ORGANOIDS
WHAT ARE
ORGANOIDS?
HOW ARE ORGANOIDS
MADE?
An organoid is a self-organized 3D tissue
Cells that make up organoids may be obtained
that is derived from stem cells, they mimic
from induced Pluripotent Stem Cells (iPSC’s)
the key functional, structural and
which can come from cell lines or Tissue cells
biological complexity of an organ.
including differentiated and cancerous cells
which come from humans or animals.
HOW ARE ORGANOIDS USED
AND HOW THEY COULD PLAY
A MAJOR ROLE IN THE
FUTURE
These cells are then cultured and grown in a
lab, producing functioning organoids for both
research and patient care.
Although the first organoids were made viable
in the early 2010s, they are proving to be
incredibly useful in drug discovery, personalised
medicine, cell therapy and various other fields
including tissue regeneration and infectious
disease treatment.
Research published in the Journal Nature has
shown organoids may be used as
transplantable material restoring function to
damaged tissues, although these experiments
have been limited to mice, the future of
organoids are interesting and could serve as
FIGURE 1: PROCESS OF PRODUCING ORGANOIDS
treatment for some conditions or diseases we
struggle with today.
Organoids have also shown great success in
personalised medicine such as in treating
cancer patients by testing the efficacy and
toxicity of drugs before use in the patient.
FIGURE 2: EXAMPLES OF HOW ORGANOIDS MAY BE USED
REFERENCES
HTTPS://JHOONLINE.BIOMEDCENTR
AL.COM/ARTICLES/10.1186/S13045022-01278-4