Copperbelt University Directorate of Distance Education and Open Learning Master of Public Health DBS800A: Thesis Serminar Assignment 12 By Chikumbi Ndolesha SIN: 21900803 Lecturer: Dr. Reuben Lembani 21th March, 2023 Assignment: Submit your Research Paper/Article/Review Paper. This is the place review the progress of your article, so this doesn't need to be a complete paper. i Topic: Analysis of factors contributing to the rising prevalence of malaria in the Copperbelt Province's Kawama East compound. ii Contents 1.0 CHAPTER ONE-INTRODUCTION………………………………………………………iv 1.1 Background .............................................................................................................................. iv 1.2 Problem statement ..................................................................................................................... 8 1.3 Objectives ..................................................................... Ошибка! Закладка не определена. 1.3.1General Objective ................................................................................................................... 8 1.3.2Specific Objectives ................................................................................................................. 8 1.4 Research Questions ................................................................................................................... 9 1.5 Rationale of the study ............................................................................................................... 9 1.6 Justification ............................................................................................................................... 9 2.0 CHAPTER TWO-LITERATURE REVIEW ............................................................................ 9 2.1 Malaria Burden ......................................................................................................................... 9 2.1.1 Global Picture ...................................................................................................................... 10 2.1.2 Sub-Saharan Africa Picture........................................ Ошибка! Закладка не определена. 2.1.3 Zambia Picture ..................................................................................................................... 11 2.2.2 Sub-Sahara Africa Region ................................................................................................... 13 3.0 CHAPTER THREE- MATERIALS AND METHODS ......................................................... 14 3.1 Study design ............................................................................................................................ 14 3.2 Study population ..................................................................................................................... 15 3.3 Study Sample .......................................................................................................................... 15 3.4 Sample Size............................................................................................................................. 15 3.5 Sampling Strategy ................................................................................................................... 15 3.6 Data collection ........................................................................................................................ 15 3.7 Data Analysis .......................................................................................................................... 15 3.8 Data Management and quality ................................................................................................ 15 Reference ...................................................................................................................................... 16 iii Appendices Appendix 1: Participant’s information sheet Appendix 2: Participants Consent Form Appendix 3: Research Work plan Appendix 1: Budget iv v CHAPTER ONE 1.0 INTRODUCTION 1.1 Background Malaria is a fatal parasitic disease that is contracted through the bite of a female anopheles mosquito carrying the Plasmodium falciparum parasite. The four parasites that are most important for public health are, in general, Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, and Plasmodium ovalea. (WHO, 2018) It is transmitted to humans through female Anopheles mosquitoes, which require a high temperature climate to thrive. Thus, malaria is commonly found in a warmer regions of the world that are closer to the equator, including tropical and subtropical countries. The malaria parasites, which develop in the mosquitoes, also require a warm environment to complete their growth cycle before reaching the stage at which they are ready to be transmitted to humans (Ramdzana,2022) Malaria burden