysm, which can cause bleeding on the
brain
Fusiform aneurysm: this type is less likely to
burst
SYMPTOMS OF ANEURYSM
● Double vision or sensitivity to light
● Nausea and vomiting
● stiff neck
● Weakness in the arms, legs or
one side of the face
● Confusion
● Seizures
● Loss of consciousness (briefly or
for a long time)
● Cardiac arrest
HOW TO PREVENT BRAIN ANEURYSM:
● Quit smoking
● Treat high blood pressure
● Do not use stimulant drugs like cocaine
● Eat a healthy diet and get plenty of
exercise
AMNESIA
Amnesia is loss of memory. People with
amnesia can struggle to form new memories or
remember recent events or experiences. People
who have amnesia might also be confused and
have trouble learning anything new.
But most people with amnesia still remember
who they are, and can often remember events
from their childhood.
Amnesia is not a medical condition on its own,
but a description of an experience. It is often a
symptom of another condition. It is usually
temporary, but can be permanent in some
situations.
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CAUSES OF AMNESIA
Concussion or head injury
Stroke
Brain inflammation due to an infection
Tumors in the area of the brain that
control memory
Seizures
Psychological conditions, such as
anxiety or depression
Dementia
Type of epilepsy (transient epileptic
amnesia)
Alcohol or drug use
Some medications, such as sedatives
After losing the supply of oxygen to the
brain, such as with a heart attack or
heart surgery
VERTIGO
Vertigo is a type of dizziness. If you have
vertigo, you may feel like you are spinning or
unbalanced, particularly when you change
position.
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SYMPTOMS OF VERTIGO:
Ringing in the ears
Nausea
Headache
MENINGITIS
Meningitis is a rare but serious infection of the
meninges. The meninges are the membranes
surrounding the brain and spinal cord.
Meningitis is usually caused by a virus or
bacteria, and sometimes it is caused by a
fungus.
Viral meningitis is usually a less dangerous form
of meningitis and most commonly affects
children. It can cause severe headaches. Viral
meningitis is usually caused by viruses that live
in fluids in the mouth and nose, and in feces.
Bacterial meningitis is usually more severe. It is
caused by bacteria that live in the nose and
throat and are usually harmless. But they can
enter the blood stream and spread to the
membrane surrounding the brain, causing
meningitis.
Bacterial meningitis is a medical emergency. It
can kill within hours, so early diagnosis and
treatment is vital.
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SYMPTOMS OF MENINGITIS:
Fever
Sensitivity to light
Very bad headache and stiff or sore neck
Nausea or vomiting and loss of appetite
Tiredness and drowsiness
Irritability
Confusion
Purple-red skin rash or bruising
Muscle and joint pains
Seizures (fits)
HOW TO PREVENT MENINGITIS:
Wash your hands regularly.
Don’t share drink bottles, cups or cutlery.
Sneeze into your elbow.
Throw tissues into the bin straight after
use and wash your hands.
Meningococcal vaccine.
ENDOCRINE SYSTEM
What is the endocrine system?
The endocrine system is made up of glands and
the hormones they secrete. Although the
endocrine glands are the primary hormone
producers, the brain, heart, lungs, liver, skin,
thymus, gastrointestinal mucosa, and placenta
also produce and release hormones.
Hormones
A hormone is a chemical transmitter. It is
released in small amounts from glands, and is
transported in the bloodstream to target organs
or other cells. Hormones are chemical
messengers, transferring information and
instructions from one set of cells to another.
Hyposecretion or hypersecretion of any
hormone can be harmful to the body.
Controlling the production of hormones can treat
many hormonal disorders in the body.
Hormones regulate growth, development, mood,
tissue function, metabolism, and sexual function.
The primary endocrine glands are the pituitary
(the master gland), pineal, thyroid, parathyroid,
islets of Langerhans, adrenals, ovaries in the
female and testes in the male.
The function of the endocrine system is the
production and regulation of chemical
substances called hormones.
The endocrine system and nervous system work
together to help maintain homeostasis…
balance. The hypothalamus is a collection of
specialized cells located in the brain, and is the
primary link between the two systems. It
produces chemicals that either stimulate or
suppress hormone secretions of the pituitary
gland.
Secretions from the anterior pituitary gland
Growth Hormone (GH): essential for the growth
and development of bones, muscles, and other
organs. It also enhances protein synthesis,
decreases the use of glucose, and promotes fat
destruction.
Adrenocorticotropin (TRŌ pun) (ACTH):
essential for the growth of the adrenal cortex.
Thyroid-Stimulating Hormone (TSH): essential
for the growth and development of the thyroid
gland.
Follicle-Stimulating Hormone (FSH): is a
gonadotropic hormone. It stimulates the growth
ovarian follicles in the female and the production
of sperm in the male.
Luteinizing Hormone (LH): is a gonadotropic
hormone stimulating the development of corpus
luteum in the female ovarian follicles and the
production of testosterone in the male. The
yellow corpus luteum remains after ovulation; it
produces estrogen and progesterone.
