NCM 116: THEORY MODULE 1: CONCEPT OF METABOLISM AND ALTERATION IN INGESTION Cebu Doctors’ University l Fated Nurses Clinical Instructor: Ms. Ortiz, J. Review of the Anatomy and Physiology of the Digestive System Esophagus • Nutrients are required by all of the body’s cells • • • • • • • Proteins Lipids Carbohydrates Vitamins Minerals Cellulose fibers and other vegetable matter Functions of Digestive System: • • • • To process food substances Absorb the products of digestion into the blood Excretion of unabsorbed materials Provide an environment for microorganisms to synthesize nutrients (vitamin K - essential in blood clotting) • • • Contains the lips, cheeks, palate, teeth, salivary glands, muscles and maxillary bone. These organs are responsible for mastication or chewing up food into smaller particles to be swallowed. Saliva amylase • • • • • Reflex salivation can be triggered by eating or even sight, smell or taste of food. The parotid, submaxillary and sublingual glands create about 1.5 Liters of saliva everyday Ptyalin (also known as salivary amylase) is a starch digestive enzyme The first breakdown of starch starts in the mouth with the help/ presence of amylase Saliva also contains water and glucose which assists lubricating the meal as it is being chewed making swallowing easier. CEBU DOCTORS’ UNIVERSITY – COLLEGE OF NURSING m2017 Found anterior to the spine and posterior to the trachea and heart in the mediastinum. It is a collapsible muscular tube about 10 inches long and it travels through the diaphragm at an opening called DIAPHRAGMATIC HIATUS The esophagus carries food from the pharynx to the stomach Stomach • • • • Mouth • Bamba • Located within the peritoneal cavity (under the left lobe of the liver) and the diaphragm (upper left part of the abdomen) Mostly covers the pancreas Hollow muscular organ that holds about 1500 ml of liquid FUNCTION: serve as a food storage during eating; secretes digestive fluids and propels the partially digested food or time into the small intestine. The stomach is divided into 4 regions: 1. The cardia, which surrounds the opening of the esophagus into the stomach 2. The fundus of stomach, which is the area above the level of the cardial orifice. 3. The body of stomach, which is the largest region of the stomach 4. The pyloric part, which is divided into the pyloric antrum and pyloric canal and is the distal end of the stomach 1 NCM 116: THEORY MODULE 1: CONCEPT OF METABOLISM AND ALTERATION IN INGESTION Cebu Doctors’ University l Fated Nurses Clinical Instructor: Ms. Ortiz, J. Small Intestine • • • • • • • • • • The stomach also has (mucous glands?) that are located in the gastric mucosa and prevent autodigestion by providing an alkaline protecting covering. 2 sphincters: > the cardiac sphincter (lower esophagus sphincter) closes off the top end of the stomach. - prevents a reflux of gastric contents into the esophagus • • Bamba m2017 which is the gastrointestinal tract’s longest part accounting for roughly three quarters of the entire length. It folds inwards and outwards providing approximately (70 m or 230 ft) of surface area It is where secretion and absorption takes place 3 Parts: Duodenum, Jejunum, Ileum Duodenum - most proximal region Jejunum - midsection Ileum - distal portion The Ileum comes to an end in the illusive valve (also known as a sphincter) regulates the flow of digested material from the ileum into the sequel part of the large intestine while preventing bacterial reflux into the small intestine. The vermiform appendix is an extension that attaches to the cecum. Physiologically, it serves little to no purpose The common bowel duct which empties into the duodenum at the ampulla of vater permits both bile and pancreatic fluids to pass through > the pyloric sphincter closes off the bottom. - which regulates the rate of the stomach emptying into the small intestine Large Intestine • • • CEBU DOCTORS’ UNIVERSITY – COLLEGE OF NURSING The length is around 5 ft or 1.5 m It is made up of an ascending section and the right side of the abdomen. Transverse segment in the upper abdomen that runs from right to left 2 NCM 116: THEORY MODULE 1: CONCEPT OF METABOLISM AND ALTERATION IN INGESTION Cebu Doctors’ University l Fated Nurses Clinical Instructor: Ms. Ortiz, J. • • • • Descending segment on the left side Sigmoid colon, rectum and anus make up the large intestine terminal section. Anal outlet is controlled by a network of striated muscle that forms both the internal and external anal sphincters FUNCTION: to absorb water and waste elimination; responsible for the synthesis of vitamin B complex and vitamin K with the help of the intestinal bacteria. Bamba Pancreas • • • • m2017 Has both an exocrine and endocrine function Exocrine gland: secretes sodium bicarbonate that neutralizes the acidity of the stomach contents that enter the duodenum Pancreatic juices contains enzymes for digesting carbohydrates, fats and proteins Endocrine gland: secretes glucose to raise blood glucose levels and secretes somatostatin to exert hypoglycemic effect. : located in the pancreas (islets of langerhans) which secretes insulin important for carbohydrate metabolism Refer to book (Table 44-1) DIGESTIVE ACCESSORY ORGAN Liver • • • • • • • • • Largest gland in the body weighing about 3 to 4 lbs It contains kupffer cells which remove bacteria in the portal venous blood Removes excess glucose and amino acids from the portal blood It synthesizes glucose, amino acids and fats It aids in the digestion of fats as it produces bile, carbohydrates and proteins Also stores and filters blood so it is highly vascularized About 200 to 400 ml of blood is being stored by the liver It also stores vitamin A, B and iron Secretes bile about 500 to 1000 ml per day which helps emulsify fats and broken down into fatty acids so that the body can use it. CEBU DOCTORS’ UNIVERSITY – COLLEGE OF NURSING Normal Digestion to Elimination Process 3 NCM 116: THEORY MODULE 1: CONCEPT OF METABOLISM AND ALTERATION IN INGESTION Clinical Instructor: Ms. Ortiz, J. 1. INGESTION • • • • Begins with Ingestion in our mouth with the help of the salivary glands. In the mouth, it is where we chew food and our food eaten has been broken down into little particles that are injected and combined with other enzymes which is also the start of the digestion process. With the help of saliva produced by the salivary glands particularly the parotid, submaxillary (submandibular) and sublingual glands. With the help in the breakdown of food. Saliva also contains ptyalin (salivary amylase) which breaks down carbohydrates. Saliva also has water and mucus which is helpful in lubricating the meal as it is being chewed making swallowing easier. 