Heparin IV
Heparin SC
Warfarin
Apixaban
Rivaroxaban
Dabigatran
Brand name
Hep-Lock
Hep-Lock
Jantovin
Eliquis
Xarelto
Pradaxa
Generic name
Heparin
LMWH
Lovenox
Coumadin
Apixaban
Rivaroxaban
Dabigatran
Idarucizum
ad
Usual dose for
adult
5,000-7,500
units
5000 units
2-10 mg
10 mg
twice
daily
75-100 mg
150 mg twice
daily
5 grams
Pharmacogenetic
considerations
Can cause
thrombocytop
enia, genetic
testing is used
to prevent
thrombocytop
enia
Can cause
thrombocyto
penia,
genetic
testing is
used to
prevent
thrombocyto
penia
Rapid onset,
medication
reaches
therapeutic
levels within
1-3 hours of
taking the
medications.
This
medication
is indicated
in patients
treated with
Pradaxa
when
reversal of
the
anticoagula
nt effects if
its needed:
It is shown
This is a
Does not
that genetic direct oral require genetic
testing does inhibitor
testing or
not prove
of the XA
coagulation
any benefits.
factor.
monitoring.
Praxbind
Praxbind
Pharmacodynami
cs
Heparin
Heparin
produces it
produces it
antithromboti antithrombot
c effect by
ic effect by
binding to
binding to
antithrombin antithrombin
III. Then it
III. Then it
continues to
continues to
bind to
bind to
thrombin
thrombin
Warfarin
inhibits
vitamin K
epoxide
reeducate
complex 1.
This is an
essential
enzyme that
activates the
available
vitamin k in
the body
This
No direct
The use of
The
inhibits
platelet
anti
inhibition of
free and
aggregation.
coagulant
thrombin
blood clot This indirectly Idarucizum
results in
bounded inhibits platelet
as an
decreased
FXa. This
aggregation
antidote.
formation of
also
induced by
This is the
fibrin and
inhibits
thrombin.
reversal of
reduces
prothrom
Rivaroxaban anticoagulati thrombin
binase
decreases
on effects of stimulated
activity
thrombin
dabigatran.
platelet
which
generation by
aggregation
inhibits inhibiting FXa.
and
clot
prevents
growth
formation of
thrombin
Administration
considerations
Frequent lab
monitor
monitoring,
patient for
monitor
bleeding, do
patient for
not take
bleeding, do aspirin at the
not take
same time
aspiring at the
same time
Monitor
patient for
bleeding,
check
patients
mouth, stool
and urine.
Monitor
patient
for
bleeding,
check
patients
mouth,
stool and
urine.
Monitor patient
for bleeding,
check patients
mouth, stool
and urine.
Monitor
patient for
bleeding,
check
patients
mouth, stool
and urine.
Thrombolitic
Risk,
Hypersensiti
vity,
Serious
Adverse
reactions
PT
INR
PT
aPTT
No lab
testing
No lab
testing
DTT
ECT
Lab test
PTT
aPTT
No lab
testing
Dietary
restrictions
Other Nursing
Considerations
Vitamin K
Leafy Greens
Vitamin K
Leafy Greens
Grapefruit
N/A
Protamine
Protamine
Advise
Advise
SulfateSulfatepatient to use patient to
Antidote.Advi
Antidote.
soft
use soft
se patient to
Advise
toothbrushes toothbrus
use soft
patient to use
, electric
hes,
toothbrushes,
soft
razors.
electric
electric razors. toothbrushes,
Antidoterazors.
electric
Vitamin K
razors.
Grapefruit
N/A
Sodium
Restricted
Diet
Advise patient
Advise
Advise
to use soft
patient to
patient to
toothbrushes,
use soft
use soft
electric razors. toothbrushes toothbrushe
, electric
s, electric
razors.
razors.