Chapter 2 Quiz BNF Cardiovascular System Questions: 1. Which of the following beta-blockers has a long duration of action? A. Sotalol B. Metoprolol C. Acebutol D. Nadolol 2. Which of the following is an example of a thiazide-like diuretic? A. Bendroflumethiazide B. Bumetanide C. Metolazone D. Triamterene 3. Mr F Ruty, has come into practice to visit you today for his annual poly pharmacy medication review. You take this time to remind Mr F Ruty about important interactions with certain medications he is taking. Which of the following medications below would you remind Mr F Ruty to avoid drinking grapefruit juice? A. B. C. D. 4. Apixaban Bisoprolol Simvastatin Warfarin Mr P just been discharged after a successful hip replacement operation. He has been discharged with Rivaroxaban 10mg 1 OD for prophylaxis of VTE. How long would you expect Mr P to take the Rivaroxaban for? A. B. C. D. 14 days 21 days 28 days 35 days 5. Normal BP lies within which range? A. 100/80 B. 120/100 C. 120/80 D. 140/100 6. Upon asking Ms O when she last used her GTN tablets, she informed you it was about 1 month ago when she overdone it in the garden but didn’t think they worked as well as when she first opened the bottle and used some 3 months ago. She proudly tells you that she carries them around with her all the time and shows you. Looking at the label on the opened bottle you can see that this was dispensed on the 19/12/19. You take this opportunity to remind Ms O how important it is to discard GTN SL after a period of time once they have been opened. When should the GTN SL tablets be discarded once they are in use? A. 1 week Chapter 2 Quiz BNF Cardiovascular System B. 2 weeks C. 4 weeks D. 8 weeks 7. Mr P has come into the pharmacy to hand in a prescription for Isosorbide Mononitrate 40mg 1 BD. He mentions that he was a bit confused as when best to take them. The doctor advised that they should be taken a little differently to normal twice daily medications and asks if you could clarify on when best to take them. When should the second dose of Isosorbide Mononitrate be taken? A. B. C. D. After 4 hours After 6 hours After 8 hours After 12 hours 8. What electrolyte disturbance would be most likely to occur with co-administration of Candesartan and Spironolactone? A. B. C. D. Hypokalaemia Hyperkalaemia Hyponatraemia Hypermagnesaemia 9. Which of the following is classed as a “Loop Diuretic”? A. B. C. D. Bumetanide Amiloride Metolazone Bendroflumethiazide 10. You are carrying out an annual polypharmacy medication review with Ms O. You note from the system that she has been diagnosed with stable angina, hypertension and hypothyroidism. Below is a list of medications, when they have last been issued and issues remaining. Drug Ramipril 10mg caps – 1 OD Atorvastatin 20mg tabs – 1 OD Levothyroxine 100mcg tabs – 1 OD Bisoprolol 5mg tabs – 1 OD Aspirin 75mg Disp tabs – 1 OD GTN SL 500mcg tabs – 1 PRN Last Issues 02,03,04/2020 02,03,04/2020 02,03,04/2020 02,03,04/2020 02,03,04/2020 Dec 2019 Issues Remaining 12/12 12/12 12/12 12/12 12/12 1/12 Upon asking Ms O when she last used her GTN tablets, she informed you it was about 1 month ago when she overdone it in the garden but didn’t think they worked as well as when she first opened the bottle and used some 3 months ago. She proudly tells you that she carries them around with her all the time and shows you. Looking at the label on the opened bottle you can see that this was dispensed on the 19/12/19. You take this opportunity to remind Ms O how important it is to discard GTN SL after a period of time once they have been opened. When should the GTN SL tablets be discarded once they are in use? Chapter 2 Quiz A. B. C. D. BNF Cardiovascular System 1 week 2 weeks 4 weeks 8 weeks 11. Mrs L has been in cold temperatures due to the winter season. She works as a lawyer and is also currently under a lot of stress. Due to this, it’s causing her blood vessels to go into spasm and is restricting blood flow to her fingers. What drug can be used to treat her symptoms? A. B. C. D. Aspirin Simvastatin Nifedipine Bisoprolol 12. Mr B comes in to collect his usual monthly prescription. Upon talking to him, he mentions that he has noticed that his urine appears to be of a blue colour sometimes. He wonders if it is related to that new water tablet he was started on. Which of the following drugs below could blue urine be associated with? A. B. C. D. Metolazone Xipamide Amiloride Triamterene 13. Some beta-blockers are classed as “Cardio-selective”. These beta-blockers predominantly work on the B1 receptors in the heart. Which of the following beta-blockers is not classed as “cardio-selective”? A. B. C. D. Atenolol Metoprolol Nebivolol Propranolol 14. You are discussing with the nursing team the number of patients who are coming into the surgery to get their INR tested due to being on warfarin. As part of a measure to try and reduce this you identify a cohort of patients who are eligible and willing to switch over to a DOAC. One of the nurses asks what a patients INR should ideally be if they are to switch over to Apixaban from Warfarin straight away? A. B. C. D. <2 <2.5 Between 2-3 >2.5 15. You are discussing a patient at a MDT meeting. This particular patient has been classed as having resistant hypertension and is currently on 3 different anti-hypertensives as listed below. Chapter 2 Quiz Perindopril 8mg 1 OD BNF Amlodipine 10mg 1 OD Cardiovascular System Indapamide 2.5mg 1 OD Despite treatment with 3 antihypertensives, the patients BP is still not adequately controlled and within target. You suggest trialling low dose spironolactone, as a 4th agent. What particular electrolyte should be monitored when initiating spironolactone, especially in combination with Perindopril? A. B. C. D. Sodium Potassium Calcium Magnesium 16. Mr Q has been admitted to hospital due to having blackouts and heart palpitations. An ECG was conducted, and Mr Q was found to have a prolonged QT interval. Upon reviewing his medication, you see that he is taking Sotalol. Which of the following drugs below can cause an increased risk of QT prolongation when taken alongside Sotalol? A. B. C. D. Citalopram Naproxen Digoxin Methotrexate 17. Which of the drugs below, used for the treatment of stable angina can cause serious skin, mucosal and eye ulceration, including gastrointestinal ulcers? A. B. C. D. Atenolol