varies from one region to another. The 2021 World Health Organization report indicates that globally, there are 1.7 billion malaria cases, 10.6 million malaria deaths recorded in the period 2000-2020. The report further highlights that out of the reported cases, 82% of the cases are from Africa with 95% deaths. Despite the above presented global picture of malaria burden, there is a significant decrease in malaria burden among Sub-Saharan Africa. This decrease varies from country to country and region to region. In some areas, within a region of low malaria burden, some areas remain hot spots. In South Africa, malaria morbidity and mortality has reduced over the period of last 10 years. Cases of malaria have reduced by 87% in 2020 compared to 2000. Mortality of Malaria has also reduced by 91% in 2020 compared to 2000. On the other hand, Malaria is endemic in Zambia and has long been the main cause of morbidity and mortality. According to recent statistics, malaria is still the main cause of morbidity and the second greatest cause of mortality in Zambia, being surpassed by HIV and AIDS. Moreover, up to 40% of infant deaths and 20% of maternal deaths in Zambia are attributable to malaria, which places a significant socioeconomic burden on the nation and particularly on the populations living in malaria-endemic areas. (Mutalimaji, 2022) Despite the fact that the disease is an endemic burden, malaria has significantly decreased during the last ten years. Regardless of this decrease, malaria remains a significant public health problem in the country with incidence varying in different provinces of the countries. There is a wide variation in 6 infection prevalence across provinces and districts. Malaria annual reported cases have declined by 52% and 65% respectively in in 2019 and 2020. However, the malaria landscape remains heterogeneous, with different levels of transmission coexisting within communities in the same district and within districts in the same province. Malaria incidence has declined in some areas but remains largely unchanged in other places since 2010. Copperbelt province where this research will be conducted, annual malaria incidence stands at 345.4 per 1000 population. (National Malaria Elimination Strategy, 20171021). The burden of malaria varies globally, regionally, nationally, and among communities due to a variety of reasons. These elements differ from community to community. In sub-Saharan Africa, factors that affect the prevalence of malaria include urban, periurban, and rural areas; malaria vectors; natural sites for vector breeding; environmental factors; urban agriculture; household and community factors; implications of vector management; and travel-related factors. (Prathiba, et al 2017). In Zambia, factors that affect the prevalence of malaria include current malaria vector control measures, such as regular use of an ITN and indoor residual spraying (IRS). According to research by Nawa and colleagues who examined the rise in malaria from 2010 to 2015, geographic location of residence, such as urban and rural, has been found to be substantially associated with malaria burden. In order to look for potential correlations between tested cases and confirmed cases, Mazaba under the Zambia National Public Health Institute (ZAMPHI) conducted another descriptive study between August 2019 and June 2020. This study demonstrated that Zambia has a high rate of malaria cases that have been classified as positive, with 3700892 cases in a span of 10 months and a mean score of 370089.Furthermore, the National Malaria Elimination Strategy, (2017-21) alludes to seasonal changes as a significant factor associated with burden. The strategy states rainy season (December to April) lead to highest peak transmission period. One common factor with all these studies is that Malaria still is a burden in Zambia and the resurgence of malaria makes one believe that traditional methods of controlling it are approaching the point of saturation. (Banguero H.1984) This research will be conducted to analyze these determinants, recommend potential solutions, and provide a scientific explanation for the malaria burden in one of the townships 7 in Copperbelt Mufulira. This is because the factors that determine the prevalence of malaria vary from one community to the next, from one region to the next, and from one district to the next. Finding social and economic elements that might be significantly influencing the problem either independently or in conjunction with epidemiology or health determinants of the disease necessitates an evaluation of the situation. 