2. PROPULSION • • • • • the ingested food that has been broken down into pieces and there is already an initial breakdown of carbohydrates. With the salivary amylase it has been passed down or propelled into our esophagus through the act of swallowing. swallowing begins initially as a voluntary action controlled by the central nervous system’s medulla oblongata swallowing center. epiglottis moves to cover the tracheal opening as a bolus of food is swallowed. This prevents food aspiration into the lungs. swallowing also forces the food bolus into the upper esophagus, thereby comes to a help as a reflex action to move the bolus of food into the system, the smooth muscle in the esophageal wall contracts into a rhythmic sequence from the upper esophagus to the stomach. This rhythmic contraction pushes down food towards the stomach. Subsequently the lower esophageal sphincter then relaxes CEBU DOCTORS’ UNIVERSITY – COLLEGE OF NURSING Cebu Doctors’ University l Fated Nurses to allow the entry food, as it relaxes it also Bamba closesm2017 tightly to prevent reflux of the stomach contents into the esophagus 3. DIGESTION - this has two processes: • Mechanical ➢ Mechanical breakdown of food happens when the contents of the stomach are being propelled toward the pylorus by the peristaltic contraction. Now the large food particles are being turned back into the stomach since it cannot pass through the pyloric sphincter. ➢ Inside our stomach the food is then mechanically broken down into small pieces or into smaller particles. • Chemical ➢ This happens when the stomach releases different gastric juices containing gastric enzymes to produce or breakdown the food particles into smaller portions so that it will pass through the pyloric sphincter, it is then known as chyme ➢ Chyme contains food particles that has been broken down mechanically by our stomach and it also contains gastric enzymes ➢ Hormones, neural regulators, and local regulators present in the gastric secretions impact the stomach’s mobility or influences the stomach’s motility and modulate the rate of secretions ➢ The duodenum, also the first part of the small intestines there is a continuation of a chemical process. With the help of the different accessory digestive organs which are the: liver, gallbladder, pancreas. They release different enzymes to help breakdown the food into absorbable particles that is utilized by our body ➢ Take note that our pancreas releases amylase which breaks down carbohydrates, lipase that digests fats, trypsin and chymotrypsin which leaves 4 NCM 116: THEORY MODULE 1: CONCEPT OF METABOLISM AND ALTERATION IN INGESTION Cebu Doctors’ University l Fated Nurses Clinical Instructor: Ms. Ortiz, J. ➢ ➢ ➢ ➢ ➢ ➢ ➢ ➢ ➢ protein. The gallbladder releases or emulsifies fats. The pancreas also releases sodium bicarbonate. Sodium bicarbonate is alkalotic in nature, so it neutralizes the chyme that has been passed from the stomach to the duodenum is alkalotic in nature, so it neutralizes the chyme that has been passed from the stomach to the duodenum so as to protect lining of the duodenum. These chemicals or enzymes are released into their common pathway which is the common bile duct, where everything drains. Common bile duct is connected to the duodenum. As these progresses, this branches out to the different organs draining into the common bile duct. From the common bile duct, this releases these combined enzymes into the duodenum to complete the chemical digestion process. The bile is released by the gallbladder passing through the cystic duct, releases and draining into the common bile duct The pancreas releases: sodium bicarbonate, amylase, lipase and trypsin through the pancreatic duct, flows and meets at common bile duct. Then release into the duodenum breaking furthermore the chyme into its absorbable contents Bile is produced in the liver and stored in the gallbladder, its function is to aid in digestion and absorption of fats through emulsification. The flow of the bile is being controlled by Sphincter of Oddi which is located at the junction of the common bile duct Pancreatic juice, bile, and small intestine gland secretions total about 1 liter each day including about 0.5 liter of bile and 3 liters of small intestine gland secretions The Small Intestine contracts twice a day in two methods: Segmentation and Contraction Segmentation contractions produce mixing waves that move the contents of the intestine back and forth. The contents CEBU DOCTORS’ UNIVERSITY – COLLEGE OF NURSING of small intestine are pushed into the Bamba colon by the intestinal peristalsis m2017 ➢ The process of digestion breaks down food into absorbable particles when it is consumed through lipids, proteins and carbohydrates. ➢ When carbohydrates are ingested, this will be broken down into glucose, fructose, maltose, sucrose and galactose. When proteins are ingested, this will be broken down into amino acids and peptides. If fats are ingested, this will be broken down into monoglycerides and fatty acids. ➢ Now the chyme lingers in the small intestine for about 6 hours, to allow nutrients to broken down and absorbed. Absorption also happens in the small intestine through the villi • • Villi are little finger-like extension that run the length of the gastrointestinal tract and serve as a liner helps the small intestine to both absorb nutrition and to create digestive enzymes Main role of the small intestine is absorption. • • Absorption of vitamins and minerals is unaffected in the small intestine. Active transport and diffusion over the intestinal wall into the circulation begin in the jejunum while nutrients are absorbed in all throughout the intestine and duodenum. Ilium is where vitamin b12 and bile salts are being absorbed. All throughout the small intestine as well absorption of magnesium phosphate and potassium happens. 5. DEFECATION AND EXPULSION Food is now being pushed through the ileocecal valve - start of defecation and expulsion happens • • Passes through the ileocecal valve Leftover waste material moves into the terminal ileum and slowly into the right colon proximal part within four hours of eating 5 NCM 116: THEORY MODULE 1: CONCEPT OF METABOLISM AND ALTERATION IN INGESTION Cebu Doctors’ University l Fated Nurses Clinical Instructor: Ms. Ortiz, J. • • • • • • • • • • Valves opens briefly and allows some of the contents of the small intestine to enter into the colon with each peristaltic wave of the small intestine The entry and the opening of the ileocecal valve is dependent on the peristaltic movement made by the small intestine As a substantial component of the contents of the large intestine, bacteria play an important role in the complete breakdown of waste materials such as proteins and bile salts that have not been digested or absorbed in the small intestine electrolyte solution and mucous are the two types of colonic secretions that are added to the leftover material Majority of the electrolyte solution in the colon is bicarbonate ▪ neutralizes the bacterial end products created in the colon Mucous protects the colonic mucosa from the interluminal contents and helps the fecal bulk cling to the feces Colonic contents are