Prolactin (PRL): stimulates the development
and growth of the mammary glands and milk
production during pregnancy. The sucking
motion of the baby stimulates prolactin
secretion.
Melanocyte-stimulating hormone (MSH):
regulates skin pigmentation and promotes the
deposit of melanine in the skin after exposure to
sunlight
Calcitonin: influences bone and calcium
metabolism; maintains a homeostasis of
calcium in the blood plasma
Thyroxine (T4) and triodothyronine (T3):
essential to BMR – basal metabolic rate (the
rate at which a person’s body burns calories
while at rest); influences physical/mental
development and growth
Hyposecretion of T3 and T4 = cretinism,
myxedema, Hashimoto’s disease
Hypersecretion of T3 and T4 = Grave’s
disease, goiter, Basedow’s disease
Secretions from the posterior lobe of the
pituitary gland
Antidiuretic Hormone (ADH): stimulates the
reabsorption of water by the renal tubules.
Hyposecretion of this hormone can result in
diabetes insipidus.
Oxytocin: stimulates the uterus to contract
during labor, delivery, and parturition. A
synthetic version of this hormone, used to
induce labor, is called Pitocin. It also stimulates
the mammary glands to release milk.
Secretions from the pineal gland
– The pineal gland is pine-cone-shaped and
only about 1 cm in diameter.
Melatonin: communicates information about
environmental lighting to various parts of the
body. Has some effect on sleep/awake cycles
and other biological events connected to them,
such as a lower production of gastric secretions
at night.
Serotonin: a neurotransmitter that regulates
intestinal movements and affects appetite,
mood, sleep, anger, and metabolism.
Secretions of the thyroid gland
– The thyroid gland plays a vital role in
metabolism and regulates the body’s metabolic
processes.
Secretions of the parathyroid gland
The two pairs of parathyroid glands are located
on the dorsal or back side of the thyroid gland.
They secrete parathyroid (PTH) which plays a
role in the metabolism of phosphorus. Too little
results in cramping; too much results in
osteoporosis or kidney stones.
The islets of Langerhans
– The islets of Langerhans are small clusters of
cells located in the pancreas.
Alpha cells facilitate the breakdown of glycogen
to glucose. This elevates the blood sugar.
Beta cells secrete the hormone insulin, which is
essential for the maintenance of normal blood
sugar levels. Inadequate levels result in
diabetes mellitus.
Delta cells suppress the release of glucagon
and insulin.
The adrenal glands
– The triangular-shaped adrenal glands are
located on the top of each kidney. The inside is
called the medulla and the outside layer is called
the cortex.
Secretions from the adrenal cortex
Cortisol: regulates carbohydrate, protein, and
fat metabolism; has an anti-inflammatory effect;
helps the body cope during times of stress
Hyposecretion results in Addison’s
disease; hypersecretion results in
Cushing’s disease
Corticosterone: like cortisol, it is a steroid;
influences potassium and sodium metabolism
Aldosterone: essential in regulating electrolyte
and water balance by promoting sodium and
chloride retention and potassium excretion.
Secretions of the testes
The testes produce the male sex
hormone called testosterone. It is
essential for normal growth and
development of the male sex organs.
Testosterone is responsible for the
erection of the penis.
Secretions of the placenta
Androgens: several hormones including
testosterone; they promote the development of
secondary sex characteristics in the male.
During pregnancy, the placenta serves
as an endocrine gland.
Secretions from the adrenal medulla
It produces chorionic gonadotropin
hormone, estrogen, and progesterone.
Dopamine – is used to treat shock. It dilates the
arteries, elevates systolic blood pressure,
increases cardiac output, and increases urinary
output.
Epinephrine – is also called adrenalin. It
elevates systolic blood pressure, increases
heart rate and cardiac output, speeds up the
release of glucose from the liver… giving a spurt
of energy, dilates the bronchial tubes and
relaxes airways, and dilates the pupils to see
more clearly. It is often used to counteract an
allergic reaction.
Norepinephrine – like epinephrine, is released
when the body is under stress. It creates the
underlying influence in the fight or flight
response. As a drug, however, it actually
triggers a drop in heart rate.
Secretions of the ovaries
The ovaries produce several estrogen hormones
and progesterone. These hormones prepare
the uterus for pregnancy, promote the
development of mammary glands, play a role in
sex drive, and develop secondary sex
characteristics in the female.
Estrogen is essential for the growth,
development, and maintenance of
female sex organs.
Secretions of the gastrointestinal
mucosa
The mucosa of the pyloric area of the
stomach secretes the hormone gastrin,
which stimulates the production of
gastric acid for digestion.
The mucosa of the duodenum and
jejunum secretes the hormone secretin,
which stimulates pancreatic juice, bile,
and intestinal secretion.
Secretions of the thymus
The thymus gland has two lobes, and is
part of the lymphatic system. It is a
ductless gland, and secretes thymosin.
This is necessary for the Thymus’ normal
production of T cells for the immune
system.