1.2 Problem statement The nation set an ambitious goal to end malaria by 2021 in the year 2017. Since then, many packages of malaria elimination key interventions have been implemented in areas, including Mufulira district, where the study area is located. Case management, malaria surveillance, chemoprophylaxis, and vector control are among these strategies. As previously mentioned, factors affecting malaria prevalence differ from place to place, which is another reason this study is focusing on a specific township and addressing the factors affecting it. A previous study by Nawa and colleagues examined the rising prevalence of malaria in Zambia and associated it with age, housing, environment, etc. Mtalimanja and colleagues conducted a similar study in which economic modelling was used to track the amount of money spent on malaria-related health care rather than focusing on the causes. This paper bridges the gap by narrowing it down to a specific study area and analyse comprehensively the factors affecting the rising prevalence. Although there have been great advancements in the management of malaria in Zambia Mufulira District inclusive, the disease still accounts for a significant portion of morbidity in the Kawama east complex. The reported incidence increased from 891, 903, and 580 over the past three years (HMIS, 2021). This suggests that either effective malaria therapies are not being used as intended or that community awareness of these interventions may be low. This is the reason why a study is necessary to establish the scientific cause. 1.3 Aim/Objectives 1.3.1General Objective To assess the effects of social and environmental factors on malaria prevelence. 1.3.2Specific Objectives i. To evaluate the relationship between environmental factors and malaria prevalence. ii. To determine if there is significant association between behavioral uptake of malaria preventive measures and high malaria prevalence in Kawama East. iii. To evaluate the relationship between malaria prevalence and behavioral uptake of preventive measures iv. To evaluate if there is a significant association between social factors and high malaria prevalence in Kawama East. 8 1.4 Research Questions i. Is there a significant association between environmental factors with high malaria incidence in Kawama East? ii. Is there a significant association between behavioral uptake of malaria preventive measures and high malaria incidence in Kawama East? iii. Is there a significant association between participant’s demographic factors and high malaria incidence in Kawama East? iv. Is there a significant association between social factors and high malaria incidence in Kawama East? 1.5 Significance of the study Regardless of Government and Non-Governmental Organizations’ effort to eliminate malaria, incidence of malaria cases in Kawama east has been increasing (HMIS, 2021). The researcher is for the view that reduction in the malaria incidence should be based on directly obtaining factors that exist in a particular locality. This therefore can be achieved through researches conducted in all areas where of the country where malaria incidence keep getting higher. To the district affected with problem, the research will be a helpful tool to the Policy Makers, District program Managers and other stakeholders battling to eliminate malaria. To the providers of health care services, therefore Nurses, public health officials and all other health professionals on the ground, the research will provide first hand scientific evidence to define what is working and what is not working in malaria elimination agenda. 1.6 Justification Taking into consideration that these factors contribution varies, the district is therefore denied with more specific interventions that can be implemented to reduce malaria burden in Kawama east compound. The findings of this study are therefore of greatest significance to deliver evidence on determinants of malaria burden in the affected compound. The research is going to be a guiding stick to the program managers and policy makers to develop interventions directly associated to the problem in order to improve the indicator. CHAPTER TWO LITERATURE REVIEW 2.1 Malaria Burden Malaria is a fatal parasitic disease caused by plasmodium parasite which is transmitted through a bite of an infected female anopheles’ mosquito. Generally there are four parasites of public health significance which are Plasmodium Falciparum, Plasmodium Vivax, Plasmodium Malariae and Plasmodium Ovalea.