Bisoprolol Nicorandil Verapamil 18. Ms G has been diagnosed as having Angina. You are counselling her on the use of the GTN spray which has been prescribed. If Ms G is experiencing symptoms of angina and uses the GTN spray. How long after administering the first dose should Ms G wait before administering a second dose if required? A. B. C. D. 1 minute 2 minutes 3 minutes 5 minutes 19. Mrs P, presents to you a prescription for Perindopril 4mg tablets. She informs you; she has just been diagnosed with having hypertension and has been put onto these tablets. What is the most accurate counselling advice to give to Mrs P, regarding Perindopril tablets? A. Take with or just after food, or a meal B. Take this medicine when your stomach is empty. This means an hour before food or 2 hours after food C. Take 30 to 60 minutes before food Chapter 2 Quiz BNF Cardiovascular System D. The first dose should preferably be given in the morning 20. Aspirin should not be given to children under the age of 16 due to the risk of developing Reye’s syndrome. Which ONE of the following signs and symptoms is least likely to occur? A. B. C. D. E. Vomiting Seizures Muscle aches Raised white cell count Delirium 21. Mrs R who develops tachycardia whilst recovering from her operation. Her pulse is 100 beats per minute. Doctors wish to control the rate whilst they investigate the cause of the atrial fibrillation. Which ONE of the agents listed should be used as first line treatment to obtain rate control? A. B. C. D. E. Amiodarone Amlodipine Digoxin Bisoprolol Verapamil 22. Mr W requires a 1-week course of H. Pylori eradication therapy previously diagnosed by their GP. He is allergic to penicillin (urticarial rash). His other medications include: Clopidogrel 75mg once a day Aspirin 75mg once a day Bisoprolol 2.5mg once a day Ramipril 5mg once a day Which of the following regimes is most appropriate for Mr W’s eradication therapy? A. Esomeprazole 20mg twice a day, Clarithromycin 250mg twice a day, Metronidazole 400mg twice a day B. Lansoprazole 30mg twice a day, Clarithromycin 250mg twice a day, Metronidazole 400mg twice a day C. Omeprazole 20mg twice a day, Clarithromycin 250mg twice a day, Metronidazole 400mg twice a day D. Pantoprazole 40mg twice a day, Amoxicillin 1g twice a day, Clarithromycin 500mg twice a day 23. Mr C who has been admitted to the hospital for emergency surgery. He normally takes dabigatran for atrial fibrillation. Surgeons need to quickly reverse the effects of his anticoagulant before operating. Mr C also takes candesartan and levothyroxine for hypertension and hypothyroidism. Which one of the following agents is most suitable to use for reversal of the effects of dabigatran? A. B. C. D. E. Idarucizumab Flumazenil Naloxone Phytomeniadone Protamine 24. Post-operatively, Mr C is returned to the ward with an epidural catheter in situ for his pain relief. In the evening, as Mr C is eating and drinking, he is prescribed all of his usual medications, as well as the post-operative medications, as per below. Chapter 2 Quiz BNF Cardiovascular System Which ONE of the following drugs should be omitted in order to have the greatest reduction in risk of complications associated with the insertion of an epidural catheter? A. B. C. D. E. Candesartan Levothyroxine Dabigatran Gliclazide Dalteparin 25. You have recently qualified as an independent prescribing pharmacist and your competency is in acute stroke and transient ischaemic attacks. Which of the following is the most appropriate use of aspirin? A. Prevention of cardiovascular events in a healthy 25-year-old made with a strong history of early-onset heart disease B. Prevention of cardiovascular events in a COPD patient who has previously had a myocardial infarction C. Prevention of cardiovascular events in a diabetic patient who has not already had a cardiovascular event D. As an enteric coated tablet in patients with a history of gastric ulcer 26. Mr ARB is a 47-year-old, Afro-Caribbean man who has just had his blood pressure measured. The machine read 177/97 mmHg. He has no other medical conditions and takes no medication. Which of the following lifestyle advice is the most appropriate to be given to Mr ARB to help reduce his blood pressure? A. B. C. D. E. Stop smoking, as there is a direct link between smoking and hypertension Restrict salt intake to no more than 9g per day Partake in aerobic exercise every day for 50 mins Alcohol consumption should be more than 4 units each day Encourage a healthy diet consisting of an intake of at least five fruit or vegetables per day 27. Mr ARB is a 47-year-old, Afro-Caribbean man who has had ambulatory blood pressure monitoring with an average of 155/95 mmHg. Which of the following medicine should be initiated for the treatment of his hypertension. A. B. C. D. Losartan 50mg daily Nifedipine 60mg daily Amlodipine 10mg daily Perindopril 8mg daily 28. Mrs Jones has been prescribed a parenteral anti-coagulant for prevention of venous thromboembolism. The doctor has decided to prescribe the low molecular weight heparin, tinzaparin. What is the rationale for prescribing a low molecular weight heparin (LMWH) in preference to unfractionated heparin? A. B. C. D. LMWH have a lower risk of heparin-induced thrombocytopenia LMWH allow people to have regular INR monitoring to ensure safety LMWH are more effective at preventing thromboembolism LMWH have a higher risk of heparin-induced thrombocytopenia Chapter 2 Quiz BNF Cardiovascular System 29. Mr INR is a 62-year-old man who has been prescribed warfarin to treat myocardial infarction. Whilst working in a community pharmacy, you check his warfarin prescription and ask to see his yellow book. What is the most appropriate target INR for Mr INR? A. B. C. D. E. 1.5 2.0 2.5 3.0 4.5 30. Mr INR is a 62-year-old man who has been prescribed warfarin to treat myocardial infarction. He has been admitted into hospital with an INR of 10.4 with minor bleeding. Which of the following is the most appropriate course of action? A. Stop warfarin; give phytomenadione (vitamin K1) by slow IV injection; give dried prothrombin 25-50 units/kg B. Stop warfarin; give phytomenadione (vitamin K1) by slow IV injection; repeat dose of phytomenadione if INR still too high after 24 hours; restart warfarin when INR <5.0 C. Stop warfarin; give phytomenadione (vitamin K1) by mouth using the