BIO 147 STUDY GUIDE FOR TEST 2 POWERPOINT Jenny Hill, MSN-Ed, RN • Some neurons have a covering composed of a whitish, fatty material called myelin • Insulates fibers and increases the rate of transmission of the nerve impulse 2 TEASPOONS TO MILLILITERS (ML) 3 SKELETAL SYSTEM WHAT DOES IT DO? ▪ Framework: ▪ 206 bones in an average adult ▪ 300 bones roughly as an infant-have more cartilage and as they grow up, some of the bones fuse together to form one bone ▪ Supports the bodies weight ▪ Protects: organs from injury: i.e., the head; ribs and pelvis ▪ Levers for movement: attached to muscles ▪ Stores Calcium salts that can be called upon if needed for remodeling; blood clotting. Growth and Development • Bone Growth • Starts in-utero through late adolescence; however, bone repair is continuous (slows down as we get older) • When bones are done growing via the epiphyseal plate they calcify, and a solid line forms the epiphyseal line • Typically, girls stop growing around 16 • Boys around 18-20’s • So, if skeletal remains are found and the plate is fused together, they can determine the skeleton is not an adolescent or child IMPORTANT CELLS IN INNATE IMMUNITY Phagocytosis: Phagocytosis, or “cell eating”, is the process by which a cell engulfs a particle and digests it Neutrophils: Neutrophils are a type of white blood cell that help heals damaged tissues and resolves infections Macrophages: Important cells of the immune system that are formed in response to an infection or accumulating damaged or dead cells Natural killer cells: NK cells are found in the lymph nodes, spleen, bone marrow, and blood. They destroy abnormal cells by secreting a protein that breaks down the plasma membrane Mast Cells: Mast cells are allergy cells responsible for immediate allergic reactions Muscles and Bones Assignment What is the name of the highlighted bone? Humerus The muscle in the highlighted area below is known as the Sternocleidomastoid. Here you have a greenstick fracture. MUSCLE DAMAGE/INJURIES Strains Delayed-onset muscle soreness (DOMS) Rhabdomyolysis Tendinitis Plantar fasciitis Shin-splints Where we give I.M. injections SKIN DISORDERS, AGING, & CANCER Aging What is lost Lesions Surface Erythema Macule Papule Vesicle pustule A https://www.cdc.gov C E http://www.skinsight.com/skinconditions/adult/pressure-ulcer-decubitusulcer?Imiw9cApl / Deep Excoriation Laceration Ulcer fissure Pressure ulcers Infections F B D BURNS AND CANCER • BURNS • CANCER SUPERFICIAL BASAL CELL SUPERFICIAL-PARTIAL THICKNESS SQUAMOUS CELL CARCINOMA DEEP-PARTIAL THICKNESS MELANOMA ABCDE RULES FULL THICKNESS https://medlineplus.gov/ CELLS OF ADAPTIVE IMMUNITY: B CELLS the B-cell sweeps up the leftover viruses after the T-cell attack Mature in the bone marrow Make important molecules called antibodies. These molecules trap specific invading viruses and bacteria Affect antimicrobial defenses and tissue inflammation React to foreign antigens and differentiate into plasma cells once activated VACCINES AND IMMUNITY • ARTIFICIAL IMMUNITY LIVE ATTENUATED INACTIVATED TOXOID GENETICALLY CREATED MRNA VIRAL VECTOR BOOSTERS • WAYS TO GET A VACCINE INJECTION (IM) ORAL (PO) INTRANASAL INFLAMMATORY RESPONSE Causes: infection, tissue damage, allergens Indications: Heat, redness, swelling, pain Stages Injured cells release histamine. Leukocytes enter tissue. Granulocytes, macrophages, mast cells Inflammatory exudate (leukocytes and tissue fluid) causes swelling, pain. Pus contains exudate, cells, pathogens, and destroyed tissue. Nearby lymph nodes enlarge. INNATE IMMUNITY Includes: Skin and mucous membranes (keeps organisms out) Coughing (forces organisms out) Sneezing (also forces organisms out) Vomiting and diarrhea (body functions to clear organisms out) TYPES OF NEUROTRANSMITTERS THE HISTAMINE RESPONSE IN THE INFLAMMATORY REACTION THE CENTRAL NERVOUS SYSTEM Know the CNS includes the brain and spinal cord Know that the CNS is sometimes referred to as the “integration and command center” of the body MONOCYTES The function of monocytes in immunity is that they capture antigens by phagocytosis and present them to lymphocytes