(WHO,2018) It is transmitted to humans through female Anopheles mosquitoes, which require a high temperature climate to thrive. Thus, malaria is commonly found in a warmer regions of the world that are closer to the 9 equator, including tropical and subtropical countries. The malaria parasites, which develop in the mosquitoes, also require a warm environment to complete their growth cycle before reaching the stage at which they are ready to be transmitted to humans (Ramdzana,2022) 2.1.1 Global Distribution for Malaria Malaria is distributed worldwide, with the majority of cases reported from the African continent (88%), Southeast Asian region (10%), and Eastern Mediterranean area (2%). According to the World Health Organization (WHO), an estimated 300–500 million cases of malaria are reported each year, with approximately one million deaths, and these occur particularly in developing countries. Most of the deaths are reported among young children. However, the World Malaria Report 2015 reported that the global incidence of malaria decreased by 37% between the years 2000 and 2015.Ramdzan,2022 Today some 40 percent of the world’s population is at risk of malaria and the vast majority live in the world’s poorest countries. The disease is found throughout the tropical and subtropical regions of the world and each year causes more than 300 million acute illness and 1 million deaths (Zambia National Malaria Elimination Center) A number of studies have shown that age and sex are significantly associated with malaria infection Malaria burden varies from one region to another. The 2021 World Health Organization report indicates that globally, there are 1.7 billion malaria cases, 10.6 million malaria deaths recorded in the period 2000-2020. The report further highlights that out of the reported cases, 82% of the cases are from Africa with 95% deaths.(WHO,2021) Different factors contribute to difference in malaria burden globally, regionally, countries and among communities. These factors vary from one community to another. According to Prathiba , etal (2017), determinants of malaria burden in sub-Sahara Africa includes Urban, Periurban and Rural, Malaria Vectors, Natural Vector Breeding Sites and Environmental Factors, Urban Agriculture, household factors, community factors, vector control implications and travel factors. Southeast Asia region 10 contributes 10% of the cases and 2% of deaths to the global picture. Although the worldwide burden of malaria substantially decreased since 2010, some high-burden countries in Africa report an increase in malaria cases. According to the WHO, the global targets for 2030 will not be achieved unless there is accelerated change.( Heinemann, et al,2018) 2.1.2 Morbidity and Mortality in Africa Nearly every minute, a child under five dies of malaria. Many of these deaths are preventable and treatable. In 2021, there were 247 million malaria cases globally that led to 619,000 deaths in total. Of these deaths, 77 per cent were children under 5 years of age. (UNICEF, 2023) Malaria is still the major cause of hospital consultations in Western Kenya with an alarming number of severe forms of the disease among the school aged children at the epidemic prone setting. Mortalities were higher among <5 children years in high infection transmission setting and among ≥15 years in low and moderate transmission settings.( Kapesa et al,2018). . In South Africa, malaria morbidity and mortality has reduced over the period of last 10 years. Cases of malaria have reduced by 87% in 2020 compared to 2000. Mortality of Malaria has also reduced by 91% in 2020 compared to 2000. On the other hand, Malaria burden remains high in Malawi. Malawi is among the top southern African countries contributing to high malaria burden in Africa. 7.4% of malaria cases in in eastern and southern Africa occur in Malawi. The country has however recorded a slight reduction in morbidity from 211 to 208 per 1,000 population in 2019 compared to 2016. It has further recoded 9% death reduction from 0.39 to 0.31 per 1,000 in the same year (Severe Malaria Observatory, 2020). In 2020, an estimated 627,000 people died of malaria—most were young children in subSaharan Africa. Within the last decade, increasing numbers of partners and resources have rapidly increased malaria control efforts (CDC, 2020) More than 16 million people are at risk of malaria in Zambia. It is estimated that in 2015, there were over 5 million malaria cases. Though major achievements have been made in malaria control, the disease remains a significant cause of morbidity and mortality in Zambia, with one in five children under age five infected with malaria parasites, and other vulnerable population groups at risk (Zambia National Malaria Elimination Center) 2.1.3 Malaria endemism in Zambia In Zambia, Malaria is an endemic disease. Despite the endemicity of the disease, malaria burden has markedly decreased with the massive scale-up of control efforts in the past 10 11 years. Regardless of this decrease, malaria remains a significant public health problem in the countries with incidence varying in different provinces of the countries. There is a wide variation in infection prevalence across provinces and districts. Malaria annual reported cases have declined by 52% and 65% respectively in in 2019 and 2020. However, the malaria landscape remains heterogeneous, with different levels of transmission coexisting within communities in the same district and within districts in the same province. Malaria incidence has declined in some areas but remains largely unchanged since 2010. Copperbelt province where this research will be conducted, annual malaria incidence stands at 345.4 per 1000 population. (National Malaria Elimination Strategy, 2017-2021). 