Medications
Medication
MOA
Type
Indication
Adverse
Drug to
Administratio
Nursing
Patient
s
Reactions
Drug
n
Consideratio
Teachin
ns
g
Interaction
s
(Antineoplastic
Alkylating
Bone Marrow
Follow safe
Agent)
Agent
Suppression
handling
Nausea
procedures when
Bonds with
Vomiting
preparing,
DNA,RNA
Stomatitis
administering, or
and protein
Alopecia
dispensing this
molecules
Renal toxicity
medication.
leading to
Gonadal
impaired DNA
suppression
Chlorambucil
For initial
replication;
therapy and
resulting in
short courses of
cell death
therapy, give
(Kills cancer
entire daily dose
cells)
at one time.
Cell Cycle –
Absorption is
nonspecific
decreased when
taken with food.
Monitor CBC
Store tablets in
refrigerator
(Antineoplastic
Antimetabolit
Nausea
Agent)
e – inhibits
Vomiting
Methotrexate
DNA
Bone marrow
replication
Suppression
and repair
Stomatitis
Renal toxicity
Doxorubucin
Cell Cycle –
Hand-foot
specific
syndrome
Antineoplastic
Bone marrow
Antibiotic –
suppression
Prevents
Nausea
RNA
Vomiting
Synthesis
Alopecia
Anorexia
Vinicristine
Tamoxifen
Cell-
Cardiac Toxicity
nonspecific
Red urine
Mitotic
Bone marrow
inhibitor –
suppression
inhibits DNA
Peripheral
and protein
neuropathies
Synthesis
Nausea/vomiting
Hormone
Hypercalcemia
Modulator –
Jaundice
inhibits RNA
Increased
synthesis
appetitie
Feminization
Sodium and
fluid retention
Nausea/vomiting
Hot flashes
Vaginal estrogen
dryness
Imatinib
Cancer cell-
Thrombocytopen
specific agent
ia
GI hemorrhage
Neutropenia
(Antimetic
Change
To control
Agents)
responsiveness
nausea and
or
vomiting
Prochlorperazin
stimulation
e
of the CTZ
in the
(phenothiazines
medulla
)
Metoclopramid
Reduces
Prevents
e
responsiveness
nausea and
to nerve cells
vomiting
(Non-
in the CDZ
phenothiazine)
to circulating
chemicals
that induce
vomiting
Ondansetron
Blocks the
Controls
receptors
nausea and
(5ht3
associated
vomiting
Receptor
with nausea
blocker)
and vomiting
in the CTZ
and locally
Hydroxyzine
Suppress
Used for
(antihistamine)
cortical areas
nausea an
of CNS
vomiting or
before
obstetrical
surgery