INHALED
CORTICOSTEROID(ICS)
NOOPUR JUED
B1421007
Dept. Biomedical sciences
ASTHMA
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Asthma Or COPD is a chronic lung disease affecting people of all
ages. It is caused by inflammation and muscle tightening around
the airways, which makes it harder to breathe.
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Symptoms include:
coughing,
wheezing,
shortness of breath
chest tightness,
rapid respiration
CORTICOSTEROID
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Corticosteroids are man-made drugs
that closely resemble cortisol, a
hormone that produce by adrenal
glands naturally.
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Commonly referred as “steroid”.
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Has potent anti-inflammatory effects.
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Two forms of a drug for treatment of
asthma
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Inhaled corticosteroids
oral corticosteroids
INHALED CORTICOSTEROID
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Inhaled corticosteroids (ICS, also known as
glucocorticosteroids, glucocorticoids, steroids) are most
effective controllers used in the treatment of asthma.
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It can effectively suppress the characteristic inflammation in
asthmatic airways, even in very low doses.
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EXAMPLES:
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Fluticasone (flovent),
Beclomethasone
Budesonide
(Qvar),
(pulmocort),
Mometasone
(asmanex) etc.
MECHANISM OF ACTION
ANTI-INFLAMMATORY EFFECTS OF CORTICOSTEROIED
ADVERSE EFFECT
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Oropharyngeal thrush (FUNGAL INFECTION)
Sore throat
Hoarseness
Cough
Increased appetite
Weight gain
Osteoporosis
Bone fractures
Decreased bone growth rate in children
HPA axis suppression
Hypercortisolism
CONTRADICTION AND CAUTION
 Active respiratory tract infection(e.g., Pneumonia, tuberculosis)
 Severe allergy to milk proteins or lactose
 Cataracts
 Diabetes
 Infection of the eye
 Gastrointestinal problems
 High blood pressure
 Any kind of infection (viral, bacterial, fungal)
 A disease of the heart, liver, thyroid, or kidney
THANK
YOU