2.2 Determinants of Malaria 2.2.1 Global Determinants Vector control: is a vital component of malaria control and elimination strategies as it is highly effective in preventing infection and reducing disease transmission. The 2 core interventions are insecticide-treated nets (ITNs) and indoor residual spraying (IRS). Therefore, areas of effective vector control are likely to experience less burden of malaria. Preventive chemotherapy: different chemoprophylaxis for malaria are used globally. These includes intermittent preventive treatment of infants (IPTi) and pregnant women (IPTp), seasonal malaria chemoprevention (SMC) and mass drug administration (MDA). These safe and cost-effective strategies are intended to complement ongoing malaria control activities, including vector control measures, prompt diagnosis of suspected malaria, and treatment of confirmed cases with antimalarial medicines. Case management Early diagnosis and treatment of malaria reduces disease, prevents deaths, and contributes to reducing transmission. WHO recommends that all suspected cases of malaria be confirmed using parasite-based diagnostic testing (through either microscopy or a rapid diagnostic test). Diagnostic testing enables health providers to swiftly distinguish between malarial and nonmalarial fevers, facilitating appropriate treatment. To improve case management, different countries have introduced community management of malaria cases. Surveillance Malaria surveillance is the continuous and systematic collection, analysis and interpretation of malaria-related data, and the use of that data in the planning, implementation, and evaluation of public health practice. Improved surveillance of malaria cases and deaths helps ministries of health determine which areas or population groups are most affected and enables countries to monitor changing disease patterns. Strong malaria surveillance systems also help countries design effective health interventions and evaluate the impact of their malaria control programs. 12 2.2.2 Sub-Sahara Africa Region Urban, Peri urban and Rural Transmission. Dozens of African cities show a clear trend of increasing malaria transmission from urban to peri urban to rural settings (Robert.V,2003). For example, in Ouagadougou, Burkina Faso, the P. falciparum parasite rate (PfPR) has been estimated at 24.1% in the urban center, 38.6% in its periurban surroundings, and 68.7% in neighboring rural areas (Wang S. J. etal 2005). This is largely because African cities tend to grow outwards with perimeters consisting of relatively underdeveloped, poorly serviced settlements. Recent migrants from rural areas tend to bring their rural practices with them, creating a multitude of vector breeding sites, and poor-quality housing provides less protection against mosquito bites. However, it should be noted that this is not a universal trend. In Libreville, Gabon, malaria transmission was found to be the highest in the urban center (EIR of 87.9 infective bites per person per year) and the lowest in the peri urban surroundings (EIR of 13.3 per person per year) because of slum-like conditions in the urban center being surrounded by more affluent peri urban suburbs ((Wang S. J. etal 2005). Malaria Vectors. Malaria in human’s results from infection by any of five species of Plasmodium transmitted by approximately 50 species of mosquitoes, all belonging to the genus Anopheles. In sub-Saharan Africa, most deaths are caused by P. falciparum and transmitted by An. gambiae and its close relative Anopheles arabinoses. The form is better adapted to rural and humid forest areas and prefers (Byrne, 2007). Natural Vector Breeding Sites and Environmental Factors. The heavy burden of malaria in rural Africa is testimony to the ability of natural breeding sites to sustain vector. Populations. Natural breeding sites, although less common in urban areas, are nevertheless present. Field studies suggest that anopheles larvae are most likely to be found in permanent, shallow, sunlit pools of water of perimeter greater than 10 m (Matthys et al, 2016). Artificial Vector Breeding Sites. The most numerous sources of mosquito larvae in African metropolitan centers are generally thought to be artificial, rather than natural, vector breeding sites [32, 36, and 37]. This is evident in Table 2, which demonstrates that in our systematic study, references to artificial vector breeding sites were