YBJOM-4677; No. of Pages 5 ARTICLE IN PRESS Available online at www.sciencedirect.com British Journal of Oral and Maxillofacial Surgery xxx (2015) xxx–xxx Unilateral sagittal split mandibular ramus osteotomy: indications and geometry Jacques Beukes a,∗ , Johan P. Reyneke b,c , Janalt Damstra d a Centre for Orthognathic Surgery and Implantology, Netcare Sunninghill, Cnr Witkoppen and Nanyuki rd, Sunninghill Park Center for Orthognathic Surgery, Mediclinic Cape Town, 21 Hof street, Oranjezicht, Cape Town, 27A Higgo crescent, Higgovale, Cape Town c Professor, Department of Maxillofacial and Oral Surgery, University of the Western Cape, Cape Town, South Africa d Fourways Mall, M30 Mezzanine Level, Fourways, Johannesburg b Accepted 24 October 2015 Abstract Small mandibular asymmetries may be corrected by unilateral sagittal split ramus osteotomy (USSO). This study had two objectives: first to define the geometric changes in the mandibular condyle and the lower incisor teeth that result from the rotation of the major segment (n=26), and secondly to examine in a clinical study the temporomandibular joints (TMJ) of 23 patients after correction of mandibular asymmetry by USSO to find out if there were any long-term adverse effects. Small mandibular asymmetries (<5 mm) can be corrected by USSO. Secondary anteroposterior changes as a result of setback or advancement on the operated side should be taken into account during the planning of treatment. The small rotational changes of the condyle did not adversely affect the TMJ. © 2015 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. Keywords: Unilateral Sagittal Split Mandibular Ramus Osteotomy Introduction Asymmetry of the face is a three-dimensional dentofacial deformity and may involve the maxilla, the mandible, or the chin, or a combination, and its correction may therefore require repositioning of one, two, or all three bones. As in the correction of other dentofacial deformities, the assessment of the anteroposterior, vertical, and transverse positions of the maxillary incisors and the cant of the maxillary occlusal plane play extremely important parts in the planning of treatment and are factors in deciding where the mandible will finally be positioned. Once the maxilla and the mandible ∗ Corresponding author. E-mail addresses: drjacquesbeukes@gmail.com (J. Beukes), drjprey@global.co.za (J.P. Reyneke), janalt@drdamstra.co.za (J. Damstra). are symmetrically positioned in the face, any remaining asymmetry of the chin can be corrected by genioplasty.1 In some patients the facial asymmetry affects only the mandible. In these cases only the lower jaw will need correction, and it would be the responsibility of the orthodontist to align the upper dental midline and arch in all three spatial planes. When only the mandible will be operated on, the upper (unoperated) dental arch will decide the final position of the mandible and the symmetry of the face. In most cases of mandibular asymmetry the correction will require a bilateral sagittal split osteotomy (BSSO), which will allow simultaneous correction of transverse, anteroposterior, and vertical problems. The transverse position of the asymmetrical mandible will be dictated by surgica coordination of the mandibular and the maxillary dental midlines, while the anteroposterior and vertical positions will be dependent on the ideal position of the maxillary incisor and dental arch. http://dx.doi.org/10.1016/j.bjoms.2015.10.029 0266-4356/© 2015 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. Please cite this article in press as: Beukes J, et al. Unilateral sagittal split mandibular ramus osteotomy: indications and geometry. Br J Oral Maxillofac Surg (2015), http://dx.doi.org/10.1016/j.bjoms.2015.10.029 ARTICLE IN PRESS YBJOM-4677; No. of Pages 5 2 J. Beukes et al. / British Journal of Oral and Maxillofacial Surgery xxx (2015) xxx–xxx Fig. 1. Superior view of the mandible: A. Condylar rotation point. B. Correction of asymmetry. C. Anteroposterior change in a unilateral sagittal split osteotomy. D. Unilateral advancement/setback. There are, however, instances when mandibular asymmetry may be corrected by a unilateral sagittal split osteotomy (USSO), and operating on only one side of the mandible will require a rotation of the tooth-bearing segment (major segment) to coordinate the lower dental midline with the midline of the upper arch. The rotation of this segment will take place around the condyle on the unoperated side of the mandible (Fig. 1), and there are certain geometrical limitations (and possible functional implications) of the rotational change of the condyle in the glenoid fossa.2 We investigated the indications for a USSO, evaluated the geometry of the rotational movement of the mandible, and evaluated retrospectively the long-term postoperative signs and symptoms in the temporomandibular joints (TMJ) of 23 patients who had had USSO for the correction of mandibular asymmetry. Patients, material, and methods Unilateral sagittal split osteotomy of the mandible It is not often possible to correct mandibular asymmetry by a USSO without a maxillary operation. Surgical coordination of the dental arches in these cases demands tedious and long orthodontic preparation in an