‎Thyroid stimulating hormone (TSH)
‎Receptor on thyroid cells
‎Thyroxine
‎Gravis Disease
‎Adnylate cyclase
‎Triiodothyronine
‎Autoantibodies to receptor on Thyroid cell
‎Long -acting thyroid stimulation hormones
‎Overstimulation of thyroid
‎ utoantibodies against acetyl-choline
A
‎receptor on muscle cell in neuromuscular
‎junction
‎Autoantibodies block binding of acetyl-choline
‎Myasthenia gravis
‎Organ Specific
‎ utoantibodies internalize and degrade acetylA
‎choline receptor
‎ o signal transmission across neuromuscular
N
‎junction
‎ estrucion of insulin-produceing beta cells in
D
‎pancrease.
‎Variation in MHC genes (MHC Class II)
‎Affect ability recognize self/non-self
‎ utoantigens: Insulin & Glutamic Acid
A
‎decarboxylase (GAD)
‎Type I Diabetes
‎ PCs process and present autoantigens to
A
‎CD4+ T cells
‎ h1, Th17, activated released proT
‎inflammatory cytokines
‎IL1, IFN-gamma, TNF-alpha
‎Destruction of pancreatic beta cell
‎ ctivate CD8+ T cells & Natural Killer (NK)
A
‎cells kill beta cells
I‎nsulin production decrease, leads to
‎hyperglycemia
‎Autoimmune Disease
‎Inflammatory disease of CNS
I‎mmune mediated demyelination,
‎neurodegradation
‎Multiple Sclerosis
‎ utoreactive T cells recognize myelin protein
A
‎as autoantigens
‎ ctivated T cell release pro-inflammatory
A
‎cytokines
‎IL-1. IFN-gamma, TNF-alpha
‎Inflammation and leads to demyelination
‎Disrupt transmission of nerve signals
‎Mainly affect women
‎ any different autoantibodies are found in
M
‎patients
‎Non-Organ Specific
‎Systemic Lupus Erythemotosus
‎ cells produce autoantibodies against selfB
‎antigens such as DNA, histones, and nuclear
‎components
‎ ormation of immune complexes composed of
F
‎autoantibodies and specific antigens
‎ eposit of the complexes in the blood vessels
D
‎in various tissues
‎Immune complex leads to inflammation
‎ elease inflammatory cytokines cause
R
‎widespread inflammation
‎ eficiency of complement proteins C1, C2,C4
D
‎increased incidence of SLE
I‎nflammatory to joints, blood vessels, lungs,
‎tissues
‎Rheumatoid Arthritis
‎ D4+ T cells, activated B cells, plasma cell
C
‎found in inflamed joint
‎ ro-inflammatory cytokines IL-1, TNF in
P
‎synovial fluid
‎ hickennd synovia membrane, cartilage
T
‎degradation, bone erosion