IV preparation orally; repeat dose of phytomenadione if INR still too high after24 hours; restart warfarin when INR <5.0 D. Stop warfarin; give phytomenadione (vitamin K1) by slow IV injection; restart warfarin when INR <5.0 E. Withhold 1 or 2 doses of warfarin and reduce subsequent maintenance 31. Mr DVT has been experiencing recurrent deep-vein thrombosis. He has been taking warfarin for several months. His last three INR readings have been stable at 2.4. What should his INR target be? A. B. C. D. E. 2 2.5 3 3.5 4.5 32. Mrs P comes into the pharmacy to speak to you about her warfarin. She states she is trying to have a baby. She confirms she is not pregnant yet. What is the most appropriate advice for Mrs P regarding her warfarin and pregnancy? A. She should speak to the anticoagulant clinic so they can monitor her INR closely during pregnancy B. She should speak to the anticoagulant clinic as soon as possible to let them know she is trying for a baby so her treatment can be reviewed C. She must stop taking the warfarin straight away if she becomes pregnant, as it is unsafe D. She should carry on taking warfarin as it does no harm to a baby E. She does not need further advice and should continue to take her warfarin as directed 33. Mr GTN has been complaining of chest pain and has been diagnosed with angina. He has a previous diagnosis of type 2 diabetes mellitus. Mr GTN has been complaining of severe headaches, which he has not experienced before. Which one of the following medicines is most likely to be causing the headaches? A. B. C. D. Aspirin Enalapril Rosuvastatin Gliclazide Chapter 2 Quiz BNF Cardiovascular System E. Isosorbide mononitrate 34. Mr Y is a 54-year-old man who was admitted to hospital 3 days ago with a diagnosis of heart failure. The medical team decide to start him on digoxin and after an oral loading dose he is maintained on 125 micrograms daily. Mr Y requires a blood test to assess his plasma digoxin concentration. When is the most appropriate time to sample Mr Y’s blood to monitor his digoxin levels? A. B. C. D. E. At least 8 hours after an oral dose has been administered Between 2-3 hours after an oral dose has been administered At least 6 hours after an oral dose has been administered Immediately after an oral dose has been administered Thirty minutes after an oral dose has been administered 35. A student technician asks you to explain the difference between generic and branded medicines. He asks why the prescription sometimes states the brand rather than the generic and vice versa. You explain that sometimes patients require a particular brand. Which one of the following does this apply to? A. B. C. D. E. Amlodipine 5mg tablets Diltiazem 90mg M/R capsules Felodipine 2.5mg M/R tablets Nifedipine 5mg capsules Verapimil 40mg tablets 36. Mrs SF who suffers from heart failure has recently been admitted to hospital due to poor symptom control. Her recent U&Es are as follows: Potassium Urea Creatinine Sodium 3.6 mmol/L (3.5-5.3) 9.2 mmol/L (2.5-7.8) 150 mmol/L (44-80) 145 mmol/L (133-146) On the ward, she complains to you of nausea and her vision is a little blurred. Looking at the observation chart you note her BP is 120/68 and pulse rate of 54. Which of the following drugs she is prescribed is the most likely to be contributing to this clinical picture? A. B. C. D. E. Bumetanide 2mg OM Bisoprolol 1.25mg OD Digoxin 125mcg OD Ramipril 5mg OD Spironolactone 12.5mg OD 37. Mr VF has been commenced on amiodarone in hospital for ventricular fibrillation. He comes to your community pharmacy 2 weeks after discharge to get a further supply. He complains that he is feeling tired and that his stools have changed from a dark brown to clay-coloured and wonders if this could be caused by the amiodarone. What is the most appropriate advice for this patient? A. B. C. D. E. The symptoms described are not known to be caused by amiodarone Stop taking the amiodarone immediately and see the GP as soon as possible He should see the GP as the dose of amiodarone may need to be increased He should see the GP as the dose of amiodarone may need to be decreased He is experiencing a side effect of amiodarone but may want to speak to the GP about an alternative but keep taking the amiodarone until then Chapter 2 Quiz BNF Cardiovascular System 38. A 10-year-old weighing 32kg is prescribed heparin 250 units/kg BD SC adjusted according to their APTT. Which of the following statements regarding the above prescription is incorrect? A. The specified dose is a licensed/indication for the treatment of thromboembolic disorders in children B. The actions of heparin can be reversed by protamine sulphate C. The child should be monitored for heparin induced thrombocytopenia D. The increase in clotting time will last for approximately 8 hours after administration E. Heparin can be administered by intramuscular, intravenous and subcutaneous injection 39. Mr P is an 80-year-old man with a past medical history of atrial fibrillation and stroke. He has been on warfarin for approximately 3 years and is on a stable dose. Last month he suffered a seizure and was admitted to hospital where he was prescribed an anti-epileptic drug. Today his INR is 1.6 (target 2.5). Which of the following drugs is most likely to be responsible for the decrease in his INR? A. B. C. D. E. Phenytoin Clobazam Gabapentin Pregabalin Sodium Valproate 40. Mrs W is an 81-year-old lady who is being treated for chronic heart failure. She has recently been prescribed new medication following a medication review with her heart failure nurse at the hospital. She tells you that ever since starting the medication, her hands and feet are feeling very cold, especially her fingers and toes. This happens especially at night and she can’t seem to keep them warm. Which of the following medication could be causing these symptoms? A. B. C. D. E. Carvedilol Verapamil Diltiazem Amlodipine Bendroflumethiazide 41. Mr KV has suffered from a pulmonary embolism, which is suggested to be as a result of deep vein thrombosis. He has been prescribed Warfarin for the treatment of this pulmonary embolism. What is the most appropriate target INR level for the warfarin therapy? A. B. C. D. E. 2.0 2.5 3.0 3.5 4.0 42. Mrs H is a 65-year-old lady who suffers from hypertension. She asks you to check her blood pressure, as she is concerned that it may be too