attempt to align the dental arches in such a fashion that the teeth will fit into occlusion after the USSO. Operating on only one side of the mandible will allow for rotation of the midline to either the left or the right by either advancing or setting back the mandible. The unoperated side will be rotated around the condyle and will have secondary anteroposterior implications, which have to be considered when planning treatment. When a USSO is done on the left side of the mandible the midline can either be rotated to the right by advancing the major segment, or to the left by setting the segment back (Fig. 1). Rotation to the right will result in slight advancement of the mandible, while rotation to the left will set the mandible back. The opposite will apply when the USSO is done on the right side (Fig. 1). These secondary anteroposterior changes will have aesthetic implications that should be considered when planning treatment. The final anteroposterior position of the upper incisor and maxilla will be dictated by the anteroposterior position of the lower incisor after correction of the midline and slight anterior or posterior alteration. This is not a consideration after a BSSO, in which case the surgeon will not be “limited” by the unoperated side of the mandible. The degree of anteroposterior change at the mandibular midline will be influenced by the relation between the length of the mandible, the amount of rotation required to achieve symmetry, and the shape of the mandible. We studied the relation between these factors by comparing the dimensions and shapes of 26 scanned mandibles. The anteroposterior changes in relation to the amount of transverse correction (amount of rotation) were correlated, as was the effect that the shape of the mandible would have on the dimensional changes. Geometry To calculate the condylar changes after USSO, 26 randomly selected scanned mandibles were analysed using SimPlant®Ortho Pro 2.1 software (Materialise Dental, Leuven, Belgium). The computed tomographic (CT) images were originally acquired from patients to produce surgical guides for dental implants. Permission to use the data for research purposes was obtained before scanning. The mandibles were scanned at 0.5 mm voxel resolution, and surface models were generated by a commercial segmentation company (SimPlant®, Johannesburg, South Africa) using a thresholding-based method. Requirements for inclusion were full acquisition of the condylar heads during the scanning and segmentation process, and the presence of at least four anterior teeth and two molars. Twenty-six scans met the inclusion criteria and were included in the study. No distinctions were made between men and women, and the investigators were unaware of the identity of the patients. The CT data and surface models were downloaded in a DICOM multifile format and imported into SimPlant®Ortho Pro 2.1 software (Materialise Dental, Leuven, Belgium). The landmarks used in the study are described in Table I (Fig. 2). To reduce any error in measurement, digital markers3 with an Ø of 1.2 mm were imported as stereolithographic (STL) files and placed in the landmark configuration described in Table 1 (Fig. 2). The landmarks were digitised using the middle of the digital markers as references. Coronal, sagittal, and axial reference planes were constructed with the “cephalometry” tool of the software. The positions of the surface models were standardised by using the “set natural head position” function of the software. An occlusal plane was constructed by connecting the tip of the lower incisor with the tips of the mesiobuccal cusps of the lower first molar Please cite this article in press as: Beukes J, et al. Unilateral sagittal split mandibular ramus osteotomy: indications and geometry. Br J Oral Maxillofac Surg (2015), http://dx.doi.org/10.1016/j.bjoms.2015.10.029 ARTICLE IN PRESS YBJOM-4677; No. of Pages 5 J. Beukes et al. / British Journal of Oral and Maxillofacial Surgery xxx (2015) xxx–xxx Fig. 2. A three-quarter view of the mandible. The digital landmarks (black) were placed on the images: 1. Co Lat. (R), 2. Co (R), 3. Co Med. (R), 4. Co (L), 5. Split point (SP) 1, 6. Split point (SP) 2, and 7. Incisor point (IP) (see Table 1). teeth. This plane was used to reposition the surface model at an angle of 9o with the axial reference plane. The standard angle of the occlusal plane to the Frankfort horizontal pane is 9o and was used as reference and was used as reference.4 Table 1 Landmarks and measurements used in this study. Abbreviation Landmarks: Co Lat (R) Co (R) Co Med (R) Co (L) Split point (SP) 1 Split point (SP) 2 Incisor point (IP) Measurements: Anteroposterior Transverse Direct split Definition The most lateral point of the right head of the condyle The most superior point of the right head of the condyle The most medial point of the right head of the condyle The most superior midpoint of the left head of the condyle A midpoint on the buccal surface of the mandibular body indicating the posterior border of the virtual sagittal split A midpoint on the buccal surface of the mandibular body indicating the anterior border of the virtul sagittal split The most inferior contact point between the left and right mandibular