Blood group type Chromosome #4 disorder; clinical symptoms; progressive degeneration of NS Hunter syndrome Gauch disease Glucose six phosphate dehydrogenase deficiency Fabrys disease o Deficiency of galctosatase A o Kids = heart and kidney problem; early death Klien Felter syndrome Sickle cell anemia Cystic fibrosis LM downla syndrome Predominance DNA manipulation Epigenic effects High level mutilation; inhibit gene activity Duchenne muscular dystrophy Dementia degradation chromosome 4