moved along the track by a slow feeble peristalsis Colon's main rule is to allow for efficient reabsorption of water and electrolytes Because of the slow movement or the slow peristalsis that is happening all throughout the large intestine, the slow movement allows reabsorption mainly of water and other nutrients o to make sure that the things that we are passing outside our body is really waste The contents are propelled for long distances with strong peristaltic waves that occur on a regular basis o usually happens when intestines stimulating hormones are released after another meal o In roughly 12 hours, the waste component from a meal reach and distend the rectum o As much as 1/4 of the waste materials from a meal may still be CEBU DOCTORS’ UNIVERSITY – COLLEGE OF NURSING in the rectum three days after the Bamba meal has been ingested m2017 6. SECRETION Undigested meals in organic elements water and bacteria make up the feces • • • • • • • • fluid content of feces is roughly 75% feces is mostly liquid in nature and only 25% of our feces is solid because a major amount of the fecal mass is of non-dietary origin produced from the secretions of the gastrointestinal tract dietary changes have little effect on decomposition bile is broken down by the bacteria that is present in the large intestine resulting in the brown color of the feces stench or the smell of the feces is largely due to chemicals produced by the bacteria present in the large intestine o methane hydrogen sulfide and ammonia are among the gases that are produced - either absorbed into the portal circulation and detoxified by the liver or ejected from the rectum are generally found in the GI tract and it is expelled as a flatus stool elimination begins with rectal distension which triggers a reflex - it relaxes the normally closed internal anal sphincter and spasms of the rectal muscles autonomic nervous system is in charge of the internal sphincter while the cerebral cortex is in charge of the external sphincter external anal sphincter relaxes freely during feces to allow the content of colon to be evacuated o normally, in a tonic contraction condition by maintaining the external anal sphincter closed Defecation can be understood as a spinal reflex that can be actively inhibited. 6 NCM 116: THEORY MODULE 1: CONCEPT OF METABOLISM AND ALTERATION IN INGESTION Cebu Doctors’ University l Fated Nurses Clinical Instructor: Ms. Ortiz, J. Digestive Enzymes • • • • Hydrochloric acid (HCl) kills microorganisms breaks down food into small particles and provides a chemical environment that facilitates gastric enzyme activation Pepsin is the chief coenzyme of gastric juice which converts proteins into proteoses and peptones intrinsic factor comes from parietal cells and is necessary for the absorption of vitamin b12 Gastrin is responsible for controlling the gastric acidity Caution: Metabolism is as a series of chemical reactions that take place inside of our bodies to sustain life. • • the requirements of life in a human being is maintaining a constant internal temperature, reproducing, growing body's ability to utilize four essential bio molecules Four essential biomolecules 1. Macromolecules a. proteins, b. fats, c. carbohydrates or carbs d. nucleic acids like DNA and RNA All of these biomolecules perform different lifesustaining reactions inside of all of the cells in our body to promote life. Metabolism is the study of how we're able to obtain these important biomolecules to sustain life. How do we obtain biomolecules? Eat food to obtain all of these important biomolecules. CEBU DOCTORS’ UNIVERSITY – COLLEGE OF NURSING m2017 Since most food comes from living organisms like plants and animals, these plants and animals also contain an array of proteins, fats, carbohydrates and nucleic acids but not necessarily in the same flavor or configuration that our bodies would prefer. What do our bodies do? In our bodies, we go ahead and eat the food. We break down this food through a process called digestion. • Two Types of Metabolism 1. Anabolism 2. Catabolism Bamba Smallest subunit of proteins is called an amino acid and our body breaks down all the different types of proteins that we digest into individual amino acids The same pattern continues for the rest of the biomolecules • • Fatty acids which are the smallest subunits of fats Carbohydrates are long chains of sugars o one of the most common subunits of carbohydrates that our body loves is called glucose Nucleic acids • • nucleotides our body has a delicate balance going on between the processes of breaking down molecules such as in the process of digestion and then taking these products and building them back up Metabolism is a balance between breaking things down and building them back up in our body. • Catabolism: (to remember, think of the letter C. Cutting. Cutting molecules up into tiny pieces. • Anabolism: used to describe the process of building molecules back up. (To remember, think of the letter A. Apex. Apex of a building. Building molecules back up requires energy. 7 NCM 116: THEORY MODULE 1: CONCEPT OF METABOLISM AND ALTERATION IN INGESTION Cebu Doctors’ University l Fated Nurses Clinical Instructor: Ms. Ortiz, J. Discussion: The energy comes from eating food. The energy currency of our bodies is a molecule called ATP or adenosine triphosphate. This high energy molecule, when it is broken down into ADP so it loses a phosphate group. It releases usable chemical energy that can fuel energy-requiring processes of in our body such as the building up process of anabolism. In order for this process to continue non-stop in our bodies, ADP must be regenerated into ATP, and that is where food comes in. Remember: We digest our food into all of these subunits. Some of these subunits such as glucose and fatty acids mainly but occasionally amino acids can essentially be used as fuels in our body. These fuels in our body can essentially be broken down even further to produce the energy that’s necessary to convert ADP back into ATP. Thus, allowing this cycle to continue. Cellular Respiration involves breaking down things even further. It is a catabolic process. Catabolism fuels anabolism. • • Catabolism is coupled with this process of building things back up. In essence, one relies on the other. These processes are really tightly regulated in our bodies because you wouldn’t want to be breaking down something while you're building something back up. In fact, catabolism and anabolism are often regulated through the use of hormones. Hormones are a form of regulation and they tell the body whether it should be in a catabolic or anabolic state. CEBU DOCTORS’ UNIVERSITY – COLLEGE OF NURSING Factors influencing an individual’s metabolic rate (MR) m2017 • • • • • • • • Bamba Activity/ Exercise Elevated body temperature Hormonal activity Digestion Age and growth Gender Climate Drugs or taking in medications FACTOR Surface Area Sex Thyroxine production Age