approximately three times higher than references to natural locations. Citation counts do not prove a comparison to be valid, but a review of the publications from which these counts were taken (Supplementary Table 1) does not reveal any glaring bias. In the literature search, urban agriculture (n = 36) received the highest citations for breeding sites, followed by drains/gutters (n = 9), ditches (n = 8), tyre tracks (n = 8), and water pipes (n = 6). Also mentioned were water tanks, construction sites, and swimming pools. Some of these sites, such as tyre tracks and swimming pools, were found to contain all life stages of An. gambiae, suggesting that they were particularly productive habitats and were found mainly in poorly-drained, periurban areas. Urban Agriculture. Urban agriculture has spread into the periphery and heart of many towns and cities in sub-Saharan Africa over the past ten years. It has the advantage of improving food security while reducing malnutrition and poverty, but it also fosters the best circumstances for vector reproduction, increasing the risk of malaria transmission in the area. Due to the creation 13 of shallow water between seed beds, agricultural trenches are excellent breeding habitats, and in a research conducted in Abidjan, Cote d'Ivoire, anopheles larvae were found in more than half of the trenches. In a different study conducted in Cote d'Ivoire, it was discovered that rice fields had the highest potential of harboring anopheles during both the wet and dry seasons (Matthys. 2006). Socio-Economic Status. Higher socioeconomic status is associated with several factors that lead to reduced malaria transmission, from piped water and better refuse collection to better education, higher exposure to TV and radio prevention campaigns, and increased ability to afford prevention methods and treatment. These factors contribute to a better awareness of vector breeding sites, malaria transmission, and control among people of higher socioeconomic status. The higher socioeconomic status of urban dwellers is a major factor contributing to their reduced risk of contracting malaria within cities, socioeconomic factors contribute to increased transmission in poorer areas with slum-like conditions, as seen in Libreville, Gabon (Jarjaval et al, 2012). Household Factors. Better-quality housing decreases the risk of malaria as it minimizes entry points for mosquitoes during the night. To illustrate this, a study in Gambia showed that houses with malaria-infected children are more likely to have mud walls, open eaves, and absent ceilings than those with uninfected children. Floors comprised of earth bricks are also associated with lower malaria risk as inhabitants are more likely to sleep on raised beds to avoid ground moisture, in turn eluding bites from An. gambiae mosquitoes which search for blood close to the ground. Interestingly, a study in Burkina Faso found that electricity use was associated with increased malaria risk, as the alternative of biomass fuel burning produces smoke that is thought to deter mosquitoes from entering houses. However, electricity use in better-quality housing would presumably not show this trend (Ndo et al, 2015). Community Factors. Hygiene, sanitation, and waste collection are key determinants of malaria transmission which, while household responsibilities, have a community level effect on disease transmission. As an example, the more the households dispose of waste properly, the lower the risk of liquid waste collecting in pools of stagnant water and forming vector breeding sites. In Accra, Ghana, being connected to a toilet was found to be even more important than waste removal in reducing community malaria mortality. However, toilets are also potential areas of mosquito activity, and septic tanks within communities are a potential source of vector breeding sites (Coene,2003) CHAPTER THREE 3.0 MATERIALS AND METHODS 3.1 Study design The study will be an analytical cross-sectional study to analyse determinants of increased malaria incidence. 14 3.2 Study population The study population will be households within Kawama east compound. 3.3 Study Sample The study sample for the research will be household members within Kawama east compound. The sample will be therefore drawn from 3156 households within the compound. 3.4 Sample Size 𝑁 n= 1+𝑁(𝑒)2 Where: n= Sample Size N= Population size e = error margin (95 confidence level) 𝑁 n= 1+𝑁(𝑒)2 3156 n=1+3156(0.05)2 3156 n=1+3156(0.0025) n=355 3.5 Sampling Strategy Multistage sampling design was used to come up with the desired sample size. At the first stage, the compound will be stratified into 4 stratums based on their locations. Hence eastern, western, northern and southern strata. To come up with the exact sample size per stratum, systematic random sampling will be used. The first household per stratum will be selected conveniently with the remaining ones being sampled systematically using snow ball technique. 