incisors The distance between the coronal reference plane and IP, measured parallel to the sagittal and axial reference planes The distance between the sagittal reference plane and IP, measured parallel to the coronal and axial reference planes The shortest distance between SP1 and SP2 3 Fig. 3. A superior view of the mandible. The rotations and measurements used for the 3-dimensional surgical simulation: (i) the rotation point at the centre of a line connecting Co Lat. (R)and Co Med. (R), (ii) clockwise coronal rotation at the condyle (positive), (iii) counterclockwise coronalrotation at the condyle (negative), (iv) anteroposterior change, (v) transverse change at the lower incisors, and (vi) the unilateral surgical advancement measured at the vertical osteotomy lines. A line was constructed to connect the left and right landmarks of condylion (Co) and used to align the mandibular surface models parallel to the coronal and axial reference planes. A virtual unilateral sagittal split was created on the left ramus of the surface model using the “surgery” tool of the software. The midpoint on a line that connected the mesial and lateral points of the right condylar head was used as a fixed rotation point to rotate the condylar head virtually (Fig. 3). For statistical reasons clockwise rotations at the condyle were considered “positive” and counter clockwise rotations as “negative”. Two virtual surgical groups were created. Positive or clockwise rotation of the condylar head indicated unilateral advancement while negative or anticlockwise rotation indicated unilateral setback (Fig. 3). Dental midline corrections of 1, 2, 3, 4, and 5 mm by USSO were simulated. The change of the angle of the condyle (rotation) and secondary anteroposterior changes at the lower incisors were recorded. Virtual surgery and measurement were done by the same operator (JD). Statistical analysis of the geometric study All statistical analyses were made with the aid of SPSS for Windows (version 16, SPSS Inc, Chicago, IL). The measurement error was calculated and the sample measured a second time after 2 weeks by the same operator (JD). Differences between the measurements were calculated and the measurement error established using Dahlberg’s formula.5 The measurement error was small (0.21 mm), which confirmed the accuracy of the method. The mean (SD) and 95% CI for the transverse, anteroposterior, and direct split differences were calculated for the Please cite this article in press as: Beukes J, et al. Unilateral sagittal split mandibular ramus osteotomy: indications and geometry. Br J Oral Maxillofac Surg (2015), http://dx.doi.org/10.1016/j.bjoms.2015.10.029 ARTICLE IN PRESS YBJOM-4677; No. of Pages 5 4 J. Beukes et al. / British Journal of Oral and Maxillofacial Surgery xxx (2015) xxx–xxx unilateral advancement and setback simulations. Possible differences between the unilateral sagittal split advancement and setback groups were also investigated. setbacks. However, the anteroposterior changes are slightly greater than for unilateral advancements. Clinical Clinical study Twenty-three patients (11 females and 12 males, mean (range) age 29 (15-46) and 25 (17-54) years, respectively, who required USSO for correction of facial asymmetry (<5 mm at the lower incisor) were included in this retrospective study. Unilateral mandibular setbacks and advancements were included. The vector of advancement and setback for the correction of the mandibular midline were recorded at the time of the operation. All the measurements were made and operations done by a single operator (JR). Bicortical screws were used for internal fixation and patients were instructed to use intermaxillary (1/4 , 3.5 oz) elastics for 3-4 weeks postoperatively. All patients were followed up for a period of at least six months and the TMJ examined for pain, clicking, mobility, or discomfort. Eight patients had unilateral setback procedures and in 15 the mandible was advanced on one side. Twelve USSO were on the left, of which nine were unilateral advancements and three unilateral setbacks. Eleven USSO were on the right, of which 6 were unilateral advancements and 5 unilateral setbacks. In one case the mandibular operation was done as a single procedure, and in 22 it was in conjunction with Le Fort I maxillary osteotomies. In four cases a genioplasty was required to correct the symmetry of the chin. Results Geometry The positive and negative rotations in unilateral advancements and setbacks are shown in Table 2. As the mandibular midline moves around the condyle (the point of rotation) the advancement of the incisors decreases the further the rotation. The opposite is true for unilateral mandibular Table 2 Asymmetry: positive and negative rotations in unilateral advancements and setbacks. Data are mean (SD). Variable Change in condylar angle (o ) Positive rotations (unilateral advancement): 0.75 (0.07) 1 mm 2 mm 1.50 (0.13) 2.24 (0.19) 3 mm 2.98 (0.25) 4 mm 5 mm 3.71 (0.31) Negative rotations (unilateral setback): 1 mm 0.76 (0.07) 1.52 (0.13) 2 mm 2.29 (0.2) 3 mm 4 mm 3.07 (0.27) 3.85 (0.33) 5 mm Anteroposterior change (mm) 0.66 (0.03) 1.31 (0.07) 1.91 (0.12) 2.52 (0.14) 3.09 (0.17) 0.68 (0.04) 1.38 (0.13) 2.08 (0.1) 2.80 (0.13) 3.58 (0.34) Nine