high. She suffers from kidney disease also. She is on the following medication: Ramipril 10mg capsules Amlodipine 5mg tablets Metformin 500mg tablets Aspirin 75mg tablets Gliclazide 80mg tablets Chapter 2 Quiz BNF Cardiovascular System What the guideline aims for her blood pressure? A. B. C. D. E. 140/90 mmHg 140/80 mmHg 120/80 mmHg 130/80 mmHg 130/90 mmHg 43. Mrs T is in her 25th week gestation and has been diagnosed with gestational hypertension. She has just been seen by the obstetrician at the hospital who has prescribed an antihypertensive for her. Which of the following is most likely to have been prescribed? A. B. C. D. Enalapril Bendroflumethiazide Felodipine Labetalol 44. A 67-year-old is currently taking Ramipril 10mg once daily. Following a recent review by the GP practice pharmacist, her renal function test showed his eGFR to be 43mL/minute/1.73m2. The pharmacist wants to alter the dose. Taking into account the patient’s eGFR, which of the following would be the most appropriate dose of Ramipril? A. B. C. D. E. 2.5mg daily 5mg daily 7.5mg daily 10mg daily Ramipril is contraindicated 45. Mr U has come into the pharmacy with a prescription for Bumetanide 2mg BD. When asking the patient how he’s been getting on with the medication and if he has been taking the medication as prescribed, he states that he’s been taking Bumetanide 2md OM for the past 4 months. Which of the following is the most appropriate action to take? A. B. C. D. E. Counsel Mr U to take the doses at 8am and 8pm Counsel Mr U to take the doses at 8am and 2pm Contact the prescriber as this is a prescribing error Contact the prescriber as bumetanide should be given once daily Ask Mr U to go back to his GP for a new prescription 46. Mrs IH is 78 years old and has minor visual impairment but struggles to read. She is prescribed warfarin and wants to know what the correct colours for each of her warfarin tablets are. Which of the following are the correct colours for the different strength warfarin tablets? A. B. C. D. E. 1mg brown, 3mg pink and 5mg blue 1mg blue, 3mg pink and 5mg brown 1mg brown, 3mg blue and 5mg pink 1mg pink, 3mg blue and 5mg brown 1mg blue, 3mg brown and 5mg pink 47. One of your regular patients presents to the community pharmacy with a prescription. She has recently been diagnosed with hypertension and the GP is commencing and antihypertensive. She is 42 years of age and originates from the Caribbean. Chapter 2 Quiz BNF Cardiovascular System According to NICE guidelines in managing hypertension in adults, which of the following is the most appropriate first-line option for the patient? A. B. C. D. E. Atenolol 25mg tablets Bendroflumethiazide 2.5mg tablets Furosemide 20mg tablets Lercanidipine 10mg tablets Ramipril 2.5mg capsules 48. Mrs D comes into the pharmacy asking about her sore leg. You ask her if you can take a look in the consultation room. You see that it is inflamed and red. Mrs D states that it is stiff and hot to touch she also states she has recently been to Malaysia for a holiday. She also takes the combined oral contraceptive pill. Which of the following is the most appropriate advice to give? A. Mrs D should take aspirin 300mg B. Mrs D should take a regular anti-inflammatory such as ibuprofen 400mg to help with the inflammation C. Mrs D should make a non-urgent GP appointment D. Mrs D should rest and keep her leg elevated to help reduce the inflammation E. Mrs D should seek immediate medical attention 49. Mrs R is a 75-year-old patient with a past medical history of atrial fibrillation and stroke. She has been on warfarin for about 2 years and has been on a stable dose. Last month, however, she suffered a seizure and was admitted to hospital where she was prescribed an antiepileptic. Today her INR is 1.6 (target 2.5) Which of the following drugs is most likely to be responsible for the decrease in her INR? A. B. C. D. E. Carbamazepine Diazepam Gabapentin Pregabalin Valproate 50. Mr S is a 71-year-old patient with hypertension and chronic heart failure. His current medication is as follows: Digoxin 125mcg daily Ramipril 5mg daily Bisoprolol 2.5mg daily Bumetanide 2mg daily Atorvastatin 80mg at NIGHT Vitamin D3 1000 units daily Which of his medications listed above is most likely to predispose Mr S to digoxin toxicity? A. B. C. D. E. Ramipril 10mg Bumetanide 2mg Bisoprolol 2.5mg Atorvastatin 40mg Vitamin D3 1000 units 51. You receive a telephone call from a local GP asking which statin to prescribe for the primary prevention of cardiovascular disease (CVD). They have just used the QRISK2 assessment tool. Which of the following is recommended for the primary prevention of CVD for people who have a 10% or greater 10-year risk of developing CVD? Chapter 2 Quiz A. B. C. D. E. BNF Cardiovascular System Simvastatin 20mg daily Rosuvastatin 5mg daily Atorvastatin 10mg daily Simvastatin 80mg daily Atorvastatin 20mg daily 52. Warfarin can be used for various thrombotic conditions for variable lengths of time. Which of the following statements is CORRECT? A. A patient with a prosthetic heart valve requires warfarin for 12 weeks B. A patient with isolated calf-vein deep-vein thrombosis requires warfarin for 12 weeks C. A patient who’s acquired a venous thromboembolism from surgery requires warfarin for 1 month D. A patient who has an unprovoked proximal deep vein thrombosis requires warfarin for at least 3 months E. A patient who has atrial fibrillation requires warfarin for 1 month 53. A woman with previous diagnosis of STEMI was admitted to hospital with chest pain. Her regular medication included aspirin and Clopidogrel. She was subsequently diagnosed with atrial fibrillation and requires long-term anticoagulation therapy. Which of the following combinations is NOT a licensed treatment, for this patient? A. B. C. D. E. Aspirin, Ticagrelor, and low-dose rivaroxaban Aspirin, Clopidogrel and warfarin Aspirin and low-dose rivaroxaban Aspirin, Clopidogrel and low-dose rivaroxaban Aspirin and warfarin 54. A 57-year-old man weighs 83kg and has a creatinine clearance of 55mL/min. he has been diagnosed with atrial fibrillation. He has been recently prescribed warfarin and would like to know if there are any dietary restrictions when taking warfarin. Which of the following would be the most appropriate advice? A. B. C. D. E. He should seek medical advice before undertaking any major changes in diet He should avoid eating green leafy vegetables He should avoid drinking orange juice He should avoid products which contain dairy He should avoid eating chicken. 