VARIATION EFFECT ON BMR Large in relation to body volume = thin/small individuals Small = large individuals Male = higher Female = Increased = Decreased = Young, rapid growth = they need more energy, more calories Aging, elderly = slower MBR Strong emotions (anger/fear) & infections 8 NCM 116: THEORY MODULE 1: CONCEPT OF METABOLISM AND ALTERATION IN INGESTION Cebu Doctors’ University l Fated Nurses Clinical Instructor: Ms. Ortiz, J. World Food Programme (WFP) • • • • • • • In-charge of food aid Largest humanitarian organization dedicated to hunger and food security in the world The largest provider of school meals Based in Rome and has offices in 80 countries Founded in 1961. It serviced 115.5 million people in 80 plus countries as of 2020 and it is the highest number since 2012 This program has been created to address deficiencies of iron vitamin A and Zinc which are ranked among the world health organization’s top 10 leading causes of death through disease in developing countries. Micronutrient Deficiencies: mostly affects children Iron • • The most prevalent form of malnutrition worldwide, affecting millions of people. Iron deficiency also impedes cognitive development, affecting 40-60% of children aged 6-24 months in developing countries. Vitamin A • • Increases the risk of dying from diarrhea, measles and malaria by 2024% Affecting 140 million preschool children in 118 countries and more than seven million pregnant women, it is also a leading cause of child blindness across developing countries. Iodine • • Affects 780 million people worldwide. The clearest symptom is a swelling of the thyroid gland. CEBU DOCTORS’ UNIVERSITY – COLLEGE OF NURSING • According to UN research, some Bamba 20 millionm2017 children are born mentally impaired because their mothers did not consume enough iodine. Zinc • Contributes to growth failure and weakened immunity in young children. It is linked to a higher risk of diarrhea and pneumonia, resulting in nearly 800,000 death per year. BODY BUILD (Type, Size, Composition) Type - refers to the category if physique. It is a description of any kind of human body shape using general body descriptors. Example: slim, fat, tall, petite, wide shoulder, pear shape, etc) Size – refers to the person’s height and weight Composition – refers to the person’s body fat percentage. 3 Extreme Body Types 1. Endomorph (Pykinic) • • • • • A pear-shaped body A rounded head Wide hips and shoulders Wider front to back rather than side to side A lot of fat on the body, upper arms, and thighs 2. Mesomorph (Sthenic) • • • • • A wedged-shaped body A cubical head Wide broad shoulders Muscled arms and legs Narrow hips 9 NCM 116: THEORY MODULE 1: CONCEPT OF METABOLISM AND ALTERATION IN INGESTION Cebu Doctors’ University l Fated Nurses Clinical Instructor: Ms. Ortiz, J. • • Narrow from front to back rather than side to side A minimum amount of fat • • 3. Ectomorph (Asthenic) • • • • • • A high forehead Receding chin Narrow shoulders and hips A narrow chest and abdomen Thin arms and legs Little muscle and fat FAT AND MUSCLE DISTRIBUTION Obesity • • Increases the risk of diabetes, heart disease stroke, arthritis, and some cancers If an obese person loses even 5-10% of his/her body weight, it can delay or even prevent some of these diseases Overweight • • Weighing too much Weight may come from muscle bone fat and or body water Note: Both terms means that a person’s weight is greater than what’s considered healthy for his or her height. Cachexia • Extreme loss of weight and body wasting associated with a serious illness • • Fat is mainly accumulated in hip, middle Bamba abdomen and thigh surroundings m2017 Aging = whole figure assumes a stooping posture and the spine is never erect due to the heavy hips and thighs Vital organs affected mostly are kidneys, uterus, intestines, bladder, and bowels Exercises or dieting will not help appreciably in reducing weight B. Android/ Apple-Shaped • • • Most are males Fat is mainly stored in abdomen Vital organs affected will be mostly the heart, live, kidneys & lungs (major risk for heart damage & heart disease due to high cholesterol) C. Ovoid/ Barrel-Shaped • • • Gait is more rolling rather than walking Fat tissues in body hinder the movement of all the internal organs & consequently affect their brisk functioning Any exercise is difficult due to the enormous size of the body Comparison of the Body Fat Percentage between a Man and a Woman Starvation • Can be reversed through refeeding A. Gynoid/ Pear-Shaped • • • • Most are females Narrow shoulders Small breast Slim waist CEBU DOCTORS’ UNIVERSITY – COLLEGE OF NURSING <3 END OF VIDEO 1 <3 10 NCM 116: THEORY MODULE 1: CONCEPT OF METABOLISM AND ALTERATION IN INGESTION Cebu Doctors’ University l Fated Nurses Clinical Instructor: Ms. Ortiz, J. Video 2: • • • • • • • • Opening or split on the upper lip, the roof of the mouth, or the palate or both are known as cleft lip and cleft palate. Cleft Lip and palate are birth abnormalities that occur when the lip or mouth of a baby does not develop normally during pregnancy. These congenital malformations are collectively known as orofacial clefts. The most frequent birth abnormalities are cleft lip and cleft palate. They are most typically found as single birth abnormalities but they are also linked to a variety of inherited genetic disorder and syndromes. Cleft lips can develop on one or both sides of the lip or in the center, which is extremely unusual. The separation can include the gum line or the palate. A cleft palate is a split or opening in the roof of the mouth. It can involve the hard palate, which is the bony front portion of the roof of the mouth and/or the soft palate, which is the soft back portion of the roof of the mouth and can be associated with a cleft lip. Cleft lip and cleft palate can occur on a one or both sides of the mouth as mentioned earlier. Because the lip and the palette develop separately, it is possible to have a cleft lip without a cleft palate. A cleft palate without a cleft lip or, both a cleft lip and a cleft palate together is the most frequently occurring defect. Cleft lip and/or cleft palate affects 1 in 1,000 babies every year and it is the 4th most common birth defect in the US. Clefts occur more often in children of Asian descent. Twice as many boys as girls have a cleft lip both with and without a cleft palate. However, twice as many girls as boys have cleft palate without a cleft lip. Pathophysiology Predisposingm2017 Factor: • Genetics Precipitating Factors: • • • Smoking Diabetes Use of certain medications such as: topiramate or valproic acid Discussion: • • • • • • • CEBU DOCTORS’ UNIVERSITY – COLLEGE OF NURSING Bamba The lips develop between the 4th and 7th week of pregnancy. Body tissue and specific cells from either side of the head grow toward the middle of the face during pregnancy and combine together to form the face. The lips and mouth for example, are formed by the connecting