Homework
1. Advantages and Disadvantages of Cohort study (K Park)
2. Difference between Cohort and Case Control study
(identify 2 mistakes) (K Park)
3. An investigator conducts a study to explore the relationship between peri-menopausal
exogenous estrogen use and the risk of coronary heart disease (CHD). A total 5000
exposed and 5000 unexposed women are enrolled and followed for 15 years for the
development of myocardial infraction (MI). A total of 200 estrogen users and 300
nonusers had MIs.
a. Identify the study design and calculate appropriate measure of association
b. Based on the result of this study is estrogen use a causative or protective factor
for MI?
4. A team of clinical researchers hypothesized that major ECG abnormalities are a risk
factor for deaths from Coronary Heart Disease (CHD). In a study designed to test this
hypothesis, 47 men 144 men in the same group with no ECG abnormalities were
recruited as subjects. Both groups were followed for 20 years a death from CHD
recorded. The table below summarizes the results.
ECG
Abnormality
Present
Absent
Total
Death form CHD
Yes
No
8
39
10
134
18
173
Total
47
144
191
a) Which study designs is this
b) Calculate the measure which will determine the association between ECG
abnormalities and deaths
c) Interpret your results
d) Based on the results, comment on the hypothesis of the researcher