55. Mrs CVS has just been diagnosed with heart failure. She is prescribed several new medications before being discharged from hospital. Which of the following would she not have been prescribed? A. B. C. D. E. Ramipril Bisoprolol Warfarin Atorvastatin 40mg Spironolactone 56. Mrs M, a 75-year-old female, calls the pharmacy and complains of feeling dizzy and offbalance. She has also noticed a yellow tint in her vision. She mentions that she started a new tablet not long ago. You check the PMR and see the following: Evacal D3 tablet – ONE twice a day Digoxin 125 mcg tablets – ONE daily Bumetanide 1mg tablets – HALF ONCE a day Which of the following is the most likely to cause for Mrs M’s visual disturbance? Chapter 2 Quiz A. B. C. D. E. BNF Cardiovascular System Hypokalaemia Hyperkalaemia Hypernatraemia Hypercalcaemia Hyponatraemia 57. A patient is starting on Ticagrelor 90g tablets for acute coronary syndrome. The GP asks you to provide counselling on the medicine. Which one of the following points would be least appropriate? A. B. C. D. E. Common side effects include constipation, diarrhoea, dizziness, dyspepsia and dyspnoea Advise the patient to discard the tablets twelve weeks after opening Let your doctor know if you get pregnant Visit your doctor after one month to monitor your renal function Take two tablets initially, then 90mg twice daily for up to 12 months 58. A sexually active woman has been prescribed tranexamic acid to manage her symptoms of menorrhagia. She comes into your pharmacy to discuss whether tranexamic acid is safe to take alongside her other medicines. Which of the following drugs is most likely to interact with tranexamic acid? A. B. C. D. E. Combined hormonal contraceptive Ciclosporin Amoxicillin Phenytoin Warfarin 59. A patient was admitted as an emergency for gastrointestinal surgery. The patient was stable on warfarin prior to the accident. His INR target was 2.5 and he was always within target range. Enoxaparin was given during the hospital stay. The patient is due to be discharged back after 2 days in hospital and warfarin is to be restarted. Which of the following is the most suitable way of restarting the warfarin? A. Enoxaparin can be given on discharge and the GP can restart the warfarin B. Enoxaparin should be stopped and then warfarin started the following day C. Warfarin should be restarted at the original dose and then enoxaparin stopped once the INR is over 2 D. Warfarin should be started at the original dose and then enoxaparin stopped the day afterwards E. Enoxaparin should be stopped and the warfarin should be prescribed as if the patient is taking for the first time. 60. Mr B comes in to collect his usual monthly prescription. Upon talking to him, he mentions that he has noticed that his urine appears to be of a blue colour sometimes. He wonders if it is related to that new water tablet he was started on. Which of the following drugs below could blue urine be associated with? A. B. C. D. Metolazone Indapamide Bendroflumethiazide Triamterene 61. Mr AF has just been commenced on a new medication from his cardiologist. He has been informed that he will need to attend his GP every 6 months so that his TFTs can be checked. Which drug below is this monitoring requirement most likely be applicable too? Chapter 2 Quiz A. B. C. D. BNF Cardiovascular System Digoxin Sotalol Valsartan Amiodarone 62. Mr BP 45-years-old, brings in a prescription for a new medication. This medication has been prescribed to help control Mr BPs blood pressure. Upon handing out this medication, you advise Mr BP that he should take the first dose of this drug at night-time, as it may cause “first-dose hypotension”. Which of the drugs below would this advice be most suitable for? A. B. C. D. Doxazosin Amlodipine Verapamil Bendroflumethiazide 63. Mrs O Mron 42-years-old, has recently had an antenatal appointment, as she has found out she is pregnant. The midwife believes that Mrs O Mron is at high risk of developing preeclampsia and writes to the GP advising if they can prescribe Aspirin 150mg to be taken. From what week during the pregnancy would you expect Mrs O Mron to commence a daily dose of 150mg Aspirin? A. B. C. D. Week 1 Week 9 Week 12 Week 36 64. Which of the drugs below, used for the treatment of stable angina can cause serious skin, mucosal and eye ulceration, including gastrointestinal ulcers? A. B. C. D. Atenolol Bisoprolol Nicorandil Verapamil 65. What electrolyte disturbance would be most likely to occur with co-administration of Ramipril and Spironolactone? A. B. C. D. Hypokalaemia Hyperkalaemia Hyponatraemia Hypermagnesia 66. Which one of the following diuretics is associated with gynecomastia? A. B. C. D. Furosemide Bumetanide Bendroflumethiazide Eplerenone 67. Mr Q has been admitted to hospital due to having blackouts and heart palpitations. An ECG was conducted, and Mr Q was found to have a prolonged QT interval. Upon reviewing his medication, you see that he is taking Sotalol. Which of the following drugs below can cause an increased risk of QT prolongation when taken alongside Sotalol? A. Haloperidol Chapter 2 Quiz BNF Cardiovascular System B. Naproxen C. Digoxin D. Methotrexate 68. Which of the following drugs has a potential interaction with cranberry juice? A. B. C. D. Apixaban Clopidogrel Warfarin Amiodarone 69. Mr F Ruty, has come into practice to visit you today for his annual poly pharmacy medication review. You take this time to remind Mr F Ruty about important interactions with certain medications he is taking. Which ONE of the following medications below would prompt you to advise Mr F Ruty to avoid drinking grapefruit juice, due to an interaction? A. B. C. D. Apixaban Aspirin Warfarin Simvastatin 70. Mr H a 47-year-old patient has recently been diagnosed with GORD. He is currently taking Aspirin 75mg OD, Atorvastatin 80mg OD, Ramipril 5mg OD, Bisoprolol 5mg OD and Clopidogrel 75mg OD. Which of the drugs below would be least suitable for Mr H? A. B. C. D. Omeprazole Rabeprazole Pantoprazole Ranitidine 71. Which one of the following diuretics is associated with gynecomastia? A. B. C. D. Spironolactone Bendroflumethiazide Furosemide Bumetanide 72. What