of tissue between the 6th and 9th week of pregnancy, the palate or the roof of the mouth is created. They are created separately. Most cases of cleft lip and palate are thought to be caused by a combination of hereditary and environmental factors. A definite reason isn’t found yet in many newborns. Cleft genes can be passed down from either the mother or the father, either alone or as part of a genetic condition that includes a cleft lip or palate as one if its symptoms. In some situations, kids are born with a gene that makes them more likely to develop a cleft and then the cleft is caused by an environmental trigger. Women who smoke during pregnancy, are more likely than non-smokers to have a baby with an orofacial cleft. When compared to a woman who did not have diabetes before pregnancy, women with diabetes had a higher risk of having a child with a cleft lip and or cleft palate. Women who took specific epilepsy medicines during their first trimester or the first three months of pregnancy which is the formation of the lip and the palate occurs such as topiramate or valproic acid had a 11 NCM 116: THEORY MODULE 1: CONCEPT OF METABOLISM AND ALTERATION IN INGESTION Cebu Doctors’ University l Fated Nurses Clinical Instructor: Ms. Ortiz, J. higher chance of having a baby with a cleft lip with or without cleft palate than women who did not take these medicines. FUSION FAILURE OF THE MAXILLARY AND PREMAXILLARY PROCESSES CLEFT PALATE FAILURE OF FUSION OF TWO PALATINE SHELVES • • • Dental problems. Tooth development Bamba may bem2017 hampered if the cleft extends through the upper gum. Speech difficulties. A cleft palate can impede the development of proper speech since the palate is utilized to generate sounds. It’s possible that the speech is too nasal(?). Challenges of coping with a medical condition. Due to disparities in appearance and the stress of rigorous medical care, children with clefts may experience social, emotional, and behavioral issues. Physical Assessment Diagnostic • • Discussion: Failure of the maxillary and premaxillary processes to fuse during the 5 th to 8th week of intrauterine life causes cleft lip while failure in the fusion of two palatine shelves result in the formation of the cleft palate. Cleft lip/palate can either be complete or incomplete. • Complications • • Difficulty feeding. Feeding is one of the most pressing concerns after birth. While most babies with a cleft lip can be breastfeed, sucking might be challenging for those with a cleft palate due to the incomplete closure of the palate not creating a seal while the baby is sucking with a separation or opening in the palate, food and liquids can pass from the mouth back through the nose. Ear infections and hearing loss. Cleft palate babies are at an increased risk of acquiring middle ear fluid resulting to hearing loss. CEBU DOCTORS’ UNIVERSITY – COLLEGE OF NURSING • • Cleft lip is diagnosed based on the newborn’s physical appearance while a cleft palate is diagnosed at delivery. During inspection, cleft palate is diagnosed at birth with a thorough examination of the newborn’s palate. This is to ensure that a cleft palate is not missed. The examiner must enter a gloved finger into the newborn’s mouth and feel the palate to ensure that it is intact. During observation, the outward appearance of the infant can be used to diagnose cleft lip and palate. Aside from that, a submucosal cleft palate which occurs only in the muscles of the soft palate is less common and is hard to diagnose. Signs and symptoms are difficulty with feedings, difficulty swallowing with potential for liquids or foods to come out on the nose. Nasal speaking voice and chronic ear infection. During pregnancy, a routine ultrasound will reveal an orofacial cleft. Surgical Management The focus of management for patients with orofacial clefts is through surgery. • Cheiloplasty. o Is reconstructive repairs a cleft lip surgery that 12 NCM 116: THEORY MODULE 1: CONCEPT OF METABOLISM AND ALTERATION IN INGESTION Cebu Doctors’ University l Fated Nurses Clinical Instructor: Ms. Ortiz, J. o Performed when the patient is at 3 months old or weighs 12 pounds. Discussion: A cleft lip may require one or two surgeries depending on the extent like if it is complete or incomplete and the width or if it is narrow or wide of the cleft. The first surgery is to close the lip usually occurs when the baby is between 3 and 6 months old or the baby weighs 12 pounds. The second surgery, if necessary, is usually done when the child is 6 months. • Bamba m2017 Image (below) of patient with a bilateral cleft lip and after bilateral cheiloplasty. Palatoplasty. o Is reconstructive surgery that repairs a cleft palate o Repair of a cleft palate is performed at 12 months Discussion: To address cleft palate, palatoplasty is performed. Repair of a cleft palate is performed at 12 months and creates a working palate and reduces the chances that fluid will develop in the middle ears. To prevent fluid buildup in the middle ear, children with cleft palate usually needs special tube placed in the eardrums to a fluid drainage and their hearing needs to be checked once a year. This is often done at the time of palate repair. Figure 2 (image below) -A and B- Pre- and postoperative aspect of cheiloplasty (surgical repair of the lip); C and D – Pre- and postoperative aspect of palatoplasty (surgical repair of the palate) Medical Management Several techniques can improve the outcomes of cleft lip and palate repairs when used appropriately before surgery. They are non-invasive and dramatically change the shape of the baby’s nose and mouth. • • • Lip-Taping Regimen o Can narrow the gap in the child’s cleft lip Nasal Elevator o Used to help form the correct shape of the baby’s nose Nasal-Alveolar Molding (NAM) o This device is used to help mold the lip tissued into a more favorable position and preparation for the lip repair Nursing Management Another image (image below) shows a complete unilateral cleft lip which also reveals the post-op condition of the patient. CEBU DOCTORS’ UNIVERSITY – COLLEGE OF NURSING This can be applicable pre and post operatively to patients with orofacial clefts. • • Suction secretions gently Place the infant on the side to prevent pressure and tearing of the suture line after CL surgery. 