Histopathologic changes in
Lung Sar-Cov2 infection
Histopathologic changes in Lung Sar-Cov2
infection
• The specimen was taken from 72
years old man
• History: diabetes, hypertension,
presented with fever and cold
• Pharyngeal swab: Positive for
Sars-Cov-2
Ground glass opacity
Histopathologic changes in Lung Sar-Cov2
infection
• The histopathologic changes seen on post mortem specimen
consistent with diffuse alveolar damage
Histopathologic changes in Lung Sar-Cov2
infection
- Diffuse alveolar damage
- Arrow 1. Denudation of alveolar lining
- Arrow 2. Reactive type II pneumocyte
Hyperplasia
- Arrow 3. Intra-alveolar fibrinous plugs
- Arrow 4. Interstitial loose fibrosis with
chronic inflammatory infiltrates
Histopathologic changes in Lung Sar-Cov2
infection
-Arrow 5. Intra alveolar loose fibrous plug
-Arrow 6. Organizing fibrin
Histopathologic changes in Lung Sar-Cov2
infection
- Blue arrow: interstitial area between
the alveoli
- Green arrow: injured epithelial cells
desquamated into alveolar space
- Immunostaining of SARS-COV-2 in lung
section, against the Rp3 NP protein
(conserved protein in SARs-coV)  Red