3.6 Data collection Quantitative and qualitative data will be collected using simplified semi-structured questionnaires administered to household members and heads. The questionnaire will be subdivided in sections according to the independent variables to be studied. 3.7 Data Analysis Frequency tables will be used to analyse the mean, standard deviation and other descriptive values of the demographic variables. The Association between independent and dependent variables will be analysed using logistic regression. To determine the likelihoods between variables, odds will be used. Chi square will be used to determine significance association between variables. All this was done through Statistical Package for Social Science (SPSS) version 20. 3.8 Data Management and quality To ensure Data Quality the data capturing tool will be pretested through a pilot study which will be conducted on 5% of the sample population in a community with similar setup with the target population. These were health facilities with similar factors to the ones under which the study was to be conducted. Corrections will be made based on errors that will arise from to the 15 pilot. Furthermore, data capturing tool will be submitted to the research supervisor for review. Data management and quality will further be attained through orientation of the two research assistants. References Antonio-Nkondjio C,Fossog B.T,Ndo C., Djantio B. M., Togouet S. Z., Awono-Ambene P., Costantini Carlo, Wondji C. S., Ranson H., “Anopheles gambiae distribution and insecticide resistance in the cities of Douala and Yaoundé (Cameroon): influence of urban ´ agriculture and pollution,” Malaria Journal, vol. 10, article 154, 2011. Byrne Neville. “Urban malaria risk in sub-Saharan Africa: where is the evidence?” Travel Medicine and Infectious Disease, vol. 5, no. 2, pp. 135–137, 2007. 16 Banguero Herold, Socioeconomic factors associated with malaria in Colombia, Social Science & Medicine, Volume 19, Issue 10,1984. Byrne Neville. “Urban malaria risk in sub-Saharan Africa: where is the evidence?” Travel Medicine and Infectious Disease, vol. 5, no. 2, pp. 135–137, 2007 Coene J. “Malaria in urban and rural Kinshasa: the entomological input,” Medical & Veterinary Entomology, vol. 7, no. 2, pp. 127–137, 1993. Mtalimanja Micheal., Abasse, Kassin.Said., Muhammad Abbas, James Lamon Mtalimanja, Xu Zhengyuan, DuWenwen, Andre Cote & Wei Xu . Tracking malaria health disbursements by source in Zambia, 2009–2018: an economic modelling study. Cost Eff Resour Alloc 20, 34 (2022). https://doi.org/10.1186/s12962-022-00371-2 Matthys Barbara, N’Goran K. Eliézer ,Kone Moussa , Benjamin G. Kuodou, Vounatsou Penelope, Cisse’ Gue’ladio, Tschannen B. Andres,Tanner Marcel, Jürg Utzinger “Spatial dispersion and characterisation of mosquito breeding habitats in urban vegetable-production areas of Abidjan, Cˆote d’Ivoire,” Annals of Tropical Medicine and Parasitology, vol. 104, no. 8, pp. 649–666, 2010. Mazaba ML. An Update on Malaria trends in Zambia (2019 to 2020); A descriptive study.Health Press Zambia Bull. 2020; 4(01); pp 13-18 Matthys Barbara, N’Goran K. Eliézer ,Kone Moussa , Benjamin G. Kuodou, Vounatsou Penelope, Cisse’ Gue’ladio, Tschannen B. Andres,Tanner Marcel, Jürg Utzinger “Urban agricultural ´ land use and characterization of mosquito larval habitats in a medium-sized town of Cote d’Ivoire,” ˆ Journal of Vector Ecology, vol. 31, no. 2, pp. 319–333, 2006. Mourou Jean-Romain, Coffinet Thierry, Jarjaval Fanny, Cotteaux Christelle, Pradines Eve, Godefroy Lydie, Kombila Maryvonne, Pagès Frédéric “Malaria transmission in Libreville: results of a one-year survey,” Malaria Journal, vol. 11, article 40, 2012. Nawa, Mukumbuta, Hangoma, Peter, Morse P. Andrew, Michelo Charles. Investigating the upsurge of malaria prevalence in Zambia between 2010 and 2015: a decomposition of determinants. Malar J 18, 61 (2019). https://doi.org/10.1186/s12936-019-2698-x National Malaria Elimination Strategy https://www.medbox.org/document/zambia-nationalmalaria-elimination-strategic-plan-2017-2021#GO Prathiba M. De Silva and John M. Marshall (2012). Factors Contributing to Urban Malaria Transmission in Sub-Saharan Africa: A Systematic Review https://www.hindawi.com/journals/jtm/2012/819563/ Severe Malaria Observatory (2020). Malaria facts Malawi [online blog] seen on the 13th February, 2022 on https://www.severemalaria.org/countries/malawi 17 Vincent Robert, Kate Macintyre, Joseph Keating, Jean-Francois Trape,Jean-Bernard Duchemin,McWilson Warren,Beier C.John “Malaria transmission in urban sub-Saharan Africa,” American Journal of Tropical Medicine and Hygiene, vol. 68, no. 2, pp. 169–176, 2003 World Health Organization (2021). Malaria Key facts. Seen on the 13th February 2022 on https://www.who.int/news-room/fact-sheets/detail/malaria. World Health Organization (2021). Malaria report. Global Malaria Program, avenue Appia CH-1211 Geneva 27 seen on 13th February 2022 on https://www.who.int/teams/globalmalaria-programme/reports/world-malaria-report-2021. Wang Shr-Jie, Lengeler Christian, Thomas. A. Smith, Vounatsou Penelope, Diadie A.Diallo, Pritroipa Xavier, Convelbo Natalie, Kientga Mathieu,Tanner Marcel “Rapid urban malaria appraisal (RUMA) I: epidemiology of urban malaria in Ouagadougou,” Malaria Journal, vol. 4, article 43, 2005. Wang Shr-Jie, Lengeler Christian, Thomas. A. Smith, Vounatsou Penelope, Diadie A.Diallo, Pritroipa Xavier, Convelbo Natalie, Kientga Mathieu,Tanner Marcel “Rapid Urban Malaria Appraisal (RUMA) IV: epidemiology of urban malaria in Cotonou (Benin),” Malaria Journal, vol. 5, article 45, 2006 . 18 Appendix 1: Participant Information Sheet Purpose of the Research Determinant of with high malaria incidences. A study of Kawama East compound. OBJECTIVES i. To determine if there is a significant association between environmental factors with high malaria incidence in Kawama East. ii. To determine if there is significant association between with malaria preventive measures and high malaria incidence in Kawama East. iii. To determine if there is a significant association between participants demographic factors and high malaria incidence in Kawama East. iv. To evaluate if there is a significant association between social factors and high malaria incidence in Kawama East. Who is associated with the Research? …………………….. Of Public Health student ……………………… Supervisor Participants’ involvement Participation in this research will be voluntary. Participants will be administered with a questionnaire or interview than will take an average of 15 minutes. Questions will be open ended with some being close ended. For the professional staffs who are key informers, an interview of not more than 15 minutes will be done. Collected Material Collected material will be anonymously represented in the research, publications, reports and presentations. No legal names will be used. Questionnaires will be coded with either numeric code or pseudo name. Interviews and questionnaires will be only accessible by the researcher and the supervisor. Generated information on the research will only be made available to the public under request. Potential risk You are free to express any of your views in case of any feeling of human right violation during interview or questionnaire responding. Participant opt-out As a participant, you are free to opt out of the study at your own discretion. For more information: contact the primary researcher: ………………………… Appendix 2: Participants Consent Form Informed Consent Form for: …………………………………………….. 19 This informed consent form is for …………………… who is a student at ………………pursuing Master of Public Health. It’s academic research were she is inviting you to participate in research, titled ‘Determinant of with high malaria incidences. A study of Kawama East compound’. Certificate of Consent (Participant) I have been invited to participate in research about analysing determinants of with high malaria incidences. A study of Kawama East compound’. I have read the foregoing information, or it has been read to me. I have had the opportunity to ask questions about it and any questions I have been asked have been answered to my satisfaction. I consent voluntarily to be a participant in this study Name of Participant__________________ Signature of Participant ________________ Date ___________________________ Day/month/year For Illiterate I have witnessed the accurate reading of the consent form to the potential participant, and the individual has had the opportunity to ask questions. I confirm that the individual has given consent freely. Name of witness ---------------------participant Signature of witness ----------------Date ________________________ Thumb print of Day/month/year Activitie s Appendix 3: Research Workplan Work Plan Months May June July August September October November December 20 Problem identification Literature Review Topic Submission Proposal Writing Proposal submission Data Collection Data Entry Data Analysis Thesis Defense Thesis Publication Appendix 1: Budget Budget 1 1.1 1.2 1.3 1.4 Item Quantity Stationary Ream of paper Pens Printing Photocpoying 1 Box 6 Pages 2208 Pages Unit Cost 6 21 Total 60 60 3 0.5 360 60 18 1104 1.5 Book Binding 2 2.1 2.2 2.3 4 copies Sub Total Orientation of reaserch Assistants Lunch Tea Break Transport Refund 350 1400 2942 10Plates 6plates 2 Sub Total 3 Payment of Research Assistants 4 Transport Cost 5 Miscellaneous Cost Publishing cost 2 50 50 100 500 300 200 500 600 700 2000 1000 1000 1000 1000 2000 8942 Grand Total 22