Anti-Diabetics Glibenclamide (Glyburide) lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally. May be taken 1-2 times per day Repaglinide (prandin)- Repaglinide helps your body regulate the amount of glucose (sugar) in your blood. It decreases the amount of glucose by stimulating the pancreas to release insulin. Metformin (Glucophage)- It decreases the amount of glucose you absorb from your food and the amount of glucose made by your liver. Metformin also increases your body's response to insulin, a natural substance that controls the amount of glucose in the blood. Exenatide (Byetta)- It works by stimulating the pancreas to secrete insulin when blood sugar levels are high. Exenatide also slows the emptying of the stomach and causes a decrease in appetite. Given subq Saxagliptin (Onglyza)- It works by increasing the amount of insulin produced by the body after meals when blood sugar is high. Given PO Pioglitazone (Actos)- It works by increasing the body's sensitivity to insulin. Given PO Acarbose (Prandase)- Acarbose works by slowing the action of certain chemicals that break down food to release glucose (sugar) into your blood. Given PO Pramlintide (Symlin Pen)- It works by slowing the movement of food through the stomach. This prevents blood sugar from rising too high after a meal, and may decrease appetite and cause weight loss. Given subq Canagliflozin (Invokana)- It lowers blood sugar by causing the kidneys to get rid of more glucose in the urine. Given PO Insulin Lispro (humalog)- Insulin lispro injection products are a short-acting, manmade version of human insulin. Insulin lispro injection products work by replacing the insulin that is normally produced by the body and by helping move sugar from the blood into other body tissues where it is used for energy. They also stops the liver from producing more sugar. Insulin lispro solution (Admelog, Humalog) is usually injected within 15 minutes before a meal or immediately after a meal. Insulin Glargine- Insulin glargine is a long-acting, manmade version of human insulin. Insulin glargine works by replacing the insulin that is normally produced by the body and by helping move sugar from the blood into other body tissues where it is used for energy. It also stops the liver from producing more sugar. It is injected once a day.