Name the non-selective Beta adrenergic blocking drugs?
- carvedilol
- propranolol (Inderal)
What are the indications/uses for carvedilol?
- heart failure
- hypertension
What are the indications/uses for propranolol (Inderal)?
- hypertension
- arrhythmias
- angina
Name the selective Beta 1 blocking drugs?
- atenolol (Tenormin)
- bisoprolol
- esmolol (Brevibloc)
- metoprolol (Lopressor)
What are the indications/uses for atenolol (Tenormin)?
- hypertension
- angina
What are the indications/uses for bisoprolol?
- hypertension
What are the indications/uses for esmolol (Brevibloc)?
- supraventricular tachycardia (SVT)
What are the indications/uses for metoprolol (Lopressor)?
- hypertension
- angina
What is the function of Beta adrenergic blocking drugs?
compete with norepinephrine for binding to beta adrenergic receptors and prevent SNS activation
What are the actions of Beta adrenergic blocking drugs?
- decrease heart rate
- decrease force of contraction
- decrease speed of conduction through heart
- less polarization of SA node
- slowed conduction through AV node
What are the types of Beta adrenergic blocking drugs?
- non-selective - block B1 & B2
- selective - block only B1
Can selective Beta 1 blocking drugs become non-selective at high doses?
yes
Can Beta blocking drugs cause hypoglycemia in diabetics?
yes
What do beta blocking drugs alter in diabetics?
carb and lipid metabolism
What are the sum of effects for beta blocking drugs?
- decreases workload of heart > decreases workload > decreases O2 consumption
Do beta blocking drugs alter carb & lipid metabolism in non-diabetics?
usually insignificant (except in OD, where it can affect heart and blood sugar levels)
What are the indications for beta blocking drugs?
- angina
- hypertension
- arrhythmias
- heart failure
- post MI
- glaucoma (to decrease IO presure)
- migraines