How is prokaryotic cell different from eukaryotic cell? Prokaryotic cells are organisms that lack a membrane-bound nucleus and other membrane-bound organelles. They are usually smaller in size and simpler in structure than eukaryotic cells. Prokaryotes are divided into two domains: Bacteria and Archaea. One of the main differences between prokaryotic and eukaryotic cells is the presence of a membrane-bound nucleus. In eukaryotic cells, DNA is found in the nucleus while in prokaryotic cells it is found in the nucleoid region of the cytoplasm. The DNA of prokaryotic cells is usually circular and not associated with histone proteins while eukaryotic DNA is linear and bound to histone proteins. Prokaryotic cells are also distinct from eukaryotic cells in the absence of membrane-bound organelles such as mitochondria, endoplasmic reticulum, and Golgi bodies. Instead, they have simpler structures like ribosomes, cytoplasm, plasma membrane, and cell wall. Prokaryotes also do not have a cytoskeleton to provide internal structure and support as in eukaryotic cells. The processes of cell division in prokaryotes occur via binary fission, which results in the division of one parental cell into two identical daughter cells. Eukaryotic cell division, on the other hand, involves mitotic division in somatic cells or meiosis during the formation of reproductive cells. All living organisms are either prokaryotes or eukaryotes, and this distinction has important consequences in terms of ecological niches, the evolution of multicellularity, and the diversity of life on Earth. In conclusion, prokaryotic cells are structurally different from eukaryotic cells due to the absence of a distinct nucleus and membrane-bound organelles. Their simplicity and small size have made them dominant organisms on Earth that play important roles in biogeochemical cycles, symbiotic relationships, and human health. References: 1. Alberts, B. et al. (2014). Molecular Biology of the Cell. 6th edition. Garland Science. 2. Campbell, N. A. and Reece, J. B. (2005). Biology. 7th edition. Pearson Education, Inc. 3. Tortora, G. J. et al. (2011). Microbiology: An Introduction. 11th edition. Pearson Education, Inc.