Multiple sclerosis
Type I and IV hypersensitivity
What it is: a paralyzing neuromuscular disease associated with lesions in the myelin
sheath that surrounds neurons in the white matter of the central nervous system
Affects: brain and spinal cord
What it does: compromises the capacity of neurons to send impulses
Caused by: T-cell and autoantibody induced damage
Results/symptoms: muscular weakness and tremors, difficulties in speech and vision,
and paralysis
Association: possible infection with human herpesvirus 6 and onset of the disease
Treatment: monoclonal antibody therapy toward T-cell antigens
Specific antibody of monoclonal used: natalizumab (Tysabri)
Used because it targets lymphocyte migration across the blood—brain barrier,
which is an early step in MS lesion formation. It also has a high recognition of
antigens
How to alleviate symptoms: use immunosuppressants such as cortisone and interferon beta
Both reduce inflammation by stopping the release of molecules that cause
inflammation
Questions:
Select all of the symptoms for multiple sclerosis:
a. Muscular weakness and tremors
b. Shortness of breath
c. Difficulty in speech and vision
d. Paralysis
What does multiple sclerosis impair?
a. The central nervous system
b. The spinal cord
c. The brain
d. All of the above
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002635/
https://player-ui.mheducation.com
https://hyperbaricsofsunvalley.com/multiple-sclerosis-and-hyperbaric-oxygen-therapy/