13 NCM 116: THEORY MODULE 1: CONCEPT OF METABOLISM AND ALTERATION IN INGESTION Cebu Doctors’ University l Fated Nurses Clinical Instructor: Ms. Ortiz, J. If the surgical site is on the patient’s left side, we should position the patient to his/her right side. Feed the infant using a commercial cleft lip nipple (Brecht or Haberman feeder) o This is for both pre-op and post-op. o • L-Larger Nipple Opening m2017 I-Incidence ^ (increased) in Males P-Prevent Crust Formation; Prevent Aspiration Evaluation • • • • • • • Method: Enlarge, Stimulate, Swallow, Rest (ESSR) o Follow the method enlarge, stimulating the infant by brushing off his or her side of the cheek allowing the infant to swallow and allowing rest period before doing another feeding. Instruct the mother how to pump or manually express breast milk to maintain a supply at this time. o This is to maintain a good milk supply at this time while the infant cannot directly latch on the mother’s breast. Bubble the infant well after feeding Offer small sips of fluid (clear water) or place drops of NSS (Normal Saline Solution) to prevent drying of the mucous membranes and crust formation Keep the suture line as clean as possible after feeding. o To prevent infection. CLEFT LIP-POST OP CARE C-Choking L-Lie on Back E-Evaluate Airway F-Feed Slowly T-Teaching CEBU DOCTORS’ UNIVERSITY – COLLEGE OF NURSING Bamba Child’s respiratory rate is 20-30 breaths per minute without retractions or obvious distress. Child ingests an adequate diet of 50 kcal/lbs. (110 kcal/kg) in 24 hours; weight is maintained within 10& of birth weight. Malnutrition -is a condition that occurs when a person’s body is not getting enough nutrients. -The cellular imbalance between supply of nutrients and energy and the body’s demand for them to ensure growth, maintenance, and specific functions (WHO). Nutrition in the first 1,000 days of a child’s life by UNICEF 1,000 days, that’s the number of deadlines for reaching MDGs and the number of days in which to save a child’s future. When children are denied the right nutrition from pregnancy to the age of two they suffer stunting, the damage to their development is irreversible, there’s no cure extended children are not only shorter than they might have been, they’re more susceptible to disease, at higher risk of obesity, diabetes, and cardiovascular disease. Their brain cells don’t grow as they should connections between brain cells fail to develop so they’re more likely to fall behind in school ☹ to earn less in the future and thus not to contribute as fully as they could to their nation’s prosperity. 165,000,000 children under the age of five stunted worldwide, no child deserve this, no society should allow it, we can prevent stunting and at relatively little cost. All it takes are micronutrients, handwashing, breast feeding, good child feeding practices, and community nutrition program. When every child can fully seize the future, it is our future that benefits as well. 14 NCM 116: THEORY MODULE 1: CONCEPT OF METABOLISM AND ALTERATION IN INGESTION Cebu Doctors’ University l Fated Nurses Clinical Instructor: Ms. Ortiz, J. The first 1,000 days of life is a critical stage of a child’s growth and development, this stage begins from the time of conception up until the second year of a child. It offers a golden opportunity for parents to shape a healthier and more prosperous future for their child. The first 1,000 days of life consist of three separate stages: 1. Pregnancy. This includes the first 270 days of the baby inside the womb to birth, during this stage a mother’s nutrition and care is a matter of utmost importance. Mothers should drink iron and folate to prevent anemia and birth defects. It is important for mothers to consume adequately iodized salt during pregnancy. Iodine deficiency may reduce IQ by as much as 10-15 points and may also lead to low birth weight or still birth. A balanced diet including rice, meat/fish, green leafy, vegetables, yellow fruits and milk/egg products can help ensure optimum health of the mother and her child. 2. Infancy. This includes from the time of baby’s birth up to their first 180 days or from zero to six months. The first hours after birth the baby will be able to receive colostrum from the mother’s breast milk, colostrum is the baby’s first vaccination and protection from life-threatening diseases it can also increase the baby’s IQ by five to seven points. 3. Toddler years. This includes the next 550 days after infancy or the baby’s first seven months after his second year. The baby can still continue to breastfeed during the toddler years. During this time, the baby is ready to take in semi-solid foods from six to twenty-three months. With proper care and nutrition; ❖ Children can overcome and prevent lifethreatening diseases. ❖ Complete 4.6 more grades of school. ❖ Have healthier families during adulthood. CEBU DOCTORS’ UNIVERSITY – COLLEGE OF NURSING In the Philippines… • • • Bamba Metro m2017 Manila (CNN Philippines, May 02, 2017)- According to Save the children foundation, 1 in 3 children below 5 years old in the Philippines is malnourished. Food and Nutrition Research Institute: 26 percent of children up to 2 years old suffer from chronic malnutrition, the highest number in 10 years. Many children, including those in poor communities, may have access to food, but they’re not eating right, because parents lack basic knowledge on proper nutrition. National Nutrition Council (NNC) under the Health Department is launching an action plan for nutrition. • • • Seeks to get commitment from partners and stakeholders, especially local government units, to support services. Reminds parents that as a rule of thumb children past the breastfeeding age should always have four things on their plate: carbohydrates, protein, vegetables, and plenty of fruits. According to DOH, it is also considered an integral part of the Philippine Development Plan 2017-2022 and the Duterte administration’s 10-points economic agenda. Causes of Malnutrition; • • • • Inadequate food intake (main problem) Poor standard of living Inadequate understanding or knowledge for optimal nutrition intake Inadequate absorption According to the Savethechildren.org.ph. 33.4% of Filipino children under the age of five are stunted. 9.1% of Filipino newborns have low birth weight due to intrauterine growth restriction. 7.1% of Filipino children under the age of five have wasting which means that they are too thin for their weight. 21.5% of Filipino children under the age of fiver are underweight. 15 NCM 116: THEORY MODULE 1: CONCEPT OF METABOLISM AND ALTERATION IN INGESTION Clinical Instructor: Ms. Ortiz, J. Cebu Doctors’ University l Fated Nurses the needs to function. Protein energy malnutrition Bamba doesn’t occur m2017 due to short-term illnesses, it is more likely due to the malnutrition over a long period of time. • • • • Healthy- Normal weight and height Wasted-Thinner than normal Stunted- Shorter than normal Wasted and Stunted- Thinner and shorter than normal World Health Organization estimates that by 2025 about 127 million children under five years old will be stunted assuming that current trends continue. With Covid-19 pandemic, there is a possibility that more children will be stunted if there are no mitigating measures that are put in place. • • • • Republic Act (RA) 11148 or the Kalusugan at Nutrisyon ng Mag-nanay Act RA 10028 of the Expanded Breastfeeding Promotion Act RA 11210 or the Expanded Maternity Leave Act Executive Order 52 or the Philippine Milk Code Kwashiorkor vs. Marasmus Discussion: Our body needs calories, protein