DIGESTIVE SYSTEM ASSIS PROF / REDHWAN AHMED ALSHAMARI The digestive system is concerned with the uptake, digestion, absorption and excretion of non-digested food. The digestion is the breakdown of food into small molecules which are then absorbed into the body. A. Anatomy of the Digestive System • 1. Digestive tract: also called alimentary tract • 2. GI tract: technically refers to stomach and intestines • 3. Accessory organs • 4. Regions – Mouth or oral cavity with salivary glands and tonsils – Pharynx (throat – Esophagus – Stomach – Small intestine (duodenum, ileum, jejunum) – Large intestine including cecum, colon, rectum – anal canal with mucous glands – Anus ORAL cavity •The oral cavity is the first portion of the digestive tube. •It extends from the lips and opens posteriorly in the oropharynx. •Vestibule •Oral cavity proper Tongue It is a highly mobile muscular organ which is formed of striated muscle fibers and covered by mucous membrane. •The mucous membrane on the dorsum of the tongue is rough, and it is covered with small projections called lingual papillae. Some of the papillae contain taste buds. There is “V”-shaped sulcus (sulcus terminalis) which separates the anterior ⅔ and posterior ⅓ of the tongue. Lymphatic follicles lie posterior to this and called "lingual tonsils" . •The tongue helps in deglutition, taste and speech. Teeth •Deciduous (milky teeth): they are 20 teeth (4 incisors & 2 canines & 4 molars). The 1st tooth to erupt is the central incisor (6th month). •Permanent teeth: they are 32 teeth (4 incisors & 2 canines & 4 premolars & 6 molars). The 1st to erupt is the 1st molar. The last to erupt is the 3rd molar (wisdom tooth). The pharynx It is a common pathway for digestive and respiratory systems. •It is musculo-membranous tube that lies behind the nose, mouth and larynx. •It is about 12 cm in length and extends from the base of skull down to the 6th cervical vertebra, where it continues as oesophagus. •Its wall is formed muscle coat lined by mucosa. The muscle coat is formed of 3 constrictor muscles. OESOPHAGES It is a muscular tube about 25 cm long. •It begins as the continuation of the lower end of pharynx (level ofC6 ). •It passes in the neck, then in the thorax through the mediastinum & then through the diaphragm to end in the stomach. •Most of its course is in the middle line but deviates to the left at the level of T7vertebra where it passes in front of descending aorta till it passes through opening of the diaphragm at level of T10. •Through its course, it is related: •Posteriorly to the cervical and thoracic vertebrae, while •Anteriorly it descends behind the trachea and heart respectively. The stomach •It lies in the upper part of the abdominal cavity, in the epigastrium and left hypochondrium. •It is commonly Jshaped that has: •2orifices •2curvatures •2 surfaces •2 portions The Small Intestine •It is 6 meters long and takes the shape of coiled loops that fill most of the abdominal cavity. •It consists of 3 divisions: •Duodenum: •It is the shortest and widest of the small intestine (about 25 cm in length). •It is “C” shaped and is formed of 4 parts. •It is firmly attached to the posterior abdominal wall and not mobile. •The head of pancreas lies in the “C” shaped concavity. •The bile duct and main pancreatic duct unit together and open in the middle of the 2nd part. Jejunum andIleum form the free part of the small intestine and are freely mobile. They are attached to the posterior abdominal wall by means of mesentery. •The jejunum extends from the duodenum and forms the first two fifths while the ileum forms the next three fifths. •The jejunum has wider diameter than the ileum. The ileum ends by opening into the medial aspect of the cecum. A muscular sphincter (ileocecal valve) is present at this opening. The Large Intestine (colon) •It is about 1.5 meters in length. It extends from the end of the ileum to the anus. •It is larger in diameter than the SMALL bowel The large intestine is divided into following parts: •Cecum is a blind pouch which hangs down at the junction of the ileum and the colon. The Ileocecal valve lies at its medial aspect and prevents the return of the faeces from the cecum into the small intestine. The appendix arises from the cecum about 2.5 cm below the ileocecal valve. •Ascending Colon extends from the cecum to the under surface of the liver where it turns to the left. This bend is called right colic (hepatic) flexure. Transverse Colon crosses the upper part of abdominal cavity from right to left and then curves sharply downwards under the lower end of the spleen forming the left colic (splenic) flexure. •D escending Colon extends from the splenic flexure to the brim of the pelvis, where it turns towards the midline to become the sigmoid colon. •S igmoid Colon extends from the descending colon at the level of pelvic brim to the rectum. It is “S” shaped. •Rectum extends from the sigmoid colon to the anal canal. It descends along the sacrum to the tip of coccyx. Its lower part shows dilatation called "ampulla of rectum". •Anal Canal is the terminal portion of the large intestine. It extends from the rectum to the anus and is about 4 cm in length. In the anal canal the circular muscle fibres are thickened to form internal anal sphincter. The external anal sphincter is composed of skeletal muscle, therefore under voluntary control. The large intestine has the following features : •Appendices epiploicae : are small peritoneal sacs filled with fat scattered on the wall of large intestine (except on cecum & appendix & rectum). •Taenia coli: the outer longitudinal muscle coat of large intestine is arranged in 3 longitudinal bands begin that at the base of appendix (they are absent in the appendix & rectum). •Sacculations: the length of taenia coli is shorter than the true length of large intestine puckering of the wall. The Salivary Glands The parotid gland: It is the largest salivary gland, which lies below and in front of