TEACHER KEY Punnett Basics Watch video of a Sample Punnett Square Problem being solved 3 GENE ALLELE GENOTYPE PHENOTYPE HOMOZYGOUS 3 HETEROZYGOUS DD Rr bb CC Ww tt GG Pp nn Hh 4 Tt tt TT pp 5 Pp PP rryy RRYY RRYy RRyy rrYy 6 RrYy RrYY Rryy rrYY 7 GGii Ggii ggIi ggII GgII GGII GgIi GGIi ggii Watch video of a Sample Punnett Square Problem being solved 8 Tt T t t Tt tt 50% t Tt tt 50% tt 4 9 Bb Bb 100% Bb Bb 0% B B BB Bb 75% Bb bb 25% b 10 b Bb B b b Bb bb 50% b Bb bb 50% bb 11 N 12 n n Nn nn 50% n Nn nn 50% Nn N n N NN Nn 100% N NN Nn 0% NN 13 NN Nn ett Punn d e t ple s that a com This are show t Father n Squ 0% mina o Do duce 10 . m o o H r n i p pr g ld wou rns offs o No H N The father is most likely Homozygous Dominant (NN) which would always produce offspring with No Horns. A heterozygous father would have a 50% chance of producing horns, so offspring with horns would appear with a large enough sample size. 5 NN N n Nn Nn n Nn Nn nn Hh H h h Hh hh 50% hh h Hh hh 14 50% ff f Probability of Black Fur f 100% F Ff Ff F Ff FF 15 Ff Probability of Yellow Fur 0% FF If the father were homozygous dominant, he could only “give” the “F” allele to offspring. This would mean all offspring would have at least one “F” and could not have yellow fur which needs “ff.” 16 FF Ff F F f Ff Ff f Ff Ff ff 9 17 3 3 1 1 6 1 1 1 Rryy Rryy Rryy rrYy rrYy rrYy rryy rryy rryy 9 7 3 3 1 RRYY RRYy RrYY RrYy RRYy RRyy RrYy Rryy RrYY RrYy rrYY rrYy RrYy Rryy rrYy rryy ● ● ● ● ● ● ● ● 18 Worked with pea plants because they are true breeding Found that parents pass traits to offspring Deduced that genes come in pairs, one from each parent Found that traits could “skip” a generation Explained the principle of dominance Developed Law of Segration Developed Law of Independent Assortment Known as the Father of Genetics RR 19 RW WW R 50% 20 R R RR RR W RW RW 25% 21 R W R RR RW W RW WW R 9 50% 50% R W RW RW W RW RW W 100% 22 W R RW RW R RW RW W 0% 23 W R RW RW W WW WW 50% A B I I I A I I A A I I B B I I B 12 A I i ii B I i I A A A I I I A A I B 0% A A I I I I A B A I I A I I A B 50% 0% 25% A I i I A I I A A I I B B I I B 13 A I i ii B I i I B B A i A I I B B I i A ii I i i 25% I i 25% 25% 50% A B I I I A I I A A I I B B I I B 14 A I B 50% A I i ii B I i A B i I i I i i A B ii I i I i 0% 0% A B I I A I i IA IA IA IB IB IB 15 I A I i IA i IB i i A IB i I B IA i ii IB i B ii I i No, the baby is NOT their child. A Type AB and Type O parent can only have children that are Type A or Type B. Type O would require an ii genotype and this is NOT possible from these parents’ gametes. Healthy Female Klinefelter Syndrome Down Syndrome Healthy Male Edward’s Syndrome Turner Syndrome 16 Edward’s Syndrome Down Syndrome Healthy Male Healthy Female 17 Klinefelter Syndrome Turner Syndrome Cystic Fibrosis is an autosomal recessive disease. Ff 18 ff FF Ff FF Ff ff A carrier is heterozygous for a recessive disease having one dominant and one recessive allele. A carrier does not have symptoms of the disease, however, they can pass the recessive allele to offspring. In a pedigree, a carrier will appear as Normal (not diseased), but can produce offspring with the disease if crossed with another carrier or homozygous recessive individual. 19 XB Y XbXb XB Xb XB XB XB Xb XbXb XB Y XbY 20 XbY Xb XbXb XbY XB Xb XB Y XB XB 21 X b XB Y Y 25% XB XB Xb XB Y Xb XbXb XbY XB Xb 25% ● American Scientist that began working in Genetics in the early 1900’s ● Worked with a team that studied Fruit Flies (Drosophila melanogaster) ● Showed that genes are linked in a series on chromosomes and are responsible for identifiable, hereditary traits ● Many of the traits he studied were sex-linked ● Awarded the Nobel Prize in 1933 22