3/25/22, 6:32 PM Weight loss outcomes with FDA-approved medications - UpToDate Official reprint from UpToDate® www.uptodate.com © 2022 UpToDate, Inc. and/or its affiliates. All Rights Reserved. Weight loss outcomes with FDA-approved medications Weight loss reflects results at 52 weeks, except for semaglutide and liraglutide, which reflect weight loss at 68 weeks. FDA: US Food and Drug Administration. https://www.uptodate.com/contents/image/print?topicKey=PC%2F5376&view=machineLearning&search=obesity drug therapy&sectionRank=1&usage… 1/2 3/25/22, 6:32 PM Weight loss outcomes with FDA-approved medications - UpToDate Courtesy of George A Bray, MD. Data from: 1. Khera R, Murad MH, Chandar AK, et al. Association of pharmacological treatments for obesity with weight loss and adverse events: A systematic review and meta-analysis. JAMA 2016; 315:2424. 2. Rubino DM, Greenway FL, Khalid U, et al. Effect of weekly subcutaneous semaglutide vs daily liraglutide on body weight in adults with overweight or obesity without diabetes: The STEP 8 randomized clinical trial. JAMA 2022; 327:138. 3. Wilding JPH, Batterham RL, Calanna S, et al. Once-weekly semaglutide in adults with overweight or obesity. N Engl J Med 2021; 384:989. Graphic 115096 Version 5.0 https://www.uptodate.com/contents/image/print?topicKey=PC%2F5376&view=machineLearning&search=obesity drug therapy&sectionRank=1&usage… 2/2