and overall general nutrients to function, without adequate nutrition our muscles waste away, our bones become brittle and our thinking becomes foggy. Calories are units of energy that our body needs to function, our body also needs a large amount of protein for without an enough protein, we might not be able to easily heal injuries or wounds. One type of malnourishment is protein, called protein energy malnutrition. Protein energy malnutrition -happens if the body has a severe calorie or protein deficiency. This can occur if a person does not consume the number of calories and protein CEBU DOCTORS’ UNIVERSITY – COLLEGE OF NURSING Kwashiorkor -occurs in people who have a severe protein deficiency. Children who develop kwashiorkor are often older than children who have marasmus. -Having a diet that is mainly carbohydrates can lead to this condition because there is no protein that has been included in child’s diet. Marasmus -a form of nutrition deficiency disorder usually occurring in children. It can be life threatening if it has not been diagnosed at an early stage. -Marasmus occur more often in young children and babies. Leads to dehydration and weight loss. Starvation is a form of this disorder; this is also due to the inadequate calorie intake. Pathophysiology: KWASHIORKOR ↓Protein (CHON) → Main S/S: protruding belly, ankle edema → Kwashiorkor Review: Protein (CHON) is required in our body for cell repair and cell regeneration. This nutrient is important during pregnancy and the child’s growth and development. Without protein in our diet resulting protein deficiency, this has an effect and alteration on the growth and development of our normal bodily function. 16 NCM 116: THEORY MODULE 1: CONCEPT OF METABOLISM AND ALTERATION IN INGESTION Cebu Doctors’ University l Fated Nurses Clinical Instructor: Ms. Ortiz, J. - CLINICAL MANIFESTATIONS OF KWASHIORKOR EDEMA The presence of edema and Kwashiorkor is correlated with very low albumin concentration. - Edema results from a loss of fluid balance between the hydrostatic and oncotic pressure across the capillary blood vessel walls due to the lack of protein which affects the body’s ability to draw fluid from the tissues into the bloodstream. - Low albumin concentration negatively influences the strength of oncotic pressure - Failure leads to buildup in the abdomen resulting in edema and belly distention. - In simpler terms, edema is a RESULT of hypoalbuminemia o Albumin comes from the protein that we ingest. o Lack of protein in the diet will result to low albumin present in our body. Our albumin is located INTRAVASCULARLY (so it is only present inside the blood vessel) - Albumin creates an oncotic pressure. Kwashiorkor=lack of albumin intravascularly Oncotic pressure is low=fluid leak of the blood vessel wall Fluid shifting- the fluid has been transferred or leaked extravascularly causing edema. HYPERKERATOSIS & DISPIGMENTATION - There is a reduction of enzymes in the skin causing hyperkeratosis and dispigmentation FATTY LIVER - Caused by a reduction of beta lipoprotein synthesis causing fatty changes inside the liver - Beta lipoprotein is essential in exporting lipids ANEMIA - Reduced globin in our body resulting to reduced hemoglobin and reduced RBC causing anemia. MARASMUS Marasmus is mainly caused by inadequate food intake of all food groups. Inadequate food intake can be caused by the following: • • Another contributing factor why edema is present in some patients with kwashiorkor is the release of the ANTI-DIURETIC HORMONE. - - our body will perceive that the pressure inside our blood vessel wall is low causing HYPOVOLEMIA As a compensatory mechanism, our body releases ADH. It restricts or it does not allow fluid to be eliminated outside of our body. o Causes edema, specifically the peripheral edema. CEBU DOCTORS’ UNIVERSITY – COLLEGE OF NURSING Plasma renin is also being stimulated Bamba causing sodium retention m2017 • Poor diet o A nutrient-rich balanced diet is important for growth, especially in children. If the child has a poor diet that lacks essential nutrients, the child may be at risk of developing marasmus. Food shortages o Marasmus is more common in developing countries that have high poverty and lack of food, these regions also have a frequent famines and natural disasters resulting in food shortages. Children and adults living in these areas are at higher risk of getting marasmus. Insufficient breast feeding o Mother's milk is rich in nutrients that help children grow, if mothers are malnourished, they are unable to feed their infants enough milk for breast feeding. This can cause or this can increase the chances of 17 NCM 116: THEORY MODULE 1: CONCEPT OF METABOLISM AND ALTERATION IN INGESTION Clinical Instructor: Ms. Ortiz, J. • • protein energy malnutrition in children. Infections and diseases o Infections and diseases caused by viruses, bacteria, parasites and other pathogens can cause a loss in appetite, this can lead to a low intake of essential nutrients in infected children and adults. Diseases such as HIV/AIDS and malaria in rural areas can cause marasmus, it can also be caused by poor absorption of nutrients due to celiac disease and pancreatic problems Anorexia o Although marasmus in developed countries is quite rare, any person can get this condition if they are subject to a severe lack of nutrients, if someone isn't getting enough food due to an eating disorder, their body will be at risk of malnutrition Cebu Doctors’ University l Fated Nurses Bamba m2017 So this is a comparative chart between a patient with marasmus and kwashiorkor. Severe protein and calorie deficiency in children can result in loss of fat and muscle mass, the most common symptom of marasmus is being underweight due to malnourishment. The following symptoms can occur due to deficiency, dehydration, electrolyte imbalance or infection if marasmus remains untreated for a long time: 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. Weight loss Stunted growth Dry skin and eyes Brittle hair Diarrhea Lower immunity Stomach infection and lactose intolerance Respiratory infections Rickets due to calcium and vitamin D deficiency Anemia due to iron deficiency Impaired brain function and intellectual disability Low blood pressure or hypotension Low body temperature or hypothermia Slow heart rate or bradycardia CEBU DOCTORS’ UNIVERSITY – COLLEGE OF NURSING 18 NCM 116: THEORY MODULE 1: CONCEPT OF METABOLISM AND ALTERATION IN INGESTION Cebu Doctors’ University l Fated Nurses Clinical Instructor: Ms. Ortiz, J. Discussion: Comparative chart for patients with kwashiorkor and marasmus. • • Appearance for kwashiorkor it usually appears between 0 to 5 years old o Deficient: Protient o Has pitting edema o Activity: apathetic & irritable o Presence of hair changes o Subcutaneous Fat: Reduced o Face: moon-shaped face o Mental changes: very common o Anemia: severe o Fatty liver: present o Dermatosis: common o Infection: most prone Appearance for marasmus it usually occurs below 1 year old o Deficient: Calories o No edema o Activity: apathetic o Wasting: markedly present o Uncommon for hair changes o Subcutaneous Fat: Absent o Face: like an old man’s o Mental changes: uncommon o Anemia: present o Fatty liver: absent o Dermatosis: does not occur o Infection: less prone PHYSICAL ASSESSMENT • • • LABORATORY ASSESSMENT • • • • • • SIGN AND SYMPTOMS: • • • • • • Clinically: failure to gain weight followed by weight loss and emaciation Fat is lost last from the cheeks = “old man’s face” Abdomen = flat or distended Muscle atrophy and hypotonia Low BMR Infant: constipated or have the “starvation type” of diarrhea with mucus CEBU DOCTORS’ UNIVERSITY – COLLEGE OF NURSING Low albumin concentration Low plasma glucose Ketonuria Low plasma amino acids Decreased K+, Mg++ Low cholesterol MANAGEMENT • Based on management of the associated conditions (infections, dehydration, anemia, diarrhea) and institution of adequate diet WHO 10 steps to management of severe acute malnutrition STABILIZATION Reduction of edema and restoration of tissue and body organ function through: MARASMIC KWASHIORKOR Child can develop pitting edema, protein insufficient, severe malnutrition m2017dietary history An accurate Evaluation of height, weight, head circumference and past rates of growth Measurement of mid-arm circumference and skin fold thickness and other tests DIAGNOSIS • • Bamba • • • • • Treatment of infection and other medical problems Providing sufficient energy and nutrients Correcting electrolyte imbalance using the formula diet F-75 that contains 75 cal and 0.9 grams of protein per 100 mL Children 60-66 aged months: SAM (severe acute malnutrition) height/weight > (-3) standard deviations of WHO standards or mid upper arm circumference of less than 115 millimeters and presence of bilateral edema SAM affects 20 million children under age of 5 and 1-2 million preventable deaths every year Risk for death compare to moderate malnutrition 19 NCM 116: THEORY MODULE 1: CONCEPT OF METABOLISM AND ALTERATION IN INGESTION Cebu Doctors’ University l Fated Nurses Clinical Instructor: Ms. Ortiz, J. • • Fatality rates remain high at about 20-60 % Children with complicated severe malnutrition those with poor appetite, fever, pneumonia, dehydration, severe edema, or infants aged in patients facilities until complication are resolved Bamba m2017 REHABILATIONS • • • • • Providing extra energy and nutrients Utilization of formula F-100 containing 100 kcal and 3 grams of protein per 100 mL Mental stimulation through play sessions Health education to the significant other Children provided with extra energy and nutrients for rapid weight gain and for rapid weight gain and catch-up growth TRACHEOESOPHAGEAL FISTULA ASSESSMENT - is an abnormal connection (fistula) between the esophagus and the trachea, TEF is a common congenital abnormality, but when occurring late in life is usually the sequela of surgical procedure such as laryngectomy UNCOMPLICATED SEVERE ACUTE MALNUTRITION (can be managed in the community) • Ready-to-use therapeutic food (RUTF) o An energy-dense micronutrientfortified food with properties similar to F-100 o Does not require cooking o Has a low moisture content giving long shelf life o Does not require supervised feeding this approach also addresses lack of the access coverage and timely treatment associated with traditional inpatient model it has been widely shown to achieve good levels of nutritional recovery to reduce mortality and to shorten the duration of inpatient treatment for children with SAM o Integrating these two arms of treatment allows referral of complicated cases presented in the community to treatment centers for stabilization and subsequent discharge of children for rehabilitation once complications are resolved CEBU DOCTORS’ UNIVERSITY – COLLEGE OF NURSING 3 C’S • • • • • • Coughing Choking Cyanosis Atresia with distal Fistula – the esophagus has been cut and another end of esophagus sticks to the trachea Atresia with double fistula- both ends of the esophagus that has been cut off a stick to trachea creating fistula Atresia with proximal fistula – upper portion of the esophagus that has been cut off stick to trachea and the other end connects to the stomach has been left 20 NCM 116: THEORY MODULE 1: CONCEPT OF METABOLISM AND ALTERATION IN INGESTION Cebu Doctors’ University l Fated Nurses Clinical Instructor: Ms. Ortiz, J. • • Atresia – the two esophagus has not been completely connected and there is not fistula or there is no end that stuck into trachea Fistula – there is no disconnection between or there is no interruption between esophagus however there is an abnormal sticking on one side of the esophagus to the trachea Diagnostic examination: • • • Sonogram Feeding tube passed stops at 10-12 cm instead of 17 cm Follow-up with Radiographics studies, absence of air in stomach- EA w/o TEF Management: • • • Gastrostomy feeding/ TPN – to support nutritional requirement of the body Closing of fistula and gastronomy insertion (to minimize gastroesophageal disease GERD) Anastomosis – reconnection of ruptured esophagus MALIGNANT TEFs • • • • • • m2017 and started promptly Individualized, Palliative care o Relief of obstruction o Diversion of contamination from the respiratory tract Procedures o Endoprosthesis (covered selfexpandable metal stent SEMS) o Esophageal exclusion or bypass, resection, or direct closure Procedure that holds upon a structure in gastrointestinal tract to allow the passage of food kind stool or other secretion related to digestion Surgeons insert stems by endoscopy inserting optic camera either passing through the mouth or the colon ton reach an area of narrowing SEMS inserted using fluoroscopy where the surgeon uses an x-ray image to guide the insertion or an adjunct to endoscopy NURSING MANAGEMENT Pre-op (prevention of aspiration and regurgitation) • • • CEBU DOCTORS’ UNIVERSITY – COLLEGE OF NURSING Bamba NPO Continuous suction Supine with elevated head (decreases pressure on thorax and minimize reflux of gastric acid secretion intro trachea and bronchi) 21 NCM 116: THEORY MODULE 1: CONCEPT OF METABOLISM AND ALTERATION IN INGESTION Clinical Instructor: Ms. Ortiz, J. Cebu Doctors’ University l Fated Nurses POST-OP:(patent airway, prevent trauma) • • • • • • • Gentle sanctioning Observation for airway obstruction NPO until bowel sounds return IV (dextrose solutions) & TPN to prevent hypoglycemia Glucose water if tolerated then formula pr breast milk for babies Pacifier to prepare for oral feeding Barium swallow: to check for any leaks before resuming 1 week after Bamba m2017 TEF Complication: Aspiration pneumonia Objective of care: • • Airway will remain patent Hydration maintained Family teaching • • Observe for esophageal stricturedysphagia, increased drooling, coughing, choking Gastrostomy, care and feeding CEBU DOCTORS’ UNIVERSITY – COLLEGE OF NURSING 22