the ears, between the mastoid processes of temporal bone and the ramus of mandible. It is a wedge-shaped with its base directed upwards and apex directed downwards. The parotid duct passes through the buccinator muscle and opens into the vestibule of the mouth opposite the upper second molar tooth. Its secretion is principally watery. The submandibular gland: It lies in contact with the inner surface of the mandible and the ducts. It opens into the floor of the mouth beside the frenulum of the tongue, behind the lower incisors. Its secretion is both watery and mucous. The sublinigual gland: It the smallest salivary gland, which lies beneath the mucous membrane of the floor of the mouth. It opens by several minute ducts into the floor of the mouth. Its secretion is principally mucous in nature. The Liver •It is the largest organ of the body weighing about 1.4 kg in an adult. •It is located in the upper part of the abdominal cavity, mainly in the right hypochondrium and epigastrium. •It is a wedge-shaped which has: •Smooth convex anterior, superior, posterior and right lateral surfaces. Collectively called diaphragmatic surface of the liver, as they are related to the diaphragm, which separates it from right pleura and lung, pericardium, left pleura and lung. •Inferior surface, which is concave and shows impressions of the underlying organs. The liver has: •Two main lobes: are theright and theleft , separated by the falciform ligament. •Two small lobes: quadrate and caudate lobes. Anatomically, these 2 lobes belong to the right lobe. While physiologically, they are part of left lobe as they are supplied by left branch of hepatic artery and portal vein. •The liver is almost entirely covered with peritoneum except posteriorly. That area is calledbare area . The right and left triangular ligaments are thickenings of the peritoneum which help to keep liver in place. •The liver has double blood supply from hepatic artery (provides 30%) and portal vein (provides 70%). •The liver is drained by 3 hepatic veins which end in the inferior vena cava. Porta hepatis • It is the hilum of the liver which lies between the caudate and quadrate lobes. •It gives passage to the following structures: •Hepatic ducts : one duct emerges from each lobe. They are anterior in position. •Hepatic artery : is intermediate in position, which divides into right and left branches; each one enters the corresponding lobe of the liver. •Portal vein : posterior in position. It enters the liver and divides right and left branches; each one enters the corresponding lobe of the liver. Biliary system : is formed of the following: •Gall Bladder: •It is a pear-shaped sac with an average capacity of 40 to 50 ml. •It is located in gall bladder fossa on the under surface of the liver. •It is formed of fundus, body and neck. •Its neck is continuous with the cystic duct. This duct is about 4 cm in length and contains spiral valve. •Right hepatic duct and left hepatic ducts: •They are coming from the right and left lobes of the liver and unite to form common hepatic duct just below the porta hepatis. •Common hepatic duct: •It is joined by cystic duct of the gallbladder at acute angle to from common bile duct. •Common bile duct: •It is about 10 cm in length. •It descends behind the head of the pancreas, where it joins the main pancreatic duct, forming a dilatation called "hepatopancreatic ampulla" that opens into the 2nd part of the duodenum. •This opening is guarded by a valve (sphincter of Oddi). The Pancreas •It is elongated gland that lies across the posterior abdominal wall at the level of 2nd lumbar vertebra. •It is not mobile as it is retro-peritoneal. •It has the following parts from right to left: •Head: •It is the broad right end which is enclosed within the “C” shaped curve of the duodenum. •It sends a downward process called uncinate process. •Neck: •It is the junction between the head and body. It is related to the beginning of the portal vein as a result of union between the splenic and superior mesenteric veins. •Body :is triangular in cross section with: •anterior surface : lies behind the lesser sac. •inferior surface : is related to small intestine. •Tail :the left narrow end which reach the visceral surface of spleen. Ducts of pancreas: •Main pancreatic duct : extends through the whole length of pancreas to unite with the common bile duct forming the hepatopancreatic ampulla which in the 2nd part of duodenum . •Accessory pancreatic duct : starts in the uncinate process & ascends in front of the main pancreatic duct and opens in the 2nd part of duodenum (1 inch proximal to the main pancreatic duct). •NB: the main and accessory ducts may communicate. •The pancreas is both an exocrine and an endocrine gland: •The exocrine portion secretes pancreatic juice. •The endocrine portion consists of irregular clumps of cells calledIslets of Langerhans . These have two types of cells which secrete insulin (produced by beta cells) and glucagon (produced by alpha cells) hormones. Arterial supply •Arterial supply : by 3 single arteries which arise from the front of the abdominal aorta: •Coeliac trunk: supplies the foregut (lower part of oesophagus, stomach, upper half of the second part of duodenum, liver, pancreas and spleen) through 3 branches: common hepatic, left gastric and splenic arteries. •Superior mesenteric artery : supplies the midgut (lower half of the second part of duodenum, jejunum, ileum, cecum, ascending colon, right ⅔ of transverse colon). •Inferior mesenteric artery : supplies the hindgut (left ⅓ of transverse colon, descending colon, pelvic colon, rectum upper half of anal canal). Venous drainage :by tributaries corresponding to the branches of arteries, which ultimately drained into the portal vein. This vein is formed by the union of superior mesenteric vein and the splenic vein behind the neck of the pancreas then, it goes to the liver. •From the liver 2 hepatic veins drain into the inferior vena cava.