About
Milstein's early education was at the
National College of Buenos Aires. He
later attended the University of Buenos
Aires, where he studied chemical
sciences. In 1953, he earned his Ph.D. in
biochemistry from the University of
Buenos Aires and began his research
career in Argentina. In 1958, he received
a fellowship to work in the UK, where he
joined the Biochemistry Department at
the University of Cambridge.
Milstein's journey had periods of
work at various institutions, including
the National Institute for Medical
Research and the Laboratory of
Molecular Biology in Cambridge. It
was during his time in Cambridge that
he made his groundbreaking
discoveries related to monoclonal
antibodies. These discoveries would
eventually lead to him being awarded
the Nobel Prize in Physiology or
123-456-7890
Medicine in 1984. He became a
fellow of the Royal Society and
received numerous honors and
awards for his achievements. César
Milstein's life and work serve as a
testament to the power of scientific
curiosity and dedication. He passed
away on March 24, 2002, leaving
behind a lasting legacy.
Let's
Connect
César Milstein was an
Argentine-born British
biochemist. He was born
in Bahía Blanca,
Argentina, on October 8,
1927, and became a
naturalized British
citizen.
By: Emy Kolta
César
Milstein
Key
contributions
1. Monoclonal Antibodies: César
Milstein is most famous for his
discovery
of
monoclonal
antibodies, which are identical
antibodies
produced
by
a
single clone of immune cells.
Before his work, the production
of antibodies was limited to
polyclonal antibodies, which
are a mixture of antibodies
produced by different immune
cells. Monoclonal antibodies
are highly specific and have a
wide range of applications in
research,
diagnostics,
and
therapy.
2. Hybridoma Technology: Milstein, along with
his colleague Georges Köhler, developed the
hybridoma technology in 1975. This
revolutionary method involves fusing a
specific antibody-producing B cell with a
cancerous cell to create a hybrid cell line that
produces a single type of monoclonal
antibody. This technology made it possible to
generate large quantities of highly specific
antibodies for various purposes.
3.Medical Diagnostics:
Monoclonal antibodies have been
instrumental in the development
of diagnostic tests. They are used
in
pregnancy
tests,
cancer
screenings,
infectious
disease
assays, and more. The specificity
and
reliability
of
monoclonal
antibodies have greatly improved
the
accuracy
of
medical
diagnoses.
4.
Immunotherapy:
Monoclonal
antibodies
are
also
used
in
immunotherapy, a treatment approach
that harnesses the immune system to
fight
diseases
like
cancer
and
autoimmune disorders. Drugs like
rituximab and trastuzumab, which are
based on monoclonal antibodies,
have been used to treat cancer
patients effectively.