electrolyte disturbance would be most likely to occur with co-administration of Candesartan and Spironolactone? A. B. C. D. Hypokalaemia Hyperkalaemia Hyponatraemia Hypermagnesia 73. Which of the drugs below is associated with causing gynecomastia? A. B. C. D. Spironolactone Bendroflumethiazide Furosemide Chlortalidone 74. You are discussing a patient at a MDT meeting. This particular patient has been classed as having resistant hypertension and is currently on 3 different anti-hypertensives as listed below: Perindopril 8mg 1 OD Chapter 2 Quiz BNF Cardiovascular System Amlodipine 10mg 1 OD Indapamide 2.5mg 1 OD Despite treatment with 3 antihypertensives, the patients BP is still not adequately controlled and within target. You suggest trialling low dose spironolactone, as a 4th agent. What particular electrolyte should be monitored when initiating spironolactone, especially in combination with Perindopril? A. B. C. D. Sodium Potassium Calcium Magnesium 75. Upon asking Ms Anne Gina when she last used her GTN tablets, she informed you it was about 1 month ago when she overdone it in the garden, but didn’t think they worked as well as when she first opened the bottle and used some 3 months ago. She proudly tells you that she carries them around with her all the time and shows you. Looking at the label on the opened bottle you can see that this was dispensed on the 19/12/2019. You take this opportunity to remind Ms O how important it is to discard GTN SL after a period of time once they have been opened. When should the GTN SL tablets be discarded once they are in use? A. B. C. D. After 1 week After 4 weeks After 8 weeks After 12 weeks 76. You are counselling Mr N Trout on a new medication. This new medication is a cardiovascular medicine which should be administered twice daily as per prescription. However, to avoid a build-up of “tolerance” to the drug, it is important that the second dose is taken around 8 hours after the first dose instead of 12 hours. Which medication below is this counselling likely to be related to? A. B. C. D. Isosorbide Mononitrate Ramipril Apixaban Nifedipine 77. Whilst working at the practice, a GP asks you for some advice. A patient is struggling to remember their night-time medications and often misses them. To help aid compliance the GP has asked you to do a meds review to see which of the drugs taken at night-time could possibly be switched to the morning. One of the drugs include a statin. Which of the following statins below would be most appropriate to be administered in the morning? A. Fluvastatin B. Pravastatin C. Atorvastatin D. Simvastatin 78. 6 monthly monitoring of TFTs should usually be conducted in patients taking which od the drugs below? A. B. C. D. Digoxin Amiodarone Sotalol Valsartan Chapter 2 Quiz BNF Cardiovascular System 79. Mr P has just been discharged after a successful hip replacement operation. He has been discharged with Rivaroxaban 10mg 1 OD for prophylaxis of VTE. How long would you expect Mr P to take the Rivaroxaban for? A. B. C. D. 14 days 21 days 28 days 35 days 80. Mrs G Estation is 37-year-old and is pregnant. She has pre-existing hypertension in which she takes Ramipril to control. The GP has referred Mrs G Estation to the specialist for management of this during her pregnancy, but in the interim, has decided to stop the Ramipril and switch it to another anti-hypertensive agent which is more suitable in pregnancy. From which of the following dugs below, would most be suitable to be used as an antihypertensive in pregnancy? A. B. C. D. Propranolol Bisoprolol Labetalol Pindolol 81. You are discussing with the nursing team the number of patients who are coming into the surgery to get their INR tested due to being on warfarin. As part of a measure to try and reduce this you identify a cohort of patients who are eligible and willing to switch over to a DOAC. One of the nurses asks what a patients INR should ideally be if they are to switch over to Apixaban from Warfarin straight away? A. B. C. D. <2 <2.5 Between 2-3 >2.5 82. Mr I Pertenshun 53-years-old, has come back to see you in your hypertension clinic at the practice. After a discussion with Mr I Pertenshun, you commence him on Ramipril to help reduce and control his blood pressure, after initial lifestyle and diet interventions failed to reduce it down to target levels. How long should be allowed to determine a response to Ramipril? A. B. C. D. At least 1 week At least 2 weeks At least 4 weeks At least 8 weeks 83. Mr Knight-Driver brings in a prescription for Amiodarone. From your PMR you can see that he hasn’t had this item dispensed from you before, and ascertain it is a new medicine. Mr. Knight-Driver asks you about side effects related to the medication. Which of the following below is not recognised as a side effect of Amiodarone? A. B. C. D. Vomiting Thyroid Disorders Yellow Vision Corneal Microdeposits 84. Mrs Ange Gina has come into the pharmacy to hand in a prescription for Isosorbide Mononitrate 40mg 1BD. She mentions that he was a bit confused as when best to take them. Chapter 2 Quiz BNF Cardiovascular System The doctor advised that they should be taken a little differently to normal twice daily medications and asks if you could clarify on when best to take them. When should the second dose of Isosorbide Mononitrate be taken? A. B. C. D. After 4 hours After 6 hours After 8 hours After 12 hours 85. Mr A Tia 67-years-old has just been commenced on medication to take in conjunction with Aspirin for the secondary prevention of TIA. This is the first time Mr A Tia is taking this medication, and you proceed to counsel him on the medication. Whilst talking you advise him that this particular medication should always be kept in its original container, and any capsules should be discarded 6 weeks after opening. Which drug from below is this information most related to? A. B. C. D. GTN S/L tablets Dipyridamole M/R capsules Apixaban Digoxin 86. Stage 1 hypertension is classified as? A. Clinic BP: 140/90 mmHg – 159/99 mmHg + ABPM/HBPM average BP: 135/85 mmHg – 149/94 mmHg B. Clinic BP: 130/80 mmHg – 149/89 mmHg + HBPM average BP: 135/85 mmHg – 149/94 mmHg C. Clinic BP: 140/80 mmHg – 159/99 mmHg + ABPM/HBPM average BP: 135/85 mmHg – 149/94 mmHg D. Clinic BP: 160/100 mmHg – 180/120 mmHg + ABPM/HBPM average BP: 135/85 mmHg – 149/94 mmHg 87. Mr P has been diagnosed