patients had unilateral advancements on the left with a mean (range) anterior vector of 2.8 (1.5-4.0) mm. Six patients had unilateral advancements on the right with a mean (range) anterior vector of 2.9 (2.0-5.0) mm. Eight patients had unilateral setback osteotomies, three on the left with a mean (range) setback of 3.7 (2.5-5) mm, and five on the right with a mean (range) setback of 3.9 (1.5-6) mm. None of the patients presented with any long-term symptoms in the TMJ. Discussion Control of the proximal segment and accurate positioning of the condyle in the glenoid fossa remain not only critical but challenging during a sagittal split ramus osteotomy.6 The inevitable rotation of the condyle of the major segment during correction of mandibular asymmetry by a USSO should therefore be a consideration. The rotation of the major segment showed inevitable anteroposterior changes that should be considered when planning treatment. Rotation of the condyle The geometric study indicated that relatively small rotations of the condyle can be expected on the major segment after correction of mandibular dental asymmetry of < 5 mm by USSO. The natural adaptability of the mandibular condyle to small changes in its relation to the glenoid fossa is certainly advantageous, and the possible reason for the lack of postoperative symptoms in the TMJ in the patients studied. The position of the condyle on the minor segment should, however, not change and be carefully controlled during the operation. Advancement of the major segment will result in a defect anteriorly between the segments, while a setback of the segment will cause a bony defect posteriorly. Any force applied between the segments of bone during placement of rigid fixation may result in peripheral condylar sag. The use of a bone clamp and lag screws should be avoided, and serious intersegmental bony defects managed by either placement of small bone grafts in the defects, contouring of the bone, or fracturing the retromolar segment before placement of rigid fixation.7 Anteroposterior changes The inevitable anteroposterior changes of the lower central incisors as a result of the rotation of the major segment must be considered when planning treatment. Correction of 5 mm mandibular asymmetry in the dental midline by advancement of a major segment (rotation) will result in 3.17 mm advancement of the lower incisors, while a setback of the major segment will cause the lower central incisors Please cite this article in press as: Beukes J, et al. Unilateral sagittal split mandibular ramus osteotomy: indications and geometry. Br J Oral Maxillofac Surg (2015), http://dx.doi.org/10.1016/j.bjoms.2015.10.029 ARTICLE IN PRESS YBJOM-4677; No. of Pages 5 J. Beukes et al. / British Journal of Oral and Maxillofacial Surgery xxx (2015) xxx–xxx 5 to move posteriorly by 3.56 mm. This anteroposterior dental change must be dealt with by either maxillary advancement or setback. Maxillary setback is, however, not aesthetically pleasing and seldom indicated. The aesthetic requirements of the case will govern the decision. Ethics statement/confirmation of patients’ permission Indication References Skeletal mandibular asymmetry is usually corrected by BSSO. However, USSO should be considered for patients who require maxillary advancement for the correction of a Class III malocclusion when there is relatively little mandibular asymmetry with a dental midline discrepancy of <5 mm. Operating on only one side of the mandible reduces possible mandibular complications by half, and also reduces the duration of treatment. We conclude that correction of relatively small mandibular asymmetries by USSO does not seem to cause adverse complications in the TMJ, but secondary anteroposterior changes in the lower central incisors should be considered when planning treatment. 1. Reyneke JP, Tsakiris P, Kienle F. A simple classification for surgical planning of maxillomandibular asymmetry. Br J Oral Maxillofac Surg 1997;35:349–51. 2. Wohlwender I, Daake G, Weingart D, et al. Condylar resorption and functional outcome after unilateral sagittal split osteotomy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;112:315–21. 3. Damstra J, Fourie Z, De Wit M, et al. A three dimensional comparison of morphometric and conventional cephalometric midsagittal planes for craniofacial asymmetry. Clin Oral Investig 2011;16:285–94. 4. Reyneke JP. Systematic patient evaluation. In: Reyneke JP, editor. Essentials of orthognathic surgery. 2nd ed. Chicago: Quintessence; 2010. p. 21–47. 5. Houston WJ. The analysis of errors in orthodontic measurement. Am J Orthod 1983;83:382–90. 6. Reyneke JP, Ferretti C. Intra-operative diagnosis of condylar sag after bilateral sagittal split ramus osteotomy. Br J Maxillofac Surg 2002;40: 285–92. 7. Ellis III E. A method to passively align the sagittal ramus osteotomy segments. J Oral Maxillofac Surg 2007;65:2125–30. Conflict of Interest Only routine records of orthognathic surgery were used. All data were anonymous. We have no conflict of interest. Please cite this article in press as: Beukes J, et al. Unilateral sagittal split mandibular ramus osteotomy: indications and geometry. Br J Oral Maxillofac Surg (2015), http://dx.doi.org/10.1016/j.bjoms.2015.10.029