with having stable angina. He has been discharged from the cardiology team. You are processing the discharge letter and updating the list of medications which are to be commenced for Mr P. Some of the drugs prescribed are to prevent CVD events from occurring again. What statin would you expect to see prescribed for Mr P? A. B. C. D. Atorvastatin 20mg Simvastatin 20mg Simvastatin 40mg Atorvastatin 80mg 88. You are counselling Mr N Trout on a new medication. This new medication is a cardiovascular medicine which should be administered twice daily as per prescription. However, to avoid a build-up of “tolerance” to the drug, it is important that the second dose is taken around 8 hours after the first dose instead of 12 hours. Which medication below is this counselling likely to be related to? A. B. C. D. Isosorbide Mononitrate Ramipril Apixaban Nifedipine 89. Some beta-blockers are classed as “cardio-selective”. These beta-blockers predominantly work on the B1 receptors in the heart. Which of the following beta-blockers is not classed as “Cardio-selective”? Chapter 2 Quiz A. B. C. D. BNF Cardiovascular System Atenolol Metoprolol Nebivolol Propranolol 90. Mr N.C has been complaining of a painful, swollen, red and warm big toe. After some more investigations and questions, you diagnose Mr N.C with having gout in his big toe. You prescribe Colchicine 500mcg QDS for 3 days. Upon looking at Mr N.C’s medical record you note that this has become a common problem over the last year. As well as dietary and lifestyle measures, you can see that there is a possibility to optimise and maybe switch one of the medications Mr N.C is taking. Which of the medications below could possibly be changed to try reduce further attacks of gout? A. B. C. D. Sildenafil Furosemide Atorvastatin Candesartan 91. Mr Q has been admitted to hospital due to having blackouts and heart palpitations. An ECG was conducted, and Mr Q was found to have a prolonged QT interval. Upon reviewing his medication, you see that he is taking Sotalol. Which of the following drugs below can cause an increased risk of QT prolongation when taken alongside Sotalol? A. B. C. D. Citalopram Naproxen Digoxin Methotrexate 92. Mrs L I Pitor has recently been started on Atorvastatin 20mg. She had her LFTs checked before starting treatment. Assuming there are no signs or symptoms suggestive of hepatotoxicity, when should she next have her LFTs checked again? A. B. C. D. Within 3 months Within 4 months Within 5 months Within 6 months 93. Mr A has just been for his annual review at the practice. As part of this review bloods are taken to monitor his eGFR, liver function, renal function, thyroid function and a FBC is also undertaken. The bloods have come back, and it is found that his Thyroid Function Tests have shown abnormal results. Which of the medicines below is most likely to have caused this change? A. B. C. D. Amiodarone Digoxin Flecainide Clopidogrel 94. Mr Night-Driver brings in a prescription for Amiodarone. From your PMR you can see that he hasn’t had this item dispensed from you before, and ascertain it is a new medicine. Mr NightDriver asks you about side effects related to the medication. Which of the following below is not recognised as a side effect of Amiodarone? Chapter 2 Quiz A. B. C. D. BNF Cardiovascular System Vomiting Thyroid disorders Yellow vision Corneal Microdeposits 95. Mrs A 39-years-old has been booked into your hypertension clinic after having her BP checked by the HCA. You commence her on Ramipril as per hypertension guidelines and review her in 3 weeks. After 2 weeks Miss A rings you to tell you she has stopped taking the Ramipril, due to developing a dry persistent cough. A few days after stopping the medication, the cough also stopped. You offer her an alternative anti-hypertensive. Which drug below is most likely to be offered as an alternative? A. B. C. D. Candesartan Perindopril Indapamide Amlodipine 96. Which of the beta-blockers below is not classed as water soluble? A. B. C. D. Atenolol Celiprolol Nadolol Bisoprolol 97. Which of the following drugs is a direct Xa inhibitor? A. B. C. D. Warfarin Aspirin Apixaban Dalteparin 98. Mr U Rick has been complaining of a painful, swollen, red and warm big toe. After some more investigations and questions, you diagnose Mr U Rick with having gout in his big toe. You prescribe Colchicine 500mcg QDS for 3 days. Upon looking at Mr U Rick medical record you note that this has become a common problem over the last year. As well as dietary and lifestyle measures, you can see that there is a possibility to optimise and maybe switch one of the medications Mr U Rick is taking. Which of the medications below could possibly be changed to try reduce further attacks of gout? A. B. C. D. Sildenafil Febuxostat Bendroflumethiazide Amlodipine 99. Mrs L I Pitor has recently been started on Atorvastatin 20mg. She had her LFTs checked before starting treatment. Assuming there are no signs or symptoms suggestive of hepatotoxicity, when should she next have her LFTs checked again? A. B. C. D. Within 3 months Within 4 months Within 5 months Within 6 months 100. Mr A has just been for his annual review at the practice. As part of this review bloods are taken to monitor his eGFR, liver function, renal function, thyroid function and a FBC is also Chapter 2 Quiz BNF Cardiovascular System undertaken. The bloods have come back, and it is found that his Thyroid Function Tests have shown abnormal results. Which of the medicines below is most likely to have caused this change? A. B. C. D. Amiodarone Digoxin Flecainide Clopidogrel 101. Some beta-blockers are classed as “cardio-selective”. These beta-blockers predominantly work on the B1 receptors in the heart. Which of the following beta-blockers is not classed as “cardio-selective”? A. B. C. D. Atenolol Metoprolol Nebivolol Propranolol 102. Which of the drugs below, used for the treatment of stable angina can cause serious skin, mucosa and eye ulceration, including gastrointestinal ulcers? A. B. C. D. 103. A. B. C. D. 104. Atenolol Bisoprolol Nicorandil Verapamil Which of the following counselling points is false regarding Warfarin use? Large amounts of green leafy vegetables should be avoided It is present in milk, therefore should be avoided in breast feeding mothers Patients should be advised to consult their GP if they develop a painful skin rash Patients should make their dentist aware that they take Warfarin before undergoing dental surgery. Which one of the following parenteral anticoagulants has a longer duration of action? A. Low-molecular heparins B. Unfractionated heparins 105. Mr Q has been admitted to hospital due to having blackouts and heart palpitations. An ECG was conducted, and Mr Q was found to have a prolonged QT interval. Upon reviewing his medication, you see that he is taking Sotalol. Which of the following drugs below can cause an increased risk of QT prolongation when taken alongside Sotalol? A. B. C. D. Haloperidol Naproxen Digoxin Methotrexate 106. What electrolyte disturbance would be most likely to occur with co-administration of Trimethoprim and Amiloride? A. B. C. D. Hypokalaemia Hyperkalaemia Hyponatraemia Hypernatraemia Chapter 2 Quiz BNF Cardiovascular System 107. Mrs F has recently been prescribed Warfarin. Your pre-reg student asks you what colour each different strength tablet is. Which of the following is correct? A. B. C. D. 0.5mg (Pink), 1mg (Brown), 3mg (Blue), 5mg (White) 0.5mg (White), 1mg (Pink), 3mg (Brown), 5mg (Blue) 0.5mg (Brown), 1mg (White), 3mg (Blue), 5mg (Pink) 0.5mg (White), 1mg (Brown), 3mg (Blue), 5mg (Pink) 108. Both Amiodarone and Digoxin can increase the risk of bradycardia. What do manufacturers advise when both drugs are given together? A. B. C. D. 109. A. B. C. D. Half the dose of Amiodarone Half the dose of Digoxin Quarter the dose of Amiodarone Quarter the dose of Digoxin Which of the following is vitamin D3? Ergocalciferol Calcitriol Colecalciferol Alfacalcidiol 110. Mrs A 39-years-old has been booked into your hypertension clinic after having her BP checked by the HCA. You commence her on Ramipril as per hypertension guidelines and review her in 3 weeks. After 2 weeks Miss A rings you to tell you she has stopped taking the Ramipril, due to developing a dry persistent cough. A few days after stopping the medication, the cough also stopped. You offer her an alternative anti-hypertensive. Which drug below is most likely to be offered as an alternative? A. B. C. D. Candesartan Bisoprolol Bendroflumethiazide Verapamil 111. Mr F 59-years-old, brings in a prescription to the pharmacy. He informs you that he has never taken medications in his life, and now has been diagnosed with high blood pressure and started on these tablets. He asks if you could explain some of the side effects relating to the drug. Upon counselling Mr F, you inform him that swollen ankles are a common side effect, affecting >1/10 people taking the medication. Which medication below is this side effect most likely to be related too? A. B. C. D. Ramipril Perindopril Doxazosin Felodipine 112. You are discussing a patient at a MDT meeting. This particular patient has been classed as having resistant hypertension and is currently on 3 different anti-hypertensives as listed below: Perindopril 8mg 1 OD Amlodipine 10mg 1 OD Indapamide 2.5mg 1 OD Despite treatment with 3 antihypertensives, the patients BP is still not adequately controlled and within target. You suggest trialling low dose spironolactone, as a 4th agent. Chapter 2 Quiz BNF Cardiovascular System What particular electrolyte should be monitored when initiating spironolactone, especially in combination with Perindopril? A. B. C. D. Sodium Potassium Calcium Magnesium 113. Mr IP 45-years-old, brings in a prescription for a new medication. This medication has been prescribed to help control Mr IP’s blood pressure. Upon handing out this medication, you advise Mr IP that he should take the first dose of this drug at night-time, as it may cause “first-dose hypotension”. Which of the drugs below would this advice be most suitable for? A. B. C. D. Doxazosin Amlodipine Verapamil Indapamide 114. Mr AF has just been commenced on a new medication from his cardiologist. He has been informed that he will need to attend his GP every 6 months so that his TFTs can be checked. Which drug below is most likely to require TFTs being checked every 6 months? A. B. C. D. Digoxin Amiodarone Sotalol Valsartan 115. Mr P has come into your clinic today for his annual review. He is 59-years-old, and is currently taking the following medication: Perindopril 4mg OD Amlodipine 10mg OD Metformin 500mg 2 BD Whilst undertaking the review you calculate Mr Ps QRISK score. This has been calculated at 23%. You discuss the relevance of this score with Mr P, and offer him a primary prevention statin. He is very keen to take this statin, however before initiating it you advise that some base line bloods need to be carried out. Which one of the following would not need to be carried out as baseline bloods for initiating a statin? A. B. C. D. Non-fasting lipid profile CRP Renal function TSH 116. Mr C Ramp 63-years-old, has come into the practice to discuss a side effect from a new medication which has been started. A few weeks ago, you had a conversation regarding CVD risk, and commenced Mr C Ramp on Atorvastatin 20mg, for the primary prevention of CVD as his QRISK was >10%. He has come back informing you that he has started to experience generalised, persistent muscle pain, which has been reported to have started after the initiation of the statin. What blood test would be the most appropriate to carry out to investigate this muscle pain? A. TSH B. Creatinine Kinase C. HbA1C Chapter 2 Quiz BNF Cardiovascular System D. U&Es 117. Some beta-blockers are classed as “cardio-selective”. These beta-blockers predominantly work on the B1 receptors in the heart. Which of the following beta-blockers is not classed as “cardio-selective”? A. B. C. D. Atenolol Metoprolol Nebivolol Propranolol 118. Which of the following diuretics can be given twice daily, if needed, without risking interfering with sleep? A. B. C. D. 119. A. B. C. D. Metazalone Bendroflumethiazide Furosemide Indapamide Which one the following diuretics is associated with gynecomastia? Bumetanide Spironolactone Furosemide Indapamide 120. You are conducting a hypertension CPD session with the clinical team at the practice. As part of this session you refresh knowledge regarding drugs and other substances which may account for secondary causes of hypertension. Which of the following drugs/substances is NOT known for causing secondary hypertension? A. B. C. D. Ciclosporin Leflunomide NSAIDs Progesterone Only Pill